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UniProtKB - Q9Y5N1 (HRH3_HUMAN)

Entry version 179 (10 Feb 2021)
Sequence version 2 (16 Nov 2001)
Previous versions | rss
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Protein

Histamine H3 receptor

Gene

HRH3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization.

Miscellaneous

Does not bind to cimetidine and tripolidine. Shows modest affinity for thioperamide, imetit, N-alpha-methylhistamine and R--alpha-methylhistamine. Isoform 4 is unable to bind to iodoproxyfan while isoforms 1 and 3 bind it with high affinity.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9Y5N1

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-390650, Histamine receptors

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9Y5N1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histamine H3 receptor
Short name:
H3R
Short name:
HH3R
Alternative name(s):
G-protein coupled receptor 97
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HRH3
Synonyms:GPCR97
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:5184, HRH3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604525, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y5N1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000101180.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 39ExtracellularSequence analysisAdd BLAST39
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei40 – 60Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini61 – 70CytoplasmicSequence analysis10
Transmembranei71 – 91Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini92 – 108ExtracellularSequence analysisAdd BLAST17
Transmembranei109 – 129Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini130 – 156CytoplasmicSequence analysisAdd BLAST27
Transmembranei157 – 177Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini178 – 196ExtracellularSequence analysisAdd BLAST19
Transmembranei197 – 217Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini218 – 359CytoplasmicSequence analysisAdd BLAST142
Transmembranei360 – 380Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini381 – 395ExtracellularSequence analysisAdd BLAST15
Transmembranei396 – 416Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini417 – 445CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		11255

Open Targets

More...OpenTargetsi		ENSG00000101180

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29458

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y5N1, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL264

Drug and drug target database

More...DrugBanki		DB01238, Aripiprazole
DB06698, Betahistine
DB05381, Histamine
DB05080, OBE101
DB00768, Olopatadine
DB11642, Pitolisant

DrugCentral

More...DrugCentrali		Q9Y5N1

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		264

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HRH3

Domain mapping of disease mutations (DMDM)

More...DMDMi		17367264

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000696901 – 445Histamine H3 receptorAdd BLAST445

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi11N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei439PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y5N1

PeptideAtlas

More...PeptideAtlasi		Q9Y5N1

PRoteomics IDEntifications database

More...PRIDEi		Q9Y5N1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		86447 [Q9Y5N1-1]
86448 [Q9Y5N1-2]
86449 [Q9Y5N1-3]
86450 [Q9Y5N1-4]
86451 [Q9Y5N1-5]
86452 [Q9Y5N1-6]
86453 [Q9Y5N1-7]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9Y5N1, 1 site

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y5N1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed predominantly in the CNS, with the greatest expression in the thalamus and caudate nucleus. The various isoforms are mainly coexpressed in brain, but their relative expression level varies in a region-specific manner. Isoform 3 and isoform 7 are highly expressed in the thalamus, caudate nucleus and cerebellum while isoform 5 and isoform 6 show a poor expression. Isoform 5 and isoform 6 show a high expression in the amygdala, substantia nigra, cerebral cortex and hypothalamus. Isoform 7 is not found in hypothalamus or substantia nigra.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000101180, Expressed in hypothalamus and 123 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9Y5N1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Y5N1, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000101180, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116416, 2 interactors

Database of interacting proteins

More...DIPi		DIP-61456N

Protein interaction database and analysis system

More...IntActi		Q9Y5N1, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000342560

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9Y5N1

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Y5N1, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi20 – 23Poly-Ala4
Compositional biasi250 – 256Poly-Pro7
Compositional biasi292 – 298Poly-Gly7

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3656, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161502

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y5N1

Identification of Orthologs from Complete Genome Data

More...OMAi		YRAQRNM

Database of Orthologous Groups

More...OrthoDBi		614573at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y5N1

TreeFam database of animal gene trees

More...TreeFami		TF351747

Family and domain databases

Conserved Domains Database

More...CDDi		cd15296, 7tmA_Histamine_H3R, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR041998, 7tmA_HRH3
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
IPR003980, Histamine_H3_rcpt

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00001, 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00237, GPCRRHODOPSN
PR01471, HISTAMINEH3R

