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Entry version 162 (07 Oct 2020)
Sequence version 2 (24 May 2004)
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Protein

General transcription factor 3C polypeptide 5

Gene

GTF3C5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9Y5Q8

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-749476, RNA Polymerase III Abortive And Retractive Initiation
R-HSA-76061, RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-HSA-76066, RNA Polymerase III Transcription Initiation From Type 2 Promoter

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
General transcription factor 3C polypeptide 5
Alternative name(s):
TF3C-epsilon
Transcription factor IIIC 63 kDa subunit
Short name:
TFIIIC 63 kDa subunit
Short name:
TFIIIC63
Transcription factor IIIC subunit epsilon
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GTF3C5
ORF Names:CDABP0017
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000148308.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4668, GTF3C5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604890, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y5Q8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9328

Open Targets

More...
OpenTargetsi
ENSG00000148308

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29056

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9Y5Q8, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GTF3C5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
47606222

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002097152 – 519General transcription factor 3C polypeptide 5Add BLAST518

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y5Q8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Y5Q8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9Y5Q8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y5Q8

PeptideAtlas

More...
PeptideAtlasi
Q9Y5Q8

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y5Q8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
86475 [Q9Y5Q8-1]
86476 [Q9Y5Q8-2]
86477 [Q9Y5Q8-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y5Q8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y5Q8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000148308, Expressed in right hemisphere of cerebellum and 216 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y5Q8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y5Q8, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000148308, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6.

Interacts with BRF1, GTF3C6 and TBP.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
114737, 79 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9Y5Q8

Database of interacting proteins

More...
DIPi
DIP-50823N

Protein interaction database and analysis system

More...
IntActi
Q9Y5Q8, 54 interactors

Molecular INTeraction database

More...
MINTi
Q9Y5Q8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000361180

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9Y5Q8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y5Q8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi478 – 514Glu-richAdd BLAST37
Compositional biasi486 – 499Poly-GluAdd BLAST14

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TFIIIC subunit 5 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2473, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00390000004458

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_026463_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y5Q8

KEGG Orthology (KO)

More...
KOi
K15202

Identification of Orthologs from Complete Genome Data

More...
OMAi
CNERDGW

Database of Orthologous Groups

More...
OrthoDBi
1111142at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y5Q8

TreeFam database of animal gene trees

More...
TreeFami
TF313581

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.200.160, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019136, TF_IIIC_su-5_HTH
IPR040454, TF_IIIC_Tfc1/Sfc1
IPR041499, Tfc1/Sfc1_N
IPR042536, TFIIIC_tauA_Sfc1

The PANTHER Classification System

More...
PANTHERi
PTHR13230, PTHR13230, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09734, Tau95, 1 hit
PF17682, Tau95_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y5Q8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAEAADLGL GAAVPVELRR ERRMVCVEYP GVVRDVAKML PTLGGEEGVS
60 70 80 90 100
RIYADPTKRL ELYFRPKDPY CHPVCANRFS TSSLLLRIRK RTRRQKGVLG
110 120 130 140 150
TEAHSEVTFD MEILGIISTI YKFQGMSDFQ YLAVHTEAGG KHTSMYDKVL
160 170 180 190 200
MLRPEKEAFF HQELPLYIPP PIFSRLDAPV DYFYRPETQH REGYNNPPIS
210 220 230 240 250
GENLIGLSRA RRPHNAIFVN FEDEEVPKQP LEAAAQTWRR VCTNPVDRKV
260 270 280 290 300
EEELRKLFDI RPIWSRNAVK ANISVHPDKL KVLLPFIAYY MITGPWRSLW
310 320 330 340 350
IRFGYDPRKN PDAKIYQVLD FRIRCGMKHG YAPSDLPVKA KRSTYNYSLP
360 370 380 390 400
ITVKKTSSQL VTMHDLKQGL GPSGTSGARK PASSKYKLKD SVYIFREGAL
410 420 430 440 450
PPYRQMFYQL CDLNVEELQK IIHRNDGAEN SCTERDGWCL PKTSDELRDT
460 470 480 490 500
MSLMIRQTIR SKRPALFSSS AKADGGKEQL TYESGEDEED EEEEEEEEED
510
FKPSDGSENE METEILDYV
Length:519
Mass (Da):59,571
Last modified:May 24, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i088B8B6125CEEF36
GO
Isoform 2 (identifier: Q9Y5Q8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     56-65: Missing.

Show »
Length:509
Mass (Da):58,266
Checksum:i58222432D6D3A333
GO
Isoform 3 (identifier: Q9Y5Q8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     389-389: K → KVSLQTLR

