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Protein

Signal recognition particle receptor subunit beta

Gene

SRPRB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei120GTP; via amide nitrogenBy similarity1
Binding sitei248GTP; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi71 – 79GTPBy similarity9
Nucleotide bindingi92 – 95GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-381038 XBP1(S) activates chaperone genes

Names & Taxonomyi

Protein namesi
Recommended name:
Signal recognition particle receptor subunit beta
Short name:
SR-beta
Alternative name(s):
Protein APMCF1
Gene namesi
Name:SRPRB
ORF Names:PSEC0230
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000144867.11
HGNCiHGNC:24085 SRPRB
MIMi616883 gene
neXtProtiNX_Q9Y5M8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei37 – 57HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi58477
OpenTargetsiENSG00000144867
PharmGKBiPA128394701

Polymorphism and mutation databases

BioMutaiSRPRB
DMDMi31340540

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001012271 – 271Signal recognition particle receptor subunit betaAdd BLAST271

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei112PhosphoserineCombined sources1
Modified residuei214PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y5M8
MaxQBiQ9Y5M8
PaxDbiQ9Y5M8
PeptideAtlasiQ9Y5M8
PRIDEiQ9Y5M8
ProteomicsDBi86446
TopDownProteomicsiQ9Y5M8

PTM databases

iPTMnetiQ9Y5M8
PhosphoSitePlusiQ9Y5M8
SwissPalmiQ9Y5M8

Expressioni

Gene expression databases

BgeeiENSG00000144867 Expressed in 229 organ(s), highest expression level in body of pancreas
CleanExiHS_SRPRB
ExpressionAtlasiQ9Y5M8 baseline and differential
GenevisibleiQ9Y5M8 HS

Organism-specific databases

HPAiHPA011173

Interactioni

Subunit structurei

Heterodimer with SRPRA.By similarity

Protein-protein interaction databases

BioGridi121810, 144 interactors
DIPiDIP-50218N
ELMiQ9Y5M8
IntActiQ9Y5M8, 56 interactors
MINTiQ9Y5M8
STRINGi9606.ENSP00000418401

Structurei

3D structure databases

ProteinModelPortaliQ9Y5M8
SMRiQ9Y5M8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SRP receptor beta subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0090 Eukaryota
COG2229 LUCA
GeneTreeiENSGT00510000048347
HOGENOMiHOG000241847
HOVERGENiHBG054206
InParanoidiQ9Y5M8
KOiK12272
OMAiNKQDQTT
OrthoDBiEOG091G0242
PhylomeDBiQ9Y5M8
TreeFamiTF106190

Family and domain databases

CDDicd04105 SR_beta, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR024156 Small_GTPase_ARF
IPR019009 SRP_receptor_beta_su
PANTHERiPTHR11485:SF34 PTHR11485:SF34, 1 hit
PfamiView protein in Pfam
PF09439 SRPRB, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9Y5M8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASADSRRVA DGGGAGGTFQ PYLDTLRQEL QQTDPTLLSV VVAVLAVLLT
60 70 80 90 100
LVFWKLIRSR RSSQRAVLLV GLCDSGKTLL FVRLLTGLYR DTQTSITDSC
110 120 130 140 150
AVYRVNNNRG NSLTLIDLPG HESLRLQFLE RFKSSARAIV FVVDSAAFQR
160 170 180 190 200
EVKDVAEFLY QVLIDSMGLK NTPSFLIACN KQDIAMAKSA KLIQQQLEKE
210 220 230 240 250
LNTLRVTRSA APSTLDSSST APAQLGKKGK EFEFSQLPLK VEFLECSAKG
260 270
GRGDVGSADI QDLEKWLAKI A
Length:271
Mass (Da):29,702
Last modified:May 30, 2003 - v3
Checksum:iEC8DBCE9EE01B2B6
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J5Z8C9J5Z8_HUMAN
Signal recognition particle recepto...
SRPRB
92Annotation score:
H7C4H2H7C4H2_HUMAN
Signal recognition particle recepto...
SRPRB
160Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti137R → G in BAB55176 (PubMed:14702039).Curated1
Sequence conflicti216D → Y in BAB55176 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0573359V → L2 PublicationsCorresponds to variant dbSNP:rs1107413Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF141882 mRNA Translation: AAD34888.3
AK027525 mRNA Translation: BAB55176.1
AK075531 mRNA Translation: BAC11675.1
BC063001 mRNA Translation: AAH63001.1
BC065299 mRNA Translation: AAH65299.1
CCDSiCCDS3081.1
RefSeqiNP_067026.3, NM_021203.3
UniGeneiHs.12152