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 7 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y5N1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MERAPPDGPL NASGALAGEA AAAGGARGFS AAWTAVLAAL MALLIVATVL 
        60         70         80         90        100
GNALVMLAFV ADSSLRTQNN FFLLNLAISD FLVGAFCIPL YVPYVLTGRW 
       110        120        130        140        150
TFGRGLCKLW LVVDYLLCTS SAFNIVLISY DRFLSVTRAV SYRAQQGDTR 
       160        170        180        190        200
RAVRKMLLVW VLAFLLYGPA ILSWEYLSGG SSIPEGHCYA EFFYNWYFLI 
       210        220        230        240        250
TASTLEFFTP FLSVTFFNLS IYLNIQRRTR LRLDGAREAA GPEPPPEAQP 
       260        270        280        290        300
SPPPPPGCWG CWQKGHGEAM PLHRYGVGEA AVGAEAGEAT LGGGGGGGSV 
       310        320        330        340        350
ASPTSSSGSS SRGTERPRSL KRGSKPSASS ASLEKRMKMV SQSFTQRFRL 
       360        370        380        390        400
SRDRKVAKSL AVIVSIFGLC WAPYTLLMII RAACHGHCVP DYWYETSFWL 
       410        420        430        440 
LWANSAVNPV LYPLCHHSFR RAFTKLLCPQ KLKIQPHSSL EHCWK
Length:445
Mass (Da):48,671
Last modified:November 16, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2ACF7440FBE95B6C
GO
Isoform 2 (identifier: Q9Y5N1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     445-445: K → KKMKKKTCL

Show »
Length:453
Mass (Da):49,633
Checksum:i4473760FA5ED7E92
GO
Isoform 3 (identifier: Q9Y5N1-3) [UniParc]FASTAAdd to basket
Also known as: H3S

The sequence of this isoform differs from the canonical sequence as follows:
     274-353: Missing.

Show »
Length:365
Mass (Da):40,624
Checksum:i4FDD1DE0CB809F9B
GO
Isoform 4 (identifier: Q9Y5N1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     85-98: Missing.

Show »
Length:431
Mass (Da):47,133
Checksum:i33C4BCC070A1DA23
GO
Isoform 5 (identifier: Q9Y5N1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     197-315: Missing.

Show »
Length:326
Mass (Da):36,396
Checksum:i2EDA2E296463E616
GO
Isoform 6 (identifier: Q9Y5N1-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     227-342: Missing.

Show »
Length:329
Mass (Da):36,943
Checksum:i94955EC0FA4C9590
GO
Isoform 7 (identifier: Q9Y5N1-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     234-263: Missing.

Show »
Length:415
Mass (Da):45,607
Checksum:i5A0505BAD0A13E02
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WZD3A0A087WZD3_HUMAN
Histamine H3 receptor
HRH3
200Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MR48A0A0A0MR48_HUMAN
Histamine H3 receptor
HRH3 hCG_41769
373Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti19E → D (PubMed:10347254).Curated1
Sequence conflicti19E → D (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_012235280A → V in a Shy-Drager syndrome patient; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs752380770Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00188185 – 98Missing in isoform 4. CuratedAdd BLAST14
Alternative sequenceiVSP_001882197 – 315Missing in isoform 5. CuratedAdd BLAST119
Alternative sequenceiVSP_001883227 – 342Missing in isoform 6. CuratedAdd BLAST116
Alternative sequenceiVSP_001884234 – 263Missing in isoform 7. CuratedAdd BLAST30
Alternative sequenceiVSP_001885274 – 353Missing in isoform 3. 1 PublicationAdd BLAST80
Alternative sequenceiVSP_001886445K → KKMKKKTCL in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF140538 mRNA Translation: AAD38151.1
AB045369 mRNA Translation: BAB20090.1
AB019000 mRNA Translation: BAB17030.1
AJ296652 Genomic DNA Translation: CAC51025.1
AJ278250 Genomic DNA Translation: CAC39434.1
AF363791 mRNA Translation: AAK50040.1
AL078633 Genomic DNA No translation available.
BC096840 mRNA Translation: AAH96840.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13493.1 [Q9Y5N1-1]

