Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q9Y5R4 (HEMK1_HUMAN)

Entry version 147 (11 Dec 2019)
Sequence version 1 (01 Nov 1999)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

MTRF1L release factor glutamine methyltransferase

Gene

HEMK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

N5-glutamine methyltransferase responsible for the methylation of the glutamine residue in the universally conserved GGQ motif of the mitochondrial translation release factor MTRF1L.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei190S-adenosyl-L-methionineBy similarity1
Binding sitei225S-adenosyl-L-methionineBy similarity1
Binding sitei239S-adenosyl-L-methionineBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
MTRF1L release factor glutamine methyltransferase1 Publication (EC:2.1.1.2971 Publication)
Alternative name(s):
HemK methyltransferase family member 1
M.HsaHemKP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HEMK1
Synonyms:HEMK
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000114735.9

Human Gene Nomenclature Database

More...HGNCi		HGNC:24923 HEMK1

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y5R4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000114735

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134884011

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y5R4 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HEMK1

Domain mapping of disease mutations (DMDM)

More...DMDMi		18203634

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001571781 – 338MTRF1L release factor glutamine methyltransferaseAdd BLAST338

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9Y5R4

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9Y5R4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9Y5R4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y5R4

PeptideAtlas

More...PeptideAtlasi		Q9Y5R4

PRoteomics IDEntifications database

More...PRIDEi		Q9Y5R4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		86481

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y5R4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y5R4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000114735 Expressed in 199 organ(s), highest expression level in fundus of stomach

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9Y5R4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Y5R4 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA034701
HPA034702

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		119527, 8 interactors

Protein interaction database and analysis system

More...IntActi		Q9Y5R4, 21 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000404843

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Y5R4 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Y5R4

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni167 – 171S-adenosyl-L-methionine bindingBy similarity5
Regioni239 – 242Substrate bindingBy similarity4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein N5-glutamine methyltransferase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2904 Eukaryota
COG2890 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000014125

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000076274

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y5R4

KEGG Orthology (KO)

More...KOi		K02493

Identification of Orthologs from Complete Genome Data

More...OMAi		IYYGHGT

Database of Orthologous Groups

More...OrthoDBi		1513943at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y5R4

TreeFam database of animal gene trees

More...TreeFami		TF324423

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002295 D21N6_MeTrfase
IPR002052 DNA_methylase_N6_adenine_CS
IPR004556 HemK-like
IPR040758 PrmC_N
IPR019874 Release_fac_Glu-N5_MeTfrase
IPR029063 SAM-dependent_MTases
IPR007848 Small_mtfrase_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05175 MTS, 1 hit
PF17827 PrmC_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00506 D21N6MTFRASE

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53335 SSF53335, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00536 hemK_fam, 1 hit
TIGR03534 RF_mod_PrmC, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00092 N6_MTASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9Y5R4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELWGRMLWA LLSGPGRRGS TRGWAFSSWQ PQPPLAGLSS AIELVSHWTG 
        60         70         80         90        100
VFEKRGIPEA RESSEYIVAH VLGAKTFQSL RPALWTQPLT SQQLQCIREL 
       110        120        130        140        150
SSRRLQRMPV QYILGEWDFQ GLSLRMVPPV FIPRPETEEL VEWVLEEVAQ 
       160        170        180        190        200
RSHAVGSPGS PLILEVGCGS GAISLSLLSQ LPQSRVIAVD KREAAISLTH 
       210        220        230        240        250
ENAQRLRLQD RIWIIHLDMT SERSWTHLPW GPMDLIVSNP PYVFHQDMEQ 
       260        270        280        290        300
LAPEIRSYED PAALDGGEEG MDIITHILAL APRLLKDSGS IFLEVDPRHP 
       310        320        330 
ELVSSWLQSR PDLYLNLVAV RRDFCGRPRF LHIRRSGP
Length:338
Mass (Da):38,231
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5AB5DF554D9978B4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F2Z2F0F2Z2F0_HUMAN
MTRF1L release factor glutamine met...
HEMK1
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C258H7C258_HUMAN
MTRF1L release factor glutamine met...
HEMK1
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049503192R → Q. Corresponds to variant dbSNP:rs2232250Ensembl.1
Natural variantiVAR_049504200H → Q. Corresponds to variant dbSNP:rs2232251Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF131220 mRNA Translation: AAD26417.1
AF172244 mRNA Translation: AAD51328.1
BC000781 mRNA Translation: AAH00781.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2830.1

