UniProtKB - Q9Y5R8 (TPPC1_HUMAN)
Protein
Trafficking protein particle complex subunit 1
Gene
TRAPPC1
Organism
Homo sapiens (Human)
Status
Functioni
May play a role in vesicular transport from endoplasmic reticulum to Golgi.
GO - Biological processi
- COPII vesicle coating Source: Reactome
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: GO_Central
- neutrophil degranulation Source: Reactome
Keywordsi
Biological process | ER-Golgi transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q9Y5R8 |
Reactomei | R-HSA-204005, COPII-mediated vesicle transport R-HSA-6798695, Neutrophil degranulation R-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs |
SignaLinki | Q9Y5R8 |
Names & Taxonomyi
Protein namesi | Recommended name: Trafficking protein particle complex subunit 1Alternative name(s): BET5 homolog Multiple myeloma protein 2 Short name: MUM-2 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19894, TRAPPC1 |
MIMi | 610969, gene |
neXtProti | NX_Q9Y5R8 |
VEuPathDBi | HostDB:ENSG00000170043.11 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum By similarity
Golgi apparatus
- cis-Golgi network By similarity
Cytosol
- cytosol Source: Reactome
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB-SubCell
Extracellular region or secreted
- extracellular region Source: Reactome
Golgi apparatus
- Golgi apparatus Source: UniProtKB-SubCell
Lysosome
- azurophil granule lumen Source: Reactome
Other locations
- TRAPP complex Source: GO_Central
Keywords - Cellular componenti
Endoplasmic reticulum, Golgi apparatusPathology & Biotechi
Organism-specific databases
DisGeNETi | 58485 |
OpenTargetsi | ENSG00000170043 |
PharmGKBi | PA134988492 |
Miscellaneous databases
Pharosi | Q9Y5R8, Tdark |
Chemistry databases
DrugBanki | DB08342, S-palmitoyl-L-cysteine |
Genetic variation databases
BioMutai | TRAPPC1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000211562 | 1 – 145 | Trafficking protein particle complex subunit 1Add BLAST | 145 |
Proteomic databases
EPDi | Q9Y5R8 |
jPOSTi | Q9Y5R8 |
MassIVEi | Q9Y5R8 |
MaxQBi | Q9Y5R8 |
PaxDbi | Q9Y5R8 |
PeptideAtlasi | Q9Y5R8 |
PRIDEi | Q9Y5R8 |
ProteomicsDBi | 86488 |
PTM databases
iPTMneti | Q9Y5R8 |
PhosphoSitePlusi | Q9Y5R8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000170043, Expressed in monocyte and 207 other tissues |
ExpressionAtlasi | Q9Y5R8, baseline and differential |
Genevisiblei | Q9Y5R8, HS |
Organism-specific databases
HPAi | ENSG00000170043, Low tissue specificity |
Interactioni
Subunit structurei
Binary interactionsi
Q9Y5R8
With | #Exp. | IntAct |
---|---|---|
TRAPPC3 [O43617] | 6 | EBI-6160554,EBI-743566 |
Protein-protein interaction databases
BioGRIDi | 121815, 39 interactors |
ComplexPortali | CPX-4749, TRAPP II complex CPX-4750, TRAPP III complex |
CORUMi | Q9Y5R8 |
DIPi | DIP-48285N |
IntActi | Q9Y5R8, 27 interactors |
STRINGi | 9606.ENSP00000302783 |
Miscellaneous databases
RNActi | Q9Y5R8, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3368, Eukaryota |
GeneTreei | ENSGT00940000153761 |
HOGENOMi | CLU_053380_4_1_1 |
InParanoidi | Q9Y5R8 |
OMAi | HDPREGF |
OrthoDBi | 1431711at2759 |
PhylomeDBi | Q9Y5R8 |
TreeFami | TF323681 |
Family and domain databases
InterProi | View protein in InterPro IPR011012, Longin-like_dom_sf IPR007233, TRAPPC |
PANTHERi | PTHR23249, PTHR23249, 1 hit |
Pfami | View protein in Pfam PF04099, Sybindin, 1 hit |
SMARTi | View protein in SMART SM01399, Sybindin, 1 hit |
SUPFAMi | SSF64356, SSF64356, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q9Y5R8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTVHNLYLFD RNGVCLHYSE WHRKKQAGIP KEEEYKLMYG MLFSIRSFVS
60 70 80 90 100
KMSPLDMKDG FLAFQTSRYK LHYYETPTGI KVVMNTDLGV GPIRDVLHHI
110 120 130 140
YSALYVELVV KNPLCPLGQT VQSELFRSRL DSYVRSLPFF SARAG
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketI3L3V5 | I3L3V5_HUMAN | Trafficking protein particle comple... | TRAPPC1 | 75 | Annotation score: | ||
I3L3S0 | I3L3S0_HUMAN | Trafficking protein particle comple... | TRAPPC1 | 95 | Annotation score: | ||
