RBM8A

Functionⁱ

Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Its removal from cytoplasmic mRNAs requires translation initiation from EJC-bearing spliced mRNAs. Associates preferentially with mRNAs produced by splicing. Does not interact with pre-mRNAs, introns, or mRNAs produced from intronless cDNAs. Associates with both nuclear mRNAs and newly exported cytoplasmic mRNAs. The MAGOH-RBM8A heterodimer is a component of the nonsense mediated decay (NMD) pathway. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly.6 Publications

GO - Molecular functionⁱ

mRNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22681889

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mRNA 3'-end processing Source: Reactome
mRNA export from nucleus Source: Reactome
mRNA splicing, via spliceosome Source: Reactome
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16209946
regulation of alternative mRNA splicing, via spliceosome
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22203037
regulation of translation Source: UniProtKB-KW
RNA export from nucleus Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	RNA-binding
Biological process	mRNA processing, mRNA splicing, mRNA transport, Nonsense-mediated mRNA decay, Translation regulation, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-109688 Cleavage of Growing Transcript in the Termination Region R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72187 mRNA 3'-end processing R-HSA-9010553 Regulation of expression of SLITs and ROBOs R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SIGNORⁱ	Q9Y5S9

Protein family/group databases

TCDBⁱ	3.A.18.1.1 the nuclear mrna exporter (mrna-e) family

TCDBⁱ

3.A.18.1.1 the nuclear mrna exporter (mrna-e) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: RNA-binding protein 8A Alternative name(s): Binder of OVCA1-1 Short name: BOV-1 RNA-binding motif protein 8A RNA-binding protein Y14 Ribonucleoprotein RBM8A
Gene namesⁱ	Name:RBM8A Synonyms:RBM8 ORF Names:HSPC114, MDS014
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000265241.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9905 RBM8A
MIMⁱ	605313 gene
neXtProtⁱ	NX_Q9Y5S9

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus, Spliceosome

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	82 – 83	EE → RR: Impaired nonsense-mediated decay activity. 1 Publication	2
Mutagenesisⁱ	106 – 108	LDR → RDE: Complete loss of nonsense-mediated decay activity. 1 Publication	3
Mutagenesisⁱ	118	L → R: Complete loss of nonsense-mediated decay activity. 1 Publication	1
Mutagenesisⁱ	149 – 150	CF → KA: Complete loss of nonsense-mediated decay activity. 1 Publication	2

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9939
GeneReviewsⁱ	RBM8A
MalaCards human disease database More...MalaCardsⁱ	RBM8A
Open Targets More...OpenTargetsⁱ	ENSG00000265241
Orphanetⁱ	3320 Thrombocytopenia-absent radius syndrome
PharmGKBⁱ	PA34270

Polymorphism and mutation databases

DMDMⁱ	10720244

DMDMⁱ

10720244

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000081763	2 – 174	RNA-binding protein 8AAdd BLAST		173

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources	1
Modified residueⁱ	24	PhosphoserineCombined sources	1
Cross-linkⁱ	27	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	42	PhosphoserineCombined sources	1
Modified residueⁱ	56	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q9Y5S9
PaxDbⁱ	Q9Y5S9
PeptideAtlas More...PeptideAtlasⁱ	Q9Y5S9
PRIDEⁱ	Q9Y5S9
ProteomicsDBⁱ	86494 86495 [Q9Y5S9-2]

PTM databases

iPTMnetⁱ	Q9Y5S9
PhosphoSitePlusⁱ	Q9Y5S9

Miscellaneous databases

PMAP-CutDBⁱ	Q9Y5S9

PMAP-CutDBⁱ

Q9Y5S9

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.

