UniProtKB - Q9Y5S2 (MRCKB_HUMAN)
Serine/threonine-protein kinase MRCK beta
CDC42BPB
Functioni
Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762).
In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160).
Phosphorylates PPP1R12A (PubMed:21457715).
In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity).
By similarity3 PublicationsCatalytic activityi
Cofactori
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 105 | ATPPROSITE-ProRule annotationBy similarity | 1 | |
Active sitei | 200 | Proton acceptorPROSITE-ProRule annotationBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 82 – 90 | ATPPROSITE-ProRule annotationBy similarity | 9 | |
Zinc fingeri | 1025 – 1075 | Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST | 51 |
GO - Molecular functioni
- ATP binding Source: UniProtKB
- magnesium ion binding Source: UniProtKB
- protein-containing complex binding Source: UniProtKB
- protein kinase activity Source: UniProtKB
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: UniProtKB
- protein serine kinase activity Source: RHEA
- small GTPase binding Source: Ensembl
GO - Biological processi
- actin cytoskeleton reorganization Source: UniProtKB
- actomyosin structure organization Source: UniProtKB
- cell migration Source: UniProtKB
- cytoskeleton organization Source: ProtInc
- establishment or maintenance of cell polarity Source: ProtInc
- peptidyl-threonine phosphorylation Source: GO_Central
- protein phosphorylation Source: UniProtKB
- signal transduction Source: ProtInc
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9Y5S2 |
Reactomei | R-HSA-9013148, CDC42 GTPase cycle R-HSA-9013406, RHOQ GTPase cycle R-HSA-9013409, RHOJ GTPase cycle |
SignaLinki | Q9Y5S2 |
SIGNORi | Q9Y5S2 |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein kinase MRCK beta (EC:2.7.11.1)Alternative name(s): CDC42-binding protein kinase beta Short name: CDC42BP-beta DMPK-like beta Myotonic dystrophy kinase-related CDC42-binding kinase beta Short name: MRCK beta Short name: Myotonic dystrophy protein kinase-like beta |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1738, CDC42BPB |
MIMi | 614062, gene |
neXtProti | NX_Q9Y5S2 |
VEuPathDBi | HostDB:ENSG00000198752 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- Cell junction 1 Publication
- lamellipodium By similarity
Note: Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent (By similarity). Detected at the leading edge of migrating cells. Localization at the leading edge of migrating cells requires interaction with catalytically active CDC42 (PubMed:21240187). Localizes in the lamellipodium in a FAM89B/LRAP25-dependent manner (By similarity).By similarity1 Publication
Cytoskeleton
- actomyosin Source: UniProtKB
- cytoskeleton Source: GO_Central
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- cell leading edge Source: UniProtKB
- cell-cell junction Source: UniProtKB
- cytoplasm Source: GO_Central
- lamellipodium Source: UniProtKB
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Cytoplasm, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 9578 |
OpenTargetsi | ENSG00000198752 |
PharmGKBi | PA26268 |
Miscellaneous databases
Pharosi | Q9Y5S2, Tchem |
Chemistry databases
ChEMBLi | CHEMBL5052 |
DrugCentrali | Q9Y5S2 |
Genetic variation databases
BioMutai | CDC42BPB |
DMDMi | 92090617 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000086394 | 1 – 1711 | Serine/threonine-protein kinase MRCK betaAdd BLAST | 1711 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 221 | Phosphoserine; by autocatalysisBy similarity | 1 | |
Modified residuei | 233 | Phosphoserine; by autocatalysisBy similarity | 1 | |
Modified residuei | 239 | Phosphothreonine; by autocatalysisBy similarity | 1 | |
Modified residuei | 423 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 671 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 954 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 1680 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1682 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1686 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1690 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1693 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
EPDi | Q9Y5S2 |
jPOSTi | Q9Y5S2 |
MassIVEi | Q9Y5S2 |
MaxQBi | Q9Y5S2 |
PaxDbi | Q9Y5S2 |
PeptideAtlasi | Q9Y5S2 |
PRIDEi | Q9Y5S2 |
ProteomicsDBi | 86490 |
PTM databases
iPTMneti | Q9Y5S2 |
MetOSitei | Q9Y5S2 |
PhosphoSitePlusi | Q9Y5S2 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000198752, Expressed in adenohypophysis and 229 other tissues |
ExpressionAtlasi | Q9Y5S2, baseline and differential |
Genevisiblei | Q9Y5S2, HS |
Organism-specific databases
HPAi | ENSG00000198752, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer and homotetramer via the coiled coil regions (PubMed:21949762).
