UniProtKB - Q9Y5L3 (ENTP2_HUMAN)
Protein
Ectonucleoside triphosphate diphosphohydrolase 2
Gene
ENTPD2
Organism
Homo sapiens (Human)
Status
Functioni
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent. The order of activity with different substrates is ATP > GTP > CTP = ITP > UTP >> ADP = UDP.
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 165 | Proton acceptorBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 204 – 208 | ATPBy similarity | 5 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- guanosine-diphosphatase activity Source: GO_Central
- nucleoside-diphosphatase activity Source: GO_Central
- nucleoside-triphosphatase activity Source: Ensembl
- uridine-diphosphatase activity Source: GO_Central
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: Ensembl
- nucleobase-containing small molecule catabolic process Source: Reactome
- nucleoside diphosphate catabolic process Source: GO_Central
- platelet activation Source: Ensembl
- purine ribonucleoside diphosphate catabolic process Source: Ensembl
Keywordsi
Molecular function | Hydrolase |
Ligand | ATP-binding, Calcium, Magnesium, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | MetaCyc:ENSG00000054179-MONOMER |
BRENDAi | 3.6.1.5, 2681 |
PathwayCommonsi | Q9Y5L3 |
Reactomei | R-HSA-8850843, Phosphate bond hydrolysis by NTPDase proteins |
SABIO-RKi | Q9Y5L3 |
Names & Taxonomyi
Protein namesi | Recommended name: Ectonucleoside triphosphate diphosphohydrolase 2 (EC:3.6.1.-)Short name: NTPDase 2 Alternative name(s): CD39 antigen-like 1 Ecto-ATP diphosphohydrolase 2 Short name: Ecto-ATPDase 2 Short name: Ecto-ATPase 2 |
Gene namesi | Name:ENTPD2 Synonyms:CD39L1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3364, ENTPD2 |
MIMi | 602012, gene |
neXtProti | NX_Q9Y5L3 |
VEuPathDBi | HostDB:ENSG00000054179.11 |
Subcellular locationi
Plasma membrane
Endoplasmic reticulum
Endoplasmic reticulum
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- basement membrane Source: Ensembl
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 7 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 8 – 28 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 29 – 462 | ExtracellularSequence analysisAdd BLAST | 434 | |
Transmembranei | 463 – 483 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 484 – 495 | CytoplasmicSequence analysisAdd BLAST | 12 |
Keywords - Cellular componenti
Cell membrane, Endoplasmic reticulum, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 399 | C → S: Abolishes ecto-ATPase activity, accumulates intracellularly. 1 Publication | 1 | |
Mutagenesisi | 443 | N → D: 7% of wild-type ATPase activity, accumulates intracellularly. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 954 |
OpenTargetsi | ENSG00000054179 |
PharmGKBi | PA27799 |
Miscellaneous databases
Pharosi | Q9Y5L3, Tchem |
Chemistry databases
ChEMBLi | CHEMBL5049 |
GuidetoPHARMACOLOGYi | 2889 |
Genetic variation databases
BioMutai | ENTPD2 |
DMDMi | 18203633 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000209906 | 1 – 495 | Ectonucleoside triphosphate diphosphohydrolase 2Add BLAST | 495 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 64 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 75 ↔ 99 | By similarity | ||
Glycosylationi | 129 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 242 ↔ 284 | By similarity | ||
Disulfide bondi | 265 ↔ 310 | By similarity | ||
Glycosylationi | 294 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 323 ↔ 328 | By similarity | ||
Disulfide bondi | 377 ↔ 399 | By similarity | ||
Glycosylationi | 378 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 443 | N-linked (GlcNAc...) asparagine1 Publication | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
CPTACi | CPTAC-1489 |
EPDi | Q9Y5L3 |
jPOSTi | Q9Y5L3 |
MassIVEi | Q9Y5L3 |
PaxDbi | Q9Y5L3 |
PeptideAtlasi | Q9Y5L3 |
PRIDEi | Q9Y5L3 |
ProteomicsDBi | 86440 [Q9Y5L3-1] 86441 [Q9Y5L3-2] |
PTM databases
GlyConnecti | 1193, 45 N-Linked glycans (5 sites) |
GlyGeni | Q9Y5L3, 5 sites, 4 N-linked glycans (2 sites) |
iPTMneti | Q9Y5L3 |
PhosphoSitePlusi | Q9Y5L3 |
Expressioni
Tissue specificityi
Brain, placenta, skeletal muscle, kidney, pancreas, heart, ovary, testis, colon, small intestine, prostate and pancreas. No expression in adult thymus, spleen, lung, liver and peripheral blood leukocytes.
