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Protein

Tumor necrosis factor receptor superfamily member 18

Gene

TNFRSF18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • tumor necrosis factor-activated receptor activity Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processApoptosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5669034 TNFs bind their physiological receptors
R-HSA-8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 18
Alternative name(s):
Activation-inducible TNFR family receptor
Glucocorticoid-induced TNFR-related protein
CD_antigen: CD357
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNFRSF18
Synonyms:AITR, GITR
ORF Names:UNQ319/PRO364
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000186891.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11914 TNFRSF18

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603905 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y5U5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26 – 162ExtracellularSequence analysisAdd BLAST137
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Topological domaini184 – 241CytoplasmicSequence analysisAdd BLAST58

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8784

Open Targets

More...
OpenTargetsi
ENSG00000186891

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36607

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3712995

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TNFRSF18

Domain mapping of disease mutations (DMDM)

More...
DMDMi
13878830

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 251 PublicationAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003459526 – 241Tumor necrosis factor receptor superfamily member 18Add BLAST216

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi34 ↔ 49By similarity
Disulfide bondi74 ↔ 86By similarity
Disulfide bondi81 ↔ 94By similarity
Disulfide bondi115 ↔ 134By similarity
Disulfide bondi128 ↔ 153By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi146N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y5U5

PeptideAtlas

More...
PeptideAtlasi
Q9Y5U5

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y5U5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
86508
86509 [Q9Y5U5-2]
86510 [Q9Y5U5-3]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q9Y5U5-2 [Q9Y5U5-2]

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in lymph node, peripheral blood leukocytes and weakly in spleen.

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000186891 Expressed in 142 organ(s), highest expression level in skin of abdomen

CleanEx database of gene expression profiles

More...
CleanExi
HS_TNFRSF18

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y5U5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y5U5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA008025

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6. Binds through its C-terminus to SIVA1/SIVA.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
TNFSF18Q9UNG22EBI-3962532,EBI-15672281

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114312, 5 interactors

Database of interacting proteins

More...
DIPi
DIP-29883N

Protein interaction database and analysis system

More...
IntActi
Q9Y5U5, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000328207

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9Y5U5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y5U5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati34 – 72TNFR-Cys 1Add BLAST39
Repeati74 – 112TNFR-Cys 2Add BLAST39
Repeati115 – 153TNFR-Cys 3Add BLAST39

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J0PX Eukaryota
ENOG410YX1D LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111424

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG054195

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y5U5

KEGG Orthology (KO)

More...
KOi
K05154

Identification of Orthologs from Complete Genome Data

More...
OMAi
RCKPWAD

Database of Orthologous Groups

More...
OrthoDBi
EOG091G03XW

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y5U5

TreeFam database of animal gene trees

More...
TreeFami
TF336151

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13417 TNFRSF18, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR022318 TNFR_18
IPR034018 TNFRSF18_N

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01968 TNFACTORR18

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00208 TNFR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y5U5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQHGAMGAF RALCGLALLC ALSLGQRPTG GPGCGPGRLL LGTGTDARCC
60 70 80 90 100
RVHTTRCCRD YPGEECCSEW DCMCVQPEFH CGDPCCTTCR HHPCPPGQGV
110 120 130 140 150
QSQGKFSFGF QCIDCASGTF SGGHEGHCKP WTDCTQFGFL TVFPGNKTHN
160 170 180 190 200
AVCVPGSPPA EPLGWLTVVL LAVAACVLLL TSAQLGLHIW QLRSQCMWPR
210 220 230 240
ETQLLLEVPP STEDARSCQF PEEERGERSA EEKGRLGDLW V
Length:241
Mass (Da):26,000
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i90DC3B4AA7E82CBE
GO
Isoform 2 (identifier: Q9Y5U5-2) [UniParc]FASTAAdd to basket
Also known as: GITR-D

The sequence of this isoform differs from the canonical sequence as follows:
     135-241: TQFGFLTVFP...EKGRLGDLWV → CWRCRRRPKT...SLAGPDGVGS

Show »
Length:255
Mass (Da):26,827
Checksum:iC986652AC97AF2CC
GO
Isoform 3 (identifier: Q9Y5U5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     194-201: SQCMWPRE → K

Show »
Length:234
Mass (Da):25,110
Checksum:i55DB593CD0B1DB45
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KT02J3KT02_HUMAN
Tumor necrosis factor receptor supe...
TNFRSF18
169Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05235443T → R. Corresponds to variant dbSNP:rs11466676Ensembl.1
Natural variantiVAR_05235564E → K. Corresponds to variant dbSNP:rs11466687Ensembl.1
Natural variantiVAR_05235683D → N. Corresponds to variant dbSNP:rs11466688Ensembl.1
Natural variantiVAR_052357173V → M. Corresponds to variant dbSNP:rs11466693Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_006508135 – 241TQFGF…GDLWV → CWRCRRRPKTPEAASSPRKS GASDRQRRRGGWETCGCEPG RPPGPPTAASPSPGAPQAAG ALRSALGRALLPWQQKWVQE GGSDQRPGPCSSAAAAGPCR RERETQSWPPSSLAGPDGVG S in isoform 2. 1 PublicationAdd BLAST107
Alternative sequenceiVSP_041021194 – 201SQCMWPRE → K in isoform 3. 1 Publication8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF125304 mRNA Translation: AAD22635.1
AF117297 mRNA Translation: AAD19694.1
AF241229 mRNA Translation: AAF63506.1
AY358877 mRNA Translation: AAQ89236.1
BT019531 mRNA Translation: AAV38338.1
BT019532 mRNA Translation: AAV38339.1
AL162741 Genomic DNA No translation available.
CH471183 Genomic DNA Translation: EAW56282.1
CH471183 Genomic DNA Translation: EAW56283.1
BC152381 mRNA Translation: AAI52382.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10.1 [Q9Y5U5-1]
CCDS30552.1 [Q9Y5U5-3]
CCDS9.1 [Q9Y5U5-2]