Gene expression databases

Bgeeⁱ	ENSG00000265241 Expressed in 230 organ(s), highest expression level in lower esophagus mucosa
CleanExⁱ	HS_RBM8A
ExpressionAtlasⁱ	Q9Y5S9 baseline and differential
Genevisibleⁱ	Q9Y5S9 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA018403

HPAⁱ

HPA018403

Interactionⁱ

Subunit structureⁱ

Heterodimer with RBM8A. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A. Interacts with PYM1; the interaction is direct and dissociates the EJC from spliced mRNAs. Found in a post-splicing complex with NXF1, RBM8A, UPF1, UPF2, UPF3A, UPF3B and RNPS1. Interacts with BAT1, MAGOH, OVCA1, UPF3B, RNPS1, SRRM1 and ALYREF/THOC4. Interacts with IPO13; the interaction mediates the nuclear import of the MAGOH-RBM8A heterodimer. Identified in the spliceosome C complex. Associates with polysomes.18 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
EIF4A3	P38919	21	EBI-447231,EBI-299104
MAGOH	P61326	30	EBI-447231,EBI-299134
MAGOHB	Q96A72	9	EBI-447231,EBI-746778
SRPK1	Q96SB4	2	EBI-447231,EBI-539478
SRPK2	P78362	2	EBI-447231,EBI-593303
UPF3A	Q9H1J1	4	EBI-447231,EBI-521530
UPF3B	Q9BZI7	9	EBI-447231,EBI-372780

Protein-protein interaction databases

BioGridⁱ	115265, 111 interactors
ComplexPortalⁱ	CPX-1941 Exon junction core complex, MAGOH variant CPX-1942 Exon junction subcomplex MAGOH-Y14 CPX-680 Exon junction subcomplex MAGOHB-Y14 CPX-682 Exon junction core complex, MAGOHB variant
CORUMⁱ	Q9Y5S9
Database of interacting proteins More...DIPⁱ	DIP-33070N
IntActⁱ	Q9Y5S9, 67 interactors
Molecular INTeraction database More...MINTⁱ	Q9Y5S9
STRINGⁱ	9606.ENSP00000333001

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	72 – 78	Combined sources	7
Helixⁱ	86 – 93	Combined sources	8
Helixⁱ	94 – 96	Combined sources	3
Beta strandⁱ	99 – 106	Combined sources	8
Turnⁱ	108 – 110	Combined sources	3
Beta strandⁱ	111 – 122	Combined sources	12
Helixⁱ	124 – 134	Combined sources	11
Beta strandⁱ	138 – 143	Combined sources	6
Beta strandⁱ	145 – 153	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9Y5S9
SMRⁱ	Q9Y5S9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9Y5S9

EvolutionaryTraceⁱ

Q9Y5S9

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	73 – 151	RRMPROSITE-ProRule annotationAdd BLAST		79

Sequence similaritiesⁱ

Belongs to the RBM8A family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0130 Eukaryota ENOG4111IHM LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000111185
HOGENOMⁱ	HOG000183826
HOVERGENⁱ	HBG055173
InParanoidⁱ	Q9Y5S9
KEGG Orthology (KO) More...KOⁱ	K12876
OMAⁱ	RDDVGHY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0PLI
PhylomeDBⁱ	Q9Y5S9
TreeFamⁱ	TF314933

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd12324 RRM_RBM8, 1 hit
Gene3Dⁱ	3.30.70.330, 1 hit
InterProⁱ	View protein in InterPro IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR008111 RNA-bd_8 IPR000504 RRM_dom IPR033744 RRM_RBM8
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00076 RRM_1, 1 hit
PRINTSⁱ	PR01738 RNABINDINGM8
SMARTⁱ	View protein in SMART SM00360 RRM, 1 hit
SUPFAMⁱ	SSF54928 SSF54928, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q9Y5S9-1) [UniParc]FASTA Add to basket

Also known as: BOV-1a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADVLDLHEA GGEDFAMDED GDESIHKLKE KAKKRKGRGF GSEEGSRARM 
        60         70         80         90        100
REDYDSVEQD GDEPGPQRSV EGWILFVTGV HEEATEEDIH DKFAEYGEIK 
       110        120        130        140        150
NIHLNLDRRT GYLKGYTLVE YETYKEAQAA MEGLNGQDLM GQPISVDWCF 
       160        170 
VRGPPKGKRR GGRRRSRSPD RRRR

