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Entry version 155 (11 Dec 2019)
Sequence version 1 (01 Nov 1999)
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Protein

Ectonucleoside triphosphate diphosphohydrolase 2

Gene

ENTPD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent. The order of activity with different substrates is ATP > GTP > CTP = ITP > UTP >> ADP = UDP.

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+1 Publication, Mg2+1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei165Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi204 – 208ATPBy similarity5

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandATP-binding, Calcium, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:ENSG00000054179-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.6.1.5 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8850843 Phosphate bond hydrolysis by NTPDase proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ectonucleoside triphosphate diphosphohydrolase 2 (EC:3.6.1.-)
Short name:
NTPDase 2
Alternative name(s):
CD39 antigen-like 1
Ecto-ATP diphosphohydrolase 2
Short name:
Ecto-ATPDase 2
Short name:
Ecto-ATPase 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ENTPD2
Synonyms:CD39L1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000054179.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3364 ENTPD2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602012 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y5L3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 7CytoplasmicSequence analysis7
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Topological domaini29 – 462ExtracellularSequence analysisAdd BLAST434
Transmembranei463 – 483HelicalSequence analysisAdd BLAST21
Topological domaini484 – 495CytoplasmicSequence analysisAdd BLAST12

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi399C → S: Abolishes ecto-ATPase activity, accumulates intracellularly. 1 Publication1
Mutagenesisi443N → D: 7% of wild-type ATPase activity, accumulates intracellularly. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
954

Open Targets

More...
OpenTargetsi
ENSG00000054179

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27799

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9Y5L3 Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5049

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2889

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ENTPD2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
18203633

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002099061 – 495Ectonucleoside triphosphate diphosphohydrolase 2Add BLAST495

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi64N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi75 ↔ 99By similarity
Glycosylationi129N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi242 ↔ 284By similarity
Disulfide bondi265 ↔ 310By similarity
Glycosylationi294N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi323 ↔ 328By similarity
Disulfide bondi377 ↔ 399By similarity
Glycosylationi378N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi443N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-1489

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y5L3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Y5L3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9Y5L3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y5L3

PeptideAtlas

More...
PeptideAtlasi
Q9Y5L3

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y5L3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
86440 [Q9Y5L3-1]
86441 [Q9Y5L3-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1193

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y5L3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y5L3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Brain, placenta, skeletal muscle, kidney, pancreas, heart, ovary, testis, colon, small intestine, prostate and pancreas. No expression in adult thymus, spleen, lung, liver and peripheral blood leukocytes.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000054179 Expressed in 132 organ(s), highest expression level in tibial nerve

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y5L3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA017676

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107392, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q9Y5L3, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000347213

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9Y5L3

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9Y5L3 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y5L3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GDA1/CD39 NTPase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1386 Eukaryota
COG5371 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00960000186639

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000059572

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y5L3

KEGG Orthology (KO)

More...
KOi
K01509

Identification of Orthologs from Complete Genome Data

More...
OMAi
SHTSMFV

Database of Orthologous Groups

More...
OrthoDBi
1337265at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y5L3

TreeFam database of animal gene trees

More...
TreeFami
TF332859

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000407 GDA1_CD39_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR11782 PTHR11782, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01150 GDA1_CD39, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01238 GDA1_CD39_NTPASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform Long (identifier: Q9Y5L3-1) [UniParc]FASTAAdd to basket
Also known as: alpha

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGKVRSLLP PLLLAAAGLA GLLLLCVPTR DVREPPALKY GIVLDAGSSH
60 70 80 90 100
TSMFIYKWPA DKENDTGIVG QHSSCDVPGG GISSYADNPS GASQSLVGCL
110 120 130 140 150
EQALQDVPKE RHAGTPLYLG ATAGMRLLNL TNPEASTSVL MAVTHTLTQY
160 170 180 190 200
PFDFRGARIL SGQEEGVFGW VTANYLLENF IKYGWVGRWF RPRKGTLGAM
210 220 230 240 250
DLGGASTQIT FETTSPAEDR ASEVQLHLYG QHYRVYTHSF LCYGRDQVLQ
260 270 280 290 300
RLLASALQTH GFHPCWPRGF STQVLLGDVY QSPCTMAQRP QNFNSSARVS
310 320 330 340 350
LSGSSDPHLC RDLVSGLFSF SSCPFSRCSF NGVFQPPVAG NFVAFSAFFY
360 370 380 390 400
TVDFLRTSMG LPVATLQQLE AAAVNVCNQT WAQLQARVPG QRARLADYCA
410 420 430 440 450
GAMFVQQLLS RGYGFDERAF GGVIFQKKAA DTAVGWALGY MLNLTNLIPA
460 470 480 490
DPPGLRKGTD FSSWVVLLLL FASALLAALV LLLRQVHSAK LPSTI
Length:495
Mass (Da):53,665
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3BDBA114A679B422
GO
Isoform Short (identifier: Q9Y5L3-2) [UniParc]FASTAAdd to basket
Also known as: beta

The sequence of this isoform differs from the canonical sequence as follows:
     383-405: Missing.

