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Protein

Transient receptor potential cation channel subfamily V member 2

Gene

TRPV2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH.1 Publication

GO - Molecular functioni

  • calcium channel activity Source: GO_Central
  • cation channel activity Source: MGI
  • ion channel activity Source: ProtInc
  • ion transmembrane transporter activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionCalcium channel, Ion channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

ReactomeiR-HSA-3295583 TRP channels

Protein family/group databases

TCDBi1.A.4.2.8 the transient receptor potential ca(2+) channel (trp-cc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily V member 2
Short name:
TrpV2
Alternative name(s):
Osm-9-like TRP channel 2
Short name:
OTRPC2
Vanilloid receptor-like protein 1
Short name:
VRL-1
Gene namesi
Name:TRPV2
Synonyms:VRL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000187688.14
HGNCiHGNC:18082 TRPV2
MIMi606676 gene
neXtProtiNX_Q9Y5S1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 390CytoplasmicSequence analysisAdd BLAST390
Transmembranei391 – 411HelicalSequence analysisAdd BLAST21
Topological domaini412 – 434ExtracellularSequence analysisAdd BLAST23
Transmembranei435 – 455HelicalSequence analysisAdd BLAST21
Topological domaini456 – 471CytoplasmicSequence analysisAdd BLAST16
Transmembranei472 – 492HelicalSequence analysisAdd BLAST21
Topological domaini493ExtracellularSequence analysis1
Transmembranei494 – 514HelicalSequence analysisAdd BLAST21
Topological domaini515 – 537CytoplasmicSequence analysisAdd BLAST23
Transmembranei538 – 558HelicalSequence analysisAdd BLAST21
Intramembranei572 – 609Pore-formingSequence analysisAdd BLAST38
Transmembranei622 – 642HelicalSequence analysisAdd BLAST21
Topological domaini643 – 764CytoplasmicSequence analysisAdd BLAST122

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi51393
OpenTargetsiENSG00000187688
PharmGKBiPA38292

Chemistry databases

ChEMBLiCHEMBL5051
GuidetoPHARMACOLOGYi508

Polymorphism and mutation databases

BioMutaiTRPV2
DMDMi62901477

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002153421 – 764Transient receptor potential cation channel subfamily V member 2Add BLAST764

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6PhosphoserineBy similarity1
Glycosylationi570N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei751PhosphoserineBy similarity1
Modified residuei763PhosphoserineBy similarity1

Post-translational modificationi

N-glycosylated.By similarity
Phosphorylated by PKA.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9Y5S1
MaxQBiQ9Y5S1
PaxDbiQ9Y5S1
PeptideAtlasiQ9Y5S1
PRIDEiQ9Y5S1
ProteomicsDBi86489

PTM databases

iPTMnetiQ9Y5S1
PhosphoSitePlusiQ9Y5S1

Expressioni

Gene expression databases

BgeeiENSG00000187688 Expressed in 147 organ(s), highest expression level in left adrenal gland
CleanExiHS_TRPV2
ExpressionAtlasiQ9Y5S1 baseline and differential
GenevisibleiQ9Y5S1 HS

Organism-specific databases

HPAiHPA044993

Interactioni

Subunit structurei

Homotetramer (Probable). Interacts with a cAMP-dependent protein kinase type II regulatory subunit (PRKAR2A or PRKAR2B) and ACBD3. Interacts with SLC50A1; the interaction probably occurs intracellularly and depends on TRPV2 N-glycosylation (By similarity).By similarityCurated

Protein-protein interaction databases

BioGridi119520, 1 interactor
IntActiQ9Y5S1, 7 interactors
MINTiQ9Y5S1
STRINGi9606.ENSP00000342222

Structurei

Secondary structure

1764
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9Y5S1
SMRiQ9Y5S1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y5S1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati72 – 114ANK 1PROSITE-ProRule annotation1 PublicationAdd BLAST43
Repeati115 – 161ANK 2PROSITE-ProRule annotation1 PublicationAdd BLAST47
Repeati162 – 207ANK 3PROSITE-ProRule annotation1 PublicationAdd BLAST46
Repeati208 – 243ANK 4PROSITE-ProRule annotation1 PublicationAdd BLAST36
Repeati244 – 292ANK 5PROSITE-ProRule annotation1 PublicationAdd BLAST49
Repeati293 – 319ANK 6PROSITE-ProRule annotation1 PublicationAdd BLAST27

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 388Required for interaction with SLC50A1By similarityAdd BLAST388

