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Entry version 151 (08 May 2019)
Sequence version 4 (27 Sep 2017)
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Protein

Methyltransferase N6AMT1

Gene

N6AMT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Methyltransferase that can methylate both proteins and DNA, and to a lower extent, arsenic (PubMed:18539146, PubMed:21193388, PubMed:30017583). Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif (PubMed:18539146) (By similarity). Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated (PubMed:18539146, PubMed:20606008). Also acts as a N6-adenine-specific DNA methyltransferase by mediating methylation of DNA on the 6th position of adenine (N6-methyladenosine) (PubMed:30017583). N6-methyladenosine (m6A) DNA is significantly enriched in exonic regions and is associated with gene transcriptional activation (PubMed:30017583). May also play a role in the modulation of arsenic-induced toxicity by mediating the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid (PubMed:21193388, PubMed:25997655). It however only plays a limited role in arsenic metabolism compared with AS3MT (PubMed:25997655).By similarity5 Publications

Caution

Although predicted to act as a DNA methyltransferase, DNA methyltransferase activity has been elusive for many years due to inability to detect N6-methyladenosine (m6A) in vertebrate cells. The development of deep sequencing allowed identification of m6A in mammal cells and identification of N6AMT1 as a N6-adenine-specific DNA methyltransferase (PubMed:30017583).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei77S-adenosyl-L-methionineBy similarity1
Binding sitei122S-adenosyl-L-methionine1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.1.1.72 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-156581 Methylation
R-HSA-72764 Eukaryotic Translation Termination

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Methyltransferase N6AMT1Curated
Alternative name(s):
HemK methyltransferase family member 21 Publication
Short name:
M.HsaHemK2P
Methylarsonite methyltransferase N6AMT1 (EC:2.1.1.-2 Publications)
N(6)-adenine-specific DNA methyltransferase 11 Publication (EC:2.1.1.721 Publication)
Protein N(5)-glutamine methyltransferaseCurated (EC:2.1.1.-1 Publication)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:N6AMT11 PublicationImported
Synonyms:C21orf127Imported, HEMK21 Publication, PRED28By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16021 N6AMT1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
614553 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y5N5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi122 – 125NPPY → AAAA: Abolished DNA methyltransferase activity. 1 Publication4

Organism-specific databases

DisGeNET

More...
DisGeNETi
29104

Open Targets

More...
OpenTargetsi
ENSG00000156239

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162396656

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
N6AMT1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
313104228

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000880491 – 214Methyltransferase N6AMT1Add BLAST214

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y5N5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Y5N5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y5N5

PeptideAtlas

More...
PeptideAtlasi
Q9Y5N5

PRoteomics IDEntifications database

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PRIDEi
Q9Y5N5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
86454
86455 [Q9Y5N5-2]

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, with highest expression in parathyroid and pituitary glands, followed by adrenal gland and kidney, and lowest expression in leukocytes and mammary gland.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000156239 Expressed in 161 organ(s), highest expression level in corpus callosum

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y5N5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB034133
CAB034135
HPA059242

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer; heterodimerizes with TRMT112.2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
118872, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q9Y5N5, 5 interactors

Molecular INTeraction database

More...
MINTi
Q9Y5N5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000303584

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9Y5N5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni53 – 57S-adenosyl-L-methionine bindingUniRule annotationBy similarity5
Regioni122 – 125Substrate bindingBy similarity4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3191 Eukaryota
COG2890 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013073

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000219949

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9Y5N5

KEGG Orthology (KO)

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KOi
K19589

Identification of Orthologs from Complete Genome Data

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OMAi
EWDDWME

Database of Orthologous Groups

More...
OrthoDBi
1450330at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y5N5

TreeFam database of animal gene trees

More...
TreeFami
TF314919

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002052 DNA_methylase_N6_adenine_CS
IPR004557 PrmC-related
IPR029063 SAM-dependent_MTases
IPR007848 Small_mtfrase_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05175 MTS, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53335 SSF53335, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR00537 hemK_rel_arch, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00092 N6_MTASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9Y5N5-1) [UniParc]FASTAAdd to basket
Also known as: Alpha1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGENFATPF HGHVGRGAFS DVYEPAEDTF LLLDALEAAA AELAGVEICL
60 70 80 90 100
EVGSGSGVVS AFLASMIGPQ ALYMCTDINP EAAACTLETA RCNKVHIQPV
110 120 130 140 150
ITDLVKGLLP RLTEKVDLLV FNPPYVVTPP QEVGSHGIEA AWAGGRNGRE
160 170 180 190 200
VMDRFFPLVP DLLSPRGLFY LVTIKENNPE EILKIMKTKG LQGTTALSRQ
210
AGQETLSVLK FTKS
Length:214
Mass (Da):22,957
Last modified:September 27, 2017 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i65512C91DC85ADDB
GO
Isoform 2 (identifier: Q9Y5N5-2) [UniParc]FASTAAdd to basket
Also known as: Beta1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     105-132: Missing.