Interacts tightly with GTP-bound but not GDP-bound CDC42.
Interacts with TJP1, when in the presence of catalytically active CDC42 (By similarity).
Forms a tripartite complex with MYO18A and LURAP1 with the latter acting as an adapter connecting CDC42BPB and MYO18A. LURAP1 binding results in activation of CDC42BPB by abolition of its negative autoregulation (PubMed:18854160).
Interacts with STRIP1, STRN3 and SIKE1 (PubMed:25743393).
Interacts with CPNE4 (via VWFA domain).
Interacts with LURAP1.
Interacts (via AGC-kinase C-terminal domain) with FAM89B/LRAP25 (via LRR repeat).
Forms a tripartite complex with FAM89B/LRAP25 and LIMK1 (By similarity).
By similarity3 PublicationsGO - Molecular functioni
- small GTPase binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 114947, 75 interactors |
IntActi | Q9Y5S2, 27 interactors |
MINTi | Q9Y5S2 |
STRINGi | 9606.ENSP00000355237 |
Chemistry databases
BindingDBi | Q9Y5S2 |
Miscellaneous databases
RNActi | Q9Y5S2, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q9Y5S2 |
SMRi | Q9Y5S2 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 76 – 342 | Protein kinasePROSITE-ProRule annotationBy similarityAdd BLAST | 267 | |
Domaini | 343 – 413 | AGC-kinase C-terminalPROSITE-ProRule annotationAdd BLAST | 71 | |
Domaini | 1095 – 1214 | PHPROSITE-ProRule annotationAdd BLAST | 120 | |
Domaini | 1240 – 1513 | CNHPROSITE-ProRule annotationAdd BLAST | 274 | |
Domaini | 1583 – 1596 | CRIBPROSITE-ProRule annotationAdd BLAST | 14 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 461 – 484 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 969 – 1009 | DisorderedSequence analysisAdd BLAST | 41 | |
Regioni | 1611 – 1711 | DisorderedSequence analysisAdd BLAST | 101 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 431 – 815 | Sequence analysisAdd BLAST | 385 | |
Coiled coili | 878 – 939 | Sequence analysisAdd BLAST | 62 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 461 – 478 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 969 – 993 | Polar residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 1628 – 1657 | Polar residuesSequence analysisAdd BLAST | 30 | |
Compositional biasi | 1660 – 1674 | Basic and acidic residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1025 – 1075 | Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST | 51 |
Keywords - Domaini
Coiled coil, Zinc-fingerPhylogenomic databases
eggNOGi | KOG0612, Eukaryota |
GeneTreei | ENSGT01030000234517 |
HOGENOMi | CLU_000288_140_3_1 |
InParanoidi | Q9Y5S2 |
OMAi | CGRSHHV |
OrthoDBi | 759391at2759 |
PhylomeDBi | Q9Y5S2 |
TreeFami | TF313551 |
Family and domain databases
CDDi | cd00029, C1, 1 hit cd05624, STKc_MRCK_beta, 1 hit |
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR046349, C1-like_sf IPR001180, CNH_dom IPR000095, CRIB_dom IPR020454, DAG/PE-bd IPR031597, KELK IPR011009, Kinase-like_dom_sf IPR033232, MRCK_beta IPR042718, MRCKB_STKc IPR014930, Myotonic_dystrophy_kinase_coil IPR002219, PE/DAG-bd IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
PANTHERi | PTHR22988:SF34, PTHR22988:SF34, 1 hit |
