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Protein

Atrial natriuretic peptide-converting enzyme

Gene

CORIN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide.
Isoform 2: has weaker endopeptidase activity compared to isoform 1.

Miscellaneous

Initially named CORIN due to its abundant expression in the heart.1 Publication

Activity regulationi

Inhibited in a dose-dependent manner by non-specific trypsin-like serine protease inhibitors including benzamidine.

Kineticsi

  1. KM=1.28 mM for pyroGlu-Phe-Lys-pNA.HCl1 Publication
  2. KM=3.52 mM for pyroGlu-Pro-Arg-pNA.HCl1 Publication
  3. KM=2.95 mM for H-D-Pro-Phe-Arg-pNA.2HCl1 Publication
  4. KM=1.92 mM for Bz-Ile-Glu-(gamma-OR)-Gly-Arg-pNA.HCl1 Publication
  5. KM=16 mM for pyroGlu-Gly-Arg-pNA.HCl1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Active sitei843Charge relay systemBy similarity1
    Active sitei892Charge relay systemBy similarity1
    Active sitei985Charge relay system1

    GO - Molecular functioni

    • serine-type endopeptidase activity Source: UniProtKB

    GO - Biological processi

    Keywordsi

    Molecular functionHydrolase, Protease, Serine protease

    Enzyme and pathway databases

    ReactomeiR-HSA-5578768 Physiological factors

    Protein family/group databases

    MEROPSiS01.019

    Names & Taxonomyi

    Protein namesi
    Gene namesi
    Name:CORIN
    Synonyms:CRN, TMPRSS10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 4

    Organism-specific databases

    EuPathDBiHostDB:ENSG00000145244.11
    HGNCiHGNC:19012 CORIN
    MIMi605236 gene
    neXtProtiNX_Q9Y5Q5

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Topological domaini1 – 45CytoplasmicSequence analysisAdd BLAST45
    Transmembranei46 – 66Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
    Topological domaini67 – 1042ExtracellularSequence analysisAdd BLAST976

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Pre-eclampsia/eclampsia 5 (PEE5)1 Publication
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionA hypertensive disorder of pregnancy characterized by new hypertension (blood pressure 140/90 or greater) presenting after 20 weeks' gestation with clinically relevant proteinuria. It impacts 2 individuals, the mother and her child, both of whom can be severely affected. Preeclampsia is one of the causes of maternal mortality and morbidity worldwide.
    See also OMIM:614595
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_067795317K → E in PEE5. 1 PublicationCorresponds to variant dbSNP:rs387906894EnsemblClinVar.1
    Natural variantiVAR_067797472S → G in PEE5. 1 PublicationCorresponds to variant dbSNP:rs387906895EnsemblClinVar.1

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Mutagenesisi26D → A: Impairs cell membrane targeting; when associated with A-30. 1 Publication1
    Mutagenesisi30M → A: Impairs cell membrane targeting; when associated with A-26. 1 Publication1
    Mutagenesisi134R → A: Does not affect autocatalytic cleavage. 1 Publication1
    Mutagenesisi164R → A: Affects autocatalytic cleavage and production of Atrial natriuretic peptide-converting enzyme, 160 kDa soluble fragment. 1 Publication1
    Mutagenesisi180R → A: Does not affect autocatalytic cleavage. 1 Publication1
    Mutagenesisi213R → A: Does not affect autocatalytic cleavage. 1 Publication1
    Mutagenesisi239R → A: Does not affect autocatalytic cleavage. 1 Publication1
    Mutagenesisi244R → A: Does not affect autocatalytic cleavage. 1 Publication1
    Mutagenesisi427R → A: Affects autocatalytic cleavage and production of Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment. 1 Publication1
    Mutagenesisi801R → A: Loss of activity towards NPPA. 2 Publications1
    Mutagenesisi985S → A: Loss of activity towards NPPA. 3 Publications1

    Organism-specific databases

    DisGeNETi10699
    MalaCardsiCORIN
    MIMi614595 phenotype
    OpenTargetsiENSG00000145244
    Orphaneti275555 Preeclampsia
    PharmGKBiPA134972424