Show »
Length:186
Mass (Da):19,813
Checksum:i2FBF1CE5562CF2EC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06044534D → N. Corresponds to variant dbSNP:rs1997607Ensembl.1
Natural variantiVAR_060446146R → K1 PublicationCorresponds to variant dbSNP:rs2205447Ensembl.1
Natural variantiVAR_060447166R → K1 PublicationCorresponds to variant dbSNP:rs2205446Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_040294105 – 132Missing in isoform 2. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF139682 mRNA Translation: AAD38520.1
AK314100 mRNA Translation: BAG36794.1
AF227510 Genomic DNA No translation available.
AL163248 Genomic DNA Translation: CAB90428.1
AMYH02037685 Genomic DNA No translation available.
KF570251 Genomic DNA No translation available.
KF457188 Genomic DNA No translation available.
KC877845 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09939.1
CH471079 Genomic DNA Translation: EAX09940.1
CH471079 Genomic DNA Translation: EAX09941.1
BC011554 mRNA Translation: AAH11554.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33525.1 [Q9Y5N5-2]
CCDS33526.1 [Q9Y5N5-1]

NCBI Reference Sequences

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RefSeqi
NP_037372.4, NM_013240.5 [Q9Y5N5-1]
NP_877426.4, NM_182749.4 [Q9Y5N5-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000303775; ENSP00000303584; ENSG00000156239 [Q9Y5N5-1]
ENST00000351429; ENSP00000286764; ENSG00000156239 [Q9Y5N5-2]
ENST00000460212; ENSP00000436490; ENSG00000156239 [Q9Y5N5-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
29104

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:29104

UCSC genome browser

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UCSCi
uc002ymo.3 human
uc002ymp.3 human [Q9Y5N5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF139682 mRNA Translation: AAD38520.1
AK314100 mRNA Translation: BAG36794.1
AF227510 Genomic DNA No translation available.
AL163248 Genomic DNA Translation: CAB90428.1
AMYH02037685 Genomic DNA No translation available.
KF570251 Genomic DNA No translation available.
KF457188 Genomic DNA No translation available.
KC877845 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09939.1
CH471079 Genomic DNA Translation: EAX09940.1
CH471079 Genomic DNA Translation: EAX09941.1
BC011554 mRNA Translation: AAH11554.1
CCDSiCCDS33525.1 [Q9Y5N5-2]
CCDS33526.1 [Q9Y5N5-1]
RefSeqiNP_037372.4, NM_013240.5 [Q9Y5N5-1]
NP_877426.4, NM_182749.4 [Q9Y5N5-2]

3D structure databases

SMRiQ9Y5N5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118872, 6 interactors
IntActiQ9Y5N5, 5 interactors
MINTiQ9Y5N5
STRINGi9606.ENSP00000303584

Polymorphism and mutation databases

BioMutaiN6AMT1
DMDMi313104228

Proteomic databases

EPDiQ9Y5N5
jPOSTiQ9Y5N5
PaxDbiQ9Y5N5
PeptideAtlasiQ9Y5N5
PRIDEiQ9Y5N5
ProteomicsDBi86454
86455 [Q9Y5N5-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
29104
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303775; ENSP00000303584; ENSG00000156239 [Q9Y5N5-1]
ENST00000351429; ENSP00000286764; ENSG00000156239 [Q9Y5N5-2]
ENST00000460212; ENSP00000436490; ENSG00000156239 [Q9Y5N5-1]
GeneIDi29104
KEGGihsa:29104
UCSCiuc002ymo.3 human
uc002ymp.3 human [Q9Y5N5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
29104
DisGeNETi29104

GeneCards: human genes, protein and diseases

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GeneCardsi
N6AMT1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0020675
HGNCiHGNC:16021 N6AMT1
HPAiCAB034133
CAB034135
HPA059242
MIMi614553 gene
neXtProtiNX_Q9Y5N5
OpenTargetsiENSG00000156239
PharmGKBiPA162396656

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3191 Eukaryota
COG2890 LUCA
GeneTreeiENSGT00390000013073
HOGENOMiHOG000219949
InParanoidiQ9Y5N5
KOiK19589
OMAiEWDDWME
OrthoDBi1450330at2759
PhylomeDBiQ9Y5N5
TreeFamiTF314919

Enzyme and pathway databases

BRENDAi2.1.1.72 2681
ReactomeiR-HSA-156581 Methylation
R-HSA-72764 Eukaryotic Translation Termination

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
29104

Protein Ontology

More...
PROi
PR:Q9Y5N5

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000156239 Expressed in 161 organ(s), highest expression level in corpus callosum
GenevisibleiQ9Y5N5 HS

Family and domain databases

InterProiView protein in InterPro
IPR002052 DNA_methylase_N6_adenine_CS
IPR004557 PrmC-related
IPR029063 SAM-dependent_MTases
IPR007848 Small_mtfrase_dom
PfamiView protein in Pfam
PF05175 MTS, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00537 hemK_rel_arch, 1 hit
PROSITEiView protein in PROSITE
PS00092 N6_MTASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiN6MT1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y5N5
Secondary accession number(s): B2RA97, Q96F73
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: September 27, 2017
Last modified: May 8, 2019
This is version 151 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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