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UniProtKB - Q9Y5R8 (TPPC1_HUMAN)

Entry version 153 (10 Feb 2021)
Sequence version 1 (01 Nov 1999)
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Protein

Trafficking protein particle complex subunit 1

Gene

TRAPPC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in vesicular transport from endoplasmic reticulum to Golgi.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processER-Golgi transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9Y5R8

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-204005, COPII-mediated vesicle transport
R-HSA-6798695, Neutrophil degranulation
R-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9Y5R8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Trafficking protein particle complex subunit 1
Alternative name(s):
BET5 homolog
Multiple myeloma protein 2
Short name:
MUM-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRAPPC1Imported
Synonyms:BET5, MUM21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:19894, TRAPPC1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		610969, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y5R8

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000170043.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		58485

Open Targets

More...OpenTargetsi		ENSG00000170043

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134988492

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y5R8, Tdark

Chemistry databases

Drug and drug target database

More...DrugBanki		DB08342, S-palmitoyl-L-cysteine

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TRAPPC1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002115621 – 145Trafficking protein particle complex subunit 1Add BLAST145

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9Y5R8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9Y5R8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9Y5R8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9Y5R8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y5R8

PeptideAtlas

More...PeptideAtlasi		Q9Y5R8

PRoteomics IDEntifications database

More...PRIDEi		Q9Y5R8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		86488

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y5R8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y5R8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000170043, Expressed in monocyte and 207 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9Y5R8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Y5R8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000170043, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of the multisubunit transport protein particle (TRAPP) complex (PubMed:11805826). The heterodimer TRAPPC6B-TRAPPC3 interacts with TRAPPC1 likely providing a core for TRAPP complex formation (PubMed:16828797).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121815, 39 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-4749, TRAPP II complex
CPX-4750, TRAPP III complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9Y5R8

Database of interacting proteins

More...DIPi		DIP-48285N

Protein interaction database and analysis system

More...IntActi		Q9Y5R8, 27 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000302783

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Y5R8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Y5R8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAPP small subunits family. BET5 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3368, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153761

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_053380_4_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y5R8

Identification of Orthologs from Complete Genome Data

More...OMAi		HDPREGF

Database of Orthologous Groups

More...OrthoDBi		1431711at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y5R8

TreeFam database of animal gene trees

More...TreeFami		TF323681

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011012, Longin-like_dom_sf
IPR007233, TRAPPC

The PANTHER Classification System

More...PANTHERi		PTHR23249, PTHR23249, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04099, Sybindin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01399, Sybindin, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF64356, SSF64356, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9Y5R8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTVHNLYLFD RNGVCLHYSE WHRKKQAGIP KEEEYKLMYG MLFSIRSFVS 
        60         70         80         90        100
KMSPLDMKDG FLAFQTSRYK LHYYETPTGI KVVMNTDLGV GPIRDVLHHI 
       110        120        130        140 
YSALYVELVV KNPLCPLGQT VQSELFRSRL DSYVRSLPFF SARAG
Length:145
Mass (Da):16,832
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7C8C81D3F0E8DCC6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L3V5I3L3V5_HUMAN
Trafficking protein particle comple...
TRAPPC1
75Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L3S0I3L3S0_HUMAN
Trafficking protein particle comple...
TRAPPC1
95Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L1R8I3L1R8_HUMAN
Trafficking protein particle comple...
TRAPPC1
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_013028129R → G in a melanoma. 1 PublicationCorresponds to variant dbSNP:rs200476704Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF129332 Genomic DNA Translation: AAD44697.1
CH471108 Genomic DNA Translation: EAW90109.1
CH471108 Genomic DNA Translation: EAW90110.1
CH471108 Genomic DNA Translation: EAW90111.1
BC032717 mRNA Translation: AAH32717.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11125.1

NCBI Reference Sequences

More...RefSeqi		NP_001160093.1, NM_001166621.1
NP_067033.1, NM_021210.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000303731; ENSP00000302783; ENSG00000170043
ENST00000540486; ENSP00000441130; ENSG00000170043

