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UniProtKB - Q9Y5U2 (TSSC4_HUMAN)
Protein
Protein TSSC4
Gene
TSSC4
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Protein TSSC4Alternative name(s): Tumor-suppressing STF cDNA 4 protein Tumor-suppressing subchromosomal transferable fragment candidate gene 4 protein |
Gene namesi | Name:TSSC4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12386, TSSC4 |
MIMi | 603852, gene |
neXtProti | NX_Q9Y5U2 |
VEuPathDBi | HostDB:ENSG00000184281 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 10078 |
OpenTargetsi | ENSG00000184281 |
PharmGKBi | PA37054 |
Miscellaneous databases
Pharosi | Q9Y5U2, Tdark |
Genetic variation databases
BioMutai | TSSC4 |
DMDMi | 296453006 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076360 | 1 – 329 | Protein TSSC4Add BLAST | 329 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 60 | PhosphoserineBy similarity | 1 | |
Modified residuei | 67 | PhosphoserineBy similarity | 1 | |
Modified residuei | 86 | PhosphoserineCombined sources | 1 | |
Modified residuei | 132 | PhosphoserineCombined sources | 1 | |
Modified residuei | 143 | PhosphoserineCombined sources | 1 | |
Modified residuei | 146 | PhosphoserineCombined sources | 1 | |
Modified residuei | 217 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 265 | PhosphoserineCombined sources | 1 | |
Modified residuei | 321 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9Y5U2 |
jPOSTi | Q9Y5U2 |
MassIVEi | Q9Y5U2 |
MaxQBi | Q9Y5U2 |
PaxDbi | Q9Y5U2 |
PeptideAtlasi | Q9Y5U2 |
PRIDEi | Q9Y5U2 |
ProteomicsDBi | 86505 [Q9Y5U2-1] 86506 [Q9Y5U2-2] |
PTM databases
iPTMneti | Q9Y5U2 |
PhosphoSitePlusi | Q9Y5U2 |
Expressioni
Tissue specificityi
Expressed in fetal brain, lung, liver and kidney. Widely expressed in adult tissues.1 Publication
Gene expression databases
Bgeei | ENSG00000184281, Expressed in left testis and 201 other tissues |
ExpressionAtlasi | Q9Y5U2, baseline and differential |
Genevisiblei | Q9Y5U2, HS |
Organism-specific databases
HPAi | ENSG00000184281, Low tissue specificity |
Interactioni
Binary interactionsi
Q9Y5U2
Protein-protein interaction databases
BioGRIDi | 115388, 112 interactors |
IntActi | Q9Y5U2, 70 interactors |
MINTi | Q9Y5U2 |
STRINGi | 9606.ENSP00000331087 |
Miscellaneous databases
RNActi | Q9Y5U2, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q9Y5U2 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 88 | DisorderedSequence analysisAdd BLAST | 88 | |
Regioni | 104 – 156 | DisorderedSequence analysisAdd BLAST | 53 | |
Regioni | 221 – 329 | DisorderedSequence analysisAdd BLAST | 109 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 23 – 37 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 221 – 235 | Basic and acidic residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the TSSC4 family.Curated
Phylogenomic databases
eggNOGi | ENOG502S07M, Eukaryota |
GeneTreei | ENSGT00390000011846 |
HOGENOMi | CLU_077569_0_0_1 |
InParanoidi | Q9Y5U2 |
OMAi | HFRNKGS |
OrthoDBi | 1538986at2759 |
PhylomeDBi | Q9Y5U2 |
TreeFami | TF335741 |
Family and domain databases
