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Protein

DnaJ homolog subfamily C member 15

Gene

DNAJC15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9.By similarity1 Publication

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processProtein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 15
Alternative name(s):
Cell growth-inhibiting gene 22 protein
Methylation-controlled J protein
Short name:
MCJ
Gene namesi
Name:DNAJC15
Synonyms:DNAJD1
ORF Names:GIG22, HSD18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000120675.5
HGNCiHGNC:20325 DNAJC15
MIMi615339 gene
neXtProtiNX_Q9Y5T4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35Mitochondrial intermembraneSequence analysisAdd BLAST35
Transmembranei36 – 58HelicalSequence analysisAdd BLAST23
Topological domaini59 – 150Mitochondrial matrixSequence analysisAdd BLAST92

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Involvement in diseasei

Absent or down-regulated in many advanced cases of ovarian adenocarcinoma, due to hypermethylation and allelic loss. Loss of expression correlates with increased resistance to antineoplastic drugs, such as cisplatin.1 Publication

Organism-specific databases

DisGeNETi29103
OpenTargetsiENSG00000120675
PharmGKBiPA134932264

Polymorphism and mutation databases

BioMutaiDNAJC15
DMDMi110808202

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002471391 – 150DnaJ homolog subfamily C member 15Add BLAST150

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei104PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y5T4
MaxQBiQ9Y5T4
PaxDbiQ9Y5T4
PeptideAtlasiQ9Y5T4
PRIDEiQ9Y5T4
ProteomicsDBi86496

PTM databases

iPTMnetiQ9Y5T4
PhosphoSitePlusiQ9Y5T4

Expressioni

Tissue specificityi

Expressed at highest levels in heart, followed by liver and kidney.2 Publications

Gene expression databases

BgeeiENSG00000120675
CleanExiHS_DNAJC15
GenevisibleiQ9Y5T4 HS

Interactioni

Subunit structurei

Interacts with the TIM23 complex. Directly interacts with PAM16/MAGMAS; this interaction counteracts DNAJC15-dependent stimulation of HSPA9 ATPase activity. Associates with complex I of the mitochondrial electron transfer chain; this interaction may interfere with the formation of supercomplexes that facilitate the transfer of electrons between complexes (By similarity).By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi118871, 8 interactors
IntActiQ9Y5T4, 5 interactors
STRINGi9606.ENSP00000368523

Structurei

3D structure databases

ProteinModelPortaliQ9Y5T4
SMRiQ9Y5T4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini96 – 150JPROSITE-ProRule annotationAdd BLAST55

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0723 Eukaryota
COG2214 LUCA
GeneTreeiENSGT00390000017303
HOGENOMiHOG000115841
HOVERGENiHBG057483
InParanoidiQ9Y5T4
KOiK09535
OMAiRYAFHLW
OrthoDBiEOG091G116P
PhylomeDBiQ9Y5T4
TreeFamiTF320584

Family and domain databases

CDDicd06257 DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR036869 J_dom_sf
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
PROSITEiView protein in PROSITE
PS50076 DNAJ_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y5T4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARGVIAPV GESLRYAEYL QPSAKRPDAD VDQQRLVRSL IAVGLGVAAL
60 70 80 90 100
AFAGRYAFRI WKPLEQVITE TAKKISTPSF SSYYKGGFEQ KMSRREAGLI
110 120 130 140 150
LGVSPSAGKA KIRTAHRRVM ILNHPDKGGS PYVAAKINEA KDLLETTTKH
Length:150
Mass (Da):16,383
Last modified:July 25, 2006 - v2
Checksum:i988059B686D39967
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34Q → R in AAP20049 (Ref. 2) Curated1
Sequence conflicti131P → S in AAP20049 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02707735R → G2 PublicationsCorresponds to variant dbSNP:rs12015Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126743 mRNA Translation: AAD38506.1
AY248898 mRNA Translation: AAP20049.1
AY512565 mRNA Translation: AAS80157.1
AK311866 mRNA Translation: BAG34807.1
AL445217 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08688.1
BC010910 mRNA Translation: AAH10910.1
BC095400 mRNA Translation: AAH95400.1
CCDSiCCDS9388.1
RefSeqiNP_037370.2, NM_013238.2
UniGeneiHs.438830

Genome annotation databases

EnsembliENST00000379221; ENSP00000368523; ENSG00000120675
GeneIDi29103
KEGGihsa:29103
UCSCiuc001uyy.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDJC15_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5T4
Secondary accession number(s): B2R4L0, Q5T219, Q6X963
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: July 18, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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