NCBI Reference Sequences

More...RefSeqi		NP_001304780.1, NM_001317851.1
NP_057257.1, NM_016173.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000232854; ENSP00000232854; ENSG00000114735
ENST00000434410; ENSP00000404843; ENSG00000114735
ENST00000455834; ENSP00000404334; ENSG00000114735

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51409

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:51409

UCSC genome browser

More...UCSCi		uc003dau.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF131220 mRNA Translation: AAD26417.1
AF172244 mRNA Translation: AAD51328.1
BC000781 mRNA Translation: AAH00781.1
CCDSiCCDS2830.1
RefSeqiNP_001304780.1, NM_001317851.1
NP_057257.1, NM_016173.4

3D structure databases

SMRiQ9Y5R4
ModBaseiSearch...

Protein-protein interaction databases

BioGridi119527, 8 interactors
IntActiQ9Y5R4, 21 interactors
STRINGi9606.ENSP00000404843

PTM databases

iPTMnetiQ9Y5R4
PhosphoSitePlusiQ9Y5R4

Polymorphism and mutation databases

BioMutaiHEMK1
DMDMi18203634

Proteomic databases

EPDiQ9Y5R4
jPOSTiQ9Y5R4
MassIVEiQ9Y5R4
PaxDbiQ9Y5R4
PeptideAtlasiQ9Y5R4
PRIDEiQ9Y5R4
ProteomicsDBi86481

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		51409

Genome annotation databases

EnsembliENST00000232854; ENSP00000232854; ENSG00000114735
ENST00000434410; ENSP00000404843; ENSG00000114735
ENST00000455834; ENSP00000404334; ENSG00000114735
GeneIDi51409
KEGGihsa:51409
UCSCiuc003dau.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51409
EuPathDBiHostDB:ENSG00000114735.9

GeneCards: human genes, protein and diseases

More...GeneCardsi		HEMK1
HGNCiHGNC:24923 HEMK1
HPAiHPA034701
HPA034702
neXtProtiNX_Q9Y5R4
OpenTargetsiENSG00000114735
PharmGKBiPA134884011

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2904 Eukaryota
COG2890 LUCA
GeneTreeiENSGT00390000014125
HOGENOMiHOG000076274
InParanoidiQ9Y5R4
KOiK02493
OMAiIYYGHGT
OrthoDBi1513943at2759
PhylomeDBiQ9Y5R4
TreeFamiTF324423

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		51409
PharosiQ9Y5R4 Tbio

Protein Ontology

More...PROi		PR:Q9Y5R4
RNActiQ9Y5R4 protein

Gene expression databases

BgeeiENSG00000114735 Expressed in 199 organ(s), highest expression level in fundus of stomach
ExpressionAtlasiQ9Y5R4 baseline and differential
GenevisibleiQ9Y5R4 HS

Family and domain databases

InterProiView protein in InterPro
IPR002295 D21N6_MeTrfase
IPR002052 DNA_methylase_N6_adenine_CS
IPR004556 HemK-like
IPR040758 PrmC_N
IPR019874 Release_fac_Glu-N5_MeTfrase
IPR029063 SAM-dependent_MTases
IPR007848 Small_mtfrase_dom
PfamiView protein in Pfam
PF05175 MTS, 1 hit
PF17827 PrmC_N, 1 hit
PRINTSiPR00506 D21N6MTFRASE
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00536 hemK_fam, 1 hit
TIGR03534 RF_mod_PrmC, 1 hit
PROSITEiView protein in PROSITE
PS00092 N6_MTASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHEMK1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y5R4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1999
Last modified: December 11, 2019
This is version 147 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again