NCBI Reference Sequences

More...
RefSeqi
NP_004186.1, NM_004195.2 [Q9Y5U5-1]
NP_683699.1, NM_148901.1 [Q9Y5U5-2]
NP_683700.1, NM_148902.1 [Q9Y5U5-3]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.212680

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000328596; ENSP00000328207; ENSG00000186891 [Q9Y5U5-2]
ENST00000379265; ENSP00000368567; ENSG00000186891 [Q9Y5U5-3]
ENST00000379268; ENSP00000368570; ENSG00000186891 [Q9Y5U5-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8784

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8784

UCSC genome browser

More...
UCSCi
uc001adb.4 human [Q9Y5U5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125304 mRNA Translation: AAD22635.1
AF117297 mRNA Translation: AAD19694.1
AF241229 mRNA Translation: AAF63506.1
AY358877 mRNA Translation: AAQ89236.1
BT019531 mRNA Translation: AAV38338.1
BT019532 mRNA Translation: AAV38339.1
AL162741 Genomic DNA No translation available.
CH471183 Genomic DNA Translation: EAW56282.1
CH471183 Genomic DNA Translation: EAW56283.1
BC152381 mRNA Translation: AAI52382.1
CCDSiCCDS10.1 [Q9Y5U5-1]
CCDS30552.1 [Q9Y5U5-3]
CCDS9.1 [Q9Y5U5-2]
RefSeqiNP_004186.1, NM_004195.2 [Q9Y5U5-1]
NP_683699.1, NM_148901.1 [Q9Y5U5-2]
NP_683700.1, NM_148902.1 [Q9Y5U5-3]
UniGeneiHs.212680

3D structure databases

ProteinModelPortaliQ9Y5U5
SMRiQ9Y5U5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114312, 5 interactors
DIPiDIP-29883N
IntActiQ9Y5U5, 3 interactors
STRINGi9606.ENSP00000328207

Chemistry databases

ChEMBLiCHEMBL3712995

Polymorphism and mutation databases

BioMutaiTNFRSF18
DMDMi13878830

Proteomic databases

PaxDbiQ9Y5U5
PeptideAtlasiQ9Y5U5
PRIDEiQ9Y5U5
ProteomicsDBi86508
86509 [Q9Y5U5-2]
86510 [Q9Y5U5-3]
TopDownProteomicsiQ9Y5U5-2 [Q9Y5U5-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
8784
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328596; ENSP00000328207; ENSG00000186891 [Q9Y5U5-2]
ENST00000379265; ENSP00000368567; ENSG00000186891 [Q9Y5U5-3]
ENST00000379268; ENSP00000368570; ENSG00000186891 [Q9Y5U5-1]
GeneIDi8784
KEGGihsa:8784
UCSCiuc001adb.4 human [Q9Y5U5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8784
DisGeNETi8784
EuPathDBiHostDB:ENSG00000186891.13

GeneCards: human genes, protein and diseases

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GeneCardsi
TNFRSF18
HGNCiHGNC:11914 TNFRSF18
HPAiHPA008025
MIMi603905 gene
neXtProtiNX_Q9Y5U5
OpenTargetsiENSG00000186891
PharmGKBiPA36607

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410J0PX Eukaryota
ENOG410YX1D LUCA
GeneTreeiENSGT00730000111424
HOVERGENiHBG054195
InParanoidiQ9Y5U5
KOiK05154
OMAiRCKPWAD
OrthoDBiEOG091G03XW
PhylomeDBiQ9Y5U5
TreeFamiTF336151

Enzyme and pathway databases

ReactomeiR-HSA-5669034 TNFs bind their physiological receptors
R-HSA-8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TNFRSF18

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8784

Protein Ontology

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PROi
PR:Q9Y5U5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000186891 Expressed in 142 organ(s), highest expression level in skin of abdomen
CleanExiHS_TNFRSF18
ExpressionAtlasiQ9Y5U5 baseline and differential
GenevisibleiQ9Y5U5 HS

Family and domain databases

CDDicd13417 TNFRSF18, 1 hit
InterProiView protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR022318 TNFR_18
IPR034018 TNFRSF18_N
PRINTSiPR01968 TNFACTORR18
SMARTiView protein in SMART
SM00208 TNFR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTNR18_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y5U5
Secondary accession number(s): B1AME1
, O95851, Q5U0I4, Q9NYJ9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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