Gene expression databases
Bgeei | ENSG00000054179, Expressed in tibial nerve and 148 other tissues |
Genevisiblei | Q9Y5L3, HS |
Organism-specific databases
HPAi | ENSG00000054179, Tissue enhanced (brain) |
Interactioni
Binary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 107392, 1 interactor |
IntActi | Q9Y5L3, 3 interactors |
STRINGi | 9606.ENSP00000347213 |
Chemistry databases
BindingDBi | Q9Y5L3 |
Miscellaneous databases
RNActi | Q9Y5L3, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the GDA1/CD39 NTPase family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1386, Eukaryota |
GeneTreei | ENSGT01020000230450 |
HOGENOMi | CLU_010246_2_3_1 |
InParanoidi | Q9Y5L3 |
OMAi | CYPANFT |
OrthoDBi | 231215at2759 |
PhylomeDBi | Q9Y5L3 |
TreeFami | TF332859 |
Family and domain databases
InterProi | View protein in InterPro IPR000407, GDA1_CD39_NTPase |
PANTHERi | PTHR11782, PTHR11782, 1 hit |
Pfami | View protein in Pfam PF01150, GDA1_CD39, 1 hit |
PROSITEi | View protein in PROSITE PS01238, GDA1_CD39_NTPASE, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketIsoform Long (identifier: Q9Y5L3-1) [UniParc]FASTAAdd to basket
Also known as: alpha
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAGKVRSLLP PLLLAAAGLA GLLLLCVPTR DVREPPALKY GIVLDAGSSH
60 70 80 90 100
TSMFIYKWPA DKENDTGIVG QHSSCDVPGG GISSYADNPS GASQSLVGCL
110 120 130 140 150
EQALQDVPKE RHAGTPLYLG ATAGMRLLNL TNPEASTSVL MAVTHTLTQY
160 170 180 190 200
PFDFRGARIL SGQEEGVFGW VTANYLLENF IKYGWVGRWF RPRKGTLGAM
210 220 230 240 250
DLGGASTQIT FETTSPAEDR ASEVQLHLYG QHYRVYTHSF LCYGRDQVLQ
260 270 280 290 300
RLLASALQTH GFHPCWPRGF STQVLLGDVY QSPCTMAQRP QNFNSSARVS
310 320 330 340 350
LSGSSDPHLC RDLVSGLFSF SSCPFSRCSF NGVFQPPVAG NFVAFSAFFY
360 370 380 390 400
TVDFLRTSMG LPVATLQQLE AAAVNVCNQT WAQLQARVPG QRARLADYCA
410 420 430 440 450
GAMFVQQLLS RGYGFDERAF GGVIFQKKAA DTAVGWALGY MLNLTNLIPA
460 470 480 490
DPPGLRKGTD FSSWVVLLLL FASALLAALV LLLRQVHSAK LPSTI
Isoform Short (identifier: Q9Y5L3-2) [UniParc]FASTAAdd to basket
Also known as: beta
The sequence of this isoform differs from the canonical sequence as follows:
383-405: Missing.
Note: Catalytically inactive.Curated
Show »Isoform gamma (identifier: Q9Y5L3-3) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
383-405: Missing.
406-428: Missing.
Note: Catalytically inactive.Curated
Show »Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050307 | 103 | A → V. Corresponds to variant dbSNP:rs34618694Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_003610 | 383 – 405 | Missing in isoform Short and isoform gamma. 1 PublicationAdd BLAST | 23 | |
Alternative sequenceiVSP_053548 | 406 – 428 | Missing in isoform gamma. CuratedAdd BLAST | 23 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U91510 mRNA Translation: AAB81013.1 AF144748 mRNA Translation: AAD40239.1 EF495152 mRNA Translation: ABP58644.1 AL807752 Genomic DNA No translation available. CH471090 Genomic DNA Translation: EAW88336.1 CH471090 Genomic DNA Translation: EAW88337.1 BC035738 mRNA Translation: AAH35738.1 |
CCDSi | CCDS7025.1 [Q9Y5L3-2] CCDS7026.1 [Q9Y5L3-1] |
RefSeqi | NP_001237.1, NM_001246.3 [Q9Y5L3-2] NP_982293.1, NM_203468.2 [Q9Y5L3-1] |
Genome annotation databases
Ensembli | ENST00000312665; ENSP00000312494; ENSG00000054179 [Q9Y5L3-2] ENST00000355097; ENSP00000347213; ENSG00000054179 [Q9Y5L3-1] |