NCBI Reference Sequences

More...RefSeqi		NP_009163.2, NM_007232.2 [Q9Y5N1-1]
XP_005260323.1, XM_005260266.3 [Q9Y5N1-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000340177; ENSP00000342560; ENSG00000101180 [Q9Y5N1-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		11255

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:11255

UCSC genome browser

More...UCSCi		uc002ycf.3, human [Q9Y5N1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140538 mRNA Translation: AAD38151.1
AB045369 mRNA Translation: BAB20090.1
AB019000 mRNA Translation: BAB17030.1
AJ296652 Genomic DNA Translation: CAC51025.1
AJ278250 Genomic DNA Translation: CAC39434.1
AF363791 mRNA Translation: AAK50040.1
AL078633 Genomic DNA No translation available.
BC096840 mRNA Translation: AAH96840.1
CCDSiCCDS13493.1 [Q9Y5N1-1]
RefSeqiNP_009163.2, NM_007232.2 [Q9Y5N1-1]
XP_005260323.1, XM_005260266.3 [Q9Y5N1-2]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi116416, 2 interactors
DIPiDIP-61456N
IntActiQ9Y5N1, 2 interactors
STRINGi9606.ENSP00000342560

Chemistry databases

BindingDBiQ9Y5N1
ChEMBLiCHEMBL264
DrugBankiDB01238, Aripiprazole
DB06698, Betahistine
DB05381, Histamine
DB05080, OBE101
DB00768, Olopatadine
DB11642, Pitolisant
DrugCentraliQ9Y5N1
GuidetoPHARMACOLOGYi264

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyGeniQ9Y5N1, 1 site
PhosphoSitePlusiQ9Y5N1

Genetic variation databases

BioMutaiHRH3
DMDMi17367264

Proteomic databases

PaxDbiQ9Y5N1
PeptideAtlasiQ9Y5N1
PRIDEiQ9Y5N1
ProteomicsDBi86447 [Q9Y5N1-1]
86448 [Q9Y5N1-2]
86449 [Q9Y5N1-3]
86450 [Q9Y5N1-4]
86451 [Q9Y5N1-5]
86452 [Q9Y5N1-6]
86453 [Q9Y5N1-7]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		14714, 483 antibodies

Genome annotation databases

EnsembliENST00000340177; ENSP00000342560; ENSG00000101180 [Q9Y5N1-1]
GeneIDi11255
KEGGihsa:11255
UCSCiuc002ycf.3, human [Q9Y5N1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		11255
DisGeNETi11255

GeneCards: human genes, protein and diseases

More...GeneCardsi		HRH3
HGNCiHGNC:5184, HRH3
HPAiENSG00000101180, Tissue enriched (brain)
MIMi604525, gene
neXtProtiNX_Q9Y5N1
OpenTargetsiENSG00000101180
PharmGKBiPA29458
VEuPathDBiHostDB:ENSG00000101180.15

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3656, Eukaryota
GeneTreeiENSGT00940000161502
InParanoidiQ9Y5N1
OMAiYRAQRNM
OrthoDBi614573at2759
PhylomeDBiQ9Y5N1
TreeFamiTF351747

Enzyme and pathway databases

PathwayCommonsiQ9Y5N1
ReactomeiR-HSA-390650, Histamine receptors
SIGNORiQ9Y5N1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		11255, 4 hits in 878 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		HRH3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Histamine_H3_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		11255
PharosiQ9Y5N1, Tclin

Protein Ontology

More...PROi		PR:Q9Y5N1
RNActiQ9Y5N1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000101180, Expressed in hypothalamus and 123 other tissues
ExpressionAtlasiQ9Y5N1, baseline and differential
GenevisibleiQ9Y5N1, HS

Family and domain databases

CDDicd15296, 7tmA_Histamine_H3R, 1 hit
InterProiView protein in InterPro
IPR041998, 7tmA_HRH3
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
IPR003980, Histamine_H3_rcpt
PfamiView protein in Pfam
PF00001, 7tm_1, 1 hit
PRINTSiPR00237, GPCRRHODOPSN
PR01471, HISTAMINEH3R
PROSITEiView protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHRH3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y5N1
Secondary accession number(s): Q4QRI7, Q9GZX2, Q9H4K8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 16, 2001
Last modified: February 10, 2021
This is version 179 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families
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