Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q9Y5S2 (MRCKB_HUMAN)

Protein

Serine/threonine-protein kinase MRCK beta

Gene

CDC42BPB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity).By similarity3 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity1 Publication

Cofactori

Mg2+By similarity

Activity regulationi

Maintained in an inactive, closed conformation by an interaction between the kinase domain and the negative autoregulatory C-terminal coiled-coil region. Agonist binding to the phorbol ester binding site disrupts this, releasing the kinase domain to allow N-terminus-mediated dimerization and kinase activation by transautophosphorylation (By similarity). Inhibited by chelerythrine chloride.By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei105ATPPROSITE-ProRule annotationBy similarity1
Active sitei200Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi82 – 90ATPPROSITE-ProRule annotationBy similarity9
Zinc fingeri1025 – 1075Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST51

GO - Molecular functioni

  • ATP binding Source: UniProtKB
  • magnesium ion binding Source: UniProtKB
  • protein-containing complex binding Source: UniProtKB
  • protein kinase activity Source: UniProtKB
  • protein serine/threonine kinase activity Source: UniProtKB
  • Rho GTPase binding Source: Ensembl
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ9Y5S2

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase MRCK beta (EC:2.7.11.1)
Alternative name(s):
CDC42-binding protein kinase beta
Short name:
CDC42BP-beta
DMPK-like beta
Myotonic dystrophy kinase-related CDC42-binding kinase beta
Short name:
MRCK beta
Short name:
Myotonic dystrophy protein kinase-like beta
Gene namesi
Name:CDC42BPBImported
Synonyms:KIAA1124Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000198752.10
HGNCiHGNC:1738 CDC42BPB
MIMi614062 gene
neXtProtiNX_Q9Y5S2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9578
OpenTargetsiENSG00000198752
PharmGKBiPA26268

Chemistry databases

ChEMBLiCHEMBL5052

Polymorphism and mutation databases

BioMutaiCDC42BPB
DMDMi92090617

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000863941 – 1711Serine/threonine-protein kinase MRCK betaAdd BLAST1711

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei221Phosphoserine; by autocatalysisBy similarity1
Modified residuei233Phosphoserine; by autocatalysisBy similarity1
Modified residuei239Phosphothreonine; by autocatalysisBy similarity1
Modified residuei423PhosphothreonineCombined sources1
Modified residuei671Omega-N-methylarginineCombined sources1
Modified residuei954PhosphotyrosineBy similarity1
Modified residuei1680PhosphoserineCombined sources1
Modified residuei1682PhosphoserineCombined sources1
Modified residuei1686PhosphoserineCombined sources1
Modified residuei1690PhosphoserineCombined sources1
Modified residuei1693PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ9Y5S2
MaxQBiQ9Y5S2
PaxDbiQ9Y5S2
PeptideAtlasiQ9Y5S2
PRIDEiQ9Y5S2
ProteomicsDBi86490

PTM databases

iPTMnetiQ9Y5S2
PhosphoSitePlusiQ9Y5S2

Expressioni

Tissue specificityi

Expressed in all tissues examined, with high levels in heart, brain, placenta and lung.1 Publication

Gene expression databases

BgeeiENSG00000198752 Expressed in 215 organ(s), highest expression level in adenohypophysis
CleanExiHS_CDC42BPB
ExpressionAtlasiQ9Y5S2 baseline and differential
GenevisibleiQ9Y5S2 HS

Organism-specific databases

HPAiHPA022821

Interactioni

Subunit structurei

Homodimer and homotetramer via the coiled coil regions (PubMed:21949762). Interacts tightly with GTP-bound but not GDP-bound CDC42. Interacts with TJP1, when in the presence of catalytically active CDC42 (By similarity). Forms a tripartite complex with MYO18A and LURAP1 with the latter acting as an adapter connecting CDC42BPB and MYO18A. LURAP1 binding results in activation of CDC42BPB by abolition of its negative autoregulation (PubMed:18854160). Interacts with STRIP1, STRN3 and SIKE1 (PubMed:25743393). Interacts with CPNE4 (via VWFA domain). Interacts with LURAP1. Interacts (via AGC-kinase C-terminal domain) with FAM89B/LRAP25 (via LRR repeat). Forms a tripartite complex with FAM89B/LRAP25 and LIMK1 (By similarity).By similarity3 Publications

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi114947, 27 interactors
IntActiQ9Y5S2, 15 interactors
MINTiQ9Y5S2
STRINGi9606.ENSP00000355237