InterProi | View protein in InterPro IPR029338, TSSC4 |
PANTHERi | PTHR13445, PTHR13445, 1 hit |
Pfami | View protein in Pfam PF15264, TSSC4, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9Y5U2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAEAGTGEPS PSVEGEHGTE YDTLPSDTVS LSDSDSDLSL PGGAEVEALS
60 70 80 90 100
PMGLPGEEDS GPDEPPSPPS GLLPATVQPF HLRGMSSTFS QRSRDIFDCL
110 120 130 140 150
EGAARRAPSS VAHTSMSDNG GFKRPLAPSG RSPVEGLGRA HRSPASPRVP
160 170 180 190 200
PVPDYVAHPE RWTKYSLEDV TEVSEQSNQA TALAFLGSQS LAAPTDCVSS
210 220 230 240 250
FNQDPSSCGE GRVIFTKPVR GVEARHERKR VLGKVGEPGR GGLGNPATDR
260 270 280 290 300
GEGPVELAHL AGPGSPEAEE WGSHHGGLQE VEALSGSVHS GSVPGLPPVE
310 320
TVGFHGSRKR SRDHFRNKSS SPEDPGAEV
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA6NCC9 | A6NCC9_HUMAN | Protein TSSC4 | TSSC4 | 127 | Annotation score: | ||
C9JHT9 | C9JHT9_HUMAN | Protein TSSC4 | TSSC4 | 203 | Annotation score: | ||
E9PME3 | E9PME3_HUMAN | Protein TSSC4 | TSSC4 | 191 | Annotation score: | ||
C9JJV1 | C9JJV1_HUMAN | Protein TSSC4 | TSSC4 | 207 | Annotation score: | ||
C9JDU0 | C9JDU0_HUMAN | Protein TSSC4 | TSSC4 | 112 | Annotation score: | ||
E9PL88 | E9PL88_HUMAN | Protein TSSC4 | TSSC4 | 110 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 72 | L → F in AAD23579 (PubMed:10072438).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_057826 | 17 | H → P. Corresponds to variant dbSNP:rs2234278Ensembl. | 1 | |
Natural variantiVAR_060194 | 124 | R → Q. Corresponds to variant dbSNP:rs1008265EnsemblClinVar. | 1 | |
Natural variantiVAR_057827 | 230 | R → S. Corresponds to variant dbSNP:rs2234280Ensembl. | 1 | |
Natural variantiVAR_057828 | 262 | G → R. Corresponds to variant dbSNP:rs2234281Ensembl. | 1 | |
Natural variantiVAR_063128 | 274 | H → P2 PublicationsCorresponds to variant dbSNP:rs2234283Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_016561 | 8 – 71 | Missing in isoform 2. 1 PublicationAdd BLAST | 64 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF125568 mRNA Translation: AAD23579.1 AC124057 Genomic DNA No translation available. BC006091 mRNA Translation: AAH06091.1 BC050616 mRNA Translation: AAH50616.1 |
CCDSi | CCDS73241.1 [Q9Y5U2-2] CCDS7735.1 [Q9Y5U2-1] |
RefSeqi | NP_001284587.1, NM_001297658.1 [Q9Y5U2-1] NP_001284588.1, NM_001297659.1 [Q9Y5U2-1] NP_001284589.1, NM_001297660.1 [Q9Y5U2-1] NP_001284590.1, NM_001297661.1 [Q9Y5U2-2] NP_005697.2, NM_005706.3 [Q9Y5U2-1] XP_006718181.1, XM_006718118.2 [Q9Y5U2-1] XP_011518132.1, XM_011519830.2 [Q9Y5U2-1] |
Genome annotation databases
Ensembli | ENST00000333256.11; ENSP00000331087.6; ENSG00000184281.15 ENST00000380996.9; ENSP00000370384.5; ENSG00000184281.15 [Q9Y5U2-2] ENST00000451491.2; ENSP00000411224.2; ENSG00000184281.15 |
GeneIDi | 10078 |
KEGGi | hsa:10078 |
MANE-Selecti | ENST00000333256.11; ENSP00000331087.6; NM_005706.4; NP_005697.2 |
UCSCi | uc001lwi.4, human [Q9Y5U2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF125568 mRNA Translation: AAD23579.1 AC124057 Genomic DNA No translation available. BC006091 mRNA Translation: AAH06091.1 BC050616 mRNA Translation: AAH50616.1 |
