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UniProtKB - Q9Y5Q6 (INSL5_HUMAN)
Protein
Insulin-like peptide INSL5
Gene
INSL5
Organism
Homo sapiens (Human)
Status
Functioni
May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor.
GO - Molecular functioni
- G protein-coupled receptor binding Source: GO_Central
- hormone activity Source: UniProtKB-KW
GO - Biological processi
- positive regulation of feeding behavior Source: GO_Central
Keywordsi
Molecular function | Hormone |
Enzyme and pathway databases
PathwayCommonsi | Q9Y5Q6 |
Reactomei | R-HSA-418594, G alpha (i) signalling events R-HSA-444821, Relaxin receptors |
SignaLinki | Q9Y5Q6 |
Names & Taxonomyi
Protein namesi | Recommended name: Insulin-like peptide INSL5Short name: Insulin-like peptide 5 Cleaved into the following 2 chains: |
Gene namesi | Name:INSL5 ORF Names:UNQ156/PRO182 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6088, INSL5 |
MIMi | 606413, gene |
neXtProti | NX_Q9Y5Q6 |
VEuPathDBi | HostDB:ENSG00000172410 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: Reactome
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 10022 |
OpenTargetsi | ENSG00000172410 |
PharmGKBi | PA29895 |
Miscellaneous databases
Pharosi | Q9Y5Q6, Tbio |
Genetic variation databases
BioMutai | INSL5 |
DMDMi | 205371762 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | 1 PublicationAdd BLAST | 22 | |
PeptideiPRO_0000016163 | 23 – 46 | Insulin-like peptide INSL5 B chainAdd BLAST | 24 | |
PropeptideiPRO_0000016164 | 49 – 114 | Connecting peptideSequence analysisAdd BLAST | 66 | |
PeptideiPRO_0000016165 | 115 – 135 | Insulin-like peptide INSL5 A chainAdd BLAST | 21 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 29 ↔ 122 | Interchain (between B and A chains)1 Publication | ||
Disulfide bondi | 41 ↔ 135 | Interchain (between B and A chains)1 Publication | ||
Modified residuei | 115 | Pyrrolidone carboxylic acid1 Publication | 1 | |
Disulfide bondi | 121 ↔ 126 | 1 Publication |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, Pyrrolidone carboxylic acidProteomic databases
MassIVEi | Q9Y5Q6 |
PaxDbi | Q9Y5Q6 |
PeptideAtlasi | Q9Y5Q6 |
PRIDEi | Q9Y5Q6 |
ProteomicsDBi | 86474 |
Expressioni
Tissue specificityi
Highly expressed in rectum with lower levels in uterus and ascending and descending colon.1 Publication
Gene expression databases
Bgeei | ENSG00000172410, Expressed in rectum and 79 other tissues |
Genevisiblei | Q9Y5Q6, HS |
Organism-specific databases
HPAi | ENSG00000172410, Tissue enriched (intestine) |
Interactioni
Subunit structurei
Heterodimer of a B chain and an A chain linked by two disulfide bonds.
Binary interactionsi
Q9Y5Q6
With | #Exp. | IntAct |
---|---|---|
ASPH - isoform 6 [Q12797-6] | 3 | EBI-21626318,EBI-12092171 |
GO - Molecular functioni
- G protein-coupled receptor binding Source: GO_Central
- hormone activity Source: UniProtKB-KW
Protein-protein interaction databases
BioGRIDi | 115339, 71 interactors |
IntActi | Q9Y5Q6, 53 interactors |
STRINGi | 9606.ENSP00000302724 |
Miscellaneous databases
RNActi | Q9Y5Q6, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q9Y5Q6 |
SMRi | Q9Y5Q6 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9Y5Q6 |
Family & Domainsi
Sequence similaritiesi
Belongs to the insulin family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S9UT, Eukaryota |
GeneTreei | ENSGT00940000154396 |
HOGENOMi | CLU_120043_1_0_1 |
InParanoidi | Q9Y5Q6 |
OMAi | YVRTVVY |
OrthoDBi | 1578838at2759 |
PhylomeDBi | Q9Y5Q6 |
TreeFami | TF333404 |
Family and domain databases
InterProi | View protein in InterPro IPR016179, Insulin-like IPR036438, Insulin-like_sf IPR022353, Insulin_CS |
Pfami | View protein in Pfam PF00049, Insulin, 1 hit |
SMARTi | View protein in SMART SM00078, IlGF, 1 hit |
SUPFAMi | SSF56994, SSF56994, 1 hit |