Length:174

Mass (Da):19,889

Last modified:November 1, 1999 - v1

Checksum:ⁱ70BBD03CDDFEECFE

GO

Isoform 2 (identifier: Q9Y5S9-2) [UniParc]FASTA Add to basket

Also known as: BOV-1b

The sequence of this isoform differs from the canonical sequence as follows:
44-44: Missing.

« Hide

        10         20         30         40         50
MADVLDLHEA GGEDFAMDED GDESIHKLKE KAKKRKGRGF GSEGSRARMR 
        60         70         80         90        100
EDYDSVEQDG DEPGPQRSVE GWILFVTGVH EEATEEDIHD KFAEYGEIKN 
       110        120        130        140        150
IHLNLDRRTG YLKGYTLVEY ETYKEAQAAM EGLNGQDLMG QPISVDWCFV 
       160        170 
RGPPKGKRRG GRRRSRSPDR RRR

Show »

Length:173

Mass (Da):19,760

Checksum:ⁱ6710C1BD9CFAF92E

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A0J9YW13	A0A0J9YW13_HUMAN		RNA-binding protein 8A RNA-binding protein 8A	RBM8A	106	Annotation score:

Sequence cautionⁱ

The sequence AAG14951 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAG16782 differs from that shown. Chimeric cDNA. A chimeric cDNA originating from chromosomes 1 and 5.Curated

The sequence AAG16782 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	130	A → V in CAG46622 (Ref. 8) Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_005810	44	Missing in isoform 2. 2 Publications		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF127761 mRNA Translation: AAD21089.1 AF198620 mRNA Translation: AAF37551.1 AF231511 mRNA Translation: AAG16781.1 AF231512 mRNA Translation: AAG16782.1 Different initiation. AF299118 mRNA Translation: AAG27091.1 AF403012 Genomic DNA Translation: AAL26999.1 AF182415 mRNA Translation: AAG14951.1 Different initiation. AF161463 mRNA Translation: AAF29078.1 CR541823 mRNA Translation: CAG46622.1 CR541805 mRNA Translation: CAG46604.1 AK075009 mRNA Translation: BAG52051.1 AL160282 Genomic DNA No translation available. CH471244 Genomic DNA Translation: EAW71419.1 BC017088 mRNA Translation: AAH17088.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS72872.1 [Q9Y5S9-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_005096.1, NM_005105.4 [Q9Y5S9-1]
UniGeneⁱ	Hs.591455

Genome annotation databases

Ensemblⁱ	ENST00000369307; ENSP00000358313; ENSG00000265241 [Q9Y5S9-2] ENST00000583313; ENSP00000463058; ENSG00000265241 [Q9Y5S9-1] ENST00000632555; ENSP00000488265; ENSG00000265241 [Q9Y5S9-1]
GeneIDⁱ	9939
KEGGⁱ	hsa:9939
UCSC genome browser More...UCSCⁱ	uc031uto.2 human [Q9Y5S9-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Y5S9	RNA-binding protein 8A		BOVIN		174	UniRef100_Q9Y5S9
RNA-binding protein 8A		MOUSE		174
RNA-binding protein 8A		RAT		174
RNA-binding protein 8A (Fragment)		ESCRO		192
RNA-binding protein 8A		HUMAN		174
+49
Q9Y5S9-2	RNA-binding protein 8A		PONAB		173	UniRef100_A0A2J8SQ73
RNA-binding protein 8A isoform X2		BALAS		173
RNA-binding protein 8A		ODORO		173
RNA-binding protein 8A		DELLE		173
RNA-binding protein 8A		ERIEU		173
+16

