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Protein

Trafficking protein particle complex subunit 1

Gene

TRAPPC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in vesicular transport from endoplasmic reticulum to Golgi.

GO - Molecular functioni

  • Rab guanyl-nucleotide exchange factor activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII-mediated vesicle transport
R-HSA-6798695 Neutrophil degranulation
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs
SignaLinkiQ9Y5R8

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex subunit 1
Alternative name(s):
BET5 homolog
Multiple myeloma protein 2
Short name:
MUM-2
Gene namesi
Name:TRAPPC1Imported
Synonyms:BET5, MUM21 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000170043.11
HGNCiHGNC:19894 TRAPPC1
MIMi610969 gene
neXtProtiNX_Q9Y5R8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

Pathology & Biotechi

Organism-specific databases

DisGeNETi58485
OpenTargetsiENSG00000170043
PharmGKBiPA134988492

Chemistry databases

DrugBankiDB08342 S-PALMITOYL-L-CYSTEINE

Polymorphism and mutation databases

BioMutaiTRAPPC1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002115621 – 145Trafficking protein particle complex subunit 1Add BLAST145

Proteomic databases

EPDiQ9Y5R8
MaxQBiQ9Y5R8
PaxDbiQ9Y5R8
PeptideAtlasiQ9Y5R8
PRIDEiQ9Y5R8
ProteomicsDBi86488

PTM databases

iPTMnetiQ9Y5R8
PhosphoSitePlusiQ9Y5R8

Expressioni

Gene expression databases

BgeeiENSG00000170043 Expressed in 192 organ(s), highest expression level in leukocyte
CleanExiHS_TRAPPC1
ExpressionAtlasiQ9Y5R8 baseline and differential
GenevisibleiQ9Y5R8 HS

Organism-specific databases

HPAiHPA052398

Interactioni

Subunit structurei

Part of the multisubunit transport protein particle (TRAPP) complex (PubMed:11805826). The heterodimer TRAPPC6B-TRAPPC3 interacts with TRAPPC1 likely providing a core for TRAPP complex formation (PubMed:16828797).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TRAPPC3O436174EBI-6160554,EBI-743566

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121815, 33 interactors
CORUMiQ9Y5R8
DIPiDIP-48285N
IntActiQ9Y5R8, 6 interactors
STRINGi9606.ENSP00000302783

Structurei

3D structure databases

ProteinModelPortaliQ9Y5R8
SMRiQ9Y5R8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3368 Eukaryota
ENOG4111X41 LUCA
GeneTreeiENSGT00510000047863
HOGENOMiHOG000172118
HOVERGENiHBG056032
InParanoidiQ9Y5R8
KOiK20300
OMAiHDPREGF
OrthoDBiEOG091G0RVD
PhylomeDBiQ9Y5R8
TreeFamiTF323681

Family and domain databases

InterProiView protein in InterPro
IPR011012 Longin-like_dom_sf
IPR007233 TRAPPC
PANTHERiPTHR23249 PTHR23249, 1 hit
PfamiView protein in Pfam
PF04099 Sybindin, 1 hit
SMARTiView protein in SMART
SM01399 Sybindin, 1 hit
SUPFAMiSSF64356 SSF64356, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9Y5R8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTVHNLYLFD RNGVCLHYSE WHRKKQAGIP KEEEYKLMYG MLFSIRSFVS
60 70 80 90 100
KMSPLDMKDG FLAFQTSRYK LHYYETPTGI KVVMNTDLGV GPIRDVLHHI
110 120 130 140
YSALYVELVV KNPLCPLGQT VQSELFRSRL DSYVRSLPFF SARAG
Length:145
Mass (Da):16,832
Last modified:November 1, 1999 - v1
Checksum:i7C8C81D3F0E8DCC6
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L3S0I3L3S0_HUMAN
Trafficking protein particle comple...
TRAPPC1
95Annotation score:
I3L3V5I3L3V5_HUMAN
Trafficking protein particle comple...
TRAPPC1
75Annotation score:
I3L1R8I3L1R8_HUMAN
Trafficking protein particle comple...
TRAPPC1
42Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_013028129R → G in a melanoma. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129332 Genomic DNA Translation: AAD44697.1
CH471108 Genomic DNA Translation: EAW90109.1
CH471108 Genomic DNA Translation: EAW90110.1
CH471108 Genomic DNA Translation: EAW90111.1
BC032717 mRNA Translation: AAH32717.1
CCDSiCCDS11125.1
RefSeqiNP_001160093.1, NM_001166621.1
NP_067033.1, NM_021210.4
UniGeneiHs.24379

