UniProtKB - Q9Y5K8 (VATD_HUMAN)

BLAST

>sp|Q9Y5K8|VATD_HUMAN V-type proton ATPase subunit D OS=Homo sapiens OX=9606 GN=ATP6V1D PE=1 SV=1
MSGKDRIEIFPSRMAQTIMKARLKGAQTGRNLLKKKSDALTLRFRQILKKIIETKMLMGE
VMREAAFSLAEAKFTAGDFSTTVIQNVNKAQVKIRAKKDNVAGVTLPVFEHYHEGTDSYE
LTGLARGGEQLAKLKRNYAKAVELLVELASLQTSFVTLDEAIKITNRRVNAIEHVIIPRI
ERTLAYIITELDEREREEFYRLKKIQEKKKILKEKSEKDLEQRRAAGEVLEPANLLAEEK
DEDLLFE

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History
Entry version 165 (07 Nov 2018)
Sequence version 1 (01 Nov 1999)
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Protein

V-type proton ATPase subunit D

Gene

ATP6V1D

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium.By similarity1 Publication

GO - Molecular functionⁱ

proton-transporting ATPase activity, rotational mechanism
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cilium assembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21844891
insulin receptor signaling pathway Source: Reactome
ion transmembrane transport Source: Reactome
neutrophil degranulation Source: Reactome
protein localization to cilium
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21844891
regulation of macroautophagy
Source: ParkinsonsUK-UCL
Non-traceable author statementⁱ
- 22982048
transferrin transport Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cilium biogenesis/degradation, Hydrogen ion transport, Ion transport, Transport

Biological process

Cilium biogenesis/degradation, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS02107-MONOMER
Reactomeⁱ	R-HSA-1222556 ROS, RNS production in phagocytes R-HSA-6798695 Neutrophil degranulation R-HSA-77387 Insulin receptor recycling R-HSA-917977 Transferrin endocytosis and recycling R-HSA-983712 Ion channel transport

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: V-type proton ATPase subunit D Short name: V-ATPase subunit D Alternative name(s): V-ATPase 28 kDa accessory protein Vacuolar proton pump subunit D
Gene namesⁱ	Name:ATP6V1D Synonyms:ATP6M, VATD
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 14

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000100554.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13527 ATP6V1D
MIMⁱ	609398 gene
neXtProtⁱ	NX_Q9Y5K8

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	51382
Open Targets More...OpenTargetsⁱ	ENSG00000100554
PharmGKBⁱ	PA25157

Polymorphism and mutation databases

BioMutaⁱ	ATP6V1D
DMDMⁱ	10720351

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000144231	1 – 247	V-type proton ATPase subunit DAdd BLAST		247

Proteomic databases

EPDⁱ	Q9Y5K8
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9Y5K8
PaxDbⁱ	Q9Y5K8
PeptideAtlas More...PeptideAtlasⁱ	Q9Y5K8
PRIDEⁱ	Q9Y5K8
ProteomicsDBⁱ	86435

PTM databases

iPTMnetⁱ	Q9Y5K8
PhosphoSitePlusⁱ	Q9Y5K8
SwissPalmⁱ	Q9Y5K8

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000100554 Expressed in 234 organ(s), highest expression level in caudate nucleus
CleanExⁱ	HS_ATP6V1D
ExpressionAtlasⁱ	Q9Y5K8 baseline and differential
Genevisibleⁱ	Q9Y5K8 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA031515 HPA057316

HPAⁱ

HPA031515
HPA057316

Interactionⁱ

Subunit structureⁱ

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d). Interacts with SNX10; may play a role in ciliogenesis.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
VPS52	Q8N1B4	5	EBI-2684998,EBI-2799833

With

Entry

#Exp.

IntAct

Notes

VPS52

Q8N1B4

EBI-2684998,EBI-2799833

Protein-protein interaction databases

BioGridⁱ	119513, 65 interactors
IntActⁱ	Q9Y5K8, 19 interactors
STRINGⁱ	9606.ENSP00000216442

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9Y5K8
SMRⁱ	Q9Y5K8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the V-ATPase D subunit family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1647 Eukaryota COG1394 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000010770
HOGENOMⁱ	HOG000230791
HOVERGENⁱ	HBG000483
InParanoidⁱ	Q9Y5K8
KEGG Orthology (KO) More...KOⁱ	K02149
OMAⁱ	SKNIMGV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0A10
PhylomeDBⁱ	Q9Y5K8
TreeFamⁱ	TF300160