CCDSi | CCDS73241.1 [Q9Y5U2-2] CCDS7735.1 [Q9Y5U2-1] |
RefSeqi | NP_001284587.1, NM_001297658.1 [Q9Y5U2-1] NP_001284588.1, NM_001297659.1 [Q9Y5U2-1] NP_001284589.1, NM_001297660.1 [Q9Y5U2-1] NP_001284590.1, NM_001297661.1 [Q9Y5U2-2] NP_005697.2, NM_005706.3 [Q9Y5U2-1] XP_006718181.1, XM_006718118.2 [Q9Y5U2-1] XP_011518132.1, XM_011519830.2 [Q9Y5U2-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
7PX3 | electron microscopy | 3.05 | T | 1-329 | [»] | |
AlphaFoldDBi | Q9Y5U2 | |||||
ModBasei | Search... | |||||
SWISS-MODEL-Workspacei | Submit a new modelling project... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115388, 112 interactors |
IntActi | Q9Y5U2, 70 interactors |
MINTi | Q9Y5U2 |
STRINGi | 9606.ENSP00000331087 |
PTM databases
iPTMneti | Q9Y5U2 |
PhosphoSitePlusi | Q9Y5U2 |
Genetic variation databases
BioMutai | TSSC4 |
DMDMi | 296453006 |
Proteomic databases
EPDi | Q9Y5U2 |
jPOSTi | Q9Y5U2 |
MassIVEi | Q9Y5U2 |
MaxQBi | Q9Y5U2 |
PaxDbi | Q9Y5U2 |
PeptideAtlasi | Q9Y5U2 |
PRIDEi | Q9Y5U2 |
ProteomicsDBi | 86505 [Q9Y5U2-1] 86506 [Q9Y5U2-2] |
Protocols and materials databases
Antibodypediai | 42107, 74 antibodies from 18 providers |
DNASUi | 10078 |
Genome annotation databases
Ensembli | ENST00000333256.11; ENSP00000331087.6; ENSG00000184281.15 ENST00000380996.9; ENSP00000370384.5; ENSG00000184281.15 [Q9Y5U2-2] ENST00000451491.2; ENSP00000411224.2; ENSG00000184281.15 |
GeneIDi | 10078 |
KEGGi | hsa:10078 |
MANE-Selecti | ENST00000333256.11; ENSP00000331087.6; NM_005706.4; NP_005697.2 |
UCSCi | uc001lwi.4, human [Q9Y5U2-1] |
Organism-specific databases
CTDi | 10078 |
DisGeNETi | 10078 |
GeneCardsi | TSSC4 |
HGNCi | HGNC:12386, TSSC4 |
HPAi | ENSG00000184281, Low tissue specificity |
MIMi | 603852, gene |
neXtProti | NX_Q9Y5U2 |
OpenTargetsi | ENSG00000184281 |
PharmGKBi | PA37054 |
VEuPathDBi | HostDB:ENSG00000184281 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S07M, Eukaryota |
GeneTreei | ENSGT00390000011846 |
HOGENOMi | CLU_077569_0_0_1 |
InParanoidi | Q9Y5U2 |
OMAi | HFRNKGS |
OrthoDBi | 1538986at2759 |
PhylomeDBi | Q9Y5U2 |
TreeFami | TF335741 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y5U2 |
SignaLinki | Q9Y5U2 |
Miscellaneous databases
BioGRID-ORCSi | 10078, 10 hits in 1073 CRISPR screens |
ChiTaRSi | TSSC4, human |
GenomeRNAii | 10078 |
Pharosi | Q9Y5U2, Tdark |
PROi | PR:Q9Y5U2 |
RNActi | Q9Y5U2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000184281, Expressed in left testis and 201 other tissues |
ExpressionAtlasi | Q9Y5U2, baseline and differential |
Genevisiblei | Q9Y5U2, HS |
Family and domain databases
InterProi | View protein in InterPro IPR029338, TSSC4 |
PANTHERi | PTHR13445, PTHR13445, 1 hit |
Pfami | View protein in Pfam PF15264, TSSC4, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TSSC4_HUMAN | |
Accessioni | Q9Y5U2Primary (citable) accession number: Q9Y5U2 Secondary accession number(s): C9JS66, Q86VL2, Q9BRS6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | May 18, 2010 | |
Last modified: | May 25, 2022 | |
This is version 142 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families