UniProtKB - Q9Y5R8 (TPPC1_HUMAN)

BLAST

>sp|Q9Y5R8|TPPC1_HUMAN Trafficking protein particle complex subunit 1 OS=Homo sapiens OX=9606 GN=TRAPPC1 PE=1 SV=1
MTVHNLYLFDRNGVCLHYSEWHRKKQAGIPKEEEYKLMYGMLFSIRSFVSKMSPLDMKDG
FLAFQTSRYKLHYYETPTGIKVVMNTDLGVGPIRDVLHHIYSALYVELVVKNPLCPLGQT
VQSELFRSRLDSYVRSLPFFSARAG

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History
Entry version 140 (07 Nov 2018)
Sequence version 1 (01 Nov 1999)
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Protein

Trafficking protein particle complex subunit 1

Gene

TRAPPC1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

May play a role in vesicular transport from endoplasmic reticulum to Golgi.

GO - Molecular functionⁱ

Rab guanyl-nucleotide exchange factor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

COPII vesicle coating Source: Reactome
ER to Golgi vesicle-mediated transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
neutrophil degranulation Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	ER-Golgi transport, Transport

Biological process

ER-Golgi transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-204005 COPII-mediated vesicle transport R-HSA-6798695 Neutrophil degranulation R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs
SignaLinkⁱ	Q9Y5R8

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Trafficking protein particle complex subunit 1 Alternative name(s): BET5 homolog Multiple myeloma protein 2 Short name: MUM-2
Gene namesⁱ	Name:TRAPPC1Imported Synonyms:BET5, MUM21 Publication
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000170043.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19894 TRAPPC1
MIMⁱ	610969 gene
neXtProtⁱ	NX_Q9Y5R8

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Golgi apparatus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	58485
Open Targets More...OpenTargetsⁱ	ENSG00000170043
PharmGKBⁱ	PA134988492

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB08342 S-PALMITOYL-L-CYSTEINE

DrugBankⁱ

DB08342 S-PALMITOYL-L-CYSTEINE

Polymorphism and mutation databases

BioMutaⁱ	TRAPPC1

BioMutaⁱ

TRAPPC1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000211562	1 – 145	Trafficking protein particle complex subunit 1Add BLAST		145

Proteomic databases

EPDⁱ	Q9Y5R8
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9Y5R8
PaxDbⁱ	Q9Y5R8
PeptideAtlas More...PeptideAtlasⁱ	Q9Y5R8
PRIDEⁱ	Q9Y5R8
ProteomicsDBⁱ	86488

PTM databases

iPTMnetⁱ	Q9Y5R8
PhosphoSitePlusⁱ	Q9Y5R8

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000170043 Expressed in 192 organ(s), highest expression level in leukocyte
CleanExⁱ	HS_TRAPPC1
ExpressionAtlasⁱ	Q9Y5R8 baseline and differential
Genevisibleⁱ	Q9Y5R8 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA052398

HPAⁱ

HPA052398

Interactionⁱ

Subunit structureⁱ

Part of the multisubunit transport protein particle (TRAPP) complex (PubMed:11805826). The heterodimer TRAPPC6B-TRAPPC3 interacts with TRAPPC1 likely providing a core for TRAPP complex formation (PubMed:16828797).2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
TRAPPC3	O43617	4	EBI-6160554,EBI-743566

With

Entry

#Exp.

IntAct

Notes

TRAPPC3

O43617

EBI-6160554,EBI-743566

GO - Molecular functionⁱ

Rab guanyl-nucleotide exchange factor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	121815, 33 interactors
CORUMⁱ	Q9Y5R8
Database of interacting proteins More...DIPⁱ	DIP-48285N
IntActⁱ	Q9Y5R8, 6 interactors
STRINGⁱ	9606.ENSP00000302783

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9Y5R8
SMRⁱ	Q9Y5R8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the TRAPP small subunits family. BET5 subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG3368 Eukaryota ENOG4111X41 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000047863
HOGENOMⁱ	HOG000172118
HOVERGENⁱ	HBG056032
InParanoidⁱ	Q9Y5R8
KEGG Orthology (KO) More...KOⁱ	K20300
OMAⁱ	HDPREGF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0RVD
PhylomeDBⁱ	Q9Y5R8
TreeFamⁱ	TF323681