Chemistry databases

BindingDBiQ9Y5S2

Structurei

Secondary structure

11711
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9Y5S2
SMRiQ9Y5S2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 342Protein kinasePROSITE-ProRule annotationBy similarityAdd BLAST267
Domaini343 – 413AGC-kinase C-terminalAdd BLAST71
Domaini1095 – 1214PHPROSITE-ProRule annotationAdd BLAST120
Domaini1240 – 1513CNHPROSITE-ProRule annotationAdd BLAST274
Domaini1583 – 1596CRIBPROSITE-ProRule annotationAdd BLAST14

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili431 – 815Sequence analysisAdd BLAST385
Coiled coili878 – 939Sequence analysisAdd BLAST62

Sequence similaritiesi

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1025 – 1075Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IT51 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118994
HOGENOMiHOG000294133
HOVERGENiHBG055933
InParanoidiQ9Y5S2
KOiK16307
OMAiDSAPQVC
OrthoDBiEOG091G09EX
PhylomeDBiQ9Y5S2
TreeFamiTF313551

Family and domain databases

CDDicd00029 C1, 1 hit
cd00132 CRIB, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR001180 CNH_dom
IPR000095 CRIB_dom
IPR020454 DAG/PE-bd
IPR031597 KELK
IPR011009 Kinase-like_dom_sf
IPR033232 MRCK_beta
IPR014930 Myotonic_dystrophy_kinase_coil
IPR002219 PE/DAG-bd
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR22988:SF34 PTHR22988:SF34, 1 hit
PfamiView protein in Pfam
PF00130 C1_1, 1 hit
PF00780 CNH, 1 hit
PF08826 DMPK_coil, 1 hit
PF15796 KELK, 1 hit
PF00069 Pkinase, 1 hit
PRINTSiPR00008 DAGPEDOMAIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD011252 Myotonic_dystrophy_kinase_coil, 1 hit
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00036 CNH, 1 hit
SM00285 PBD, 1 hit
SM00233 PH, 1 hit
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS50219 CNH, 1 hit
PS50108 CRIB, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9Y5S2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAKVRLKKL EQLLLDGPWR NESALSVETL LDVLVCLYTE CSHSALRRDK 
        60         70         80         90        100
YVAEFLEWAK PFTQLVKEMQ LHREDFEIIK VIGRGAFGEV AVVKMKNTER 
       110        120        130        140        150
IYAMKILNKW EMLKRAETAC FREERDVLVN GDCQWITALH YAFQDENHLY 
       160        170        180        190        200
LVMDYYVGGD LLTLLSKFED KLPEDMARFY IGEMVLAIDS IHQLHYVHRD 
       210        220        230        240        250
IKPDNVLLDV NGHIRLADFG SCLKMNDDGT VQSSVAVGTP DYISPEILQA 
       260        270        280        290        300
MEDGMGKYGP ECDWWSLGVC MYEMLYGETP FYAESLVETY GKIMNHEERF 
       310        320        330        340        350
QFPSHVTDVS EEAKDLIQRL ICSRERRLGQ NGIEDFKKHA FFEGLNWENI 
       360        370        380        390        400
RNLEAPYIPD VSSPSDTSNF DVDDDVLRNT EILPPGSHTG FSGLHLPFIG 
       410        420        430        440        450
FTFTTESCFS DRGSLKSIMQ SNTLTKDEDV QRDLEHSLQM EAYERRIRRL 
       460        470        480        490        500
EQEKLELSRK LQESTQTVQS LHGSSRALSN SNRDKEIKKL NEEIERLKNK 
       510        520        530        540        550
IADSNRLERQ LEDTVALRQE REDSTQRLRG LEKQHRVVRQ EKEELHKQLV 
       560        570        580        590        600
EASERLKSQA KELKDAHQQR KLALQEFSEL NERMAELRAQ KQKVSRQLRD 
       610        620        630        640        650
KEEEMEVATQ KVDAMRQEMR RAEKLRKELE AQLDDAVAEA SKERKLREHS 
       660        670        680        690        700
ENFCKQMESE LEALKVKQGG RGAGATLEHQ QEISKIKSEL EKKVLFYEEE 
       710        720        730        740        750
LVRREASHVL EVKNVKKEVH DSESHQLALQ KEILMLKDKL EKSKRERHNE 
       760        770        780        790        800
MEEAVGTIKD KYERERAMLF DENKKLTAEN EKLCSFVDKL TAQNRQLEDE 
       810        820        830        840        850
LQDLAAKKES VAHWEAQIAE IIQWVSDEKD ARGYLQALAS KMTEELEALR 
       860        870        880        890        900
SSSLGSRTLD PLWKVRRSQK LDMSARLELQ SALEAEIRAK QLVQEELRKV 
       910        920        930        940        950
KDANLTLESK LKDSEAKNRE LLEEMEILKK KMEEKFRADT GLKLPDFQDS 
       960        970        980        990       1000
IFEYFNTAPL AHDLTFRTSS ASEQETQAPK PEASPSMSVA ASEQQEDMAR 
      1010       1020       1030       1040       1050
PPQRPSAVPL PTTQALALAG PKPKAHQFSI KSFSSPTQCS HCTSLMVGLI 
      1060       1070       1080       1090       1100
RQGYACEVCS FACHVSCKDG APQVCPIPPE QSKRPLGVDV QRGIGTAYKG 
      1110       1120       1130       1140       1150
HVKVPKPTGV KKGWQRAYAV VCDCKLFLYD LPEGKSTQPG VIASQVLDLR 
      1160       1170       1180       1190       1200
DDEFSVSSVL ASDVIHATRR DIPCIFRVTA SLLGAPSKTS SLLILTENEN 
      1210       1220       1230       1240       1250
EKRKWVGILE GLQSILHKNR LRNQVVHVPL EAYDSSLPLI KAILTAAIVD 
      1260       1270       1280       1290       1300
ADRIAVGLEE GLYVIEVTRD VIVRAADCKK VHQIELAPRE KIVILLCGRN 
      1310       1320       1330       1340       1350
HHVHLYPWSS LDGAEGSFDI KLPETKGCQL MATATLKRNS GTCLFVAVKR 
      1360       1370       1380       1390       1400
LILCYEIQRT KPFHRKFNEI VAPGSVQCLA VLRDRLCVGY PSGFCLLSIQ 
      1410       1420       1430       1440       1450
GDGQPLNLVN PNDPSLAFLS QQSFDALCAV ELESEEYLLC FSHMGLYVDP 
      1460       1470       1480       1490       1500
QGRRARAQEL MWPAAPVACS CSPTHVTVYS EYGVDVFDVR TMEWVQTIGL 
      1510       1520       1530       1540       1550
RRIRPLNSEG TLNLLNCEPP RLIYFKSKFS GAVLNVPDTS DNSKKQMLRT 
      1560       1570       1580       1590       1600
RSKRRFVFKV PEEERLQQRR EMLRDPELRS KMISNPTNFN HVAHMGPGDG 
      1610       1620       1630       1640       1650
MQVLMDLPLS AVPPSQEERP GPAPTNLARQ PPSRNKPYIS WPSSGGSEPS 
      1660       1670       1680       1690       1700
VTVPLRSMSD PDQDFDKEPD SDSTKHSTPS NSSNPSGPPS PNSPHRSQLP 
      1710 
LEGLEQPACD T
Length:1,711
Mass (Da):194,315
Last modified:April 4, 2006 - v2
Checksum:i041A009E0273ABE0
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YLY0H0YLY0_HUMAN
Serine/threonine-protein kinase MRC...
CDC42BPB
666Annotation score:
A0A0U1RRC3A0A0U1RRC3_HUMAN
Serine/threonine-protein kinase MRC...
CDC42BPB
129Annotation score:

Sequence cautioni

The sequence AAH47871 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA86438 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1017A → V in AAD37506 (PubMed:10198171).Curated1
Sequence conflicti1123D → E in AAD37506 (PubMed:10198171).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_040834500K → E in a breast infiltrating ductal carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_040835555R → Q1 PublicationCorresponds to variant dbSNP:rs36001612Ensembl.1
Natural variantiVAR_040836671R → Q1 PublicationCorresponds to variant dbSNP:rs55948035Ensembl.1
Natural variantiVAR_040837876R → W in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0258471077I → V1 PublicationCorresponds to variant dbSNP:rs34822377Ensembl.1
Natural variantiVAR_0708861203R → K2 PublicationsCorresponds to variant dbSNP:rs146298297Ensembl.1
Natural variantiVAR_0408381315E → K in a lung large cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0408391633S → Y1 PublicationCorresponds to variant dbSNP:rs56412851Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF128625 mRNA Translation: AAD37506.1
AB032950 mRNA Translation: BAA86438.2 Different initiation.
DQ355971 Genomic DNA Translation: ABC67469.1
BC047871 mRNA Translation: AAH47871.1 Sequence problems.
BC155541 mRNA Translation: AAI55542.1
CCDSiCCDS9978.1
RefSeqiNP_006026.3, NM_006035.3
UniGeneiHs.654634