Family and domain databases

InterProⁱ	View protein in InterPro IPR002699 V_ATPase_D
PANTHERⁱ	PTHR11671 PTHR11671, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01813 ATP-synt_D, 1 hit
TIGRFAMsⁱ	TIGR00309 V_ATPase_subD, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show all Align All

Q9Y5K8-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MSGKDRIEIF PSRMAQTIMK ARLKGAQTGR NLLKKKSDAL TLRFRQILKK 
        60         70         80         90        100
IIETKMLMGE VMREAAFSLA EAKFTAGDFS TTVIQNVNKA QVKIRAKKDN 
       110        120        130        140        150
VAGVTLPVFE HYHEGTDSYE LTGLARGGEQ LAKLKRNYAK AVELLVELAS 
       160        170        180        190        200
LQTSFVTLDE AIKITNRRVN AIEHVIIPRI ERTLAYIITE LDEREREEFY 
       210        220        230        240 
RLKKIQEKKK ILKEKSEKDL EQRRAAGEVL EPANLLAEEK DEDLLFE

Length:247

Mass (Da):28,263

Last modified:November 1, 1999 - v1

Checksum:ⁱ4185E5F6A74EFB1C

Computationally mapped potential isoform sequencesⁱ

There are 9 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

G3V2S6	G3V2S6_HUMAN	V-type proton ATPase subunit D V-type proton ATPase subunit D	ATP6V1D	192	Annotation score:
H0YJH8	H0YJH8_HUMAN	V-type proton ATPase subunit D V-type proton ATPase subunit D	ATP6V1D	153	Annotation score:
G3V2V6	G3V2V6_HUMAN	V-type proton ATPase subunit D V-type proton ATPase subunit D	ATP6V1D	148	Annotation score:
H0YJS0	H0YJS0_HUMAN	V-type proton ATPase subunit D V-type proton ATPase subunit D	ATP6V1D	119	Annotation score:
G3V559	G3V559_HUMAN	V-type proton ATPase subunit D V-type proton ATPase subunit D	ATP6V1D	179	Annotation score:
G3V3T8	G3V3T8_HUMAN	V-type proton ATPase subunit D V-type proton ATPase subunit D	ATP6V1D	86	Annotation score:
G3V341	G3V341_HUMAN	V-type proton ATPase subunit D V-type proton ATPase subunit D	ATP6V1D	72	Annotation score:
H0YJ55	H0YJ55_HUMAN	V-type proton ATPase subunit D V-type proton ATPase subunit D	ATP6V1D	44	Annotation score:
G3V5S7	G3V5S7_HUMAN	V-type proton ATPase subunit D V-type proton ATPase subunit D	ATP6V1D	59	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	228 – 235	EVLEPANL → RCWSLLIF in AAD40384 (PubMed:10931946).Curated		8

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF145316 mRNA Translation: AAD33953.1 AF100741 mRNA Translation: AAD40384.1 AF104629 mRNA Translation: AAG30726.1 AK315784 mRNA Translation: BAG38130.1 CH471061 Genomic DNA Translation: EAW80931.1 BC001411 mRNA Translation: AAH01411.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9780.1
NCBI Reference Sequences More...RefSeqⁱ	NP_057078.1, NM_015994.3
UniGeneⁱ	Hs.272630

Genome annotation databases

Ensemblⁱ	ENST00000216442; ENSP00000216442; ENSG00000100554 ENST00000554087; ENSP00000451167; ENSG00000100554
GeneIDⁱ	51382
KEGGⁱ	hsa:51382
UCSC genome browser More...UCSCⁱ	uc001xjf.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Y5K8	V-type proton ATPase subunit D		PONAB		247	UniRef100_Q9Y5K8
ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D, isoform CRA_a		HUMAN		247
ATPase H+ transporting V1 subunit D		MACMU		247
ATP6V1D isoform 1		PANTR		247
ATPase H+ transporting V1 subunit D		MACFA		247
+12

Protein	Similar proteins		Species	Score	Length	Source
Q9Y5K8	V-type proton ATPase subunit D		PONAB		247	UniRef90_Q9Y5K8
V-type proton ATPase subunit D		RABIT		247
ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D, isoform CRA_a		HUMAN		247
ATPase H+ transporting V1 subunit D		MACMU		247
ATP6V1D isoform 1		PANTR		247
+126