Database of genes from NCBI RefSeq genomes

More...GeneIDi		58485

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:58485

UCSC genome browser

More...UCSCi		uc002gjo.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129332 Genomic DNA Translation: AAD44697.1
CH471108 Genomic DNA Translation: EAW90109.1
CH471108 Genomic DNA Translation: EAW90110.1
CH471108 Genomic DNA Translation: EAW90111.1
BC032717 mRNA Translation: AAH32717.1
CCDSiCCDS11125.1
RefSeqiNP_001160093.1, NM_001166621.1
NP_067033.1, NM_021210.4

3D structure databases

SMRiQ9Y5R8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121815, 39 interactors
ComplexPortaliCPX-4749, TRAPP II complex
CPX-4750, TRAPP III complex
CORUMiQ9Y5R8
DIPiDIP-48285N
IntActiQ9Y5R8, 27 interactors
STRINGi9606.ENSP00000302783

Chemistry databases

DrugBankiDB08342, S-palmitoyl-L-cysteine

PTM databases

iPTMnetiQ9Y5R8
PhosphoSitePlusiQ9Y5R8

Genetic variation databases

BioMutaiTRAPPC1

Proteomic databases

EPDiQ9Y5R8
jPOSTiQ9Y5R8
MassIVEiQ9Y5R8
MaxQBiQ9Y5R8
PaxDbiQ9Y5R8
PeptideAtlasiQ9Y5R8
PRIDEiQ9Y5R8
ProteomicsDBi86488

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		24467, 65 antibodies

The DNASU plasmid repository

More...DNASUi		58485

Genome annotation databases

EnsembliENST00000303731; ENSP00000302783; ENSG00000170043
ENST00000540486; ENSP00000441130; ENSG00000170043
GeneIDi58485
KEGGihsa:58485
UCSCiuc002gjo.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		58485
DisGeNETi58485

GeneCards: human genes, protein and diseases

More...GeneCardsi		TRAPPC1
HGNCiHGNC:19894, TRAPPC1
HPAiENSG00000170043, Low tissue specificity
MIMi610969, gene
neXtProtiNX_Q9Y5R8
OpenTargetsiENSG00000170043
PharmGKBiPA134988492
VEuPathDBiHostDB:ENSG00000170043.11

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3368, Eukaryota
GeneTreeiENSGT00940000153761
HOGENOMiCLU_053380_4_1_1
InParanoidiQ9Y5R8
OMAiHDPREGF
OrthoDBi1431711at2759
PhylomeDBiQ9Y5R8
TreeFamiTF323681

Enzyme and pathway databases

PathwayCommonsiQ9Y5R8
ReactomeiR-HSA-204005, COPII-mediated vesicle transport
R-HSA-6798695, Neutrophil degranulation
R-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs
SignaLinkiQ9Y5R8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		58485, 712 hits in 887 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TRAPPC1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		58485
PharosiQ9Y5R8, Tdark

Protein Ontology

More...PROi		PR:Q9Y5R8
RNActiQ9Y5R8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000170043, Expressed in monocyte and 207 other tissues
ExpressionAtlasiQ9Y5R8, baseline and differential
GenevisibleiQ9Y5R8, HS

Family and domain databases

InterProiView protein in InterPro
IPR011012, Longin-like_dom_sf
IPR007233, TRAPPC
PANTHERiPTHR23249, PTHR23249, 1 hit
PfamiView protein in Pfam
PF04099, Sybindin, 1 hit
SMARTiView protein in SMART
SM01399, Sybindin, 1 hit
SUPFAMiSSF64356, SSF64356, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTPPC1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y5R8
Secondary accession number(s): D3DTR0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: November 1, 1999
Last modified: February 10, 2021
This is version 153 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human variants curated from literature reports
    Index of human variants curated from literature reports
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  5. Human entries with genetic variants
    List of human entries with genetic variants
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Main funding by: National Institutes of Health

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