Show »
Length:526
Mass (Da):60,369
Checksum:iFAA2A99DF60A0718
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T7U1Q5T7U1_HUMAN
General transcription factor 3C pol...
GTF3C5 hCG_31454
457Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BY84H7BY84_HUMAN
General transcription factor 3C pol...
GTF3C5
345Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T7U4Q5T7U4_HUMAN
General transcription factor 3C pol...
GTF3C5
244Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T7U0Q5T7U0_HUMAN
General transcription factor 3C pol...
GTF3C5
224Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y5D2H0Y5D2_HUMAN
General transcription factor 3C pol...
GTF3C5
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti372P → R in AAD41476 (PubMed:10373544).Curated1
Sequence conflicti375T → A in BAC04993 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053727445D → N. Corresponds to variant dbSNP:rs637435Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01035556 – 65Missing in isoform 2. 1 Publication10
Alternative sequenceiVSP_035196389K → KVSLQTLR in isoform 3. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF133124 mRNA Translation: AAD41476.1
AY007123 mRNA Translation: AAG01991.1
AK055092 mRNA Translation: BAG51466.1
AK097295 mRNA Translation: BAC04993.1
AL162417 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW88026.1
CH471090 Genomic DNA Translation: EAW88029.1
BC009741 mRNA Translation: AAH09741.2
BC011355 mRNA Translation: AAH11355.1
BC017337 mRNA Translation: AAH17337.1
BC030157 mRNA Translation: AAH30157.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS48050.1 [Q9Y5Q8-3]
CCDS6958.1 [Q9Y5Q8-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001116295.1, NM_001122823.1 [Q9Y5Q8-3]
NP_001273638.1, NM_001286709.1
NP_036219.2, NM_012087.3 [Q9Y5Q8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000372097; ENSP00000361169; ENSG00000148308 [Q9Y5Q8-1]
ENST00000372108; ENSP00000361180; ENSG00000148308 [Q9Y5Q8-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9328

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9328

UCSC genome browser

More...
UCSCi
uc004cci.5, human [Q9Y5Q8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133124 mRNA Translation: AAD41476.1
AY007123 mRNA Translation: AAG01991.1
AK055092 mRNA Translation: BAG51466.1
AK097295 mRNA Translation: BAC04993.1
AL162417 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW88026.1
CH471090 Genomic DNA Translation: EAW88029.1
BC009741 mRNA Translation: AAH09741.2
BC011355 mRNA Translation: AAH11355.1
BC017337 mRNA Translation: AAH17337.1
BC030157 mRNA Translation: AAH30157.2
CCDSiCCDS48050.1 [Q9Y5Q8-3]
CCDS6958.1 [Q9Y5Q8-1]
RefSeqiNP_001116295.1, NM_001122823.1 [Q9Y5Q8-3]
NP_001273638.1, NM_001286709.1
NP_036219.2, NM_012087.3 [Q9Y5Q8-1]

3D structure databases

SMRiQ9Y5Q8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi114737, 79 interactors
CORUMiQ9Y5Q8
DIPiDIP-50823N
IntActiQ9Y5Q8, 54 interactors
MINTiQ9Y5Q8
STRINGi9606.ENSP00000361180

PTM databases

iPTMnetiQ9Y5Q8
PhosphoSitePlusiQ9Y5Q8

Polymorphism and mutation databases

BioMutaiGTF3C5
DMDMi47606222

Proteomic databases

EPDiQ9Y5Q8
jPOSTiQ9Y5Q8
MassIVEiQ9Y5Q8
PaxDbiQ9Y5Q8
PeptideAtlasiQ9Y5Q8
PRIDEiQ9Y5Q8
ProteomicsDBi86475 [Q9Y5Q8-1]
86476 [Q9Y5Q8-2]
86477 [Q9Y5Q8-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
18242, 186 antibodies

The DNASU plasmid repository

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DNASUi
9328

Genome annotation databases

EnsembliENST00000372097; ENSP00000361169; ENSG00000148308 [Q9Y5Q8-1]
ENST00000372108; ENSP00000361180; ENSG00000148308 [Q9Y5Q8-3]
GeneIDi9328
KEGGihsa:9328
UCSCiuc004cci.5, human [Q9Y5Q8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9328
DisGeNETi9328
EuPathDBiHostDB:ENSG00000148308.17

GeneCards: human genes, protein and diseases

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GeneCardsi
GTF3C5
HGNCiHGNC:4668, GTF3C5
HPAiENSG00000148308, Low tissue specificity
MIMi604890, gene
neXtProtiNX_Q9Y5Q8
OpenTargetsiENSG00000148308
PharmGKBiPA29056

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2473, Eukaryota
GeneTreeiENSGT00390000004458
HOGENOMiCLU_026463_0_0_1
InParanoidiQ9Y5Q8
KOiK15202
OMAiCNERDGW
OrthoDBi1111142at2759
PhylomeDBiQ9Y5Q8
TreeFamiTF313581

Enzyme and pathway databases

PathwayCommonsiQ9Y5Q8
ReactomeiR-HSA-749476, RNA Polymerase III Abortive And Retractive Initiation
R-HSA-76061, RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-HSA-76066, RNA Polymerase III Transcription Initiation From Type 2 Promoter

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
9328, 511 hits in 883 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GTF3C5, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
GTF3C5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9328
PharosiQ9Y5Q8, Tdark

Protein Ontology

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PROi
PR:Q9Y5Q8
RNActiQ9Y5Q8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000148308, Expressed in right hemisphere of cerebellum and 216 other tissues
ExpressionAtlasiQ9Y5Q8, baseline and differential
GenevisibleiQ9Y5Q8, HS

Family and domain databases

Gene3Di3.30.200.160, 1 hit
InterProiView protein in InterPro
IPR019136, TF_IIIC_su-5_HTH
IPR040454, TF_IIIC_Tfc1/Sfc1
IPR041499, Tfc1/Sfc1_N
IPR042536, TFIIIC_tauA_Sfc1
PANTHERiPTHR13230, PTHR13230, 1 hit
PfamiView protein in Pfam
PF09734, Tau95, 1 hit
PF17682, Tau95_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTF3C5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y5Q8
Secondary accession number(s): A6NI44
, A6NJB9, Q5T7U2, Q5T7U3, Q8N2U7, Q8N857, Q96GD9, Q9H4P2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: October 7, 2020
This is version 162 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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