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UniProtKB - Q9Y5U2 (TSSC4_HUMAN)

Entry version 142 (25 May 2022)
Sequence version 3 (18 May 2010)
Previous versions | rss
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Protein

Protein TSSC4

Gene

TSSC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9Y5U2

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9Y5U2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein TSSC4
Alternative name(s):
Tumor-suppressing STF cDNA 4 protein
Tumor-suppressing subchromosomal transferable fragment candidate gene 4 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TSSC4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:12386, TSSC4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603852, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y5U2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000184281

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		10078

Open Targets

More...OpenTargetsi		ENSG00000184281

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37054

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y5U2, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TSSC4

Domain mapping of disease mutations (DMDM)

More...DMDMi		296453006

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000763601 – 329Protein TSSC4Add BLAST329

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei60PhosphoserineBy similarity1
Modified residuei67PhosphoserineBy similarity1
Modified residuei86PhosphoserineCombined sources1
Modified residuei132PhosphoserineCombined sources1
Modified residuei143PhosphoserineCombined sources1
Modified residuei146PhosphoserineCombined sources1
Modified residuei217N6-acetyllysineCombined sources1
Modified residuei265PhosphoserineCombined sources1
Modified residuei321PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9Y5U2

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9Y5U2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9Y5U2

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9Y5U2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y5U2

PeptideAtlas

More...PeptideAtlasi		Q9Y5U2

PRoteomics IDEntifications database

More...PRIDEi		Q9Y5U2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		86505 [Q9Y5U2-1]
86506 [Q9Y5U2-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y5U2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y5U2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in fetal brain, lung, liver and kidney. Widely expressed in adult tissues.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000184281, Expressed in left testis and 201 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9Y5U2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Y5U2, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000184281, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115388, 112 interactors

Protein interaction database and analysis system

More...IntActi		Q9Y5U2, 70 interactors

Molecular INTeraction database

More...MINTi		Q9Y5U2

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000331087

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Y5U2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9Y5U2

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 88DisorderedSequence analysisAdd BLAST88
Regioni104 – 156DisorderedSequence analysisAdd BLAST53
Regioni221 – 329DisorderedSequence analysisAdd BLAST109

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi23 – 37Polar residuesSequence analysisAdd BLAST15
Compositional biasi221 – 235Basic and acidic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TSSC4 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S07M, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000011846

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_077569_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y5U2

Identification of Orthologs from Complete Genome Data

More...OMAi		HFRNKGS

Database of Orthologous Groups

More...OrthoDBi		1538986at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y5U2

TreeFam database of animal gene trees

More...TreeFami		TF335741

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029338, TSSC4

The PANTHER Classification System

More...PANTHERi		PTHR13445, PTHR13445, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15264, TSSC4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y5U2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEAGTGEPS PSVEGEHGTE YDTLPSDTVS LSDSDSDLSL PGGAEVEALS 
        60         70         80         90        100
PMGLPGEEDS GPDEPPSPPS GLLPATVQPF HLRGMSSTFS QRSRDIFDCL 
       110        120        130        140        150
EGAARRAPSS VAHTSMSDNG GFKRPLAPSG RSPVEGLGRA HRSPASPRVP 
       160        170        180        190        200
PVPDYVAHPE RWTKYSLEDV TEVSEQSNQA TALAFLGSQS LAAPTDCVSS 
       210        220        230        240        250
FNQDPSSCGE GRVIFTKPVR GVEARHERKR VLGKVGEPGR GGLGNPATDR 
       260        270        280        290        300
GEGPVELAHL AGPGSPEAEE WGSHHGGLQE VEALSGSVHS GSVPGLPPVE 
       310        320 
TVGFHGSRKR SRDHFRNKSS SPEDPGAEV
Length:329
Mass (Da):34,326
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAFC2D5CBD93844F0
GO
Isoform 2 (identifier: Q9Y5U2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     8-71: Missing.

Show »
Length:265
Mass (Da):27,935
Checksum:i72811C9774FC24C4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6NCC9A6NCC9_HUMAN
Protein TSSC4
TSSC4
127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JHT9C9JHT9_HUMAN
Protein TSSC4
TSSC4
203Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PME3E9PME3_HUMAN
Protein TSSC4
TSSC4
191Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JJV1C9JJV1_HUMAN
Protein TSSC4
TSSC4
207Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JDU0C9JDU0_HUMAN
Protein TSSC4
TSSC4
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PL88E9PL88_HUMAN
Protein TSSC4
TSSC4
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti72L → F in AAD23579 (PubMed:10072438).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05782617H → P. Corresponds to variant dbSNP:rs2234278Ensembl.1
Natural variantiVAR_060194124R → Q. Corresponds to variant dbSNP:rs1008265EnsemblClinVar.1
Natural variantiVAR_057827230R → S. Corresponds to variant dbSNP:rs2234280Ensembl.1
Natural variantiVAR_057828262G → R. Corresponds to variant dbSNP:rs2234281Ensembl.1
Natural variantiVAR_063128274H → P2 PublicationsCorresponds to variant dbSNP:rs2234283Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0165618 – 71Missing in isoform 2. 1 PublicationAdd BLAST64

