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Entry version 152 (18 Sep 2019)
Sequence version 2 (31 May 2011)
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Protein

Doublesex- and mab-3-related transcription factor 2

Gene

DMRT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional activator that directly regulates early activation of the myogenic determination gene MYF5 by binding in a sequence-specific manner to the early epaxial enhancer element of it. Involved in somitogenesis during embryogenesis and somite development and differentiation into sclerotome and dermomyotome. Required for the initiation and/or maintenance of proper organization of the sclerotome, dermomyotome and myotome (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi123 – 170DMPROSITE-ProRule annotationAdd BLAST48

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Doublesex- and mab-3-related transcription factor 2
Alternative name(s):
Doublesex-like 2 protein
Short name:
DSXL-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DMRT2
Synonyms:DSXL2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2935 DMRT2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604935 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y5R5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10655

Open Targets

More...
OpenTargetsi
ENSG00000173253

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27382

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DMRT2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
334302783

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002070481 – 561Doublesex- and mab-3-related transcription factor 2Add BLAST561

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9Y5R5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y5R5

PeptideAtlas

More...
PeptideAtlasi
Q9Y5R5

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y5R5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
86482 [Q9Y5R5-1]
86483 [Q9Y5R5-2]
86484 [Q9Y5R5-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y5R5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y5R5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in testis, kidney and skeletal muscle.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000173253 Expressed in 115 organ(s), highest expression level in adult mammalian kidney

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y5R5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y5R5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA029297

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115898, 1 interactor

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q9Y5R5

Protein interaction database and analysis system

More...
IntActi
Q9Y5R5, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000371686

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y5R5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DMRT family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3815 Eukaryota
ENOG410XSK9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156282

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000049088

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y5R5

KEGG Orthology (KO)

More...
KOi
K19489

Identification of Orthologs from Complete Genome Data

More...
OMAi
ALLYQQC

Database of Orthologous Groups

More...
OrthoDBi
897429at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y5R5

TreeFam database of animal gene trees

More...
TreeFami
TF317837

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.1040.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001275 DM_DNA-bd
IPR036407 DM_DNA-bd_sf
IPR026607 DMRT/dsx/mab-3

The PANTHER Classification System

More...
PANTHERi
PTHR12322 PTHR12322, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00751 DM, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00301 DM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82927 SSF82927, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS40000 DM_1, 1 hit
PS50809 DM_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y5R5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADPQAGSAA GDWEIDVESL ELEEDVCGAP RSTPPGPSPP PADGDCEDDE
60 70 80 90 100
DDDGVDEDAE EEGDGEEAGA SPGMPGQPEQ RGGPQPRPPL APQASPAGTG
110 120 130 140 150
PRERCTPAGG GAEPRKLSRT PKCARCRNHG VVSCLKGHKR FCRWRDCQCA
160 170 180 190 200
NCLLVVERQR VMAAQVALRR QQATEDKKGL SGKQNNFERK AVYQRQVRAP
210 220 230 240 250
SLLAKSILEG YRPIPAETYV GGTFPLPPPV SDRMRKRRAF ADKELENIML
260 270 280 290 300
EREYKEREML ETSQAAALFL PNRMVPGPDY NSYKSAYSPS PVEPPSKDFC
310 320 330 340 350
NFLPTCLDLT MQYSGSGNME LISSNVSVAT TYRQYPLSSR FLVWPKCGPI
360 370 380 390 400
SDTLLYQQCL LNATTSVQAL KPGASWDLKG ARVQDGLSAE QDMMPSKLEG
410 420 430 440 450
SLVLPHTPEI QTTRSDLQGH QAVPERSAFS PPRRNFSPIV DTDSLAAQGH
460 470 480 490 500
VLTKISKENT RHPLPLRHNP FHSLFQQTLT DKSGPELKTP FVKEAFEETP
510 520 530 540 550
KKHRECLVKD NQKYTFTIDR CAKDLFVAKQ VGTKLSVNEP LSFSVESILK
560
RPSSAITRVS Q
Length:561
Mass (Da):61,814
Last modified:May 31, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i17D856C78EBB43CB
GO
Isoform 2 (identifier: Q9Y5R5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     210-226: GYRPIPAETYVGGTFPL → VLLGLFYSYYVYIMNHL
     227-561: Missing.

