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Protein

Olfactory receptor 51B2

Gene

OR51B2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G protein-coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 51B2
Alternative name(s):
Odorant receptor HOR5'beta3
Olfactory receptor 51B1
Gene namesi
Name:OR51B2
Synonyms:OR51B1P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000184881.3
HostDB:ENSG00000279012.1
HGNCiHGNC:14703 OR51B2
neXtProtiNX_Q9Y5P1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 44Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini45 – 52CytoplasmicSequence analysis8
Transmembranei53 – 73Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini74 – 97ExtracellularSequence analysisAdd BLAST24
Transmembranei98 – 118Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini119 – 137CytoplasmicSequence analysisAdd BLAST19
Transmembranei138 – 158Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini159 – 194ExtracellularSequence analysisAdd BLAST36
Transmembranei195 – 215Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini216 – 235CytoplasmicSequence analysisAdd BLAST20
Transmembranei236 – 256Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini257 – 271ExtracellularSequence analysisAdd BLAST15
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 312CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32364

Polymorphism and mutation databases

BioMutaiOR51B2
DMDMi296439490

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507451 – 312Olfactory receptor 51B2Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Y5P1
PeptideAtlasiQ9Y5P1
PRIDEiQ9Y5P1
ProteomicsDBi86458

PTM databases

iPTMnetiQ9Y5P1
PhosphoSitePlusiQ9Y5P1

Expressioni

Gene expression databases

BgeeiENSG00000279012 Expressed in 2 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExiHS_OR51B2
ExpressionAtlasiQ9Y5P1 baseline and differential
GenevisibleiQ9Y5P1 HS

Interactioni

Protein-protein interaction databases

IntActiQ9Y5P1, 1 interactor
STRINGi9606.ENSP00000327540

Structurei

3D structure databases

ProteinModelPortaliQ9Y5P1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVJQ Eukaryota
ENOG4111CPY LUCA
GeneTreeiENSGT00930000150933
HOGENOMiHOG000041363
HOVERGENiHBG017625
InParanoidiQ9Y5P1
KOiK04257
OMAiTFIYRFG
OrthoDBiEOG091G0AZH
PhylomeDBiQ9Y5P1
TreeFamiTF342735

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y5P1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWPNITAAPF LLTGFPGLEA AHHWISIPFF AVYVCILLGN GMLLYLIKHD
60 70 80 90 100
HSLHEPMYYF LTMLAGTDLM VTLTTMPTVM GILWVNHREI SSVGCFLQAY
110 120 130 140 150
FIHSLSVVES GSLLAMAYDC FIAIRNPLRY ASILTNTRVI ALGVGVFLRG
160 170 180 190 200
FVSILPVILR LFSFSYCKSH VITRAFCLHQ EIMRLACADI TFNRLYPVIL
210 220 230 240 250
ISLTIFLDCL IILFSYILIL NTVIGIASGE ERAKALNTCI SHISCVLIFY
260 270 280 290 300
VTVMGLTFIY RFGKNVPEVV HIIMSYIYFL FPPLMNPVIY SIKTKQIQYG
310
IIRLLSKHRF SS
Length:312
Mass (Da):35,373
Last modified:May 18, 2010 - v4
Checksum:i47E1BA5852C36966
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_063114120C → R2 PublicationsCorresponds to variant dbSNP:rs7952293Ensembl.1
Natural variantiVAR_063115134L → F2 PublicationsCorresponds to variant dbSNP:rs10837814Ensembl.1
Natural variantiVAR_063116209C → S3 PublicationsCorresponds to variant dbSNP:rs7937237Ensembl.1
Natural variantiVAR_057576283P → S1 PublicationCorresponds to variant dbSNP:rs11036815Ensembl.1
Natural variantiVAR_063117312S → R1 PublicationCorresponds to variant dbSNP:rs11036814Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137396 Genomic DNA Translation: AAD29425.2
AC104389 Genomic DNA No translation available.
BC117461 mRNA Translation: AAI17462.1
AF399503 Genomic DNA Translation: AAK94988.1
RefSeqiNP_149420.4, NM_033180.4
UniGeneiHs.680163

Genome annotation databases

EnsembliENST00000624187; ENSP00000485407; ENSG00000279012
GeneIDi79345
KEGGihsa:79345
UCSCiuc001mao.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137396 Genomic DNA Translation: AAD29425.2
AC104389 Genomic DNA No translation available.
BC117461 mRNA Translation: AAI17462.1
AF399503 Genomic DNA Translation: AAK94988.1
RefSeqiNP_149420.4, NM_033180.4
UniGeneiHs.680163

3D structure databases

ProteinModelPortaliQ9Y5P1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9Y5P1, 1 interactor
STRINGi9606.ENSP00000327540

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9Y5P1
PhosphoSitePlusiQ9Y5P1

Polymorphism and mutation databases

BioMutaiOR51B2
DMDMi296439490

Proteomic databases

PaxDbiQ9Y5P1
PeptideAtlasiQ9Y5P1
PRIDEiQ9Y5P1
ProteomicsDBi86458

Protocols and materials databases

DNASUi79345
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000624187; ENSP00000485407; ENSG00000279012
GeneIDi79345
KEGGihsa:79345
UCSCiuc001mao.2 human

Organism-specific databases

CTDi79345
EuPathDBiHostDB:ENSG00000184881.3
HostDB:ENSG00000279012.1
GeneCardsiOR51B2
HGNCiHGNC:14703 OR51B2
neXtProtiNX_Q9Y5P1
PharmGKBiPA32364
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVJQ Eukaryota
ENOG4111CPY LUCA
GeneTreeiENSGT00930000150933
HOGENOMiHOG000041363
HOVERGENiHBG017625
InParanoidiQ9Y5P1
KOiK04257
OMAiTFIYRFG
OrthoDBiEOG091G0AZH
PhylomeDBiQ9Y5P1
TreeFamiTF342735

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR51B2
GenomeRNAii79345
PROiPR:Q9Y5P1

Gene expression databases

BgeeiENSG00000279012 Expressed in 2 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExiHS_OR51B2
ExpressionAtlasiQ9Y5P1 baseline and differential
GenevisibleiQ9Y5P1 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO51B2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5P1
Secondary accession number(s): Q17R53, Q96RD4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 153 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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