HRH3

Functionⁱ

The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization.

Miscellaneous

Does not bind to cimetidine and tripolidine. Shows modest affinity for thioperamide, imetit, N-alpha-methylhistamine and R^--alpha-methylhistamine. Isoform 4 is unable to bind to iodoproxyfan while isoforms 1 and 3 bind it with high affinity.

GO - Molecular functionⁱ

G protein-coupled acetylcholine receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
G protein-coupled receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
G protein-coupled serotonin receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
histamine receptor activity
Source: ProtInc
Traceable author statementⁱ
- 10347254
neurotransmitter receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
chemical synaptic transmission
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cognition
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
G protein-coupled receptor signaling pathway Source: Reactome
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of glutamate secretion
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of serotonin secretion
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
neurotransmitter secretion
Source: ProtInc
Traceable author statementⁱ
- 10347254
regulation of norepinephrine secretion
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-HSA-390650 Histamine receptors R-HSA-418594 G alpha (i) signalling events

Reactomeⁱ

R-HSA-390650 Histamine receptors
R-HSA-418594 G alpha (i) signalling events

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Histamine H3 receptor Short name: H3R Short name: HH3R Alternative name(s): G-protein coupled receptor 97
Gene namesⁱ	Name:HRH3 Synonyms:GPCR97
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000101180.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5184 HRH3
MIMⁱ	604525 gene
neXtProtⁱ	NX_Q9Y5N1

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 39	ExtracellularSequence analysisAdd BLAST	39
Transmembraneⁱ	40 – 60	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	61 – 70	CytoplasmicSequence analysis	10
Transmembraneⁱ	71 – 91	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	92 – 108	ExtracellularSequence analysisAdd BLAST	17
Transmembraneⁱ	109 – 129	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	130 – 156	CytoplasmicSequence analysisAdd BLAST	27
Transmembraneⁱ	157 – 177	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	178 – 196	ExtracellularSequence analysisAdd BLAST	19
Transmembraneⁱ	197 – 217	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	218 – 359	CytoplasmicSequence analysisAdd BLAST	142
Transmembraneⁱ	360 – 380	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	381 – 395	ExtracellularSequence analysisAdd BLAST	15
Transmembraneⁱ	396 – 416	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	417 – 445	CytoplasmicSequence analysisAdd BLAST	29

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	11255
Open Targets More...OpenTargetsⁱ	ENSG00000101180
PharmGKBⁱ	PA29458

Chemistry databases

ChEMBLⁱ	CHEMBL264
Drug and drug target database More...DrugBankⁱ	DB06698 Betahistine DB05381 Histamine DB00370 Mirtazapine DB05080 OBE101
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	264

Polymorphism and mutation databases

BioMutaⁱ	HRH3
DMDMⁱ	17367264

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069690	1 – 445	Histamine H3 receptorAdd BLAST		445

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	11	N-linked (GlcNAc...) asparagineSequence analysis		1
Modified residueⁱ	439	PhosphoserineBy similarity		1

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q9Y5N1
PeptideAtlas More...PeptideAtlasⁱ	Q9Y5N1
PRIDEⁱ	Q9Y5N1
ProteomicsDBⁱ	86447 86448 [Q9Y5N1-2] 86449 [Q9Y5N1-3] 86450 [Q9Y5N1-4] 86451 [Q9Y5N1-5] 86452 [Q9Y5N1-6] 86453 [Q9Y5N1-7]

PTM databases

PhosphoSitePlusⁱ	Q9Y5N1

PhosphoSitePlusⁱ

Q9Y5N1

Expressionⁱ

Tissue specificityⁱ

Expressed predominantly in the CNS, with the greatest expression in the thalamus and caudate nucleus. The various isoforms are mainly coexpressed in brain, but their relative expression level varies in a region-specific manner. Isoform 3 and isoform 7 are highly expressed in the thalamus, caudate nucleus and cerebellum while isoform 5 and isoform 6 show a poor expression. Isoform 5 and isoform 6 show a high expression in the amygdala, substantia nigra, cerebral cortex and hypothalamus. Isoform 7 is not found in hypothalamus or substantia nigra.