Genome annotation databases

EnsembliENST00000303731; ENSP00000302783; ENSG00000170043
ENST00000540486; ENSP00000441130; ENSG00000170043
GeneIDi58485
KEGGihsa:58485
UCSCiuc002gjo.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129332 Genomic DNA Translation: AAD44697.1
CH471108 Genomic DNA Translation: EAW90109.1
CH471108 Genomic DNA Translation: EAW90110.1
CH471108 Genomic DNA Translation: EAW90111.1
BC032717 mRNA Translation: AAH32717.1
CCDSiCCDS11125.1
RefSeqiNP_001160093.1, NM_001166621.1
NP_067033.1, NM_021210.4
UniGeneiHs.24379

3D structure databases

ProteinModelPortaliQ9Y5R8
SMRiQ9Y5R8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121815, 33 interactors
CORUMiQ9Y5R8
DIPiDIP-48285N
IntActiQ9Y5R8, 6 interactors
STRINGi9606.ENSP00000302783

Chemistry databases

DrugBankiDB08342 S-PALMITOYL-L-CYSTEINE

PTM databases

iPTMnetiQ9Y5R8
PhosphoSitePlusiQ9Y5R8

Polymorphism and mutation databases

BioMutaiTRAPPC1

Proteomic databases

EPDiQ9Y5R8
MaxQBiQ9Y5R8
PaxDbiQ9Y5R8
PeptideAtlasiQ9Y5R8
PRIDEiQ9Y5R8
ProteomicsDBi86488

Protocols and materials databases

DNASUi58485
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303731; ENSP00000302783; ENSG00000170043
ENST00000540486; ENSP00000441130; ENSG00000170043
GeneIDi58485
KEGGihsa:58485
UCSCiuc002gjo.3 human

Organism-specific databases

CTDi58485
DisGeNETi58485
EuPathDBiHostDB:ENSG00000170043.11
GeneCardsiTRAPPC1
HGNCiHGNC:19894 TRAPPC1
HPAiHPA052398
MIMi610969 gene
neXtProtiNX_Q9Y5R8
OpenTargetsiENSG00000170043
PharmGKBiPA134988492
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3368 Eukaryota
ENOG4111X41 LUCA
GeneTreeiENSGT00510000047863
HOGENOMiHOG000172118
HOVERGENiHBG056032
InParanoidiQ9Y5R8
KOiK20300
OMAiHDPREGF
OrthoDBiEOG091G0RVD
PhylomeDBiQ9Y5R8
TreeFamiTF323681

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII-mediated vesicle transport
R-HSA-6798695 Neutrophil degranulation
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs
SignaLinkiQ9Y5R8

Miscellaneous databases

ChiTaRSiTRAPPC1 human
GenomeRNAii58485
PROiPR:Q9Y5R8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170043 Expressed in 192 organ(s), highest expression level in leukocyte
CleanExiHS_TRAPPC1
ExpressionAtlasiQ9Y5R8 baseline and differential
GenevisibleiQ9Y5R8 HS

Family and domain databases

InterProiView protein in InterPro
IPR011012 Longin-like_dom_sf
IPR007233 TRAPPC
PANTHERiPTHR23249 PTHR23249, 1 hit
PfamiView protein in Pfam
PF04099 Sybindin, 1 hit
SMARTiView protein in SMART
SM01399 Sybindin, 1 hit
SUPFAMiSSF64356 SSF64356, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTPPC1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5R8
Secondary accession number(s): D3DTR0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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