I3L1R8 | I3L1R8_HUMAN | Trafficking protein particle comple... | TRAPPC1 | 42 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_013028 | 129 | R → G in a melanoma. 1 PublicationCorresponds to variant dbSNP:rs200476704Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF129332 Genomic DNA Translation: AAD44697.1 CH471108 Genomic DNA Translation: EAW90109.1 CH471108 Genomic DNA Translation: EAW90110.1 CH471108 Genomic DNA Translation: EAW90111.1 BC032717 mRNA Translation: AAH32717.1 |
CCDSi | CCDS11125.1 |
RefSeqi | NP_001160093.1, NM_001166621.1 NP_067033.1, NM_021210.4 |
Genome annotation databases
Ensembli | ENST00000303731; ENSP00000302783; ENSG00000170043 ENST00000540486; ENSP00000441130; ENSG00000170043 |
GeneIDi | 58485 |
KEGGi | hsa:58485 |
UCSCi | uc002gjo.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF129332 Genomic DNA Translation: AAD44697.1 CH471108 Genomic DNA Translation: EAW90109.1 CH471108 Genomic DNA Translation: EAW90110.1 CH471108 Genomic DNA Translation: EAW90111.1 BC032717 mRNA Translation: AAH32717.1 |
CCDSi | CCDS11125.1 |
RefSeqi | NP_001160093.1, NM_001166621.1 NP_067033.1, NM_021210.4 |
3D structure databases
SMRi | Q9Y5R8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121815, 39 interactors |
ComplexPortali | CPX-4749, TRAPP II complex CPX-4750, TRAPP III complex |
CORUMi | Q9Y5R8 |
DIPi | DIP-48285N |
IntActi | Q9Y5R8, 27 interactors |
STRINGi | 9606.ENSP00000302783 |
Chemistry databases
DrugBanki | DB08342, S-palmitoyl-L-cysteine |
PTM databases
iPTMneti | Q9Y5R8 |
PhosphoSitePlusi | Q9Y5R8 |
Genetic variation databases
BioMutai | TRAPPC1 |
Proteomic databases
EPDi | Q9Y5R8 |
jPOSTi | Q9Y5R8 |
MassIVEi | Q9Y5R8 |
MaxQBi | Q9Y5R8 |
PaxDbi | Q9Y5R8 |
PeptideAtlasi | Q9Y5R8 |
PRIDEi | Q9Y5R8 |
ProteomicsDBi | 86488 |
Protocols and materials databases
Antibodypediai | 24467, 68 antibodies |
DNASUi | 58485 |
Genome annotation databases
Ensembli | ENST00000303731; ENSP00000302783; ENSG00000170043 ENST00000540486; ENSP00000441130; ENSG00000170043 |
GeneIDi | 58485 |
KEGGi | hsa:58485 |
UCSCi | uc002gjo.3, human |
Organism-specific databases
CTDi | 58485 |
DisGeNETi | 58485 |
GeneCardsi | TRAPPC1 |
HGNCi | HGNC:19894, TRAPPC1 |
HPAi | ENSG00000170043, Low tissue specificity |
MIMi | 610969, gene |
neXtProti | NX_Q9Y5R8 |
OpenTargetsi | ENSG00000170043 |
PharmGKBi | PA134988492 |
VEuPathDBi | HostDB:ENSG00000170043.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3368, Eukaryota |
GeneTreei | ENSGT00940000153761 |
HOGENOMi | CLU_053380_4_1_1 |
InParanoidi | Q9Y5R8 |
OMAi | HDPREGF |
OrthoDBi | 1431711at2759 |
PhylomeDBi | Q9Y5R8 |
TreeFami | TF323681 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y5R8 |
Reactomei | R-HSA-204005, COPII-mediated vesicle transport R-HSA-6798695, Neutrophil degranulation R-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs |
SignaLinki | Q9Y5R8 |
Miscellaneous databases
BioGRID-ORCSi | 58485, 739 hits in 1012 CRISPR screens |
ChiTaRSi | TRAPPC1, human |
GenomeRNAii | 58485 |
Pharosi | Q9Y5R8, Tdark |
PROi | PR:Q9Y5R8 |
RNActi | Q9Y5R8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000170043, Expressed in monocyte and 207 other tissues |
ExpressionAtlasi | Q9Y5R8, baseline and differential |
Genevisiblei | Q9Y5R8, HS |
Family and domain databases
InterProi | View protein in InterPro IPR011012, Longin-like_dom_sf IPR007233, TRAPPC |
PANTHERi | PTHR23249, PTHR23249, 1 hit |
Pfami | View protein in Pfam PF04099, Sybindin, 1 hit |
SMARTi | View protein in SMART SM01399, Sybindin, 1 hit |
SUPFAMi | SSF64356, SSF64356, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TPPC1_HUMAN | |
Accessioni | Q9Y5R8Primary (citable) accession number: Q9Y5R8 Secondary accession number(s): D3DTR0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2002 |
Last sequence update: | November 1, 1999 | |
Last modified: | April 7, 2021 | |
This is version 154 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families