Gene expression databases

Bgeeⁱ	ENSG00000101180 Expressed in 118 organ(s), highest expression level in hypothalamus
CleanExⁱ	HS_HRH3
ExpressionAtlasⁱ	Q9Y5N1 baseline and differential
Genevisibleⁱ	Q9Y5N1 HS

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	116416, 1 interactor
Database of interacting proteins More...DIPⁱ	DIP-61456N
IntActⁱ	Q9Y5N1, 2 interactors
STRINGⁱ	9606.ENSP00000342560

Chemistry databases

BindingDBⁱ

Q9Y5N1

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9Y5N1
SMRⁱ	Q9Y5N1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	20 – 23	Poly-Ala	4
Compositional biasⁱ	250 – 256	Poly-Pro	7
Compositional biasⁱ	292 – 298	Poly-Gly	7

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00780000121874
HOGENOMⁱ	HOG000048707
HOVERGENⁱ	HBG102132
InParanoidⁱ	Q9Y5N1
KEGG Orthology (KO) More...KOⁱ	K04151
OMAⁱ	ILCPKRQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G097A
PhylomeDBⁱ	Q9Y5N1
TreeFamⁱ	TF351747

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR003980 Histamine_H3_rcpt
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR01471 HISTAMINEH3R
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequences (7+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 7 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Additional isoforms seem to exist.

This entry has 7 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9Y5N1-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERAPPDGPL NASGALAGEA AAAGGARGFS AAWTAVLAAL MALLIVATVL 
        60         70         80         90        100
GNALVMLAFV ADSSLRTQNN FFLLNLAISD FLVGAFCIPL YVPYVLTGRW 
       110        120        130        140        150
TFGRGLCKLW LVVDYLLCTS SAFNIVLISY DRFLSVTRAV SYRAQQGDTR 
       160        170        180        190        200
RAVRKMLLVW VLAFLLYGPA ILSWEYLSGG SSIPEGHCYA EFFYNWYFLI 
       210        220        230        240        250
TASTLEFFTP FLSVTFFNLS IYLNIQRRTR LRLDGAREAA GPEPPPEAQP 
       260        270        280        290        300
SPPPPPGCWG CWQKGHGEAM PLHRYGVGEA AVGAEAGEAT LGGGGGGGSV 
       310        320        330        340        350
ASPTSSSGSS SRGTERPRSL KRGSKPSASS ASLEKRMKMV SQSFTQRFRL 
       360        370        380        390        400
SRDRKVAKSL AVIVSIFGLC WAPYTLLMII RAACHGHCVP DYWYETSFWL 
       410        420        430        440 
LWANSAVNPV LYPLCHHSFR RAFTKLLCPQ KLKIQPHSSL EHCWK

Length:445

Mass (Da):48,671

Last modified:November 16, 2001 - v2

Checksum:ⁱ2ACF7440FBE95B6C

GO

Isoform 2 (identifier: Q9Y5N1-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
445-445: K → KKMKKKTCL

« Hide

        10         20         30         40         50
MERAPPDGPL NASGALAGEA AAAGGARGFS AAWTAVLAAL MALLIVATVL 
        60         70         80         90        100
GNALVMLAFV ADSSLRTQNN FFLLNLAISD FLVGAFCIPL YVPYVLTGRW 
       110        120        130        140        150
TFGRGLCKLW LVVDYLLCTS SAFNIVLISY DRFLSVTRAV SYRAQQGDTR 
       160        170        180        190        200
RAVRKMLLVW VLAFLLYGPA ILSWEYLSGG SSIPEGHCYA EFFYNWYFLI 
       210        220        230        240        250
TASTLEFFTP FLSVTFFNLS IYLNIQRRTR LRLDGAREAA GPEPPPEAQP 
       260        270        280        290        300
SPPPPPGCWG CWQKGHGEAM PLHRYGVGEA AVGAEAGEAT LGGGGGGGSV 
       310        320        330        340        350
ASPTSSSGSS SRGTERPRSL KRGSKPSASS ASLEKRMKMV SQSFTQRFRL 
       360        370        380        390        400
SRDRKVAKSL AVIVSIFGLC WAPYTLLMII RAACHGHCVP DYWYETSFWL 
       410        420        430        440        450
LWANSAVNPV LYPLCHHSFR RAFTKLLCPQ KLKIQPHSSL EHCWKKMKKK 

TCL

Show »

Length:453

Mass (Da):49,633

Checksum:ⁱ4473760FA5ED7E92

GO

Isoform 3 (identifier: Q9Y5N1-3) [UniParc]FASTA Add to basket

Also known as: H3S

The sequence of this isoform differs from the canonical sequence as follows:
274-353: Missing.

