INSL5

Functionⁱ

May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor.

GO - Molecular functionⁱ

G protein-coupled receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
hormone activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

G protein-coupled receptor signaling pathway Source: Reactome
positive regulation of feeding behavior
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hormone

Molecular function

Hormone

Enzyme and pathway databases

Reactomeⁱ	R-HSA-418594 G alpha (i) signalling events R-HSA-444821 Relaxin receptors

Reactomeⁱ

R-HSA-418594 G alpha (i) signalling events
R-HSA-444821 Relaxin receptors

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Insulin-like peptide INSL5 Short name: Insulin-like peptide 5 Cleaved into the following 2 chains: Insulin-like peptide INSL5 B chain Insulin-like peptide INSL5 A chain
Gene namesⁱ	Name:INSL5 ORF Names:UNQ156/PRO182
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000172410.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6088 INSL5
MIMⁱ	606413 gene
neXtProtⁱ	NX_Q9Y5Q6

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000172410
PharmGKBⁱ	PA29895

Polymorphism and mutation databases

BioMutaⁱ	INSL5
DMDMⁱ	205371762

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 22	1 PublicationAdd BLAST	22
PeptideⁱPRO_0000016163	23 – 46	Insulin-like peptide INSL5 B chainAdd BLAST	24
PropeptideⁱPRO_0000016164	49 – 114	Connecting peptideSequence analysisAdd BLAST	66
PeptideⁱPRO_0000016165	115 – 135	Insulin-like peptide INSL5 A chainAdd BLAST	21

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	29 ↔ 122	Interchain (between B and A chains)1 Publication
Disulfide bondⁱ	41 ↔ 135	Interchain (between B and A chains)1 Publication
Modified residueⁱ	115	Pyrrolidone carboxylic acid1 Publication	1
Disulfide bondⁱ	121 ↔ 126	1 Publication

Keywords - PTMⁱ

Cleavage on pair of basic residues, Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbⁱ	Q9Y5Q6
PeptideAtlas More...PeptideAtlasⁱ	Q9Y5Q6
PRIDEⁱ	Q9Y5Q6
ProteomicsDBⁱ	86474

Expressionⁱ

Tissue specificityⁱ

Highly expressed in rectum with lower levels in uterus and ascending and descending colon.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000172410 Expressed in 51 organ(s), highest expression level in mucosa of sigmoid colon
CleanExⁱ	HS_INSL5
Genevisibleⁱ	Q9Y5Q6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB033849 HPA030100

HPAⁱ

CAB033849
HPA030100

Interactionⁱ

Subunit structureⁱ

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

GO - Molecular functionⁱ

G protein-coupled receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
hormone activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	115339, 59 interactors
STRINGⁱ	9606.ENSP00000302724

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	31 – 45	Combined sources	15
Turnⁱ	116 – 118	Combined sources	3
Helixⁱ	119 – 123	Combined sources	5
Helixⁱ	128 – 131	Combined sources	4
Turnⁱ	132 – 134	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9Y5Q6
SMRⁱ	Q9Y5Q6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

Q9Y5Q6

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the insulin family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410J4WA Eukaryota ENOG410YMTH LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000049372
HOGENOMⁱ	HOG000111888
HOVERGENⁱ	HBG052135
InParanoidⁱ	Q9Y5Q6
KEGG Orthology (KO) More...KOⁱ	K22001
OMAⁱ	CTEGCSM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0XXD
PhylomeDBⁱ	Q9Y5Q6
TreeFamⁱ	TF333404

Family and domain databases

InterProⁱ	View protein in InterPro IPR016179 Insulin-like IPR036438 Insulin-like_sf IPR022353 Insulin_CS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00049 Insulin, 1 hit
SMARTⁱ	View protein in SMART SM00078 IlGF, 1 hit
SUPFAMⁱ	SSF56994 SSF56994, 1 hit
PROSITEⁱ	View protein in PROSITE PS00262 INSULIN, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q9Y5Q6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKGSIFTLFL FSVLFAISEV RSKESVRLCG LEYIRTVIYI CASSRWRRHQ 
        60         70         80         90        100
EGIPQAQQAE TGNSFQLPHK REFSEENPAQ NLPKVDASGE DRLWGGQMPT 
       110        120        130 
EELWKSKKHS VMSRQDLQTL CCTDGCSMTD LSALC

Length:135

Mass (Da):15,333

Last modified:September 2, 2008 - v2

Checksum:ⁱA932D7EDE9D173F5

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_046099	50	Q → L3 PublicationsCorresponds to variant dbSNP:rs549148Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF133816 mRNA Translation: AAD29686.1 AY359030 mRNA Translation: AAQ89389.1 AL354978 Genomic DNA No translation available. BC101646 mRNA Translation: AAI01647.1 BC101648 mRNA Translation: AAI01649.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS634.1
NCBI Reference Sequences More...RefSeqⁱ	NP_005469.2, NM_005478.4
UniGeneⁱ	Hs.251380