    Polymorphism and mutation databases

    DMDMi317373348

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_0000417986? – 801Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragmentCurated
    ChainiPRO_00000886731 – 1042Atrial natriuretic peptide-converting enzymeAdd BLAST1042
    ChainiPRO_00003917651 – 801Atrial natriuretic peptide-converting enzyme, N-terminal propeptideCuratedAdd BLAST801
    ChainiPRO_0000417984165 – 801Atrial natriuretic peptide-converting enzyme, 160 kDa soluble fragmentCuratedAdd BLAST637
    ChainiPRO_0000417985428 – 801Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragmentCuratedAdd BLAST374
    ChainiPRO_0000391766802 – 1042Atrial natriuretic peptide-converting enzyme, activated protease fragmentCuratedAdd BLAST241

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Glycosylationi80N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi135N-linked (GlcNAc...) asparagineSequence analysis1
    Disulfide bondi139 ↔ 199By similarity
    Glycosylationi141N-linked (GlcNAc...) asparagineSequence analysis1
    Disulfide bondi147 ↔ 192By similarity
    Disulfide bondi183 ↔ 223By similarity
    Disulfide bondi212 ↔ 256By similarity
    Disulfide bondi216 ↔ 240By similarity
    Glycosylationi231N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi245N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi251N-linked (GlcNAc...) asparagineSequence analysis1
    Disulfide bondi269 ↔ 282By similarity
    Disulfide bondi277 ↔ 295By similarity
    Disulfide bondi289 ↔ 304By similarity
    Glycosylationi305N-linked (GlcNAc...) asparagineSequence analysis1
    Disulfide bondi306 ↔ 318By similarity
    Disulfide bondi313 ↔ 331By similarity
    Glycosylationi320N-linked (GlcNAc...) asparagineSequence analysis1
    Disulfide bondi325 ↔ 340By similarity
    Disulfide bondi342 ↔ 355By similarity
    Disulfide bondi350 ↔ 368By similarity
    Disulfide bondi362 ↔ 377By similarity
    Glycosylationi376N-linked (GlcNAc...) asparagineSequence analysis1
    Disulfide bondi379 ↔ 392By similarity
    Disulfide bondi387 ↔ 405By similarity
    Disulfide bondi399 ↔ 414By similarity
    Glycosylationi413N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi446N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi451N-linked (GlcNAc...) asparagineSequence analysis1
    Disulfide bondi455 ↔ 518By similarity
    Disulfide bondi463 ↔ 511By similarity
    Glycosylationi469N-linked (GlcNAc...) asparagineSequence analysis1
    Disulfide bondi502 ↔ 540By similarity
    Disulfide bondi529 ↔ 570By similarity
    Disulfide bondi533 ↔ 557By similarity
    Glycosylationi567N-linked (GlcNAc...) asparagineSequence analysis1
    Disulfide bondi580 ↔ 592By similarity
    Disulfide bondi587 ↔ 605By similarity
    Disulfide bondi599 ↔ 614By similarity
    Disulfide bondi616 ↔ 630By similarity
    Disulfide bondi624 ↔ 643By similarity
    Disulfide bondi637 ↔ 652By similarity
    Glycosylationi651N-linked (GlcNAc...) asparagineSequence analysis1
    Disulfide bondi655 ↔ 667By similarity
    Disulfide bondi662 ↔ 680By similarity
    Disulfide bondi674 ↔ 689By similarity
    Glycosylationi697N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi761N-linked (GlcNAc...) asparagineSequence analysis1
    Disulfide bondi790 ↔ 912Interchain (between N-terminal propeptide and activated protease fragment chains)1 Publication
    Disulfide bondi828 ↔ 844By similarity
    Disulfide bondi926 ↔ 991By similarity
    Disulfide bondi955 ↔ 970By similarity
    Disulfide bondi981 ↔ 1010By similarity
    Glycosylationi1022N-linked (GlcNAc...) asparagineSequence analysis1

    Post-translational modificationi

    N-glycosylated; required for processing and activation.2 Publications
    Activated through proteolytic processing by a trypsin-like protease; cleaved into a N-terminal propeptide and an activated corin protease fragment. Different soluble forms are produced by cleavage and autocatalytic cleavage: Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment is produced by cleavage by ADAM10, while 160 kDa and 100 kDa soluble fragments are produced by autocatalytic cleavage. Cleavage by ADAM10 to produce soluble 180 kDa soluble fragment takes place after the transmembrane region and before FZ 1.
    A disulfide bond links the activated corin protease fragment and the N-terminal propeptide. The disulfide bond also links the activated corin protease fragment with soluble fragments (100 kDa, 160 kDa and 180 kDa fragments).

