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Protein

Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta

Gene

PPP2R3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

Miscellaneous

The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi401 – 412PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

  • cell cycle arrest Source: ProtInc
  • protein dephosphorylation Source: UniProtKB

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1
R-HSA-69231 Cyclin D associated events in G1
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta
Alternative name(s):
PP2A subunit B isoform PR48
Protein phosphatase 2A 48 kDa regulatory subunit
Gene namesi
Name:PPP2R3B
Synonyms:PPP2R3L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000167393.17
HGNCiHGNC:13417 PPP2R3B
MIMi300339 gene
neXtProtiNX_Q9Y5P8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi28227
OpenTargetsiENSG00000167393
PharmGKBiPA134878872

Polymorphism and mutation databases

BioMutaiPPP2R3B
DMDMi158523346

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000714441 – 575Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit betaAdd BLAST575

Proteomic databases

EPDiQ9Y5P8
PaxDbiQ9Y5P8
PeptideAtlasiQ9Y5P8
PRIDEiQ9Y5P8
ProteomicsDBi86468
86469 [Q9Y5P8-2]

PTM databases

iPTMnetiQ9Y5P8
PhosphoSitePlusiQ9Y5P8

Expressioni

Gene expression databases

BgeeiENSG00000167393 Expressed in 146 organ(s), highest expression level in apex of heart
CleanExiHS_PPP2R3B
ExpressionAtlasiQ9Y5P8 baseline and differential
GenevisibleiQ9Y5P8 HS

Organism-specific databases

HPAiHPA074545

Interactioni

Subunit structurei

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with N-terminal region of CDC6. Interacts with NOD2 (PubMed:27812135).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
DUSP12Q9UNI64EBI-2479826,EBI-715161

Protein-protein interaction databases

BioGridi118179, 20 interactors
CORUMiQ9Y5P8
IntActiQ9Y5P8, 11 interactors
MINTiQ9Y5P8
STRINGi9606.ENSP00000375080

Structurei

Secondary structure

1575
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9Y5P8
SMRiQ9Y5P8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini388 – 423EF-handPROSITE-ProRule annotationAdd BLAST36

Phylogenomic databases

eggNOGiKOG2562 Eukaryota
ENOG410XRBK LUCA
GeneTreeiENSGT00530000063265
HOGENOMiHOG000265086
HOVERGENiHBG000010
KOiK11583
OMAiDNMAIEP
OrthoDBiEOG091G03UQ
PhylomeDBiQ9Y5P8
TreeFamiTF105554

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
SUPFAMiSSF47473 SSF47473, 2 hits
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y5P8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPPGKVLQPV LKMKVDELFL YWLSEASTQR MLQDCLRRIK APGRDQPTPG
60 70 80 90 100
DGEQPGAWPT APLAAPRPSG LEPPGTPGPG PALPLGAASS PRNAPHVRGT
110 120 130 140 150
RRSAGTRVVQ TRKEEPLPPA TSQSIPTFYF PRGRPQDSVN VDAVISKIES
160 170 180 190 200
TFARFPHERA TMDDMGLVAK ACGCPLYWKG PLFYGAGGER TGSVSVHKFV
210 220 230 240 250
AMWRKILQNC HDDAAKFVHL LMSPGCNYLV QEDFVPFLQD VVNTHPGLSF
260 270 280 290 300
LKEASEFHSR YITTVIQRIF YAVNRSWSGR ITCAELRRSS FLQNVALLEE
310 320 330 340 350
EADINQLTEF FSYEHFYVIY CKFWELDTDH DLLIDADDLA RHNDHALSTK
360 370 380 390 400
MIDRIFSGAV TRGRKVQKEG KISYADFVWF LISEEDKKTP TSIEYWFRCM
410 420 430 440 450
DLDGDGALSM FELEYFYEEQ CRRLDSMAIE ALPFQDCLCQ MLDLVKPRTE
460 470 480 490 500
GKITLQDLKR CKLANVFFDT FFNIEKYLDH EQKEQISLLR DGDSGGPELS
510 520 530 540 550
DWEKYAAEEY DILVAEETAG EPWEDGFEAE LSPVEQKLSA LRSPLAQRPF
560 570
FEAPSPLGAV DLYEYACGDE DLEPL
Length:575
Mass (Da):65,061
Last modified:September 11, 2007 - v2
Checksum:i9FDE046345C1F85F
GO
Isoform 2 (identifier: Q9Y5P8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-399: Missing.

