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Protein

Sorting nexin-13

Gene

SNX13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in several stages of intracellular trafficking. May play a role in endosome homeostasis (By similarity). Acts as a GAP for Galphas.By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei612Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei614Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei639Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei653Phosphatidylinositol 3-phosphateBy similarity1

GO - Molecular functioni

  • phosphatidylinositol-3-phosphate binding Source: GO_Central
  • phosphatidylinositol binding Source: UniProtKB

GO - Biological processi

  • intracellular protein transport Source: UniProtKB
  • negative regulation of signal transduction Source: UniProtKB-KW
  • positive regulation of GTPase activity Source: UniProtKB

Keywordsi

Molecular functionSignal transduction inhibitor
Biological processProtein transport, Transport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-13
Alternative name(s):
RGS domain- and PHOX domain-containing protein
RGS-PX1
Gene namesi
Name:SNX13
Synonyms:KIAA0713
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000071189.21
HGNCiHGNC:21335 SNX13
MIMi606589 gene
neXtProtiNX_Q9Y5W8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23161
OpenTargetsiENSG00000071189
PharmGKBiPA129697240

Polymorphism and mutation databases

BioMutaiSNX13
DMDMi24418867

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002138601 – 968Sorting nexin-13Add BLAST968

Proteomic databases

EPDiQ9Y5W8
PaxDbiQ9Y5W8
PeptideAtlasiQ9Y5W8
PRIDEiQ9Y5W8
ProteomicsDBi86522
86523 [Q9Y5W8-2]

PTM databases

iPTMnetiQ9Y5W8
PhosphoSitePlusiQ9Y5W8

Expressioni

Gene expression databases

BgeeiENSG00000071189 Expressed in 228 organ(s), highest expression level in stomach
CleanExiHS_SNX13
ExpressionAtlasiQ9Y5W8 baseline and differential
GenevisibleiQ9Y5W8 HS

Interactioni

Protein-protein interaction databases

BioGridi116773, 10 interactors
IntActiQ9Y5W8, 4 interactors
STRINGi9606.ENSP00000398789

Structurei

3D structure databases

ProteinModelPortaliQ9Y5W8
SMRiQ9Y5W8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini97 – 284PXAPROSITE-ProRule annotationAdd BLAST188
Domaini373 – 496RGSPROSITE-ProRule annotationAdd BLAST124
Domaini570 – 691PXPROSITE-ProRule annotationAdd BLAST122

Domaini

The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.1 Publication

Sequence similaritiesi

Belongs to the sorting nexin family.Curated

Phylogenomic databases

eggNOGiENOG410IMHZ Eukaryota
ENOG410XRJ0 LUCA
GeneTreeiENSGT00800000124081
HOGENOMiHOG000059640
HOVERGENiHBG060026
InParanoidiQ9Y5W8
KOiK17925
OMAiQYIIWMI
OrthoDBiEOG091G033E
PhylomeDBiQ9Y5W8
TreeFamiTF324055