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sitei164 – 165Cleavage; by autolysis2
    Sitei427 – 428Cleavage; by autolysis2
    Sitei801 – 802CleavageCurated2

    Keywords - PTMi

    Autocatalytic cleavage, Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    PaxDbiQ9Y5Q5
    PeptideAtlasiQ9Y5Q5
    PRIDEiQ9Y5Q5
    ProteomicsDBi86472
    86473 [Q9Y5Q5-2]

    PTM databases

    iPTMnetiQ9Y5Q5
    PhosphoSitePlusiQ9Y5Q5

    Expressioni

    Tissue specificityi

    Highly expressed in heart. Expressed in heart myocytes. Also expressed in pregnant uterus. Detected in blood, in plasma as well as in serum (at protein level).3 Publications

    Gene expression databases

    BgeeiENSG00000145244 Expressed in 118 organ(s), highest expression level in heart
    CleanExiHS_CORIN
    ExpressionAtlasiQ9Y5Q5 baseline and differential
    GenevisibleiQ9Y5Q5 HS

    Organism-specific databases

    HPAiHPA070941

    Interactioni

    Protein-protein interaction databases

    IntActiQ9Y5Q5, 4 interactors
    STRINGi9606.ENSP00000273857

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y5Q5
    SMRiQ9Y5Q5
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Domaini134 – 259FZ 1PROSITE-ProRule annotationAdd BLAST126
    Domaini268 – 304LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST37
    Domaini305 – 340LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST36
    Domaini341 – 377LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST37
    Domaini378 – 415LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST38
    Domaini450 – 573FZ 2PROSITE-ProRule annotationAdd BLAST124
    Domaini579 – 614LDL-receptor class A 5PROSITE-ProRule annotationAdd BLAST36
    Domaini615 – 653LDL-receptor class A 6PROSITE-ProRule annotationAdd BLAST39
    Domaini654 – 689LDL-receptor class A 7PROSITE-ProRule annotationAdd BLAST36
    Domaini690 – 801SRCRAdd BLAST112
    Domaini802 – 1035Peptidase S1PROSITE-ProRule annotationAdd BLAST234

    Motif

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Motifi26 – 29DDNN motif4

    Domaini

    The DDNN motif is required for targeting to the cell membrane and enzyme activation.1 Publication

    Sequence similaritiesi

    Belongs to the peptidase S1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG3577 Eukaryota
    KOG3627 Eukaryota
    COG5640 LUCA
    GeneTreeiENSGT00760000118962
    HOGENOMiHOG000060148
    HOVERGENiHBG051079
    InParanoidiQ9Y5Q5
    KOiK09614
    OMAiHECVSRD
    OrthoDBiEOG091G0DF7
    PhylomeDBiQ9Y5Q5
    TreeFamiTF351678

    Family and domain databases

    CDDicd00112 LDLa, 7 hits
    cd00190 Tryp_SPc, 1 hit
    Gene3Di1.10.2000.10, 2 hits
    InterProiView protein in InterPro
    IPR017052 Corin
    IPR020067 Frizzled_dom
    IPR036790 Frizzled_dom_sf
    IPR036055 LDL_receptor-like_sf
    IPR023415 LDLR_class-A_CS
    IPR002172 LDrepeatLR_classA_rpt
    IPR009003 Peptidase_S1_PA
    IPR017448 SRCR-like_dom
    IPR036772 SRCR-like_dom_sf
    IPR001254 Trypsin_dom
    IPR033116 TRYPSIN_SER
    PfamiView protein in Pfam
    PF01392 Fz, 2 hits
    PF00057 Ldl_recept_a, 6 hits
    PF15494 SRCR_2, 1 hit
    PF00089 Trypsin, 1 hit
    PIRSFiPIRSF036376 Corin, 1 hit
    PRINTSiPR00261 LDLRECEPTOR
    SMARTiView protein in SMART
    SM00063 FRI, 2 hits
    SM00192 LDLa, 7 hits
    SM00202 SR, 1 hit
    SM00020 Tryp_SPc, 1 hit
    SUPFAMiSSF50494 SSF50494, 1 hit
    SSF56487 SSF56487, 1 hit
    SSF57424 SSF57424, 7 hits
    SSF63501 SSF63501, 2 hits
    PROSITEiView protein in PROSITE
    PS50038 FZ, 2 hits
    PS01209 LDLRA_1, 6 hits
    PS50068 LDLRA_2, 7 hits
    PS00420 SRCR_1, 1 hit
    PS50240 TRYPSIN_DOM, 1 hit
    PS00135 TRYPSIN_SER, 1 hit