Show »
Length:176
Mass (Da):20,111
Checksum:i6B819D28EBF3AE5F
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JNR6A0A0G2JNR6_HUMAN
Serine/threonine-protein phosphatas...
PPP2R3B
575Annotation score:
A0A0G2JN52A0A0G2JN52_HUMAN
Serine/threonine-protein phosphatas...
PPP2R3B
575Annotation score:
C9JMU6C9JMU6_HUMAN
Serine/threonine-protein phosphatas...
PPP2R3B
169Annotation score:

Sequence cautioni

The sequence AAD38515 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035109163D → E. Corresponds to variant dbSNP:rs3813594Ensembl.1
Natural variantiVAR_055356519A → V1 PublicationCorresponds to variant dbSNP:rs1133520Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0373101 – 399Missing in isoform 2. 1 PublicationAdd BLAST399

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954664 Genomic DNA No translation available.
BX000476 Genomic DNA No translation available.
BC009032 mRNA Translation: AAH09032.1
BC063429 mRNA Translation: AAH63429.1
AF135016 mRNA Translation: AAD38515.1 Different initiation.
BK000521 mRNA Translation: DAA00385.1
CCDSiCCDS14104.1 [Q9Y5P8-1]
RefSeqiNP_037371.2, NM_013239.4 [Q9Y5P8-1]
UniGeneiHs.124942

Genome annotation databases

EnsembliENST00000390665; ENSP00000375080; ENSG00000167393 [Q9Y5P8-1]
GeneIDi28227
KEGGihsa:28227
UCSCiuc004cpg.4 human [Q9Y5P8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954664 Genomic DNA No translation available.
BX000476 Genomic DNA No translation available.
BC009032 mRNA Translation: AAH09032.1
BC063429 mRNA Translation: AAH63429.1
AF135016 mRNA Translation: AAD38515.1 Different initiation.
BK000521 mRNA Translation: DAA00385.1
CCDSiCCDS14104.1 [Q9Y5P8-1]
RefSeqiNP_037371.2, NM_013239.4 [Q9Y5P8-1]
UniGeneiHs.124942

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4I5LX-ray2.43B/E122-490[»]
4I5NX-ray2.80B/E122-490[»]
4MEWX-ray1.99A130-483[»]
ProteinModelPortaliQ9Y5P8
SMRiQ9Y5P8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118179, 20 interactors
CORUMiQ9Y5P8
IntActiQ9Y5P8, 11 interactors
MINTiQ9Y5P8
STRINGi9606.ENSP00000375080

PTM databases

iPTMnetiQ9Y5P8
PhosphoSitePlusiQ9Y5P8

Polymorphism and mutation databases

BioMutaiPPP2R3B
DMDMi158523346

Proteomic databases

EPDiQ9Y5P8
PaxDbiQ9Y5P8
PeptideAtlasiQ9Y5P8
PRIDEiQ9Y5P8
ProteomicsDBi86468
86469 [Q9Y5P8-2]

Protocols and materials databases

DNASUi28227
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000390665; ENSP00000375080; ENSG00000167393 [Q9Y5P8-1]
GeneIDi28227
KEGGihsa:28227
UCSCiuc004cpg.4 human [Q9Y5P8-1]

Organism-specific databases

CTDi28227
DisGeNETi28227
EuPathDBiHostDB:ENSG00000167393.17
GeneCardsiPPP2R3B
H-InvDBiHIX0038850
HIX0176522
HIX0177602
HGNCiHGNC:13417 PPP2R3B
HPAiHPA074545
MIMi300339 gene
neXtProtiNX_Q9Y5P8
OpenTargetsiENSG00000167393
PharmGKBiPA134878872
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2562 Eukaryota
ENOG410XRBK LUCA
GeneTreeiENSGT00530000063265
HOGENOMiHOG000265086
HOVERGENiHBG000010
KOiK11583
OMAiDNMAIEP
OrthoDBiEOG091G03UQ
PhylomeDBiQ9Y5P8
TreeFamiTF105554

Enzyme and pathway databases

ReactomeiR-HSA-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1
R-HSA-69231 Cyclin D associated events in G1
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition

Miscellaneous databases

ChiTaRSiPPP2R3B human
GeneWikiiPPP2R3B
GenomeRNAii28227
PROiPR:Q9Y5P8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167393 Expressed in 146 organ(s), highest expression level in apex of heart
CleanExiHS_PPP2R3B
ExpressionAtlasiQ9Y5P8 baseline and differential
GenevisibleiQ9Y5P8 HS

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
SUPFAMiSSF47473 SSF47473, 2 hits
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiP2R3B_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5P8
Secondary accession number(s): Q6P4G9, Q7RTT1, Q96H01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: September 11, 2007
Last modified: November 7, 2018
This is version 165 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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