Family and domain databases

InterProⁱ	View protein in InterPro IPR011012 Longin-like_dom_sf IPR007233 TRAPPC
PANTHERⁱ	PTHR23249 PTHR23249, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04099 Sybindin, 1 hit
SMARTⁱ	View protein in SMART SM01399 Sybindin, 1 hit
SUPFAMⁱ	SSF64356 SSF64356, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

Q9Y5R8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTVHNLYLFD RNGVCLHYSE WHRKKQAGIP KEEEYKLMYG MLFSIRSFVS 
        60         70         80         90        100
KMSPLDMKDG FLAFQTSRYK LHYYETPTGI KVVMNTDLGV GPIRDVLHHI 
       110        120        130        140 
YSALYVELVV KNPLCPLGQT VQSELFRSRL DSYVRSLPFF SARAG

Length:145

Mass (Da):16,832

Last modified:November 1, 1999 - v1

Checksum:ⁱ7C8C81D3F0E8DCC6

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

I3L3S0	I3L3S0_HUMAN	Trafficking protein particle comple... Trafficking protein particle complex subunit 1	TRAPPC1	95	Annotation score:
I3L3V5	I3L3V5_HUMAN	Trafficking protein particle comple... Trafficking protein particle complex subunit 1	TRAPPC1	75	Annotation score:
I3L1R8	I3L1R8_HUMAN	Trafficking protein particle comple... Trafficking protein particle complex subunit 1	TRAPPC1	42	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_013028	129	R → G in a melanoma. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF129332 Genomic DNA Translation: AAD44697.1 CH471108 Genomic DNA Translation: EAW90109.1 CH471108 Genomic DNA Translation: EAW90110.1 CH471108 Genomic DNA Translation: EAW90111.1 BC032717 mRNA Translation: AAH32717.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11125.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001160093.1, NM_001166621.1 NP_067033.1, NM_021210.4
UniGeneⁱ	Hs.24379

Genome annotation databases

Ensemblⁱ	ENST00000303731; ENSP00000302783; ENSG00000170043 ENST00000540486; ENSP00000441130; ENSG00000170043
GeneIDⁱ	58485
KEGGⁱ	hsa:58485
UCSC genome browser More...UCSCⁱ	uc002gjo.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Y5R8	Trafficking protein particle complex subunit 1		BOVIN		145	UniRef100_Q9Y5R8
TRAPPC1 isoform 2		PANTR		145
Trafficking protein particle complex 1		CALJA		145
BET5-like protein		MACMU		145
Uncharacterized protein (Fragment)		AILME		145
+36

Protein	Similar proteins		Species	Score	Length	Source
Q9Y5R8	Trafficking protein particle complex subunit 1		BOVIN		145	UniRef90_Q9Y5R8
Trafficking protein particle complex subunit 1	)	MOUSE		145
Trafficking protein particle complex subunit 1		RAT		145
TRAPPC1 isoform 2		PANTR		145
Trafficking protein particle complex 1		CALJA		145
+82

Protein	Similar proteins		Species	Score	Length	Source
Q9Y5R8	Trafficking protein particle complex subunit 1		BOVIN		145	UniRef50_Q9Y5R8
Trafficking protein particle complex subunit 1	)	MOUSE		145
Trafficking protein particle complex subunit 1		RAT		145
TRAPPC1 isoform 2		PANTR		145
Trafficking protein particle complex 1		CALJA		145
+87

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF129332 Genomic DNA Translation: AAD44697.1 CH471108 Genomic DNA Translation: EAW90109.1 CH471108 Genomic DNA Translation: EAW90110.1 CH471108 Genomic DNA Translation: EAW90111.1 BC032717 mRNA Translation: AAH32717.1
CCDSⁱ	CCDS11125.1
RefSeqⁱ	NP_001160093.1, NM_001166621.1 NP_067033.1, NM_021210.4
UniGeneⁱ	Hs.24379