    Sequences (2+)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q9Y5Q5-1) [UniParc]FASTAAdd to basket
    Also known as: E1, hE1

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MKQSPALAPE ERCRRAGSPK PVLRADDNNM GNGCSQKLAT ANLLRFLLLV
    60 70 80 90 100
    LIPCICALVL LLVILLSYVG TLQKVYFKSN GSEPLVTDGE IQGSDVILTN
    110 120 130 140 150
    TIYNQSTVVS TAHPDQHVPA WTTDASLPGD QSHRNTSACM NITHSQCQML
    160 170 180 190 200
    PYHATLTPLL SVVRNMEMEK FLKFFTYLHR LSCYQHIMLF GCTLAFPECI
    210 220 230 240 250
    IDGDDSHGLL PCRSFCEAAK EGCESVLGMV NYSWPDFLRC SQFRNQTESS
    260 270 280 290 300
    NVSRICFSPQ QENGKQLLCG RGENFLCASG ICIPGKLQCN GYNDCDDWSD
    310 320 330 340 350
    EAHCNCSENL FHCHTGKCLN YSLVCDGYDD CGDLSDEQNC DCNPTTEHRC
    360 370 380 390 400
    GDGRCIAMEW VCDGDHDCVD KSDEVNCSCH SQGLVECRNG QCIPSTFQCD
    410 420 430 440 450
    GDEDCKDGSD EENCSVIQTS CQEGDQRCLY NPCLDSCGGS SLCDPNNSLN
    460 470 480 490 500
    NCSQCEPITL ELCMNLPYNS TSYPNYFGHR TQKEASISWE SSLFPALVQT
    510 520 530 540 550
    NCYKYLMFFS CTILVPKCDV NTGEHIPPCR ALCEHSKERC ESVLGIVGLQ
    560 570 580 590 600
    WPEDTDCSQF PEENSDNQTC LMPDEYVEEC SPSHFKCRSG QCVLASRRCD
    610 620 630 640 650
    GQADCDDDSD EENCGCKERD LWECPSNKQC LKHTVICDGF PDCPDYMDEK
    660 670 680 690 700
    NCSFCQDDEL ECANHACVSR DLWCDGEADC SDSSDEWDCV TLSINVNSSS
    710 720 730 740 750
    FLMVHRAATE HHVCADGWQE ILSQLACKQM GLGEPSVTKL IQEQEKEPRW
    760 770 780 790 800
    LTLHSNWESL NGTTLHELLV NGQSCESRSK ISLLCTKQDC GRRPAARMNK
    810 820 830 840 850
    RILGGRTSRP GRWPWQCSLQ SEPSGHICGC VLIAKKWVLT VAHCFEGREN
    860 870 880 890 900
    AAVWKVVLGI NNLDHPSVFM QTRFVKTIIL HPRYSRAVVD YDISIVELSE
    910 920 930 940 950
    DISETGYVRP VCLPNPEQWL EPDTYCYITG WGHMGNKMPF KLQEGEVRII
    960 970 980 990 1000
    SLEHCQSYFD MKTITTRMIC AGYESGTVDS CMGDSGGPLV CEKPGGRWTL
    1010 1020 1030 1040
    FGLTSWGSVC FSKVLGPGVY SNVSYFVEWI KRQIYIQTFL LN
    Length:1,042
    Mass (Da):116,486
    Last modified:January 11, 2011 - v2
    Checksum:iA3F1CB8EBB676F78
    GO
    Isoform 2 (identifier: Q9Y5Q5-2) [UniParc]FASTAAdd to basket
    Also known as: E1a, hE1a

    The sequence of this isoform differs from the canonical sequence as follows:
         1-29: Missing.

