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Protein

Lens epithelial cell protein LEP503

Gene

LENEP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in lens epithelial cell differentiation.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA binding Source: ProtInc

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lens epithelial cell protein LEP503
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LENEP
Synonyms:LEP503
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000163352.5

Human Gene Nomenclature Database

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HGNCi
HGNC:14429 LENEP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607377 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y5L5

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000163352

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30333

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LENEP

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000844031 – 61Lens epithelial cell protein LEP503Add BLAST61

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9Y5L5

PRoteomics IDEntifications database

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PRIDEi
Q9Y5L5

ProteomicsDB human proteome resource

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ProteomicsDBi
86443

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9Y5L5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9Y5L5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Restricted to lens epithelial cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000163352 Expressed in 61 organ(s), highest expression level in adrenal tissue

CleanEx database of gene expression profiles

More...
CleanExi
HS_LENEP

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y5L5 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
120981, 11 interactors

Protein interaction database and analysis system

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IntActi
Q9Y5L5, 1 interactor

STRING: functional protein association networks

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STRINGi
9606.ENSP00000357412

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9Y5L5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9Y5L5

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410J2XU Eukaryota
ENOG41113ZS LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000002996

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000072679

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9Y5L5

Identification of Orthologs from Complete Genome Data

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OMAi
MKMGTGW

Database of Orthologous Groups

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OrthoDBi
1613751at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y5L5

TreeFam database of animal gene trees

More...
TreeFami
TF341569

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029194 LEP503

The PANTHER Classification System

More...
PANTHERi
PTHR16968 PTHR16968, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15221 LEP503, 1 hit

ProDom; a protein domain database

More...
ProDomi
View protein in ProDom or Entries sharing at least one domain
PD336054 PD336054, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9Y5L5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQPRTQPLAQ TLPFFLGGAP RDTGLRVPVI KMGTGWEGFQ RTLKEVAYIL
60
LCCWCIKELL D
Length:61
Mass (Da):6,908
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i677A4A062E6F97EB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF268478 mRNA Translation: AAF73074.1
AF144412 Genomic DNA Translation: AAD38378.1
AB451457 mRNA Translation: BAG70271.1
AL451085 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53152.1
BC069140 mRNA Translation: AAH69140.1
BC096714 mRNA Translation: AAH96714.1
BC098148 mRNA Translation: AAH98148.1
BC098246 mRNA Translation: AAH98246.1
BC098253 mRNA Translation: AAH98253.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1080.1

NCBI Reference Sequences

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RefSeqi
NP_061125.1, NM_018655.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.272399

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000368427; ENSP00000357412; ENSG00000163352
ENST00000392487; ENSP00000376278; ENSG00000163352

Database of genes from NCBI RefSeq genomes

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GeneIDi
55891

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55891

UCSC genome browser

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UCSCi
uc001fgi.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF268478 mRNA Translation: AAF73074.1
AF144412 Genomic DNA Translation: AAD38378.1
AB451457 mRNA Translation: BAG70271.1
AL451085 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53152.1
BC069140 mRNA Translation: AAH69140.1
BC096714 mRNA Translation: AAH96714.1
BC098148 mRNA Translation: AAH98148.1
BC098246 mRNA Translation: AAH98246.1
BC098253 mRNA Translation: AAH98253.1
CCDSiCCDS1080.1
RefSeqiNP_061125.1, NM_018655.2
UniGeneiHs.272399

3D structure databases

ProteinModelPortaliQ9Y5L5
SMRiQ9Y5L5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120981, 11 interactors
IntActiQ9Y5L5, 1 interactor
STRINGi9606.ENSP00000357412

PTM databases

iPTMnetiQ9Y5L5
PhosphoSitePlusiQ9Y5L5

Polymorphism and mutation databases

BioMutaiLENEP

Proteomic databases

PaxDbiQ9Y5L5
PRIDEiQ9Y5L5
ProteomicsDBi86443

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368427; ENSP00000357412; ENSG00000163352
ENST00000392487; ENSP00000376278; ENSG00000163352
GeneIDi55891
KEGGihsa:55891
UCSCiuc001fgi.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55891
EuPathDBiHostDB:ENSG00000163352.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LENEP
HGNCiHGNC:14429 LENEP
MIMi607377 gene
neXtProtiNX_Q9Y5L5
OpenTargetsiENSG00000163352
PharmGKBiPA30333

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J2XU Eukaryota
ENOG41113ZS LUCA
GeneTreeiENSGT00390000002996
HOGENOMiHOG000072679
InParanoidiQ9Y5L5
OMAiMKMGTGW
OrthoDBi1613751at2759
PhylomeDBiQ9Y5L5
TreeFamiTF341569

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55891

Protein Ontology

More...
PROi
PR:Q9Y5L5

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000163352 Expressed in 61 organ(s), highest expression level in adrenal tissue
CleanExiHS_LENEP
GenevisibleiQ9Y5L5 HS

Family and domain databases

InterProiView protein in InterPro
IPR029194 LEP503
PANTHERiPTHR16968 PTHR16968, 1 hit
PfamiView protein in Pfam
PF15221 LEP503, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD336054 PD336054, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLENEP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y5L5
Secondary accession number(s): B5BUM1, Q5T1A4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: January 16, 2019
This is version 108 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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