Protein	Similar proteins		Species	Score	Length	Source
Q9Y5K8	V-type proton ATPase subunit D		PONAB		247	UniRef50_Q9Y5K8
V-type proton ATPase subunit D		RABIT		247
V-type proton ATPase subunit D 1		DROME		246
ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D, isoform CRA_a		HUMAN		247
ATPase H+ transporting V1 subunit D		MACMU		247
+227

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF145316 mRNA Translation: AAD33953.1 AF100741 mRNA Translation: AAD40384.1 AF104629 mRNA Translation: AAG30726.1 AK315784 mRNA Translation: BAG38130.1 CH471061 Genomic DNA Translation: EAW80931.1 BC001411 mRNA Translation: AAH01411.1
CCDSⁱ	CCDS9780.1
RefSeqⁱ	NP_057078.1, NM_015994.3
UniGeneⁱ	Hs.272630

3D structure databases

ProteinModelPortalⁱ	Q9Y5K8
SMRⁱ	Q9Y5K8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119513, 65 interactors
IntActⁱ	Q9Y5K8, 19 interactors
STRINGⁱ	9606.ENSP00000216442

PTM databases

iPTMnetⁱ	Q9Y5K8
PhosphoSitePlusⁱ	Q9Y5K8
SwissPalmⁱ	Q9Y5K8

Polymorphism and mutation databases

BioMutaⁱ	ATP6V1D
DMDMⁱ	10720351

Proteomic databases

EPDⁱ	Q9Y5K8
MaxQBⁱ	Q9Y5K8
PaxDbⁱ	Q9Y5K8
PeptideAtlasⁱ	Q9Y5K8
PRIDEⁱ	Q9Y5K8
ProteomicsDBⁱ	86435

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	51382
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000216442; ENSP00000216442; ENSG00000100554 ENST00000554087; ENSP00000451167; ENSG00000100554
GeneIDⁱ	51382
KEGGⁱ	hsa:51382
UCSCⁱ	uc001xjf.4 human

Organism-specific databases

CTDⁱ	51382
DisGeNETⁱ	51382
EuPathDBⁱ	HostDB:ENSG00000100554.11
GeneCardsⁱ	ATP6V1D
HGNCⁱ	HGNC:13527 ATP6V1D
HPAⁱ	HPA031515 HPA057316
MIMⁱ	609398 gene
neXtProtⁱ	NX_Q9Y5K8
OpenTargetsⁱ	ENSG00000100554
PharmGKBⁱ	PA25157
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1647 Eukaryota COG1394 LUCA
GeneTreeⁱ	ENSGT00390000010770
HOGENOMⁱ	HOG000230791
HOVERGENⁱ	HBG000483
InParanoidⁱ	Q9Y5K8
KOⁱ	K02149
OMAⁱ	SKNIMGV
OrthoDBⁱ	EOG091G0A10
PhylomeDBⁱ	Q9Y5K8
TreeFamⁱ	TF300160

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS02107-MONOMER
Reactomeⁱ	R-HSA-1222556 ROS, RNS production in phagocytes R-HSA-6798695 Neutrophil degranulation R-HSA-77387 Insulin receptor recycling R-HSA-917977 Transferrin endocytosis and recycling R-HSA-983712 Ion channel transport

Miscellaneous databases

ChiTaRSⁱ	ATP6V1D human
GeneWikiⁱ	ATP6V1D
GenomeRNAiⁱ	51382
Protein Ontology More...PROⁱ	PR:Q9Y5K8
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000100554 Expressed in 234 organ(s), highest expression level in caudate nucleus
CleanExⁱ	HS_ATP6V1D
ExpressionAtlasⁱ	Q9Y5K8 baseline and differential
Genevisibleⁱ	Q9Y5K8 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR002699 V_ATPase_D
PANTHERⁱ	PTHR11671 PTHR11671, 1 hit
Pfamⁱ	View protein in Pfam PF01813 ATP-synt_D, 1 hit
TIGRFAMsⁱ	TIGR00309 V_ATPase_subD, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	VATD_HUMAN
Accessionⁱ	Q9Y5K8Primary (citable) accession number: Q9Y5K8 Secondary accession number(s): B2RE33, Q9Y688
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
	Last sequence update:	November 1, 1999
	Last modified:	November 7, 2018
	This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM

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UniParc

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UniProtKB - Q9Y5K8 (VATD_HUMAN)

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V-type proton ATPase subunit D

ATP6V1D

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Extracellular region or secreted

Lysosome

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