GeneIDi | 954 |
KEGGi | hsa:954 |
UCSCi | uc004ckw.3, human [Q9Y5L3-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U91510 mRNA Translation: AAB81013.1 AF144748 mRNA Translation: AAD40239.1 EF495152 mRNA Translation: ABP58644.1 AL807752 Genomic DNA No translation available. CH471090 Genomic DNA Translation: EAW88336.1 CH471090 Genomic DNA Translation: EAW88337.1 BC035738 mRNA Translation: AAH35738.1 |
CCDSi | CCDS7025.1 [Q9Y5L3-2] CCDS7026.1 [Q9Y5L3-1] |
RefSeqi | NP_001237.1, NM_001246.3 [Q9Y5L3-2] NP_982293.1, NM_203468.2 [Q9Y5L3-1] |
3D structure databases
SMRi | Q9Y5L3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 107392, 1 interactor |
IntActi | Q9Y5L3, 3 interactors |
STRINGi | 9606.ENSP00000347213 |
Chemistry databases
BindingDBi | Q9Y5L3 |
ChEMBLi | CHEMBL5049 |
GuidetoPHARMACOLOGYi | 2889 |
PTM databases
GlyConnecti | 1193, 45 N-Linked glycans (5 sites) |
GlyGeni | Q9Y5L3, 5 sites, 4 N-linked glycans (2 sites) |
iPTMneti | Q9Y5L3 |
PhosphoSitePlusi | Q9Y5L3 |
Genetic variation databases
BioMutai | ENTPD2 |
DMDMi | 18203633 |
Proteomic databases
CPTACi | CPTAC-1489 |
EPDi | Q9Y5L3 |
jPOSTi | Q9Y5L3 |
MassIVEi | Q9Y5L3 |
PaxDbi | Q9Y5L3 |
PeptideAtlasi | Q9Y5L3 |
PRIDEi | Q9Y5L3 |
ProteomicsDBi | 86440 [Q9Y5L3-1] 86441 [Q9Y5L3-2] |
Protocols and materials databases
Antibodypediai | 2981, 216 antibodies |
DNASUi | 954 |
Genome annotation databases
Ensembli | ENST00000312665; ENSP00000312494; ENSG00000054179 [Q9Y5L3-2] ENST00000355097; ENSP00000347213; ENSG00000054179 [Q9Y5L3-1] |
GeneIDi | 954 |
KEGGi | hsa:954 |
UCSCi | uc004ckw.3, human [Q9Y5L3-1] |
Organism-specific databases
CTDi | 954 |
DisGeNETi | 954 |
GeneCardsi | ENTPD2 |
HGNCi | HGNC:3364, ENTPD2 |
HPAi | ENSG00000054179, Tissue enhanced (brain) |
MIMi | 602012, gene |
neXtProti | NX_Q9Y5L3 |
OpenTargetsi | ENSG00000054179 |
PharmGKBi | PA27799 |
VEuPathDBi | HostDB:ENSG00000054179.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1386, Eukaryota |
GeneTreei | ENSGT01020000230450 |
HOGENOMi | CLU_010246_2_3_1 |
InParanoidi | Q9Y5L3 |
OMAi | CYPANFT |
OrthoDBi | 231215at2759 |
PhylomeDBi | Q9Y5L3 |
TreeFami | TF332859 |
Enzyme and pathway databases
BioCyci | MetaCyc:ENSG00000054179-MONOMER |
BRENDAi | 3.6.1.5, 2681 |
PathwayCommonsi | Q9Y5L3 |
Reactomei | R-HSA-8850843, Phosphate bond hydrolysis by NTPDase proteins |
SABIO-RKi | Q9Y5L3 |
Miscellaneous databases
BioGRID-ORCSi | 954, 8 hits in 979 CRISPR screens |
ChiTaRSi | ENTPD2, human |
GeneWikii | ENTPD2 |
GenomeRNAii | 954 |
Pharosi | Q9Y5L3, Tchem |
PROi | PR:Q9Y5L3 |
RNActi | Q9Y5L3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000054179, Expressed in tibial nerve and 148 other tissues |
Genevisiblei | Q9Y5L3, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000407, GDA1_CD39_NTPase |
PANTHERi | PTHR11782, PTHR11782, 1 hit |
Pfami | View protein in Pfam PF01150, GDA1_CD39, 1 hit |
PROSITEi | View protein in PROSITE PS01238, GDA1_CD39_NTPASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ENTP2_HUMAN | |
Accessioni | Q9Y5L3Primary (citable) accession number: Q9Y5L3 Secondary accession number(s): O15464, Q5SPY6, Q5SPY7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 29, 2001 |
Last sequence update: | November 1, 1999 | |
Last modified: | April 7, 2021 | |
This is version 163 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families