Protein	Similar proteins		Species	Score	Length	Source
Q9Y5S9	RNA-binding protein 8A		BOVIN		174	UniRef90_Q9Y5S9
RNA-binding protein 8A		MOUSE		174
RNA-binding protein 8A		RAT		174
RNA-binding protein 8A-A		XENLA		174
RNA-binding protein 8A (Fragment)		ESCRO		192
+68
Q9Y5S9-2	RNA-binding protein 8A		ORYLA		173	UniRef90_Q8JJC6
RNA-binding protein 8A		NOTKU		204
RNA-binding protein 8A		NOTFU		175
RNA-binding protein 8A		Nothobranchius korthausae		175
RNA-binding protein 8A		Nothobranchius kadleci		175
+92

Protein	Similar proteins		Species	Score	Length	Source
Q9Y5S9	RNA-binding protein 8A		BOVIN		174	UniRef50_Q9Y5S9
RNA-binding protein 8A		MOUSE		174
RNA-binding protein 8A		RAT		174
RNA-binding protein 8A-A		XENLA		174
RNA-binding protein 8A (Fragment)		ESCRO		192
+78
Q9Y5S9-2	RNA-binding protein 8A		XENTR		174	UniRef50_Q28BZ1
RNA-binding protein 8A		SALSA		175
RNA-binding protein 8A-B		XENLA		174
RNA-binding protein 8A		RABIT		177
RNA-binding protein 8A		wild yak		177
+135

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF127761 mRNA Translation: AAD21089.1 AF198620 mRNA Translation: AAF37551.1 AF231511 mRNA Translation: AAG16781.1 AF231512 mRNA Translation: AAG16782.1 Different initiation. AF299118 mRNA Translation: AAG27091.1 AF403012 Genomic DNA Translation: AAL26999.1 AF182415 mRNA Translation: AAG14951.1 Different initiation. AF161463 mRNA Translation: AAF29078.1 CR541823 mRNA Translation: CAG46622.1 CR541805 mRNA Translation: CAG46604.1 AK075009 mRNA Translation: BAG52051.1 AL160282 Genomic DNA No translation available. CH471244 Genomic DNA Translation: EAW71419.1 BC017088 mRNA Translation: AAH17088.1
CCDSⁱ	CCDS72872.1 [Q9Y5S9-1]
RefSeqⁱ	NP_005096.1, NM_005105.4 [Q9Y5S9-1]
UniGeneⁱ	Hs.591455

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1P27	X-ray	2.00	B/D	50-155	[»]
	2HYI	X-ray	2.30	B/H	64-154	[»]
	2J0Q	X-ray	3.20	D/G	66-174	[»]
	2J0S	X-ray	2.21	D	66-154	[»]
	2XB2	X-ray	3.40	D/Z	66-155	[»]
	3EX7	X-ray	2.30	B/G	51-174	[»]
	5XJC	electron microscopy	3.60	w	1-174	[»]
	5YZG	electron microscopy	4.10	w	1-174	[»]
ProteinModelPortalⁱ	Q9Y5S9
SMRⁱ	Q9Y5S9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115265, 111 interactors
ComplexPortalⁱ	CPX-1941 Exon junction core complex, MAGOH variant CPX-1942 Exon junction subcomplex MAGOH-Y14 CPX-680 Exon junction subcomplex MAGOHB-Y14 CPX-682 Exon junction core complex, MAGOHB variant
CORUMⁱ	Q9Y5S9
DIPⁱ	DIP-33070N
IntActⁱ	Q9Y5S9, 67 interactors
MINTⁱ	Q9Y5S9
STRINGⁱ	9606.ENSP00000333001