    Show »
    Length:1,013
    Mass (Da):113,297
    Checksum:iF4084E8B3AFFFDB8
    GO

    Computationally mapped potential isoform sequencesi

    There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A087X1D5A0A087X1D5_HUMAN
    Atrial natriuretic peptide-converti...
    CORIN
    938Annotation score:
    J3KR88J3KR88_HUMAN
    Atrial natriuretic peptide-converti...
    CORIN
    975Annotation score:
    J3KR90J3KR90_HUMAN
    Atrial natriuretic peptide-converti...
    CORIN
    1,005Annotation score:
    E7EQE7E7EQE7_HUMAN
    Atrial natriuretic peptide-converti...
    CORIN
    903Annotation score:
    J3KR83J3KR83_HUMAN
    Atrial natriuretic peptide-converti...
    CORIN
    734Annotation score:

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti854W → R in AAF21966 (PubMed:11082206).Curated1
    Sequence conflicti876K → R in AAF21966 (PubMed:11082206).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_03800013C → Y2 PublicationsCorresponds to variant dbSNP:rs2289433Ensembl.1
    Natural variantiVAR_067795317K → E in PEE5. 1 PublicationCorresponds to variant dbSNP:rs387906894EnsemblClinVar.1
    Natural variantiVAR_067796444D → G. Corresponds to variant dbSNP:rs13105608Ensembl.1
    Natural variantiVAR_067797472S → G in PEE5. 1 PublicationCorresponds to variant dbSNP:rs387906895EnsemblClinVar.1
    Natural variantiVAR_038001525H → R3 PublicationsCorresponds to variant dbSNP:rs11934749Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Alternative sequenceiVSP_0439521 – 29Missing in isoform 2. CuratedAdd BLAST29

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF133845 mRNA Translation: AAD31850.1
    AC092597 Genomic DNA No translation available.
    AC104646 Genomic DNA Translation: AAY40991.1
    AC107068 Genomic DNA Translation: AAY40917.1
    EU326305 Genomic DNA Translation: ACA05911.1
    BC110451 mRNA Translation: AAI10452.1
    AF113248 mRNA Translation: AAF21966.1
    CCDSiCCDS3477.1 [Q9Y5Q5-1]
    RefSeqiNP_001265514.1, NM_001278585.1
    NP_006578.2, NM_006587.3 [Q9Y5Q5-1]
    UniGeneiHs.518618
    Hs.604887

    Genome annotation databases

    EnsembliENST00000273857; ENSP00000273857; ENSG00000145244 [Q9Y5Q5-1]
    GeneIDi10699
    KEGGihsa:10699
    UCSCiuc003gxm.5 human [Q9Y5Q5-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Similar proteinsi

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF133845 mRNA Translation: AAD31850.1
    AC092597 Genomic DNA No translation available.
    AC104646 Genomic DNA Translation: AAY40991.1
    AC107068 Genomic DNA Translation: AAY40917.1
    EU326305 Genomic DNA Translation: ACA05911.1
    BC110451 mRNA Translation: AAI10452.1
    AF113248 mRNA Translation: AAF21966.1
    CCDSiCCDS3477.1 [Q9Y5Q5-1]
    RefSeqiNP_001265514.1, NM_001278585.1
    NP_006578.2, NM_006587.3 [Q9Y5Q5-1]
    UniGeneiHs.518618
    Hs.604887

    3D structure databases

    ProteinModelPortaliQ9Y5Q5
    SMRiQ9Y5Q5
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    IntActiQ9Y5Q5, 4 interactors
    STRINGi9606.ENSP00000273857

    Protein family/group databases

    MEROPSiS01.019

    PTM databases

    iPTMnetiQ9Y5Q5
    PhosphoSitePlusiQ9Y5Q5

    Polymorphism and mutation databases

    DMDMi317373348

    Proteomic databases

    PaxDbiQ9Y5Q5
    PeptideAtlasiQ9Y5Q5
    PRIDEiQ9Y5Q5
    ProteomicsDBi86472
    86473 [Q9Y5Q5-2]

