UniProtKB - Q9Y5N1 (HRH3_HUMAN)
Histamine H3 receptor
HRH3
Functioni
The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization.
Miscellaneous
GO - Molecular functioni
- G protein-coupled acetylcholine receptor activity Source: GO_Central
- G protein-coupled serotonin receptor activity Source: GO_Central
- histamine receptor activity Source: ProtInc
- neurotransmitter receptor activity Source: GO_Central
GO - Biological processi
- adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway Source: GO_Central
- chemical synaptic transmission Source: GO_Central
- cognition Source: GO_Central
- G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
- negative regulation of glutamate secretion Source: GO_Central
- negative regulation of serotonin secretion Source: GO_Central
- neurotransmitter secretion Source: ProtInc
- regulation of norepinephrine secretion Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | Q9Y5N1 |
Reactomei | R-HSA-390650, Histamine receptors |
SignaLinki | Q9Y5N1 |
SIGNORi | Q9Y5N1 |
Names & Taxonomyi
Protein namesi | Recommended name: Histamine H3 receptorShort name: H3R Short name: HH3R Alternative name(s): G-protein coupled receptor 97 |
Gene namesi | Name:HRH3 Synonyms:GPCR97 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:5184, HRH3 |
MIMi | 604525, gene |
neXtProti | NX_Q9Y5N1 |
VEuPathDBi | HostDB:ENSG00000101180 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
Other locations
- dendrite Source: GO_Central
- presynapse Source: GOC
- synapse Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 39 | ExtracellularSequence analysisAdd BLAST | 39 | |
Transmembranei | 40 – 60 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 61 – 70 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 71 – 91 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 92 – 108 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 109 – 129 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 130 – 156 | CytoplasmicSequence analysisAdd BLAST | 27 | |
Transmembranei | 157 – 177 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 178 – 196 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 197 – 217 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 218 – 359 | CytoplasmicSequence analysisAdd BLAST | 142 | |
Transmembranei | 360 – 380 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 381 – 395 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 396 – 416 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 417 – 445 | CytoplasmicSequence analysisAdd BLAST | 29 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 11255 |
OpenTargetsi | ENSG00000101180 |
PharmGKBi | PA29458 |
Miscellaneous databases
Pharosi | Q9Y5N1, Tclin |
Chemistry databases
ChEMBLi | CHEMBL264 |
DrugBanki | DB01238, Aripiprazole DB06698, Betahistine DB05381, Histamine DB05080, OBE101 DB00768, Olopatadine DB11642, Pitolisant |
DrugCentrali | Q9Y5N1 |
GuidetoPHARMACOLOGYi | 264 |
Genetic variation databases
BioMutai | HRH3 |
DMDMi | 17367264 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069690 | 1 – 445 | Histamine H3 receptorAdd BLAST | 445 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 11 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 439 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | Q9Y5N1 |
PeptideAtlasi | Q9Y5N1 |
PRIDEi | Q9Y5N1 |
PTM databases
GlyGeni | Q9Y5N1, 1 site |
PhosphoSitePlusi | Q9Y5N1 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000101180, Expressed in hypothalamus and 123 other tissues |
ExpressionAtlasi | Q9Y5N1, baseline and differential |
Genevisiblei | Q9Y5N1, HS |
Organism-specific databases
HPAi | ENSG00000101180, Tissue enriched (brain) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 116416, 4 interactors |
DIPi | DIP-61456N |
IntActi | Q9Y5N1, 2 interactors |
STRINGi | 9606.ENSP00000342560 |
Chemistry databases
BindingDBi | Q9Y5N1 |
Miscellaneous databases
RNActi | Q9Y5N1, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 237 – 260 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 288 – 336 | DisorderedSequence analysisAdd BLAST | 49 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 243 – 259 | Pro residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 299 – 314 | Polar residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000161502 |
InParanoidi | Q9Y5N1 |
OMAi | APGCWGC |
OrthoDBi | 614573at2759 |
PhylomeDBi | Q9Y5N1 |
TreeFami | TF351747 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR003980, Histamine_H3_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01471, HISTAMINEH3R |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
s (7+)i Sequence
Sequence statusi: Complete.