Family and domain databases

CDDicd06873 PX_SNX13, 1 hit
cd08719 RGS_SNX13, 1 hit
Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR001683 Phox
IPR003114 Phox_assoc
IPR036871 PX_dom_sf
IPR016137 RGS
IPR036305 RGS_sf
IPR037437 SNX13_PX
IPR037896 SNX13_RGS
IPR013937 Sorting_nexin_C
PfamiView protein in Pfam
PF08628 Nexin_C, 1 hit
PF00787 PX, 1 hit
PF02194 PXA, 1 hit
PF00615 RGS, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SM00313 PXA, 1 hit
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit
PS51207 PXA, 1 hit
PS50132 RGS, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y5W8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLTEASLSIW GWGSLGIVLF LITFGPFVIF YLTFYILCFV GGGLVVTLLF
60 70 80 90 100
GKTNSEKYLE QCEHSFLPPT SPGVPKCLEE MKREARTIKI DRRLTGANII
110 120 130 140 150
DEPLQQVIQF SLRDYVQYWY YTLSDDESFL LEIRQTLQNA LIQFATRSKE
160 170 180 190 200
IDWQPYFTTR IVDDFGTHLR VFRKAQQKIT EKDDQVKGTA EDLVDTFFEV
210 220 230 240 250
EVEMEKEVCR DLVCTSPKDE EGFLRDLCEV LLYLLLPPGD FQNKIMRYFV
260 270 280 290 300
REILARGILL PLINQLSDPD YINQYVIWMI RDSNCNYEAF MNIIKLSDNI
310 320 330 340 350
GELEAVRDKA AEELQYLRSL DTAGDDINTI KNQINSLLFV KKVCDSRIQR
360 370 380 390 400
LQSGKEINTV KLAANFGKLC TVPLDSILVD NVALQFFMDY MQQTGGQAHL
410 420 430 440 450
FFWMTVEGYR VTAQQQLEVL LSRQRDGKHQ TNQTKGLLRA AAVGIYEQYL
460 470 480 490 500
SEKASPRVTV DDYLVAKLAD TLNHEDPTPE IFDDIQRKVY ELMLRDERFY
510 520 530 540 550
PSFRQNALYV RMLAELDMLK DPSFRGSDDG DGESFNGSPT GSINLSLDDL
560 570 580 590 600
SNVSSDDSVQ LHAYISDTVY ADYDPYAVAG VCNDHGKTYA LYAITVHRRN
610 620 630 640 650
LNSEEMWKTY RRYSDFHDFH MRITEQFESL SSILKLPGKK TFNNMDRDFL
660 670 680 690 700
EKRKKDLNAY LQLLLAPEMM KASPALAHYV YDFLENKAYS KGKGDFARKM
710 720 730 740 750
DTFVNPLRNS MRNVSNAVKS LPDSLAEGMT KMSDNMGKMS ERLGQDIKQS
760 770 780 790 800
FFKVPPLIPK TDSDPEHRRV SAQLDDNVDD NIPLRVMLLL MDEVFDLKER
810 820 830 840 850
NQWLRRNIKN LLQQLIRATY GDTINRKIVD HVDWMTSPEQ VADSVKRFRD
860 870 880 890 900
AFWPNGILAE AVPCRDKSIR MRTRVAGKTK LLAIMPDELK HIIGAETTRK
910 920 930 940 950
GILRVFEMFQ HNQLNRRMVY VFLEGFLETL FPQYKFRELF NKLHSRSKQM
960
QKYKQKLQTT QAPSLQKR
Length:968
Mass (Da):112,189
Last modified:October 25, 2002 - v4
Checksum:i532994AE0B347FB5
GO
Isoform 2 (identifier: Q9Y5W8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     569-579: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.
Show »
Length:957
Mass (Da):110,960
Checksum:iAC41207BE22F3557
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WUZ7A0A087WUZ7_HUMAN
Sorting nexin 13, isoform CRA_g
SNX13 hCG_2009798
888Annotation score:
Q9NSH0Q9NSH0_HUMAN
Sorting nexin 13, isoform CRA_d
SNX13 DKFZp761E0611, hCG_2009798
189Annotation score:
F8W8A9F8W8A9_HUMAN
Sorting nexin-13
SNX13
154Annotation score:
F8WB11F8WB11_HUMAN
Sorting nexin-13
SNX13
43Annotation score:

Sequence cautioni

The sequence AAH22060 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA34433 differs from that shown. Reason: Frameshift at position 887.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti638G → E in BAA34433 (PubMed:11729322).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057333472L → S. Corresponds to variant dbSNP:rs35113148Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006192569 – 579Missing in isoform 2. 2 PublicationsAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF420470 mRNA Translation: AAL37728.1
AB018256 mRNA Translation: BAA34433.1 Frameshift.
AK315135 mRNA Translation: BAG37586.1
AF121862 mRNA Translation: AAD27835.1
CH471073 Genomic DNA Translation: EAW93690.1
BC022060 mRNA Translation: AAH22060.1 Different initiation.
CCDSiCCDS47551.1 [Q9Y5W8-2]
RefSeqiNP_055947.1, NM_015132.4 [Q9Y5W8-2]
XP_005249729.1, XM_005249672.1
UniGeneiHs.487648