Sequence similaritiesi

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3676 Eukaryota
ENOG4110DG4 LUCA
GeneTreeiENSGT00550000074425
HOGENOMiHOG000234630
HOVERGENiHBG054085
InParanoidiQ9Y5S1
KOiK04971
OMAiVEEVNWA
OrthoDBiEOG091G02AF
PhylomeDBiQ9Y5S1
TreeFamiTF314711

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR005821 Ion_trans_dom
IPR004729 TRP_channel
IPR024862 TRPV
IPR008347 TRPV1-4_channel
IPR024865 TRPV2_channel
PANTHERiPTHR10582 PTHR10582, 1 hit
PTHR10582:SF5 PTHR10582:SF5, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR01768 TRPVRECEPTOR
SMARTiView protein in SMART
SM00248 ANK, 4 hits
SUPFAMiSSF48403 SSF48403, 1 hit
TIGRFAMsiTIGR00870 trp, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q9Y5S1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSPSSSPVF RLETLDGGQE DGSEADRGKL DFGSGLPPME SQFQGEDRKF
60 70 80 90 100
APQIRVNLNY RKGTGASQPD PNRFDRDRLF NAVSRGVPED LAGLPEYLSK
110 120 130 140 150
TSKYLTDSEY TEGSTGKTCL MKAVLNLKDG VNACILPLLQ IDRDSGNPQP
160 170 180 190 200
LVNAQCTDDY YRGHSALHIA IEKRSLQCVK LLVENGANVH ARACGRFFQK
210 220 230 240 250
GQGTCFYFGE LPLSLAACTK QWDVVSYLLE NPHQPASLQA TDSQGNTVLH
260 270 280 290 300
ALVMISDNSA ENIALVTSMY DGLLQAGARL CPTVQLEDIR NLQDLTPLKL
310 320 330 340 350
AAKEGKIEIF RHILQREFSG LSHLSRKFTE WCYGPVRVSL YDLASVDSCE
360 370 380 390 400
ENSVLEIIAF HCKSPHRHRM VVLEPLNKLL QAKWDLLIPK FFLNFLCNLI
410 420 430 440 450
YMFIFTAVAY HQPTLKKQAA PHLKAEVGNS MLLTGHILIL LGGIYLLVGQ
460 470 480 490 500
LWYFWRRHVF IWISFIDSYF EILFLFQALL TVVSQVLCFL AIEWYLPLLV
510 520 530 540 550
SALVLGWLNL LYYTRGFQHT GIYSVMIQKV ILRDLLRFLL IYLVFLFGFA
560 570 580 590 600
VALVSLSQEA WRPEAPTGPN ATESVQPMEG QEDEGNGAQY RGILEASLEL
610 620 630 640 650
FKFTIGMGEL AFQEQLHFRG MVLLLLLAYV LLTYILLLNM LIALMSETVN
660 670 680 690 700
SVATDSWSIW KLQKAISVLE MENGYWWCRK KQRAGVMLTV GTKPDGSPDE
710 720 730 740 750
RWCFRVEEVN WASWEQTLPT LCEDPSGAGV PRTLENPVLA SPPKEDEDGA
760
SEENYVPVQL LQSN
Length:764
Mass (Da):85,981
Last modified:November 1, 1999 - v1
Checksum:iA73E3696E70F91E9
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BZK2H7BZK2_HUMAN
Transient receptor potential cation...
TRPV2
266Annotation score:
K7EKG5K7EKG5_HUMAN
Transient receptor potential cation...
TRPV2
138Annotation score:
K7ELL3K7ELL3_HUMAN
Transient receptor potential cation...
TRPV2
96Annotation score:
K7EIQ6K7EIQ6_HUMAN
Transient receptor potential cation...
TRPV2
77Annotation score:
K7EPY7K7EPY7_HUMAN
Transient receptor potential cation...
TRPV2
90Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52P → S in AAD41724 (Ref. 2) Curated1
Sequence conflicti82A → V in AAD41724 (Ref. 2) Curated1
Sequence conflicti200K → N in AAD41724 (Ref. 2) Curated1
Sequence conflicti459V → L in AAD41724 (Ref. 2) Curated1
Sequence conflicti465 – 466FI → YT in AAD41724 (Ref. 2) Curated2
Sequence conflicti477 – 478QA → HS in AAD41724 (Ref. 2) Curated2
Sequence conflicti485Q → L in AAD41724 (Ref. 2) Curated1
Sequence conflicti491A → V in AAD41724 (Ref. 2) Curated1
Sequence conflicti535 – 536LL → MV in AAD41724 (Ref. 2) Curated2
Sequence conflicti540L → V in AAD41724 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02467817G → A. Corresponds to variant dbSNP:rs3813768Ensembl.1
Natural variantiVAR_059838764N → S. Corresponds to variant dbSNP:rs8071215Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129112 mRNA Translation: AAD26363.1
AF103906 mRNA Translation: AAD41724.1
AJ487963 mRNA Translation: CAD32310.1
AK289705 mRNA Translation: BAF82394.1
AC093484 Genomic DNA No translation available.
CH471222 Genomic DNA Translation: EAX04508.1
BC018926 mRNA Translation: AAH18926.1
BC051305 mRNA Translation: AAH51305.1
CCDSiCCDS32576.1
RefSeqiNP_057197.2, NM_016113.4
UniGeneiHs.279746

