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Protein

V-type proton ATPase subunit D

Gene

ATP6V1D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium.By similarity1 Publication

GO - Molecular functioni

  • proton-transporting ATPase activity, rotational mechanism Source: GO_Central

GO - Biological processi

  • cilium assembly Source: UniProtKB
  • insulin receptor signaling pathway Source: Reactome
  • ion transmembrane transport Source: Reactome
  • neutrophil degranulation Source: Reactome
  • protein localization to cilium Source: UniProtKB
  • regulation of macroautophagy Source: ParkinsonsUK-UCL
  • transferrin transport Source: Reactome

Keywordsi

Biological processCilium biogenesis/degradation, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciMetaCyc:HS02107-MONOMER
ReactomeiR-HSA-1222556 ROS, RNS production in phagocytes
R-HSA-6798695 Neutrophil degranulation
R-HSA-77387 Insulin receptor recycling
R-HSA-917977 Transferrin endocytosis and recycling
R-HSA-983712 Ion channel transport

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit D
Short name:
V-ATPase subunit D
Alternative name(s):
V-ATPase 28 kDa accessory protein
Vacuolar proton pump subunit D
Gene namesi
Name:ATP6V1D
Synonyms:ATP6M, VATD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000100554.11
HGNCiHGNC:13527 ATP6V1D
MIMi609398 gene
neXtProtiNX_Q9Y5K8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi51382
OpenTargetsiENSG00000100554
PharmGKBiPA25157

Polymorphism and mutation databases

BioMutaiATP6V1D
DMDMi10720351

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001442311 – 247V-type proton ATPase subunit DAdd BLAST247

Proteomic databases

EPDiQ9Y5K8
MaxQBiQ9Y5K8
PaxDbiQ9Y5K8
PeptideAtlasiQ9Y5K8
PRIDEiQ9Y5K8
ProteomicsDBi86435

PTM databases

iPTMnetiQ9Y5K8
PhosphoSitePlusiQ9Y5K8
SwissPalmiQ9Y5K8

Expressioni

Gene expression databases

BgeeiENSG00000100554 Expressed in 234 organ(s), highest expression level in caudate nucleus
CleanExiHS_ATP6V1D
ExpressionAtlasiQ9Y5K8 baseline and differential
GenevisibleiQ9Y5K8 HS

Organism-specific databases

HPAiHPA031515
HPA057316

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d). Interacts with SNX10; may play a role in ciliogenesis.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
VPS52Q8N1B45EBI-2684998,EBI-2799833

Protein-protein interaction databases

BioGridi119513, 65 interactors
IntActiQ9Y5K8, 19 interactors
STRINGi9606.ENSP00000216442

Structurei

3D structure databases

ProteinModelPortaliQ9Y5K8
SMRiQ9Y5K8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase D subunit family.Curated

Phylogenomic databases

eggNOGiKOG1647 Eukaryota
COG1394 LUCA
GeneTreeiENSGT00390000010770
HOGENOMiHOG000230791
HOVERGENiHBG000483
InParanoidiQ9Y5K8
KOiK02149
OMAiSKNIMGV
OrthoDBiEOG091G0A10
PhylomeDBiQ9Y5K8
TreeFamiTF300160

Family and domain databases

InterProiView protein in InterPro
IPR002699 V_ATPase_D
PANTHERiPTHR11671 PTHR11671, 1 hit
PfamiView protein in Pfam
PF01813 ATP-synt_D, 1 hit
TIGRFAMsiTIGR00309 V_ATPase_subD, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

Q9Y5K8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGKDRIEIF PSRMAQTIMK ARLKGAQTGR NLLKKKSDAL TLRFRQILKK
60 70 80 90 100
IIETKMLMGE VMREAAFSLA EAKFTAGDFS TTVIQNVNKA QVKIRAKKDN
110 120 130 140 150
VAGVTLPVFE HYHEGTDSYE LTGLARGGEQ LAKLKRNYAK AVELLVELAS
160 170 180 190 200
LQTSFVTLDE AIKITNRRVN AIEHVIIPRI ERTLAYIITE LDEREREEFY
210 220 230 240
RLKKIQEKKK ILKEKSEKDL EQRRAAGEVL EPANLLAEEK DEDLLFE
Length:247
Mass (Da):28,263
Last modified:November 1, 1999 - v1
Checksum:i4185E5F6A74EFB1C
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V2S6G3V2S6_HUMAN
V-type proton ATPase subunit D
ATP6V1D
192Annotation score:
H0YJH8H0YJH8_HUMAN
V-type proton ATPase subunit D
ATP6V1D
153Annotation score:
G3V2V6G3V2V6_HUMAN
V-type proton ATPase subunit D
ATP6V1D
148Annotation score:
H0YJS0H0YJS0_HUMAN
V-type proton ATPase subunit D
ATP6V1D
119Annotation score:
G3V559G3V559_HUMAN
V-type proton ATPase subunit D
ATP6V1D
179Annotation score:
G3V3T8G3V3T8_HUMAN
V-type proton ATPase subunit D
ATP6V1D
86Annotation score:
G3V341G3V341_HUMAN
V-type proton ATPase subunit D
ATP6V1D
72Annotation score:
H0YJ55H0YJ55_HUMAN
V-type proton ATPase subunit D
ATP6V1D
44Annotation score:
G3V5S7G3V5S7_HUMAN
V-type proton ATPase subunit D
ATP6V1D
59Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti228 – 235EVLEPANL → RCWSLLIF in AAD40384 (PubMed:10931946).Curated8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF145316 mRNA Translation: AAD33953.1
AF100741 mRNA Translation: AAD40384.1
AF104629 mRNA Translation: AAG30726.1
AK315784 mRNA Translation: BAG38130.1
CH471061 Genomic DNA Translation: EAW80931.1
BC001411 mRNA Translation: AAH01411.1
CCDSiCCDS9780.1
RefSeqiNP_057078.1, NM_015994.3
UniGeneiHs.272630