Protein family/group databases

TCDBⁱ	3.A.18.1.1 the nuclear mrna exporter (mrna-e) family

TCDBⁱ

3.A.18.1.1 the nuclear mrna exporter (mrna-e) family

PTM databases

iPTMnetⁱ	Q9Y5S9
PhosphoSitePlusⁱ	Q9Y5S9

Polymorphism and mutation databases

DMDMⁱ	10720244

DMDMⁱ

10720244

Proteomic databases

EPDⁱ	Q9Y5S9
PaxDbⁱ	Q9Y5S9
PeptideAtlasⁱ	Q9Y5S9
PRIDEⁱ	Q9Y5S9
ProteomicsDBⁱ	86494 86495 [Q9Y5S9-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	9939
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000369307; ENSP00000358313; ENSG00000265241 [Q9Y5S9-2] ENST00000583313; ENSP00000463058; ENSG00000265241 [Q9Y5S9-1] ENST00000632555; ENSP00000488265; ENSG00000265241 [Q9Y5S9-1]
GeneIDⁱ	9939
KEGGⁱ	hsa:9939
UCSCⁱ	uc031uto.2 human [Q9Y5S9-1]

Organism-specific databases

CTDⁱ	9939
DisGeNETⁱ	9939
EuPathDBⁱ	HostDB:ENSG00000265241.6
GeneCardsⁱ	RBM8A
GeneReviewsⁱ	RBM8A
HGNCⁱ	HGNC:9905 RBM8A
HPAⁱ	HPA018403
MalaCardsⁱ	RBM8A
MIMⁱ	605313 gene
neXtProtⁱ	NX_Q9Y5S9
OpenTargetsⁱ	ENSG00000265241
Orphanetⁱ	3320 Thrombocytopenia-absent radius syndrome
PharmGKBⁱ	PA34270
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0130 Eukaryota ENOG4111IHM LUCA
GeneTreeⁱ	ENSGT00730000111185
HOGENOMⁱ	HOG000183826
HOVERGENⁱ	HBG055173
InParanoidⁱ	Q9Y5S9
KOⁱ	K12876
OMAⁱ	RDDVGHY
OrthoDBⁱ	EOG091G0PLI
PhylomeDBⁱ	Q9Y5S9
TreeFamⁱ	TF314933

Enzyme and pathway databases

Reactomeⁱ	R-HSA-109688 Cleavage of Growing Transcript in the Termination Region R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72187 mRNA 3'-end processing R-HSA-9010553 Regulation of expression of SLITs and ROBOs R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SIGNORⁱ	Q9Y5S9

Miscellaneous databases

ChiTaRSⁱ	RBM8A human
EvolutionaryTraceⁱ	Q9Y5S9
GeneWikiⁱ	RBM8A
GenomeRNAiⁱ	9939
PMAP-CutDBⁱ	Q9Y5S9
Protein Ontology More...PROⁱ	PR:Q9Y5S9
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000265241 Expressed in 230 organ(s), highest expression level in lower esophagus mucosa
CleanExⁱ	HS_RBM8A
ExpressionAtlasⁱ	Q9Y5S9 baseline and differential
Genevisibleⁱ	Q9Y5S9 HS

Family and domain databases

CDDⁱ	cd12324 RRM_RBM8, 1 hit
Gene3Dⁱ	3.30.70.330, 1 hit
InterProⁱ	View protein in InterPro IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR008111 RNA-bd_8 IPR000504 RRM_dom IPR033744 RRM_RBM8
Pfamⁱ	View protein in Pfam PF00076 RRM_1, 1 hit
PRINTSⁱ	PR01738 RNABINDINGM8
SMARTⁱ	View protein in SMART SM00360 RRM, 1 hit
SUPFAMⁱ	SSF54928 SSF54928, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RBM8A_HUMAN
Accessionⁱ	Q9Y5S9Primary (citable) accession number: Q9Y5S9 Secondary accession number(s): B3KQI9 , Q6FHD1, Q6IQ40, Q9GZX8, Q9NZI4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
	Last sequence update:	November 1, 1999
	Last modified:	November 7, 2018
	This is version 209 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9Y5S9 (RBM8A_HUMAN)

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RNA-binding protein 8A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