Genome annotation databases

EnsembliENST00000466490; ENSP00000418401; ENSG00000144867
GeneIDi58477
KEGGihsa:58477
UCSCiuc003epx.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF141882 mRNA Translation: AAD34888.3
AK027525 mRNA Translation: BAB55176.1
AK075531 mRNA Translation: BAC11675.1
BC063001 mRNA Translation: AAH63001.1
BC065299 mRNA Translation: AAH65299.1
CCDSiCCDS3081.1
RefSeqiNP_067026.3, NM_021203.3
UniGeneiHs.12152

3D structure databases

ProteinModelPortaliQ9Y5M8
SMRiQ9Y5M8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121810, 144 interactors
DIPiDIP-50218N
ELMiQ9Y5M8
IntActiQ9Y5M8, 56 interactors
MINTiQ9Y5M8
STRINGi9606.ENSP00000418401

PTM databases

iPTMnetiQ9Y5M8
PhosphoSitePlusiQ9Y5M8
SwissPalmiQ9Y5M8

Polymorphism and mutation databases

BioMutaiSRPRB
DMDMi31340540

Proteomic databases

EPDiQ9Y5M8
MaxQBiQ9Y5M8
PaxDbiQ9Y5M8
PeptideAtlasiQ9Y5M8
PRIDEiQ9Y5M8
ProteomicsDBi86446
TopDownProteomicsiQ9Y5M8

Protocols and materials databases

DNASUi58477
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000466490; ENSP00000418401; ENSG00000144867
GeneIDi58477
KEGGihsa:58477
UCSCiuc003epx.2 human

Organism-specific databases

CTDi58477
DisGeNETi58477
EuPathDBiHostDB:ENSG00000144867.11
GeneCardsiSRPRB
HGNCiHGNC:24085 SRPRB
HPAiHPA011173
MIMi616883 gene
neXtProtiNX_Q9Y5M8
OpenTargetsiENSG00000144867
PharmGKBiPA128394701
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0090 Eukaryota
COG2229 LUCA
GeneTreeiENSGT00510000048347
HOGENOMiHOG000241847
HOVERGENiHBG054206
InParanoidiQ9Y5M8
KOiK12272
OMAiNKQDQTT
OrthoDBiEOG091G0242
PhylomeDBiQ9Y5M8
TreeFamiTF106190

Enzyme and pathway databases

ReactomeiR-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-381038 XBP1(S) activates chaperone genes

Miscellaneous databases

ChiTaRSiSRPRB human
GeneWikiiSRPRB
GenomeRNAii58477
PROiPR:Q9Y5M8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000144867 Expressed in 229 organ(s), highest expression level in body of pancreas
CleanExiHS_SRPRB
ExpressionAtlasiQ9Y5M8 baseline and differential
GenevisibleiQ9Y5M8 HS

Family and domain databases

CDDicd04105 SR_beta, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR024156 Small_GTPase_ARF
IPR019009 SRP_receptor_beta_su
PANTHERiPTHR11485:SF34 PTHR11485:SF34, 1 hit
PfamiView protein in Pfam
PF09439 SRPRB, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSRPRB_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5M8
Secondary accession number(s): Q6P595, Q8N2D8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 30, 2003
Last modified: September 12, 2018
This is version 161 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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