Genome annotation databases

EnsembliENST00000216442; ENSP00000216442; ENSG00000100554
ENST00000554087; ENSP00000451167; ENSG00000100554
GeneIDi51382
KEGGihsa:51382
UCSCiuc001xjf.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF145316 mRNA Translation: AAD33953.1
AF100741 mRNA Translation: AAD40384.1
AF104629 mRNA Translation: AAG30726.1
AK315784 mRNA Translation: BAG38130.1
CH471061 Genomic DNA Translation: EAW80931.1
BC001411 mRNA Translation: AAH01411.1
CCDSiCCDS9780.1
RefSeqiNP_057078.1, NM_015994.3
UniGeneiHs.272630

3D structure databases

ProteinModelPortaliQ9Y5K8
SMRiQ9Y5K8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119513, 65 interactors
IntActiQ9Y5K8, 19 interactors
STRINGi9606.ENSP00000216442

PTM databases

iPTMnetiQ9Y5K8
PhosphoSitePlusiQ9Y5K8
SwissPalmiQ9Y5K8

Polymorphism and mutation databases

BioMutaiATP6V1D
DMDMi10720351

Proteomic databases

EPDiQ9Y5K8
MaxQBiQ9Y5K8
PaxDbiQ9Y5K8
PeptideAtlasiQ9Y5K8
PRIDEiQ9Y5K8
ProteomicsDBi86435

Protocols and materials databases

DNASUi51382
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216442; ENSP00000216442; ENSG00000100554
ENST00000554087; ENSP00000451167; ENSG00000100554
GeneIDi51382
KEGGihsa:51382
UCSCiuc001xjf.4 human

Organism-specific databases

CTDi51382
DisGeNETi51382
EuPathDBiHostDB:ENSG00000100554.11
GeneCardsiATP6V1D
HGNCiHGNC:13527 ATP6V1D
HPAiHPA031515
HPA057316
MIMi609398 gene
neXtProtiNX_Q9Y5K8
OpenTargetsiENSG00000100554
PharmGKBiPA25157
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1647 Eukaryota
COG1394 LUCA
GeneTreeiENSGT00390000010770
HOGENOMiHOG000230791
HOVERGENiHBG000483
InParanoidiQ9Y5K8
KOiK02149
OMAiSKNIMGV
OrthoDBiEOG091G0A10
PhylomeDBiQ9Y5K8
TreeFamiTF300160

Enzyme and pathway databases

BioCyciMetaCyc:HS02107-MONOMER
ReactomeiR-HSA-1222556 ROS, RNS production in phagocytes
R-HSA-6798695 Neutrophil degranulation
R-HSA-77387 Insulin receptor recycling
R-HSA-917977 Transferrin endocytosis and recycling
R-HSA-983712 Ion channel transport

Miscellaneous databases

ChiTaRSiATP6V1D human
GeneWikiiATP6V1D
GenomeRNAii51382
PROiPR:Q9Y5K8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100554 Expressed in 234 organ(s), highest expression level in caudate nucleus
CleanExiHS_ATP6V1D
ExpressionAtlasiQ9Y5K8 baseline and differential
GenevisibleiQ9Y5K8 HS

Family and domain databases

InterProiView protein in InterPro
IPR002699 V_ATPase_D
PANTHERiPTHR11671 PTHR11671, 1 hit
PfamiView protein in Pfam
PF01813 ATP-synt_D, 1 hit
TIGRFAMsiTIGR00309 V_ATPase_subD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVATD_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5K8
Secondary accession number(s): B2RE33, Q9Y688
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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