Genome annotation databases

EnsembliENST00000428135; ENSP00000398789; ENSG00000071189 [Q9Y5W8-2]
GeneIDi23161
KEGGihsa:23161
UCSCiuc003stv.4 human [Q9Y5W8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF420470 mRNA Translation: AAL37728.1
AB018256 mRNA Translation: BAA34433.1 Frameshift.
AK315135 mRNA Translation: BAG37586.1
AF121862 mRNA Translation: AAD27835.1
CH471073 Genomic DNA Translation: EAW93690.1
BC022060 mRNA Translation: AAH22060.1 Different initiation.
CCDSiCCDS47551.1 [Q9Y5W8-2]
RefSeqiNP_055947.1, NM_015132.4 [Q9Y5W8-2]
XP_005249729.1, XM_005249672.1
UniGeneiHs.487648

3D structure databases

ProteinModelPortaliQ9Y5W8
SMRiQ9Y5W8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116773, 10 interactors
IntActiQ9Y5W8, 4 interactors
STRINGi9606.ENSP00000398789

PTM databases

iPTMnetiQ9Y5W8
PhosphoSitePlusiQ9Y5W8

Polymorphism and mutation databases

BioMutaiSNX13
DMDMi24418867

Proteomic databases

EPDiQ9Y5W8
PaxDbiQ9Y5W8
PeptideAtlasiQ9Y5W8
PRIDEiQ9Y5W8
ProteomicsDBi86522
86523 [Q9Y5W8-2]

Protocols and materials databases

DNASUi23161
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000428135; ENSP00000398789; ENSG00000071189 [Q9Y5W8-2]
GeneIDi23161
KEGGihsa:23161
UCSCiuc003stv.4 human [Q9Y5W8-1]

Organism-specific databases

CTDi23161
DisGeNETi23161
EuPathDBiHostDB:ENSG00000071189.21
GeneCardsiSNX13
H-InvDBiHIX0006501
HGNCiHGNC:21335 SNX13
MIMi606589 gene
neXtProtiNX_Q9Y5W8
OpenTargetsiENSG00000071189
PharmGKBiPA129697240
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IMHZ Eukaryota
ENOG410XRJ0 LUCA
GeneTreeiENSGT00800000124081
HOGENOMiHOG000059640
HOVERGENiHBG060026
InParanoidiQ9Y5W8
KOiK17925
OMAiQYIIWMI
OrthoDBiEOG091G033E
PhylomeDBiQ9Y5W8
TreeFamiTF324055

Miscellaneous databases

GeneWikiiSNX13
GenomeRNAii23161
PROiPR:Q9Y5W8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000071189 Expressed in 228 organ(s), highest expression level in stomach
CleanExiHS_SNX13
ExpressionAtlasiQ9Y5W8 baseline and differential
GenevisibleiQ9Y5W8 HS

Family and domain databases

CDDicd06873 PX_SNX13, 1 hit
cd08719 RGS_SNX13, 1 hit
Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR001683 Phox
IPR003114 Phox_assoc
IPR036871 PX_dom_sf
IPR016137 RGS
IPR036305 RGS_sf
IPR037437 SNX13_PX
IPR037896 SNX13_RGS
IPR013937 Sorting_nexin_C
PfamiView protein in Pfam
PF08628 Nexin_C, 1 hit
PF00787 PX, 1 hit
PF02194 PXA, 1 hit
PF00615 RGS, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SM00313 PXA, 1 hit
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit
PS51207 PXA, 1 hit
PS50132 RGS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSNX13_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5W8
Secondary accession number(s): B2RCI9
, O94821, Q8WVZ2, Q8WXH8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 25, 2002
Last modified: November 7, 2018
This is version 161 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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