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000273857; ENSP00000273857; ENSG00000145244 [Q9Y5Q5-1]
    GeneIDi10699
    KEGGihsa:10699
    UCSCiuc003gxm.5 human [Q9Y5Q5-1]

    Organism-specific databases

    CTDi10699
    DisGeNETi10699
    EuPathDBiHostDB:ENSG00000145244.11
    GeneCardsiCORIN
    H-InvDBiHIX0024555
    HGNCiHGNC:19012 CORIN
    HPAiHPA070941
    MalaCardsiCORIN
    MIMi605236 gene
    614595 phenotype
    neXtProtiNX_Q9Y5Q5
    OpenTargetsiENSG00000145244
    Orphaneti275555 Preeclampsia
    PharmGKBiPA134972424
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiKOG3577 Eukaryota
    KOG3627 Eukaryota
    COG5640 LUCA
    GeneTreeiENSGT00760000118962
    HOGENOMiHOG000060148
    HOVERGENiHBG051079
    InParanoidiQ9Y5Q5
    KOiK09614
    OMAiHECVSRD
    OrthoDBiEOG091G0DF7
    PhylomeDBiQ9Y5Q5
    TreeFamiTF351678

    Enzyme and pathway databases

    ReactomeiR-HSA-5578768 Physiological factors

    Miscellaneous databases

    ChiTaRSiCORIN human
    GeneWikiiCORIN
    GenomeRNAii10699
    PROiPR:Q9Y5Q5
    SOURCEiSearch...

    Gene expression databases

    BgeeiENSG00000145244 Expressed in 118 organ(s), highest expression level in heart
    CleanExiHS_CORIN
    ExpressionAtlasiQ9Y5Q5 baseline and differential
    GenevisibleiQ9Y5Q5 HS

    Family and domain databases

    CDDicd00112 LDLa, 7 hits
    cd00190 Tryp_SPc, 1 hit
    Gene3Di1.10.2000.10, 2 hits
    InterProiView protein in InterPro
    IPR017052 Corin
    IPR020067 Frizzled_dom
    IPR036790 Frizzled_dom_sf
    IPR036055 LDL_receptor-like_sf
    IPR023415 LDLR_class-A_CS
    IPR002172 LDrepeatLR_classA_rpt
    IPR009003 Peptidase_S1_PA
    IPR017448 SRCR-like_dom
    IPR036772 SRCR-like_dom_sf
    IPR001254 Trypsin_dom
    IPR033116 TRYPSIN_SER
    PfamiView protein in Pfam
    PF01392 Fz, 2 hits
    PF00057 Ldl_recept_a, 6 hits
    PF15494 SRCR_2, 1 hit
    PF00089 Trypsin, 1 hit
    PIRSFiPIRSF036376 Corin, 1 hit
    PRINTSiPR00261 LDLRECEPTOR
    SMARTiView protein in SMART
    SM00063 FRI, 2 hits
    SM00192 LDLa, 7 hits
    SM00202 SR, 1 hit
    SM00020 Tryp_SPc, 1 hit
    SUPFAMiSSF50494 SSF50494, 1 hit
    SSF56487 SSF56487, 1 hit
    SSF57424 SSF57424, 7 hits
    SSF63501 SSF63501, 2 hits
    PROSITEiView protein in PROSITE
    PS50038 FZ, 2 hits
    PS01209 LDLRA_1, 6 hits
    PS50068 LDLRA_2, 7 hits
    PS00420 SRCR_1, 1 hit
    PS50240 TRYPSIN_DOM, 1 hit
    PS00135 TRYPSIN_SER, 1 hit
    ProtoNetiSearch...

    Entry informationi

    Entry nameiCORIN_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y5Q5
    Secondary accession number(s): B0ZBE3
    , Q2TBD2, Q4W5E5, Q4W5G6, Q9UHY2
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: January 11, 2011
    Last modified: November 7, 2018
    This is version 173 of the entry and version 2 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Peptidase families
      Classification of peptidase families and list of entries
    5. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    6. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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