PROSITEi | View protein in PROSITE PS00262, INSULIN, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9Y5Q6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKGSIFTLFL FSVLFAISEV RSKESVRLCG LEYIRTVIYI CASSRWRRHQ
60 70 80 90 100
EGIPQAQQAE TGNSFQLPHK REFSEENPAQ NLPKVDASGE DRLWGGQMPT
110 120 130
EELWKSKKHS VMSRQDLQTL CCTDGCSMTD LSALC
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_046099 | 50 | Q → L3 PublicationsCorresponds to variant dbSNP:rs549148Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF133816 mRNA Translation: AAD29686.1 AY359030 mRNA Translation: AAQ89389.1 AL354978 Genomic DNA No translation available. BC101646 mRNA Translation: AAI01647.1 BC101648 mRNA Translation: AAI01649.1 |
CCDSi | CCDS634.1 |
RefSeqi | NP_005469.2, NM_005478.4 |
Genome annotation databases
Ensembli | ENST00000304526.3; ENSP00000302724.2; ENSG00000172410.5 |
GeneIDi | 10022 |
KEGGi | hsa:10022 |
MANE-Selecti | ENST00000304526.3; ENSP00000302724.2; NM_005478.6; NP_005469.2 |
UCSCi | uc001dcw.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF133816 mRNA Translation: AAD29686.1 AY359030 mRNA Translation: AAQ89389.1 AL354978 Genomic DNA No translation available. BC101646 mRNA Translation: AAI01647.1 BC101648 mRNA Translation: AAI01649.1 |
CCDSi | CCDS634.1 |
RefSeqi | NP_005469.2, NM_005478.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2K1V | NMR | - | A | 116-135 | [»] | |
2KBC | NMR | - | A | 116-135 | [»] | |
B | 23-46 | [»] | ||||
AlphaFoldDBi | Q9Y5Q6 | |||||
SMRi | Q9Y5Q6 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115339, 71 interactors |
IntActi | Q9Y5Q6, 53 interactors |
STRINGi | 9606.ENSP00000302724 |
Genetic variation databases
BioMutai | INSL5 |
DMDMi | 205371762 |
Proteomic databases
MassIVEi | Q9Y5Q6 |
PaxDbi | Q9Y5Q6 |
PeptideAtlasi | Q9Y5Q6 |
PRIDEi | Q9Y5Q6 |
ProteomicsDBi | 86474 |
Protocols and materials databases
Antibodypediai | 33391, 74 antibodies from 21 providers |
DNASUi | 10022 |
Genome annotation databases
Ensembli | ENST00000304526.3; ENSP00000302724.2; ENSG00000172410.5 |
GeneIDi | 10022 |
KEGGi | hsa:10022 |
MANE-Selecti | ENST00000304526.3; ENSP00000302724.2; NM_005478.6; NP_005469.2 |
UCSCi | uc001dcw.4, human |
Organism-specific databases
CTDi | 10022 |
DisGeNETi | 10022 |
GeneCardsi | INSL5 |
HGNCi | HGNC:6088, INSL5 |
HPAi | ENSG00000172410, Tissue enriched (intestine) |
MIMi | 606413, gene |
neXtProti | NX_Q9Y5Q6 |
OpenTargetsi | ENSG00000172410 |
PharmGKBi | PA29895 |
VEuPathDBi | HostDB:ENSG00000172410 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S9UT, Eukaryota |
GeneTreei | ENSGT00940000154396 |
HOGENOMi | CLU_120043_1_0_1 |
InParanoidi | Q9Y5Q6 |
OMAi | YVRTVVY |
OrthoDBi | 1578838at2759 |
PhylomeDBi | Q9Y5Q6 |
TreeFami | TF333404 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y5Q6 |
Reactomei | R-HSA-418594, G alpha (i) signalling events R-HSA-444821, Relaxin receptors |
SignaLinki | Q9Y5Q6 |
Miscellaneous databases
BioGRID-ORCSi | 10022, 8 hits in 1058 CRISPR screens |
EvolutionaryTracei | Q9Y5Q6 |
GeneWikii | INSL5 |
GenomeRNAii | 10022 |
Pharosi | Q9Y5Q6, Tbio |
PROi | PR:Q9Y5Q6 |
RNActi | Q9Y5Q6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000172410, Expressed in rectum and 79 other tissues |
Genevisiblei | Q9Y5Q6, HS |
Family and domain databases
InterProi | View protein in InterPro IPR016179, Insulin-like IPR036438, Insulin-like_sf IPR022353, Insulin_CS |
Pfami | View protein in Pfam PF00049, Insulin, 1 hit |
SMARTi | View protein in SMART SM00078, IlGF, 1 hit |
SUPFAMi | SSF56994, SSF56994, 1 hit |
PROSITEi | View protein in PROSITE PS00262, INSULIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | INSL5_HUMAN | |
Accessioni | Q9Y5Q6Primary (citable) accession number: Q9Y5Q6 Secondary accession number(s): Q3MIY4, Q5VYD8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | September 2, 2008 | |
Last modified: | May 25, 2022 | |
This is version 165 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families