This entry describes 7 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 7 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MERAPPDGPL NASGALAGEA AAAGGARGFS AAWTAVLAAL MALLIVATVL
60 70 80 90 100
GNALVMLAFV ADSSLRTQNN FFLLNLAISD FLVGAFCIPL YVPYVLTGRW
110 120 130 140 150
TFGRGLCKLW LVVDYLLCTS SAFNIVLISY DRFLSVTRAV SYRAQQGDTR
160 170 180 190 200
RAVRKMLLVW VLAFLLYGPA ILSWEYLSGG SSIPEGHCYA EFFYNWYFLI
210 220 230 240 250
TASTLEFFTP FLSVTFFNLS IYLNIQRRTR LRLDGAREAA GPEPPPEAQP
260 270 280 290 300
SPPPPPGCWG CWQKGHGEAM PLHRYGVGEA AVGAEAGEAT LGGGGGGGSV
310 320 330 340 350
ASPTSSSGSS SRGTERPRSL KRGSKPSASS ASLEKRMKMV SQSFTQRFRL
360 370 380 390 400
SRDRKVAKSL AVIVSIFGLC WAPYTLLMII RAACHGHCVP DYWYETSFWL
410 420 430 440
LWANSAVNPV LYPLCHHSFR RAFTKLLCPQ KLKIQPHSSL EHCWK
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WZD3 | A0A087WZD3_HUMAN | Histamine H3 receptor | HRH3 | 200 | Annotation score: | ||
A0A0A0MR48 | A0A0A0MR48_HUMAN | Histamine H3 receptor | HRH3 hCG_41769 | 373 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 19 | E → D (PubMed:10347254).Curated | 1 | |
Sequence conflicti | 19 | E → D (Ref. 5) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_012235 | 280 | A → V in a Shy-Drager syndrome patient; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs752380770Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001881 | 85 – 98 | Missing in isoform 4. CuratedAdd BLAST | 14 | |
Alternative sequenceiVSP_001882 | 197 – 315 | Missing in isoform 5. CuratedAdd BLAST | 119 | |
Alternative sequenceiVSP_001883 | 227 – 342 | Missing in isoform 6. CuratedAdd BLAST | 116 | |
Alternative sequenceiVSP_001884 | 234 – 263 | Missing in isoform 7. CuratedAdd BLAST | 30 | |
Alternative sequenceiVSP_001885 | 274 – 353 | Missing in isoform 3. 1 PublicationAdd BLAST | 80 | |
Alternative sequenceiVSP_001886 | 445 | K → KKMKKKTCL in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF140538 mRNA Translation: AAD38151.1 AB045369 mRNA Translation: BAB20090.1 AB019000 mRNA Translation: BAB17030.1 AJ296652 Genomic DNA Translation: CAC51025.1 AJ278250 Genomic DNA Translation: CAC39434.1 AF363791 mRNA Translation: AAK50040.1 AL078633 Genomic DNA No translation available. BC096840 mRNA Translation: AAH96840.1 |
CCDSi | CCDS13493.1 [Q9Y5N1-1] |
RefSeqi | NP_009163.2, NM_007232.2 [Q9Y5N1-1] XP_005260323.1, XM_005260266.3 [Q9Y5N1-2] |
Genome annotation databases
Ensembli | ENST00000340177; ENSP00000342560; ENSG00000101180 |
GeneIDi | 11255 |
KEGGi | hsa:11255 |
MANE-Selecti | ENST00000340177.10; ENSP00000342560.5; NM_007232.3; NP_009163.2 |
UCSCi | uc002ycf.3, human [Q9Y5N1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF140538 mRNA Translation: AAD38151.1 AB045369 mRNA Translation: BAB20090.1 AB019000 mRNA Translation: BAB17030.1 AJ296652 Genomic DNA Translation: CAC51025.1 AJ278250 Genomic DNA Translation: CAC39434.1 AF363791 mRNA Translation: AAK50040.1 AL078633 Genomic DNA No translation available. BC096840 mRNA Translation: AAH96840.1 |
