Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Chondrosarcoma-associated gene 2/3 protein

Gene

CSAG2

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Drug-resistance related protein, its expression is associated with the chemotherapy resistant and neoplastic phenotype. May also be linked to the malignant phenotype.

GO - Biological processi

  • response to drug Source: ProtInc

Names & Taxonomyi

Protein namesi
Recommended name:
Chondrosarcoma-associated gene 2/3 protein
Alternative name(s):
Cancer/testis antigen 24.2
Short name:
CT24.2
Taxol-resistant-associated gene 3 protein
Short name:
TRAG-3
Gene namesi
Name:CSAG2
Synonyms:TRAG3
AND
Name:CSAG3
Synonyms:CSAG3A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:16847 CSAG2
HGNC:26237 CSAG3
neXtProtiNX_Q9Y5P2

Pathology & Biotechi

Organism-specific databases

DisGeNETi102723547
389903
OpenTargetsiENSG00000268916
PharmGKBiPA134919230

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000793901 – 127Chondrosarcoma-associated gene 2/3 proteinAdd BLAST127

Proteomic databases

PRIDEiQ9Y5P2
ProteomicsDBi86459
86460 [Q9Y5P2-2]
86461 [Q9Y5P2-3]

PTM databases

iPTMnetiQ9Y5P2
PhosphoSitePlusiQ9Y5P2

Expressioni

Tissue specificityi

Weakly expressed in kidney. Expressed in various tumor cell lines including carcinomas, myeloid and lymphoid malignancies, melanomas and prostate cancer. Overexpressed in taxol-resistant breast cancer line MDA 435TR and the doxorubicin-resistant multiple myelanoma lines RPMI-8226/Dox40 and RPMI-8226/MDR10V.

Gene expression databases

CleanExiHS_CSAG3

Organism-specific databases

HPAiHPA078264

Structurei

3D structure databases

ProteinModelPortaliQ9Y5P2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000012766
HOGENOMiHOG000112006
HOVERGENiHBG099380
InParanoidiQ9Y5P2
PhylomeDBiQ9Y5P2

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y5P2-1) [UniParc]FASTAAdd to basket
Also known as: Long, TRAG-3L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWMGLIQLVE GVKRKDQGFL EKEFYHKTNI KMRCEFLACW PAFTVLGEAW
60 70 80 90 100
RDQVDWSRLL RDAGLVKMSR KPRASSPLSN NHPPTPKRRG SGRHPLNPGP
110 120
EALSKFPRQP GREKGPIKEV PGTKGSP
Length:127
Mass (Da):14,430
Last modified:July 22, 2008 - v2
Checksum:iEC1B2C1758129BCC
GO
Isoform 2 (identifier: Q9Y5P2-2) [UniParc]FASTAAdd to basket
Also known as: Short, TRAG-3S

The sequence of this isoform differs from the canonical sequence as follows:
     89-105: Missing.

Show »
Length:110
Mass (Da):12,675
Checksum:i060CB7D5E3D93027
GO
Isoform 3 (identifier: Q9Y5P2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-67: Missing.
     94-105: Missing.

Show »
Length:48
Mass (Da):5,217
Checksum:iAAEC2A40DBA90889
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2PPV0A0A1W2PPV0_HUMAN
Chondrosarcoma-associated gene 2/3 ...
CSAG2
127Annotation score:
A0A1W2PQG5A0A1W2PQG5_HUMAN
Chondrosarcoma-associated gene 2/3 ...
CSAG2
110Annotation score:
A0A1W2PR38A0A1W2PR38_HUMAN
Chondrosarcoma-associated gene 2/3 ...
CSAG2
78Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33R → H in AAC29487 (PubMed:10095106).Curated1
Sequence conflicti33R → H in AAD37859 (Ref. 2) Curated1
Sequence conflicti37L → H in AAC29487 (PubMed:10095106).Curated1
Sequence conflicti37L → H in AAD37859 (Ref. 2) Curated1
Sequence conflicti58R → I in AAC29487 (PubMed:10095106).Curated1
Sequence conflicti58R → I in AAD37859 (Ref. 2) Curated1
Sequence conflicti110P → L in AAC29487 (PubMed:10095106).Curated1
Sequence conflicti110P → L in AAD37859 (Ref. 2) Curated1
Sequence conflicti118K → E in AAC29487 (PubMed:10095106).Curated1
Sequence conflicti118K → E in AAD37859 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0349121 – 67Missing in isoform 3. 1 PublicationAdd BLAST67
Alternative sequenceiVSP_00446989 – 105Missing in isoform 2. 2 PublicationsAdd BLAST17
Alternative sequenceiVSP_03491394 – 105Missing in isoform 3. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080246 mRNA Translation: AAC29487.1
AF136715 mRNA Translation: AAD37859.1
CH471169 Genomic DNA Translation: EAW99428.1
BC007228 mRNA Translation: AAH07228.1
BC119734 mRNA Translation: AAI19735.1
BC119735 mRNA Translation: AAI19736.1
RefSeqiNP_001123298.1, NM_001129826.2 [Q9Y5P2-1]
NP_001123300.1, NM_001129828.2 [Q9Y5P2-2]
UniGeneiHs.721609
Hs.735281
Hs.741932

Genome annotation databases

EnsembliENST00000599845; ENSP00000491011; ENSG00000268916 [Q9Y5P2-1]
ENST00000638835; ENSP00000492276; ENSG00000268916 [Q9Y5P2-2]
GeneIDi389903
KEGGihsa:389903

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080246 mRNA Translation: AAC29487.1
AF136715 mRNA Translation: AAD37859.1
CH471169 Genomic DNA Translation: EAW99428.1
BC007228 mRNA Translation: AAH07228.1
BC119734 mRNA Translation: AAI19735.1
BC119735 mRNA Translation: AAI19736.1
RefSeqiNP_001123298.1, NM_001129826.2 [Q9Y5P2-1]
NP_001123300.1, NM_001129828.2 [Q9Y5P2-2]
UniGeneiHs.721609
Hs.735281
Hs.741932

3D structure databases

ProteinModelPortaliQ9Y5P2
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ9Y5P2
PhosphoSitePlusiQ9Y5P2

Proteomic databases

PRIDEiQ9Y5P2
ProteomicsDBi86459
86460 [Q9Y5P2-2]
86461 [Q9Y5P2-3]

Protocols and materials databases

DNASUi389903
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000599845; ENSP00000491011; ENSG00000268916 [Q9Y5P2-1]
ENST00000638835; ENSP00000492276; ENSG00000268916 [Q9Y5P2-2]
GeneIDi389903
KEGGihsa:389903

Organism-specific databases

CTDi389903
DisGeNETi102723547
389903
GeneCardsiCSAG2
CSAG3
H-InvDBiHIX0010307
HIX0056157
HIX0176527
HIX0176530
HGNCiHGNC:16847 CSAG2
HGNC:26237 CSAG3
HPAiHPA078264
neXtProtiNX_Q9Y5P2
OpenTargetsiENSG00000268916
PharmGKBiPA134919230
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000012766
HOGENOMiHOG000112006
HOVERGENiHBG099380
InParanoidiQ9Y5P2
PhylomeDBiQ9Y5P2

Miscellaneous databases

GenomeRNAii389903
PROiPR:Q9Y5P2

Gene expression databases

CleanExiHS_CSAG3

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCSAG2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5P2
Secondary accession number(s): O75605, Q0VDC3, Q96IU8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 22, 2008
Last modified: June 20, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again