Genome annotation databases

EnsembliENST00000361246; ENSP00000355237; ENSG00000198752
GeneIDi9578
KEGGihsa:9578
UCSCiuc001ymi.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF128625 mRNA Translation: AAD37506.1
AB032950 mRNA Translation: BAA86438.2 Different initiation.
DQ355971 Genomic DNA Translation: ABC67469.1
BC047871 mRNA Translation: AAH47871.1 Sequence problems.
BC155541 mRNA Translation: AAI55542.1
CCDSiCCDS9978.1
RefSeqiNP_006026.3, NM_006035.3
UniGeneiHs.654634

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3QFVX-ray2.65A/B1-415[»]
3TKUX-ray2.15A/B2-417[»]
4UAKX-ray1.73A2-417[»]
4UALX-ray1.71A2-417[»]
5OTEX-ray1.68A2-417[»]
5OTFX-ray2.00A2-417[»]
ProteinModelPortaliQ9Y5S2
SMRiQ9Y5S2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114947, 27 interactors
IntActiQ9Y5S2, 15 interactors
MINTiQ9Y5S2
STRINGi9606.ENSP00000355237

Chemistry databases

BindingDBiQ9Y5S2
ChEMBLiCHEMBL5052

PTM databases

iPTMnetiQ9Y5S2
PhosphoSitePlusiQ9Y5S2

Polymorphism and mutation databases

BioMutaiCDC42BPB
DMDMi92090617

Proteomic databases

EPDiQ9Y5S2
MaxQBiQ9Y5S2
PaxDbiQ9Y5S2
PeptideAtlasiQ9Y5S2
PRIDEiQ9Y5S2
ProteomicsDBi86490

Protocols and materials databases

DNASUi9578
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361246; ENSP00000355237; ENSG00000198752
GeneIDi9578
KEGGihsa:9578
UCSCiuc001ymi.2 human

Organism-specific databases

CTDi9578
DisGeNETi9578
EuPathDBiHostDB:ENSG00000198752.10
GeneCardsiCDC42BPB
H-InvDBiHIX0011995
HIX0011996
HGNCiHGNC:1738 CDC42BPB
HPAiHPA022821
MIMi614062 gene
neXtProtiNX_Q9Y5S2
OpenTargetsiENSG00000198752
PharmGKBiPA26268
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IT51 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118994
HOGENOMiHOG000294133
HOVERGENiHBG055933
InParanoidiQ9Y5S2
KOiK16307
OMAiDSAPQVC
OrthoDBiEOG091G09EX
PhylomeDBiQ9Y5S2
TreeFamiTF313551

Enzyme and pathway databases

SignaLinkiQ9Y5S2

Miscellaneous databases

ChiTaRSiCDC42BPB human
GenomeRNAii9578
PROiPR:Q9Y5S2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198752 Expressed in 215 organ(s), highest expression level in adenohypophysis
CleanExiHS_CDC42BPB
ExpressionAtlasiQ9Y5S2 baseline and differential
GenevisibleiQ9Y5S2 HS

Family and domain databases

CDDicd00029 C1, 1 hit
cd00132 CRIB, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR001180 CNH_dom
IPR000095 CRIB_dom
IPR020454 DAG/PE-bd
IPR031597 KELK
IPR011009 Kinase-like_dom_sf
IPR033232 MRCK_beta
IPR014930 Myotonic_dystrophy_kinase_coil
IPR002219 PE/DAG-bd
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR22988:SF34 PTHR22988:SF34, 1 hit
PfamiView protein in Pfam
PF00130 C1_1, 1 hit
PF00780 CNH, 1 hit
PF08826 DMPK_coil, 1 hit
PF15796 KELK, 1 hit
PF00069 Pkinase, 1 hit
PRINTSiPR00008 DAGPEDOMAIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD011252 Myotonic_dystrophy_kinase_coil, 1 hit
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00036 CNH, 1 hit
SM00285 PBD, 1 hit
SM00233 PH, 1 hit
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS50219 CNH, 1 hit
PS50108 CRIB, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMRCKB_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5S2
Secondary accession number(s): A9JR72
, Q2L7A5, Q86TJ1, Q9ULU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: April 4, 2006
Last modified: September 12, 2018
This is version 171 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again