Pfami | View protein in Pfam PF00130, C1_1, 1 hit PF00780, CNH, 1 hit PF08826, DMPK_coil, 1 hit PF15796, KELK, 1 hit PF00069, Pkinase, 1 hit |
PRINTSi | PR00008, DAGPEDOMAIN |
SMARTi | View protein in SMART SM00109, C1, 1 hit SM00036, CNH, 1 hit SM00285, PBD, 1 hit SM00233, PH, 1 hit SM00133, S_TK_X, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit SSF57889, SSF57889, 1 hit |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS50219, CNH, 1 hit PS50108, CRIB, 1 hit PS50003, PH_DOMAIN, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS00479, ZF_DAG_PE_1, 1 hit PS50081, ZF_DAG_PE_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MSAKVRLKKL EQLLLDGPWR NESALSVETL LDVLVCLYTE CSHSALRRDK
60 70 80 90 100
YVAEFLEWAK PFTQLVKEMQ LHREDFEIIK VIGRGAFGEV AVVKMKNTER
110 120 130 140 150
IYAMKILNKW EMLKRAETAC FREERDVLVN GDCQWITALH YAFQDENHLY
160 170 180 190 200
LVMDYYVGGD LLTLLSKFED KLPEDMARFY IGEMVLAIDS IHQLHYVHRD
210 220 230 240 250
IKPDNVLLDV NGHIRLADFG SCLKMNDDGT VQSSVAVGTP DYISPEILQA
260 270 280 290 300
MEDGMGKYGP ECDWWSLGVC MYEMLYGETP FYAESLVETY GKIMNHEERF
310 320 330 340 350
QFPSHVTDVS EEAKDLIQRL ICSRERRLGQ NGIEDFKKHA FFEGLNWENI
360 370 380 390 400
RNLEAPYIPD VSSPSDTSNF DVDDDVLRNT EILPPGSHTG FSGLHLPFIG
410 420 430 440 450
FTFTTESCFS DRGSLKSIMQ SNTLTKDEDV QRDLEHSLQM EAYERRIRRL
460 470 480 490 500
EQEKLELSRK LQESTQTVQS LHGSSRALSN SNRDKEIKKL NEEIERLKNK
510 520 530 540 550
IADSNRLERQ LEDTVALRQE REDSTQRLRG LEKQHRVVRQ EKEELHKQLV
560 570 580 590 600
EASERLKSQA KELKDAHQQR KLALQEFSEL NERMAELRAQ KQKVSRQLRD
610 620 630 640 650
KEEEMEVATQ KVDAMRQEMR RAEKLRKELE AQLDDAVAEA SKERKLREHS
660 670 680 690 700
ENFCKQMESE LEALKVKQGG RGAGATLEHQ QEISKIKSEL EKKVLFYEEE
710 720 730 740 750
LVRREASHVL EVKNVKKEVH DSESHQLALQ KEILMLKDKL EKSKRERHNE
760 770 780 790 800
MEEAVGTIKD KYERERAMLF DENKKLTAEN EKLCSFVDKL TAQNRQLEDE
810 820 830 840 850
LQDLAAKKES VAHWEAQIAE IIQWVSDEKD ARGYLQALAS KMTEELEALR
860 870 880 890 900
SSSLGSRTLD PLWKVRRSQK LDMSARLELQ SALEAEIRAK QLVQEELRKV
910 920 930 940 950
KDANLTLESK LKDSEAKNRE LLEEMEILKK KMEEKFRADT GLKLPDFQDS
960 970 980 990 1000
IFEYFNTAPL AHDLTFRTSS ASEQETQAPK PEASPSMSVA ASEQQEDMAR
1010 1020 1030 1040 1050
PPQRPSAVPL PTTQALALAG PKPKAHQFSI KSFSSPTQCS HCTSLMVGLI
1060 1070 1080 1090 1100
RQGYACEVCS FACHVSCKDG APQVCPIPPE QSKRPLGVDV QRGIGTAYKG
1110 1120 1130 1140 1150
HVKVPKPTGV KKGWQRAYAV VCDCKLFLYD LPEGKSTQPG VIASQVLDLR
1160 1170 1180 1190 1200
DDEFSVSSVL ASDVIHATRR DIPCIFRVTA SLLGAPSKTS SLLILTENEN
1210 1220 1230 1240 1250
EKRKWVGILE GLQSILHKNR LRNQVVHVPL EAYDSSLPLI KAILTAAIVD
1260 1270 1280 1290 1300
ADRIAVGLEE GLYVIEVTRD VIVRAADCKK VHQIELAPRE KIVILLCGRN
1310 1320 1330 1340 1350
HHVHLYPWSS LDGAEGSFDI KLPETKGCQL MATATLKRNS GTCLFVAVKR
1360 1370 1380 1390 1400
LILCYEIQRT KPFHRKFNEI VAPGSVQCLA VLRDRLCVGY PSGFCLLSIQ
1410 1420 1430 1440 1450
GDGQPLNLVN PNDPSLAFLS QQSFDALCAV ELESEEYLLC FSHMGLYVDP
1460 1470 1480 1490 1500
QGRRARAQEL MWPAAPVACS CSPTHVTVYS EYGVDVFDVR TMEWVQTIGL
1510 1520 1530 1540 1550
RRIRPLNSEG TLNLLNCEPP RLIYFKSKFS GAVLNVPDTS DNSKKQMLRT
1560 1570 1580 1590 1600
RSKRRFVFKV PEEERLQQRR EMLRDPELRS KMISNPTNFN HVAHMGPGDG
1610 1620 1630 1640 1650
MQVLMDLPLS AVPPSQEERP GPAPTNLARQ PPSRNKPYIS WPSSGGSEPS
1660 1670 1680 1690 1700