« Hide

        10         20         30         40         50
MERAPPDGPL NASGALAGEA AAAGGARGFS AAWTAVLAAL MALLIVATVL 
        60         70         80         90        100
GNALVMLAFV ADSSLRTQNN FFLLNLAISD FLVGAFCIPL YVPYVLTGRW 
       110        120        130        140        150
TFGRGLCKLW LVVDYLLCTS SAFNIVLISY DRFLSVTRAV SYRAQQGDTR 
       160        170        180        190        200
RAVRKMLLVW VLAFLLYGPA ILSWEYLSGG SSIPEGHCYA EFFYNWYFLI 
       210        220        230        240        250
TASTLEFFTP FLSVTFFNLS IYLNIQRRTR LRLDGAREAA GPEPPPEAQP 
       260        270        280        290        300
SPPPPPGCWG CWQKGHGEAM PLHRKVAKSL AVIVSIFGLC WAPYTLLMII 
       310        320        330        340        350
RAACHGHCVP DYWYETSFWL LWANSAVNPV LYPLCHHSFR RAFTKLLCPQ 
       360 
KLKIQPHSSL EHCWK

Show »

Length:365

Mass (Da):40,624

Checksum:ⁱ4FDD1DE0CB809F9B

GO

Isoform 4 (identifier: Q9Y5N1-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
85-98: Missing.

« Hide

        10         20         30         40         50
MERAPPDGPL NASGALAGEA AAAGGARGFS AAWTAVLAAL MALLIVATVL 
        60         70         80         90        100
GNALVMLAFV ADSSLRTQNN FFLLNLAISD FLVGRWTFGR GLCKLWLVVD 
       110        120        130        140        150
YLLCTSSAFN IVLISYDRFL SVTRAVSYRA QQGDTRRAVR KMLLVWVLAF 
       160        170        180        190        200
LLYGPAILSW EYLSGGSSIP EGHCYAEFFY NWYFLITAST LEFFTPFLSV 
       210        220        230        240        250
TFFNLSIYLN IQRRTRLRLD GAREAAGPEP PPEAQPSPPP PPGCWGCWQK 
       260        270        280        290        300
GHGEAMPLHR YGVGEAAVGA EAGEATLGGG GGGGSVASPT SSSGSSSRGT 
       310        320        330        340        350
ERPRSLKRGS KPSASSASLE KRMKMVSQSF TQRFRLSRDR KVAKSLAVIV 
       360        370        380        390        400
SIFGLCWAPY TLLMIIRAAC HGHCVPDYWY ETSFWLLWAN SAVNPVLYPL 
       410        420        430 
CHHSFRRAFT KLLCPQKLKI QPHSSLEHCW K

Show »

Length:431

Mass (Da):47,133

Checksum:ⁱ33C4BCC070A1DA23

GO

Isoform 5 (identifier: Q9Y5N1-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
197-315: Missing.

« Hide

        10         20         30         40         50
MERAPPDGPL NASGALAGEA AAAGGARGFS AAWTAVLAAL MALLIVATVL 
        60         70         80         90        100
GNALVMLAFV ADSSLRTQNN FFLLNLAISD FLVGAFCIPL YVPYVLTGRW 
       110        120        130        140        150
TFGRGLCKLW LVVDYLLCTS SAFNIVLISY DRFLSVTRAV SYRAQQGDTR 
       160        170        180        190        200
RAVRKMLLVW VLAFLLYGPA ILSWEYLSGG SSIPEGHCYA EFFYNWRPRS 
       210        220        230        240        250
LKRGSKPSAS SASLEKRMKM VSQSFTQRFR LSRDRKVAKS LAVIVSIFGL 
       260        270        280        290        300
CWAPYTLLMI IRAACHGHCV PDYWYETSFW LLWANSAVNP VLYPLCHHSF 
       310        320 
RRAFTKLLCP QKLKIQPHSS LEHCWK

Show »

Length:326

Mass (Da):36,396

Checksum:ⁱ2EDA2E296463E616

GO

Isoform 6 (identifier: Q9Y5N1-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
227-342: Missing.