Genome annotation databases

EnsembliENST00000338560; ENSP00000342222; ENSG00000187688
GeneIDi51393
KEGGihsa:51393
UCSCiuc002gpy.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129112 mRNA Translation: AAD26363.1
AF103906 mRNA Translation: AAD41724.1
AJ487963 mRNA Translation: CAD32310.1
AK289705 mRNA Translation: BAF82394.1
AC093484 Genomic DNA No translation available.
CH471222 Genomic DNA Translation: EAX04508.1
BC018926 mRNA Translation: AAH18926.1
BC051305 mRNA Translation: AAH51305.1
CCDSiCCDS32576.1
RefSeqiNP_057197.2, NM_016113.4
UniGeneiHs.279746

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2F37X-ray1.70A/B69-319[»]
ProteinModelPortaliQ9Y5S1
SMRiQ9Y5S1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119520, 1 interactor
IntActiQ9Y5S1, 7 interactors
MINTiQ9Y5S1
STRINGi9606.ENSP00000342222

Chemistry databases

ChEMBLiCHEMBL5051
GuidetoPHARMACOLOGYi508

Protein family/group databases

TCDBi1.A.4.2.8 the transient receptor potential ca(2+) channel (trp-cc) family

PTM databases

iPTMnetiQ9Y5S1
PhosphoSitePlusiQ9Y5S1

Polymorphism and mutation databases

BioMutaiTRPV2
DMDMi62901477

Proteomic databases

EPDiQ9Y5S1
MaxQBiQ9Y5S1
PaxDbiQ9Y5S1
PeptideAtlasiQ9Y5S1
PRIDEiQ9Y5S1
ProteomicsDBi86489

Protocols and materials databases

DNASUi51393
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338560; ENSP00000342222; ENSG00000187688
GeneIDi51393
KEGGihsa:51393
UCSCiuc002gpy.3 human

Organism-specific databases

CTDi51393
DisGeNETi51393
EuPathDBiHostDB:ENSG00000187688.14
GeneCardsiTRPV2
HGNCiHGNC:18082 TRPV2
HPAiHPA044993
MIMi606676 gene
neXtProtiNX_Q9Y5S1
OpenTargetsiENSG00000187688
PharmGKBiPA38292
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3676 Eukaryota
ENOG4110DG4 LUCA
GeneTreeiENSGT00550000074425
HOGENOMiHOG000234630
HOVERGENiHBG054085
InParanoidiQ9Y5S1
KOiK04971
OMAiVEEVNWA
OrthoDBiEOG091G02AF
PhylomeDBiQ9Y5S1
TreeFamiTF314711

Enzyme and pathway databases

ReactomeiR-HSA-3295583 TRP channels

Miscellaneous databases

ChiTaRSiTRPV2 human
EvolutionaryTraceiQ9Y5S1
GeneWikiiTRPV2
GenomeRNAii51393
PROiPR:Q9Y5S1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000187688 Expressed in 147 organ(s), highest expression level in left adrenal gland
CleanExiHS_TRPV2
ExpressionAtlasiQ9Y5S1 baseline and differential
GenevisibleiQ9Y5S1 HS

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR005821 Ion_trans_dom
IPR004729 TRP_channel
IPR024862 TRPV
IPR008347 TRPV1-4_channel
IPR024865 TRPV2_channel
PANTHERiPTHR10582 PTHR10582, 1 hit
PTHR10582:SF5 PTHR10582:SF5, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR01768 TRPVRECEPTOR
SMARTiView protein in SMART
SM00248 ANK, 4 hits
SUPFAMiSSF48403 SSF48403, 1 hit
TIGRFAMsiTIGR00870 trp, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRPV2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5S1
Secondary accession number(s): A6NML2, A8K0Z0, Q9Y670
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: November 1, 1999
Last modified: September 12, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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