Genome annotation databases

Ensemblⁱ	ENST00000304526; ENSP00000302724; ENSG00000172410
GeneIDⁱ	10022
KEGGⁱ	hsa:10022
UCSC genome browser More...UCSCⁱ	uc001dcw.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Y5Q6	Insulin-like peptide INSL5		PANTR		135	UniRef90_Q9Y5Q6
Uncharacterized protein		PANPA		135
Insulin like 5		MACFA		135
Uncharacterized protein		MACMU		135
Uncharacterized protein		MACNE		135
+14

Protein	Similar proteins		Species	Score	Length	Source
Q9Y5Q6	Insulin-like peptide INSL5		PANTR		135	UniRef50_Q9Y5Q6
Uncharacterized protein		CHLSB		135
Uncharacterized protein		PAPAN		135
Uncharacterized protein		MANLE		135
Insulin like 5		MACFA		135
+47

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF133816 mRNA Translation: AAD29686.1 AY359030 mRNA Translation: AAQ89389.1 AL354978 Genomic DNA No translation available. BC101646 mRNA Translation: AAI01647.1 BC101648 mRNA Translation: AAI01649.1
CCDSⁱ	CCDS634.1
RefSeqⁱ	NP_005469.2, NM_005478.4
UniGeneⁱ	Hs.251380

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2K1V	NMR	-	A	116-135	[»]
	2KBC	NMR	-	A	116-135	[»]
				B	23-46	[»]
ProteinModelPortalⁱ	Q9Y5Q6
SMRⁱ	Q9Y5Q6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115339, 59 interactors
STRINGⁱ	9606.ENSP00000302724

Polymorphism and mutation databases

BioMutaⁱ	INSL5
DMDMⁱ	205371762

Proteomic databases

PaxDbⁱ	Q9Y5Q6
PeptideAtlasⁱ	Q9Y5Q6
PRIDEⁱ	Q9Y5Q6
ProteomicsDBⁱ	86474

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10022
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000304526; ENSP00000302724; ENSG00000172410
GeneIDⁱ	10022
KEGGⁱ	hsa:10022
UCSCⁱ	uc001dcw.4 human

Organism-specific databases

CTDⁱ	10022
EuPathDBⁱ	HostDB:ENSG00000172410.4
GeneCardsⁱ	INSL5
H-InvDBⁱ	HIX0028561
HGNCⁱ	HGNC:6088 INSL5
HPAⁱ	CAB033849 HPA030100
MIMⁱ	606413 gene
neXtProtⁱ	NX_Q9Y5Q6
OpenTargetsⁱ	ENSG00000172410
PharmGKBⁱ	PA29895
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J4WA Eukaryota ENOG410YMTH LUCA
GeneTreeⁱ	ENSGT00510000049372
HOGENOMⁱ	HOG000111888
HOVERGENⁱ	HBG052135
InParanoidⁱ	Q9Y5Q6
KOⁱ	K22001
OMAⁱ	CTEGCSM
OrthoDBⁱ	EOG091G0XXD
PhylomeDBⁱ	Q9Y5Q6
TreeFamⁱ	TF333404

Enzyme and pathway databases

Reactomeⁱ	R-HSA-418594 G alpha (i) signalling events R-HSA-444821 Relaxin receptors

Reactomeⁱ

R-HSA-418594 G alpha (i) signalling events
R-HSA-444821 Relaxin receptors

Miscellaneous databases

EvolutionaryTraceⁱ	Q9Y5Q6
GeneWikiⁱ	INSL5
GenomeRNAiⁱ	10022
Protein Ontology More...PROⁱ	PR:Q9Y5Q6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000172410 Expressed in 51 organ(s), highest expression level in mucosa of sigmoid colon
CleanExⁱ	HS_INSL5
Genevisibleⁱ	Q9Y5Q6 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR016179 Insulin-like IPR036438 Insulin-like_sf IPR022353 Insulin_CS
Pfamⁱ	View protein in Pfam PF00049 Insulin, 1 hit
SMARTⁱ	View protein in SMART SM00078 IlGF, 1 hit
SUPFAMⁱ	SSF56994 SSF56994, 1 hit
PROSITEⁱ	View protein in PROSITE PS00262 INSULIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	INSL5_HUMAN
Accessionⁱ	Q9Y5Q6Primary (citable) accession number: Q9Y5Q6 Secondary accession number(s): Q3MIY4, Q5VYD8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	September 2, 2008
	Last modified:	November 7, 2018
	This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9Y5Q6 (INSL5_HUMAN)

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Insulin-like peptide INSL5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