« Hide

        10         20         30         40         50
MERAPPDGPL NASGALAGEA AAAGGARGFS AAWTAVLAAL MALLIVATVL 
        60         70         80         90        100
GNALVMLAFV ADSSLRTQNN FFLLNLAISD FLVGAFCIPL YVPYVLTGRW 
       110        120        130        140        150
TFGRGLCKLW LVVDYLLCTS SAFNIVLISY DRFLSVTRAV SYRAQQGDTR 
       160        170        180        190        200
RAVRKMLLVW VLAFLLYGPA ILSWEYLSGG SSIPEGHCYA EFFYNWYFLI 
       210        220        230        240        250
TASTLEFFTP FLSVTFFNLS IYLNIQSFTQ RFRLSRDRKV AKSLAVIVSI 
       260        270        280        290        300
FGLCWAPYTL LMIIRAACHG HCVPDYWYET SFWLLWANSA VNPVLYPLCH 
       310        320 
HSFRRAFTKL LCPQKLKIQP HSSLEHCWK

Show »

Length:329

Mass (Da):36,943

Checksum:ⁱ94955EC0FA4C9590

GO

Isoform 7 (identifier: Q9Y5N1-7) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
234-263: Missing.

« Hide

        10         20         30         40         50
MERAPPDGPL NASGALAGEA AAAGGARGFS AAWTAVLAAL MALLIVATVL 
        60         70         80         90        100
GNALVMLAFV ADSSLRTQNN FFLLNLAISD FLVGAFCIPL YVPYVLTGRW 
       110        120        130        140        150
TFGRGLCKLW LVVDYLLCTS SAFNIVLISY DRFLSVTRAV SYRAQQGDTR 
       160        170        180        190        200
RAVRKMLLVW VLAFLLYGPA ILSWEYLSGG SSIPEGHCYA EFFYNWYFLI 
       210        220        230        240        250
TASTLEFFTP FLSVTFFNLS IYLNIQRRTR LRLKGHGEAM PLHRYGVGEA 
       260        270        280        290        300
AVGAEAGEAT LGGGGGGGSV ASPTSSSGSS SRGTERPRSL KRGSKPSASS 
       310        320        330        340        350
ASLEKRMKMV SQSFTQRFRL SRDRKVAKSL AVIVSIFGLC WAPYTLLMII 
       360        370        380        390        400
RAACHGHCVP DYWYETSFWL LWANSAVNPV LYPLCHHSFR RAFTKLLCPQ 
       410 
KLKIQPHSSL EHCWK

Show »

Length:415

Mass (Da):45,607

Checksum:ⁱ5A0505BAD0A13E02

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0A0MR48	A0A0A0MR48_HUMAN	Histamine H3 receptor Histamine H3 receptor (Histamine receptor H3, isoform CRA_b)	HRH3 hCG_41769	373	Annotation score:
A0A087WZD3	A0A087WZD3_HUMAN	Histamine H3 receptor Histamine H3 receptor	HRH3	200	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	19	E → D (PubMed:10347254).Curated		1
Sequence conflictⁱ	19	E → D (Ref. 5) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_012235	280	A → V in one Shy-Drager syndrome patient; rare variant with unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs752380770Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_001881	85 – 98	Missing in isoform 4. CuratedAdd BLAST	14
Alternative sequenceⁱVSP_001882	197 – 315	Missing in isoform 5. CuratedAdd BLAST	119
Alternative sequenceⁱVSP_001883	227 – 342	Missing in isoform 6. CuratedAdd BLAST	116
Alternative sequenceⁱVSP_001884	234 – 263	Missing in isoform 7. CuratedAdd BLAST	30
Alternative sequenceⁱVSP_001885	274 – 353	Missing in isoform 3. 1 PublicationAdd BLAST	80
Alternative sequenceⁱVSP_001886	445	K → KKMKKKTCL in isoform 2. 1 Publication	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF140538 mRNA Translation: AAD38151.1 AB045369 mRNA Translation: BAB20090.1 AB019000 mRNA Translation: BAB17030.1 AJ296652 Genomic DNA Translation: CAC51025.1 AJ278250 Genomic DNA Translation: CAC39434.1 AF363791 mRNA Translation: AAK50040.1 AL078633 Genomic DNA No translation available. BC096840 mRNA Translation: AAH96840.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13493.1 [Q9Y5N1-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_009163.2, NM_007232.2 [Q9Y5N1-1] XP_005260323.1, XM_005260266.3 [Q9Y5N1-2]
UniGeneⁱ	Hs.251399