3D structure databases

ProteinModelPortalⁱ	Q9Y5R8
SMRⁱ	Q9Y5R8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121815, 33 interactors
CORUMⁱ	Q9Y5R8
DIPⁱ	DIP-48285N
IntActⁱ	Q9Y5R8, 6 interactors
STRINGⁱ	9606.ENSP00000302783

Chemistry databases

DrugBankⁱ	DB08342 S-PALMITOYL-L-CYSTEINE

DrugBankⁱ

DB08342 S-PALMITOYL-L-CYSTEINE

PTM databases

iPTMnetⁱ	Q9Y5R8
PhosphoSitePlusⁱ	Q9Y5R8

Polymorphism and mutation databases

BioMutaⁱ	TRAPPC1

BioMutaⁱ

TRAPPC1

Proteomic databases

EPDⁱ	Q9Y5R8
MaxQBⁱ	Q9Y5R8
PaxDbⁱ	Q9Y5R8
PeptideAtlasⁱ	Q9Y5R8
PRIDEⁱ	Q9Y5R8
ProteomicsDBⁱ	86488

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	58485
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000303731; ENSP00000302783; ENSG00000170043 ENST00000540486; ENSP00000441130; ENSG00000170043
GeneIDⁱ	58485
KEGGⁱ	hsa:58485
UCSCⁱ	uc002gjo.3 human

Organism-specific databases

CTDⁱ	58485
DisGeNETⁱ	58485
EuPathDBⁱ	HostDB:ENSG00000170043.11
GeneCardsⁱ	TRAPPC1
HGNCⁱ	HGNC:19894 TRAPPC1
HPAⁱ	HPA052398
MIMⁱ	610969 gene
neXtProtⁱ	NX_Q9Y5R8
OpenTargetsⁱ	ENSG00000170043
PharmGKBⁱ	PA134988492
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3368 Eukaryota ENOG4111X41 LUCA
GeneTreeⁱ	ENSGT00510000047863
HOGENOMⁱ	HOG000172118
HOVERGENⁱ	HBG056032
InParanoidⁱ	Q9Y5R8
KOⁱ	K20300
OMAⁱ	HDPREGF
OrthoDBⁱ	EOG091G0RVD
PhylomeDBⁱ	Q9Y5R8
TreeFamⁱ	TF323681

Enzyme and pathway databases

Reactomeⁱ	R-HSA-204005 COPII-mediated vesicle transport R-HSA-6798695 Neutrophil degranulation R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs
SignaLinkⁱ	Q9Y5R8

Miscellaneous databases

ChiTaRSⁱ	TRAPPC1 human
GenomeRNAiⁱ	58485
Protein Ontology More...PROⁱ	PR:Q9Y5R8
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000170043 Expressed in 192 organ(s), highest expression level in leukocyte
CleanExⁱ	HS_TRAPPC1
ExpressionAtlasⁱ	Q9Y5R8 baseline and differential
Genevisibleⁱ	Q9Y5R8 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR011012 Longin-like_dom_sf IPR007233 TRAPPC
PANTHERⁱ	PTHR23249 PTHR23249, 1 hit
Pfamⁱ	View protein in Pfam PF04099 Sybindin, 1 hit
SMARTⁱ	View protein in SMART SM01399 Sybindin, 1 hit
SUPFAMⁱ	SSF64356 SSF64356, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TPPC1_HUMAN
Accessionⁱ	Q9Y5R8Primary (citable) accession number: Q9Y5R8 Secondary accession number(s): D3DTR0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 16, 2002
	Last sequence update:	November 1, 1999
	Last modified:	November 7, 2018
	This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM

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UniParc

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UniRef

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Supporting data

UniProtKB - Q9Y5R8 (TPPC1_HUMAN)

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Trafficking protein particle complex subunit 1

TRAPPC1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Endoplasmic reticulum

Cytosol

Endoplasmic reticulum

Extracellular region or secreted

Golgi apparatus

Lysosome

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