Note: Catalytically inactive.Curated
Show »
Length:472
Mass (Da):51,162
Checksum:i72F7EF732D7E2835
GO
Isoform gamma (identifier: Q9Y5L3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     383-405: Missing.
     406-428: Missing.

Note: Catalytically inactive.Curated
Show »
Length:449
Mass (Da):48,535
Checksum:i27AD75755F92FC13
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050307103A → V. Corresponds to variant dbSNP:rs34618694Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_003610383 – 405Missing in isoform Short and isoform gamma. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_053548406 – 428Missing in isoform gamma. CuratedAdd BLAST23

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U91510 mRNA Translation: AAB81013.1
AF144748 mRNA Translation: AAD40239.1
EF495152 mRNA Translation: ABP58644.1
AL807752 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW88336.1
CH471090 Genomic DNA Translation: EAW88337.1
BC035738 mRNA Translation: AAH35738.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7025.1 [Q9Y5L3-2]
CCDS7026.1 [Q9Y5L3-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001237.1, NM_001246.3 [Q9Y5L3-2]
NP_982293.1, NM_203468.2 [Q9Y5L3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000312665; ENSP00000312494; ENSG00000054179 [Q9Y5L3-2]
ENST00000355097; ENSP00000347213; ENSG00000054179 [Q9Y5L3-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
954

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:954

UCSC genome browser

More...
UCSCi
uc004ckw.3 human [Q9Y5L3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91510 mRNA Translation: AAB81013.1
AF144748 mRNA Translation: AAD40239.1
EF495152 mRNA Translation: ABP58644.1
AL807752 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW88336.1
CH471090 Genomic DNA Translation: EAW88337.1
BC035738 mRNA Translation: AAH35738.1
CCDSiCCDS7025.1 [Q9Y5L3-2]
CCDS7026.1 [Q9Y5L3-1]
RefSeqiNP_001237.1, NM_001246.3 [Q9Y5L3-2]
NP_982293.1, NM_203468.2 [Q9Y5L3-1]

3D structure databases

SMRiQ9Y5L3
ModBaseiSearch...

Protein-protein interaction databases

BioGridi107392, 1 interactor
IntActiQ9Y5L3, 1 interactor
STRINGi9606.ENSP00000347213

Chemistry databases

BindingDBiQ9Y5L3
ChEMBLiCHEMBL5049
GuidetoPHARMACOLOGYi2889

PTM databases

GlyConnecti1193
iPTMnetiQ9Y5L3
PhosphoSitePlusiQ9Y5L3

Polymorphism and mutation databases

BioMutaiENTPD2
DMDMi18203633

Proteomic databases

CPTACiCPTAC-1489
EPDiQ9Y5L3
jPOSTiQ9Y5L3
MassIVEiQ9Y5L3
PaxDbiQ9Y5L3
PeptideAtlasiQ9Y5L3
PRIDEiQ9Y5L3
ProteomicsDBi86440 [Q9Y5L3-1]
86441 [Q9Y5L3-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
954

Genome annotation databases

EnsembliENST00000312665; ENSP00000312494; ENSG00000054179 [Q9Y5L3-2]
ENST00000355097; ENSP00000347213; ENSG00000054179 [Q9Y5L3-1]
GeneIDi954
KEGGihsa:954
UCSCiuc004ckw.3 human [Q9Y5L3-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
954
DisGeNETi954
EuPathDBiHostDB:ENSG00000054179.11

GeneCards: human genes, protein and diseases

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GeneCardsi
ENTPD2
HGNCiHGNC:3364 ENTPD2
HPAiHPA017676
MIMi602012 gene
neXtProtiNX_Q9Y5L3
OpenTargetsiENSG00000054179
PharmGKBiPA27799

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1386 Eukaryota
COG5371 LUCA
GeneTreeiENSGT00960000186639
HOGENOMiHOG000059572
InParanoidiQ9Y5L3
KOiK01509
OMAiSHTSMFV
OrthoDBi1337265at2759
PhylomeDBiQ9Y5L3
TreeFamiTF332859

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000054179-MONOMER
BRENDAi3.6.1.5 2681
ReactomeiR-HSA-8850843 Phosphate bond hydrolysis by NTPDase proteins

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ENTPD2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ENTPD2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
954
PharosiQ9Y5L3 Tchem

Protein Ontology

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PROi
PR:Q9Y5L3
RNActiQ9Y5L3 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000054179 Expressed in 132 organ(s), highest expression level in tibial nerve
GenevisibleiQ9Y5L3 HS

Family and domain databases

InterProiView protein in InterPro
IPR000407 GDA1_CD39_NTPase
PANTHERiPTHR11782 PTHR11782, 1 hit
PfamiView protein in Pfam
PF01150 GDA1_CD39, 1 hit
PROSITEiView protein in PROSITE
PS01238 GDA1_CD39_NTPASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiENTP2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y5L3
Secondary accession number(s): O15464, Q5SPY6, Q5SPY7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: November 1, 1999
Last modified: December 11, 2019
This is version 155 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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