Genome annotation databases

Ensemblⁱ	ENST00000340177; ENSP00000342560; ENSG00000101180 [Q9Y5N1-1]
GeneIDⁱ	11255
KEGGⁱ	hsa:11255
UCSC genome browser More...UCSCⁱ	uc002ycf.3 human [Q9Y5N1-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Y5N1-3	Histamine H3 receptor		HUMAN		373	UniRef100_A0A0A0MR48
HRH3 isoform 2		PANTR		373
Uncharacterized protein		NOMLE		373
Histamine receptor H3		GORGO		373
Uncharacterized protein		PANPA		347

Protein	Similar proteins		Species	Score	Length	Source
Q9Y5N1	Isoform 2 of Histamine H3 receptor		HUMAN		453	UniRef90_Q9Y5N1
histamine H3 receptor		PHYCD		454
histamine H3 receptor isoform X1		ODORO		453
Uncharacterized protein		PROCO		452
Uncharacterized protein		OTOGA		449
+44
Q9Y5N1-3	Histamine receptor H3		FELCA		365	UniRef90_M3XG45
Uncharacterized protein		CALJA		374
Uncharacterized protein		Cebus capucinus imitator		374
Histamine H3 receptor isoform 4		HUMAN		373
Uncharacterized protein		PAPAN		373
+17

Protein	Similar proteins		Species	Score	Length	Source
Q9Y5N1	Histamine H3 receptor		RAT		445	UniRef50_Q9QYN8
Histamine H3 receptor		MOUSE		445
Histamine H3 receptor		CAVPO		445
Uncharacterized protein		PIG		455
Histamine H3 receptor long form		PHOSU		445
+173
Q9Y5N1-3	Histamine receptor H3		FELCA		365	UniRef50_M3XG45
Uncharacterized protein		Cebus capucinus imitator		374
Uncharacterized protein		CALJA		374
Uncharacterized protein		CERAT		373
Uncharacterized protein		MACNE		373
+24
Q9Y5N1-5	Isoform 6 of Histamine H3 receptor		HUMAN		329	UniRef50_Q9Y5N1-6
Histamine H3 receptor		MOUSE		301
Uncharacterized protein		MACFA		309
histamine H3 receptor isoform X3		ODORO		307
UPI0005298BB1		COLST		324
+14
Q9Y5N1-6	Isoform 5 of Histamine H3 receptor		HUMAN		326	UniRef50_Q9Y5N1-6
Histamine H3 receptor		MOUSE		301
Uncharacterized protein		MACFA		309
histamine H3 receptor isoform X3		ODORO		307
UPI0005298BB1		COLST		324
+14
Q9Y5N1-7	Isoform 3 of Histamine H3 receptor		RAT		397	UniRef50_Q9QYN8-3
Isoform Short of Histamine H3 receptor		CAVPO		415
Uncharacterized protein		Cebus capucinus imitator		414
Uncharacterized protein		MACMU		413
Uncharacterized protein		PAPAN		413
+193