VTVPLRSMSD PDQDFDKEPD SDSTKHSTPS NSSNPSGPPS PNSPHRSQLP
1710
LEGLEQPACD T
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YLY0 | H0YLY0_HUMAN | Non-specific serine/threonine prote... | CDC42BPB | 666 | Annotation score: | ||
A0A0U1RRC3 | A0A0U1RRC3_HUMAN | Serine/threonine-protein kinase MRC... | CDC42BPB | 129 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1017 | A → V in AAD37506 (PubMed:10198171).Curated | 1 | |
Sequence conflicti | 1123 | D → E in AAD37506 (PubMed:10198171).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_040834 | 500 | K → E in a breast infiltrating ductal carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1158962067Ensembl. | 1 | |
Natural variantiVAR_040835 | 555 | R → Q1 PublicationCorresponds to variant dbSNP:rs36001612Ensembl. | 1 | |
Natural variantiVAR_040836 | 671 | R → Q1 PublicationCorresponds to variant dbSNP:rs55948035Ensembl. | 1 | |
Natural variantiVAR_040837 | 876 | R → W in a colorectal adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1595472741EnsemblClinVar. | 1 | |
Natural variantiVAR_025847 | 1077 | I → V1 PublicationCorresponds to variant dbSNP:rs34822377Ensembl. | 1 | |
Natural variantiVAR_070886 | 1203 | R → K2 PublicationsCorresponds to variant dbSNP:rs146298297Ensembl. | 1 | |
Natural variantiVAR_040838 | 1315 | E → K in a lung large cell carcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_040839 | 1633 | S → Y1 PublicationCorresponds to variant dbSNP:rs56412851Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF128625 mRNA Translation: AAD37506.1 AB032950 mRNA Translation: BAA86438.2 Different initiation. DQ355971 Genomic DNA Translation: ABC67469.1 BC047871 mRNA Translation: AAH47871.1 Sequence problems. BC155541 mRNA Translation: AAI55542.1 |
CCDSi | CCDS9978.1 |
RefSeqi | NP_006026.3, NM_006035.3 |
Genome annotation databases
Ensembli | ENST00000361246.7; ENSP00000355237.2; ENSG00000198752.11 |
GeneIDi | 9578 |
KEGGi | hsa:9578 |
MANE-Selecti | ENST00000361246.7; ENSP00000355237.2; NM_006035.4; NP_006026.3 |
UCSCi | uc001ymi.2, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF128625 mRNA Translation: AAD37506.1 AB032950 mRNA Translation: BAA86438.2 Different initiation. DQ355971 Genomic DNA Translation: ABC67469.1 BC047871 mRNA Translation: AAH47871.1 Sequence problems. BC155541 mRNA Translation: AAI55542.1 |
CCDSi | CCDS9978.1 |
RefSeqi | NP_006026.3, NM_006035.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3QFV | X-ray | 2.65 | A/B | 1-415 | [»] | |
3TKU | X-ray | 2.15 | A/B | 2-417 | [»] | |
4UAK | X-ray | 1.73 | A | 2-417 | [»] | |
4UAL | X-ray | 1.71 | A | 2-417 | [»] | |
5OTE | X-ray | 1.68 | A | 2-417 | [»] | |
5OTF | X-ray | 2.00 | A | 2-417 | [»] | |
AlphaFoldDBi | Q9Y5S2 | |||||
SMRi | Q9Y5S2 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114947, 75 interactors |
IntActi | Q9Y5S2, 27 interactors |
MINTi | Q9Y5S2 |
STRINGi | 9606.ENSP00000355237 |
Chemistry databases
BindingDBi | Q9Y5S2 |
ChEMBLi | CHEMBL5052 |
DrugCentrali | Q9Y5S2 |
PTM databases
iPTMneti | Q9Y5S2 |
MetOSitei | Q9Y5S2 |
PhosphoSitePlusi | Q9Y5S2 |
Genetic variation databases
BioMutai | CDC42BPB |
DMDMi | 92090617 |