CCDSi | CCDS13493.1 [Q9Y5N1-1] |
RefSeqi | NP_009163.2, NM_007232.2 [Q9Y5N1-1] XP_005260323.1, XM_005260266.3 [Q9Y5N1-2] |
3D structure databases
SMRi | Q9Y5N1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116416, 4 interactors |
DIPi | DIP-61456N |
IntActi | Q9Y5N1, 2 interactors |
STRINGi | 9606.ENSP00000342560 |
Chemistry databases
BindingDBi | Q9Y5N1 |
ChEMBLi | CHEMBL264 |
DrugBanki | DB01238, Aripiprazole DB06698, Betahistine DB05381, Histamine DB05080, OBE101 DB00768, Olopatadine DB11642, Pitolisant |
DrugCentrali | Q9Y5N1 |
GuidetoPHARMACOLOGYi | 264 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q9Y5N1, 1 site |
PhosphoSitePlusi | Q9Y5N1 |
Genetic variation databases
BioMutai | HRH3 |
DMDMi | 17367264 |
Proteomic databases
PaxDbi | Q9Y5N1 |
PeptideAtlasi | Q9Y5N1 |
PRIDEi | Q9Y5N1 |
Protocols and materials databases
Antibodypediai | 14714, 497 antibodies from 36 providers |
DNASUi | 11255 |
Genome annotation databases
Ensembli | ENST00000340177; ENSP00000342560; ENSG00000101180 |
GeneIDi | 11255 |
KEGGi | hsa:11255 |
MANE-Selecti | ENST00000340177.10; ENSP00000342560.5; NM_007232.3; NP_009163.2 |
UCSCi | uc002ycf.3, human [Q9Y5N1-1] |
Organism-specific databases
CTDi | 11255 |
DisGeNETi | 11255 |
GeneCardsi | HRH3 |
HGNCi | HGNC:5184, HRH3 |
HPAi | ENSG00000101180, Tissue enriched (brain) |
MIMi | 604525, gene |
neXtProti | NX_Q9Y5N1 |
OpenTargetsi | ENSG00000101180 |
PharmGKBi | PA29458 |
VEuPathDBi | HostDB:ENSG00000101180 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000161502 |
InParanoidi | Q9Y5N1 |
OMAi | APGCWGC |
OrthoDBi | 614573at2759 |
PhylomeDBi | Q9Y5N1 |
TreeFami | TF351747 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y5N1 |
Reactomei | R-HSA-390650, Histamine receptors |
SignaLinki | Q9Y5N1 |
SIGNORi | Q9Y5N1 |
Miscellaneous databases
BioGRID-ORCSi | 11255, 7 hits in 1041 CRISPR screens |
ChiTaRSi | HRH3, human |
GeneWikii | Histamine_H3_receptor |
GenomeRNAii | 11255 |
Pharosi | Q9Y5N1, Tclin |
PROi | PR:Q9Y5N1 |
RNActi | Q9Y5N1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000101180, Expressed in hypothalamus and 123 other tissues |
ExpressionAtlasi | Q9Y5N1, baseline and differential |
Genevisiblei | Q9Y5N1, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR003980, Histamine_H3_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01471, HISTAMINEH3R |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HRH3_HUMAN | |
Accessioni | Q9Y5N1Primary (citable) accession number: Q9Y5N1 Secondary accession number(s): Q4QRI7, Q9GZX2, Q9H4K8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 16, 2001 |
Last sequence update: | November 16, 2001 | |
Last modified: | February 23, 2022 | |
This is version 183 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families