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF140538 mRNA Translation: AAD38151.1 AB045369 mRNA Translation: BAB20090.1 AB019000 mRNA Translation: BAB17030.1 AJ296652 Genomic DNA Translation: CAC51025.1 AJ278250 Genomic DNA Translation: CAC39434.1 AF363791 mRNA Translation: AAK50040.1 AL078633 Genomic DNA No translation available. BC096840 mRNA Translation: AAH96840.1
CCDSⁱ	CCDS13493.1 [Q9Y5N1-1]
RefSeqⁱ	NP_009163.2, NM_007232.2 [Q9Y5N1-1] XP_005260323.1, XM_005260266.3 [Q9Y5N1-2]
UniGeneⁱ	Hs.251399

3D structure databases

ProteinModelPortalⁱ	Q9Y5N1
SMRⁱ	Q9Y5N1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116416, 1 interactor
DIPⁱ	DIP-61456N
IntActⁱ	Q9Y5N1, 2 interactors
STRINGⁱ	9606.ENSP00000342560

Chemistry databases

BindingDBⁱ	Q9Y5N1
ChEMBLⁱ	CHEMBL264
DrugBankⁱ	DB06698 Betahistine DB05381 Histamine DB00370 Mirtazapine DB05080 OBE101
GuidetoPHARMACOLOGYⁱ	264

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

PhosphoSitePlusⁱ	Q9Y5N1

PhosphoSitePlusⁱ

Q9Y5N1

Polymorphism and mutation databases

BioMutaⁱ	HRH3
DMDMⁱ	17367264

Proteomic databases

PaxDbⁱ	Q9Y5N1
PeptideAtlasⁱ	Q9Y5N1
PRIDEⁱ	Q9Y5N1
ProteomicsDBⁱ	86447 86448 [Q9Y5N1-2] 86449 [Q9Y5N1-3] 86450 [Q9Y5N1-4] 86451 [Q9Y5N1-5] 86452 [Q9Y5N1-6] 86453 [Q9Y5N1-7]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000340177; ENSP00000342560; ENSG00000101180 [Q9Y5N1-1]
GeneIDⁱ	11255
KEGGⁱ	hsa:11255
UCSCⁱ	uc002ycf.3 human [Q9Y5N1-1]

Organism-specific databases

CTDⁱ	11255
DisGeNETⁱ	11255
EuPathDBⁱ	HostDB:ENSG00000101180.15
GeneCardsⁱ	HRH3
HGNCⁱ	HGNC:5184 HRH3
MIMⁱ	604525 gene
neXtProtⁱ	NX_Q9Y5N1
OpenTargetsⁱ	ENSG00000101180
PharmGKBⁱ	PA29458
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
GeneTreeⁱ	ENSGT00780000121874
HOGENOMⁱ	HOG000048707
HOVERGENⁱ	HBG102132
InParanoidⁱ	Q9Y5N1
KOⁱ	K04151
OMAⁱ	ILCPKRQ
OrthoDBⁱ	EOG091G097A
PhylomeDBⁱ	Q9Y5N1
TreeFamⁱ	TF351747

Enzyme and pathway databases

Reactomeⁱ	R-HSA-390650 Histamine receptors R-HSA-418594 G alpha (i) signalling events

Reactomeⁱ

R-HSA-390650 Histamine receptors
R-HSA-418594 G alpha (i) signalling events

Miscellaneous databases

ChiTaRSⁱ	HRH3 human
GeneWikiⁱ	Histamine_H3_receptor
GenomeRNAiⁱ	11255
Protein Ontology More...PROⁱ	PR:Q9Y5N1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000101180 Expressed in 118 organ(s), highest expression level in hypothalamus
CleanExⁱ	HS_HRH3
ExpressionAtlasⁱ	Q9Y5N1 baseline and differential
Genevisibleⁱ	Q9Y5N1 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR003980 Histamine_H3_rcpt
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR01471 HISTAMINEH3R
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HRH3_HUMAN
Accessionⁱ	Q9Y5N1Primary (citable) accession number: Q9Y5N1 Secondary accession number(s): Q4QRI7, Q9GZX2, Q9H4K8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 16, 2001
	Last sequence update:	November 16, 2001
	Last modified:	November 7, 2018
	This is version 164 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

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UniProtKB - Q9Y5N1 (HRH3_HUMAN)

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Histamine H3 receptor

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