Proteomic databases
EPDi | Q9Y5S2 |
jPOSTi | Q9Y5S2 |
MassIVEi | Q9Y5S2 |
MaxQBi | Q9Y5S2 |
PaxDbi | Q9Y5S2 |
PeptideAtlasi | Q9Y5S2 |
PRIDEi | Q9Y5S2 |
ProteomicsDBi | 86490 |
Protocols and materials databases
Antibodypediai | 14692, 174 antibodies from 28 providers |
DNASUi | 9578 |
Genome annotation databases
Ensembli | ENST00000361246.7; ENSP00000355237.2; ENSG00000198752.11 |
GeneIDi | 9578 |
KEGGi | hsa:9578 |
MANE-Selecti | ENST00000361246.7; ENSP00000355237.2; NM_006035.4; NP_006026.3 |
UCSCi | uc001ymi.2, human |
Organism-specific databases
CTDi | 9578 |
DisGeNETi | 9578 |
GeneCardsi | CDC42BPB |
HGNCi | HGNC:1738, CDC42BPB |
HPAi | ENSG00000198752, Low tissue specificity |
MIMi | 614062, gene |
neXtProti | NX_Q9Y5S2 |
OpenTargetsi | ENSG00000198752 |
PharmGKBi | PA26268 |
VEuPathDBi | HostDB:ENSG00000198752 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0612, Eukaryota |
GeneTreei | ENSGT01030000234517 |
HOGENOMi | CLU_000288_140_3_1 |
InParanoidi | Q9Y5S2 |
OMAi | CGRSHHV |
OrthoDBi | 759391at2759 |
PhylomeDBi | Q9Y5S2 |
TreeFami | TF313551 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y5S2 |
Reactomei | R-HSA-9013148, CDC42 GTPase cycle R-HSA-9013406, RHOQ GTPase cycle R-HSA-9013409, RHOJ GTPase cycle |
SignaLinki | Q9Y5S2 |
SIGNORi | Q9Y5S2 |
Miscellaneous databases
BioGRID-ORCSi | 9578, 12 hits in 1111 CRISPR screens |
ChiTaRSi | CDC42BPB, human |
GenomeRNAii | 9578 |
Pharosi | Q9Y5S2, Tchem |
PROi | PR:Q9Y5S2 |
RNActi | Q9Y5S2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000198752, Expressed in adenohypophysis and 229 other tissues |
ExpressionAtlasi | Q9Y5S2, baseline and differential |
Genevisiblei | Q9Y5S2, HS |
Family and domain databases
CDDi | cd00029, C1, 1 hit cd05624, STKc_MRCK_beta, 1 hit |
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR046349, C1-like_sf IPR001180, CNH_dom IPR000095, CRIB_dom IPR020454, DAG/PE-bd IPR031597, KELK IPR011009, Kinase-like_dom_sf IPR033232, MRCK_beta IPR042718, MRCKB_STKc IPR014930, Myotonic_dystrophy_kinase_coil IPR002219, PE/DAG-bd IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
PANTHERi | PTHR22988:SF34, PTHR22988:SF34, 1 hit |
Pfami | View protein in Pfam PF00130, C1_1, 1 hit PF00780, CNH, 1 hit PF08826, DMPK_coil, 1 hit PF15796, KELK, 1 hit PF00069, Pkinase, 1 hit |
PRINTSi | PR00008, DAGPEDOMAIN |
SMARTi | View protein in SMART SM00109, C1, 1 hit SM00036, CNH, 1 hit SM00285, PBD, 1 hit SM00233, PH, 1 hit SM00133, S_TK_X, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit SSF57889, SSF57889, 1 hit |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS50219, CNH, 1 hit PS50108, CRIB, 1 hit PS50003, PH_DOMAIN, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS00479, ZF_DAG_PE_1, 1 hit PS50081, ZF_DAG_PE_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MRCKB_HUMAN | |
Accessioni | Q9Y5S2Primary (citable) accession number: Q9Y5S2 Secondary accession number(s): A9JR72 Q9ULU5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 8, 2005 |
Last sequence update: | April 4, 2006 | |
Last modified: | May 25, 2022 | |
This is version 195 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families