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF125568 mRNA Translation: AAD23579.1
AC124057 Genomic DNA No translation available.
BC006091 mRNA Translation: AAH06091.1
BC050616 mRNA Translation: AAH50616.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS73241.1 [Q9Y5U2-2]
CCDS7735.1 [Q9Y5U2-1]

NCBI Reference Sequences

More...RefSeqi		NP_001284587.1, NM_001297658.1 [Q9Y5U2-1]
NP_001284588.1, NM_001297659.1 [Q9Y5U2-1]
NP_001284589.1, NM_001297660.1 [Q9Y5U2-1]
NP_001284590.1, NM_001297661.1 [Q9Y5U2-2]
NP_005697.2, NM_005706.3 [Q9Y5U2-1]
XP_006718181.1, XM_006718118.2 [Q9Y5U2-1]
XP_011518132.1, XM_011519830.2 [Q9Y5U2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000333256.11; ENSP00000331087.6; ENSG00000184281.15
ENST00000380996.9; ENSP00000370384.5; ENSG00000184281.15 [Q9Y5U2-2]
ENST00000451491.2; ENSP00000411224.2; ENSG00000184281.15

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10078

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10078

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000333256.11; ENSP00000331087.6; NM_005706.4; NP_005697.2

UCSC genome browser

More...UCSCi		uc001lwi.4, human [Q9Y5U2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125568 mRNA Translation: AAD23579.1
AC124057 Genomic DNA No translation available.
BC006091 mRNA Translation: AAH06091.1
BC050616 mRNA Translation: AAH50616.1
CCDSiCCDS73241.1 [Q9Y5U2-2]
CCDS7735.1 [Q9Y5U2-1]
RefSeqiNP_001284587.1, NM_001297658.1 [Q9Y5U2-1]
NP_001284588.1, NM_001297659.1 [Q9Y5U2-1]
NP_001284589.1, NM_001297660.1 [Q9Y5U2-1]
NP_001284590.1, NM_001297661.1 [Q9Y5U2-2]
NP_005697.2, NM_005706.3 [Q9Y5U2-1]
XP_006718181.1, XM_006718118.2 [Q9Y5U2-1]
XP_011518132.1, XM_011519830.2 [Q9Y5U2-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
7PX3electron microscopy3.05T1-329[»]
AlphaFoldDBiQ9Y5U2
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115388, 112 interactors
IntActiQ9Y5U2, 70 interactors
MINTiQ9Y5U2
STRINGi9606.ENSP00000331087

PTM databases

iPTMnetiQ9Y5U2
PhosphoSitePlusiQ9Y5U2

Genetic variation databases

BioMutaiTSSC4
DMDMi296453006

Proteomic databases

EPDiQ9Y5U2
jPOSTiQ9Y5U2
MassIVEiQ9Y5U2
MaxQBiQ9Y5U2
PaxDbiQ9Y5U2
PeptideAtlasiQ9Y5U2
PRIDEiQ9Y5U2
ProteomicsDBi86505 [Q9Y5U2-1]
86506 [Q9Y5U2-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		42107, 74 antibodies from 18 providers

The DNASU plasmid repository

More...DNASUi		10078

Genome annotation databases

EnsembliENST00000333256.11; ENSP00000331087.6; ENSG00000184281.15
ENST00000380996.9; ENSP00000370384.5; ENSG00000184281.15 [Q9Y5U2-2]
ENST00000451491.2; ENSP00000411224.2; ENSG00000184281.15
GeneIDi10078
KEGGihsa:10078
MANE-SelectiENST00000333256.11; ENSP00000331087.6; NM_005706.4; NP_005697.2
UCSCiuc001lwi.4, human [Q9Y5U2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10078
DisGeNETi10078

GeneCards: human genes, protein and diseases

More...GeneCardsi		TSSC4
HGNCiHGNC:12386, TSSC4
HPAiENSG00000184281, Low tissue specificity
MIMi603852, gene
neXtProtiNX_Q9Y5U2
OpenTargetsiENSG00000184281
PharmGKBiPA37054
VEuPathDBiHostDB:ENSG00000184281

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S07M, Eukaryota
GeneTreeiENSGT00390000011846
HOGENOMiCLU_077569_0_0_1
InParanoidiQ9Y5U2
OMAiHFRNKGS
OrthoDBi1538986at2759
PhylomeDBiQ9Y5U2
TreeFamiTF335741

Enzyme and pathway databases

PathwayCommonsiQ9Y5U2
SignaLinkiQ9Y5U2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10078, 10 hits in 1073 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TSSC4, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10078
PharosiQ9Y5U2, Tdark

Protein Ontology

More...PROi		PR:Q9Y5U2
RNActiQ9Y5U2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000184281, Expressed in left testis and 201 other tissues
ExpressionAtlasiQ9Y5U2, baseline and differential
GenevisibleiQ9Y5U2, HS

Family and domain databases

InterProiView protein in InterPro
IPR029338, TSSC4
PANTHERiPTHR13445, PTHR13445, 1 hit
PfamiView protein in Pfam
PF15264, TSSC4, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTSSC4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y5U2
Secondary accession number(s): C9JS66, Q86VL2, Q9BRS6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: May 18, 2010
Last modified: May 25, 2022
This is version 142 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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