Note: Produced by DMRT2 bicistronic transcripts (AF284223/AF284224) from non-overlapping reading frame, according to PubMed:10729224.
Show »
Length:226
Mass (Da):24,469
Checksum:iD6DE6CB7EF5EDD43
GO
Isoform 3 (identifier: Q9Y5R5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-233: Missing.

Note: Produced by DMRT2 bicistronic transcripts (AF284223/AF284224) from non-overlapping reading frame, according to PubMed:10729224.
Show »
Length:328
Mass (Da):36,884
Checksum:i7E02085D125017DE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MR18A0A0A0MR18_HUMAN
Doublesex- and mab-3-related transc...
DMRT2
405Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti329A → G in AAF86292 (PubMed:10729224).Curated1
Sequence conflicti329A → G in AAF86294 (PubMed:10729224).Curated1
Sequence conflicti329A → G in AAF86295 (PubMed:10729224).Curated1
Sequence conflicti372P → H in AAF86292 (PubMed:10729224).Curated1
Sequence conflicti372P → H in AAF86294 (PubMed:10729224).Curated1
Sequence conflicti372P → H in AAF86295 (PubMed:10729224).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_067719381A → P1 PublicationCorresponds to variant dbSNP:rs3824419Ensembl.1
Natural variantiVAR_067720458E → Q. Corresponds to variant dbSNP:rs17641078Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0412471 – 233Missing in isoform 3. 1 PublicationAdd BLAST233
Alternative sequenceiVSP_041248210 – 226GYRPI…GTFPL → VLLGLFYSYYVYIMNHL in isoform 2. 3 PublicationsAdd BLAST17
Alternative sequenceiVSP_041249227 – 561Missing in isoform 2. 3 PublicationsAdd BLAST335

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF130729 mRNA Translation: AAD40475.1
AF284223 mRNA Translation: AAF86291.1
AF284223 mRNA Translation: AAF86292.1
AF284224 mRNA Translation: AAF86293.1
AF284224 mRNA Translation: AAF86294.1
AF284225 mRNA Translation: AAF86295.1
Y19052 mRNA Translation: CAB59891.1
AL358976 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58816.1
BC136493 mRNA Translation: AAI36494.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6444.1 [Q9Y5R5-1]
CCDS6445.1 [Q9Y5R5-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001124337.1, NM_001130865.2 [Q9Y5R5-2]
NP_006548.1, NM_006557.6 [Q9Y5R5-2]
NP_870987.2, NM_181872.4 [Q9Y5R5-1]
XP_011515989.1, XM_011517687.1 [Q9Y5R5-1]
XP_011515992.1, XM_011517690.2 [Q9Y5R5-1]
XP_011515996.1, XM_011517694.2 [Q9Y5R5-3]
XP_016869702.1, XM_017014213.1 [Q9Y5R5-1]
XP_016869703.1, XM_017014214.1 [Q9Y5R5-1]
XP_016869704.1, XM_017014215.1 [Q9Y5R5-1]
XP_016869705.1, XM_017014216.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000259622; ENSP00000259622; ENSG00000173253 [Q9Y5R5-2]
ENST00000358146; ENSP00000350865; ENSG00000173253 [Q9Y5R5-1]
ENST00000382251; ENSP00000371686; ENSG00000173253 [Q9Y5R5-1]
ENST00000382255; ENSP00000371690; ENSG00000173253 [Q9Y5R5-2]
ENST00000412350; ENSP00000397494; ENSG00000173253 [Q9Y5R5-2]
ENST00000635183; ENSP00000489226; ENSG00000173253 [Q9Y5R5-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10655

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10655

UCSC genome browser

More...
UCSCi
uc003zhb.5 human [Q9Y5R5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF130729 mRNA Translation: AAD40475.1
AF284223 mRNA Translation: AAF86291.1
AF284223 mRNA Translation: AAF86292.1
AF284224 mRNA Translation: AAF86293.1
AF284224 mRNA Translation: AAF86294.1
AF284225 mRNA Translation: AAF86295.1
Y19052 mRNA Translation: CAB59891.1
AL358976 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58816.1
BC136493 mRNA Translation: AAI36494.1
CCDSiCCDS6444.1 [Q9Y5R5-1]
CCDS6445.1 [Q9Y5R5-2]
RefSeqiNP_001124337.1, NM_001130865.2 [Q9Y5R5-2]
NP_006548.1, NM_006557.6 [Q9Y5R5-2]
NP_870987.2, NM_181872.4 [Q9Y5R5-1]
XP_011515989.1, XM_011517687.1 [Q9Y5R5-1]
XP_011515992.1, XM_011517690.2 [Q9Y5R5-1]
XP_011515996.1, XM_011517694.2 [Q9Y5R5-3]
XP_016869702.1, XM_017014213.1 [Q9Y5R5-1]
XP_016869703.1, XM_017014214.1 [Q9Y5R5-1]
XP_016869704.1, XM_017014215.1 [Q9Y5R5-1]
XP_016869705.1, XM_017014216.1

3D structure databases

SMRiQ9Y5R5
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115898, 1 interactor
ELMiQ9Y5R5
IntActiQ9Y5R5, 2 interactors
STRINGi9606.ENSP00000371686

PTM databases

iPTMnetiQ9Y5R5
PhosphoSitePlusiQ9Y5R5

Polymorphism and mutation databases

BioMutaiDMRT2
DMDMi334302783

Proteomic databases

MassIVEiQ9Y5R5
PaxDbiQ9Y5R5
PeptideAtlasiQ9Y5R5
PRIDEiQ9Y5R5
ProteomicsDBi86482 [Q9Y5R5-1]
86483 [Q9Y5R5-2]
86484 [Q9Y5R5-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259622; ENSP00000259622; ENSG00000173253 [Q9Y5R5-2]
ENST00000358146; ENSP00000350865; ENSG00000173253 [Q9Y5R5-1]
ENST00000382251; ENSP00000371686; ENSG00000173253 [Q9Y5R5-1]
ENST00000382255; ENSP00000371690; ENSG00000173253 [Q9Y5R5-2]
ENST00000412350; ENSP00000397494; ENSG00000173253 [Q9Y5R5-2]
ENST00000635183; ENSP00000489226; ENSG00000173253 [Q9Y5R5-2]
GeneIDi10655
KEGGihsa:10655
UCSCiuc003zhb.5 human [Q9Y5R5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10655
DisGeNETi10655

GeneCards: human genes, protein and diseases

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GeneCardsi
DMRT2
HGNCiHGNC:2935 DMRT2
HPAiHPA029297
MIMi604935 gene
neXtProtiNX_Q9Y5R5
OpenTargetsiENSG00000173253
PharmGKBiPA27382

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3815 Eukaryota
ENOG410XSK9 LUCA
GeneTreeiENSGT00940000156282
HOGENOMiHOG000049088
InParanoidiQ9Y5R5
KOiK19489
OMAiALLYQQC
OrthoDBi897429at2759
PhylomeDBiQ9Y5R5
TreeFamiTF317837

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
DMRT2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10655

Pharos

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Pharosi
Q9Y5R5

Protein Ontology

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PROi
PR:Q9Y5R5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000173253 Expressed in 115 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiQ9Y5R5 baseline and differential
GenevisibleiQ9Y5R5 HS

Family and domain databases

Gene3Di4.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR001275 DM_DNA-bd
IPR036407 DM_DNA-bd_sf
IPR026607 DMRT/dsx/mab-3
PANTHERiPTHR12322 PTHR12322, 1 hit
PfamiView protein in Pfam
PF00751 DM, 1 hit
SMARTiView protein in SMART
SM00301 DM, 1 hit
SUPFAMiSSF82927 SSF82927, 1 hit
PROSITEiView protein in PROSITE
PS40000 DM_1, 1 hit
PS50809 DM_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDMRT2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y5R5
Secondary accession number(s): B1ANC0
, B9EGJ1, Q9NPG6, Q9NQR6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 31, 2011
Last modified: September 18, 2019
This is version 152 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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