UniProtKB - Q9Y5K8 (VATD_HUMAN)
Protein
V-type proton ATPase subunit D
Gene
ATP6V1D
Organism
Homo sapiens (Human)
Status
Functioni
Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium.By similarity1 Publication
GO - Molecular functioni
- proton-transporting ATPase activity, rotational mechanism Source: GO_Central
GO - Biological processi
- cilium assembly Source: UniProtKB
- insulin receptor signaling pathway Source: Reactome
- ion transmembrane transport Source: Reactome
- neutrophil degranulation Source: Reactome
- phagosome acidification Source: Reactome
- protein localization to cilium Source: UniProtKB
- regulation of macroautophagy Source: ParkinsonsUK-UCL
- transferrin transport Source: Reactome
Keywordsi
Biological process | Cilium biogenesis/degradation, Hydrogen ion transport, Ion transport, Transport |
Enzyme and pathway databases
BioCyci | MetaCyc:HS02107-MONOMER |
PathwayCommonsi | Q9Y5K8 |
Reactomei | R-HSA-1222556, ROS and RNS production in phagocytes R-HSA-6798695, Neutrophil degranulation R-HSA-77387, Insulin receptor recycling R-HSA-917977, Transferrin endocytosis and recycling R-HSA-9639288, Amino acids regulate mTORC1 R-HSA-983712, Ion channel transport |
Names & Taxonomyi
Protein namesi | Recommended name: V-type proton ATPase subunit DShort name: V-ATPase subunit D Alternative name(s): V-ATPase 28 kDa accessory protein Vacuolar proton pump subunit D |
Gene namesi | Name:ATP6V1D Synonyms:ATP6M, VATD |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13527, ATP6V1D |
MIMi | 609398, gene |
neXtProti | NX_Q9Y5K8 |
VEuPathDBi | HostDB:ENSG00000100554.11 |
Subcellular locationi
Other locations
- Membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication
Note: Localizes to centrosome and the base of the cilium.
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Lysosome
- lysosomal membrane Source: UniProtKB
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- membrane Source: UniProtKB
- proton-transporting V-type ATPase complex Source: UniProtKB
- specific granule membrane Source: Reactome
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 51382 |
OpenTargetsi | ENSG00000100554 |
PharmGKBi | PA25157 |
Miscellaneous databases
Pharosi | Q9Y5K8, Tbio |
Chemistry databases
DrugBanki | DB01133, Tiludronic acid |
Genetic variation databases
BioMutai | ATP6V1D |
DMDMi | 10720351 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000144231 | 1 – 247 | V-type proton ATPase subunit DAdd BLAST | 247 |
Proteomic databases
EPDi | Q9Y5K8 |
jPOSTi | Q9Y5K8 |
MassIVEi | Q9Y5K8 |
MaxQBi | Q9Y5K8 |
PaxDbi | Q9Y5K8 |
PeptideAtlasi | Q9Y5K8 |
PRIDEi | Q9Y5K8 |
ProteomicsDBi | 86435 |
PTM databases
iPTMneti | Q9Y5K8 |
PhosphoSitePlusi | Q9Y5K8 |
SwissPalmi | Q9Y5K8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000100554, Expressed in caudate nucleus and 245 other tissues |
ExpressionAtlasi | Q9Y5K8, baseline and differential |
Genevisiblei | Q9Y5K8, HS |
Organism-specific databases
HPAi | ENSG00000100554, Low tissue specificity |
Interactioni
Subunit structurei
V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).
Interacts with SNX10; may play a role in ciliogenesis.
1 PublicationBinary interactionsi
Hide detailsQ9Y5K8
Protein-protein interaction databases
BioGRIDi | 119513, 72 interactors |
IntActi | Q9Y5K8, 36 interactors |
MINTi | Q9Y5K8 |
STRINGi | 9606.ENSP00000216442 |
Miscellaneous databases
RNActi | Q9Y5K8, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the V-ATPase D subunit family.Curated
Phylogenomic databases
eggNOGi | KOG1647, Eukaryota |
GeneTreei | ENSGT00390000010770 |
HOGENOMi | CLU_069688_0_0_1 |
InParanoidi | Q9Y5K8 |
OMAi | SKNIMGV |
OrthoDBi | 1313938at2759 |
PhylomeDBi | Q9Y5K8 |
TreeFami | TF300160 |
Family and domain databases
InterProi | View protein in InterPro IPR002699, V_ATPase_D |
PANTHERi | PTHR11671, PTHR11671, 1 hit |
Pfami | View protein in Pfam PF01813, ATP-synt_D, 1 hit |
TIGRFAMsi | TIGR00309, V_ATPase_subD, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
Q9Y5K8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGKDRIEIF PSRMAQTIMK ARLKGAQTGR NLLKKKSDAL TLRFRQILKK
60 70 80 90 100
IIETKMLMGE VMREAAFSLA EAKFTAGDFS TTVIQNVNKA QVKIRAKKDN
110 120 130 140 150
VAGVTLPVFE HYHEGTDSYE LTGLARGGEQ LAKLKRNYAK AVELLVELAS
160 170 180 190 200
LQTSFVTLDE AIKITNRRVN AIEHVIIPRI ERTLAYIITE LDEREREEFY
210 220 230 240
RLKKIQEKKK ILKEKSEKDL EQRRAAGEVL EPANLLAEEK DEDLLFE
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3V2S6 | G3V2S6_HUMAN | V-type proton ATPase subunit D | ATP6V1D | 192 | Annotation score: | ||
G3V2V6 | G3V2V6_HUMAN | V-type proton ATPase subunit D | ATP6V1D | 148 | Annotation score: | ||
G3V559 | G3V559_HUMAN | V-type proton ATPase subunit D | ATP6V1D | 179 | Annotation score: | ||
H0YJH8 | H0YJH8_HUMAN | V-type proton ATPase subunit D | ATP6V1D | 153 | Annotation score: | ||
H0YJS0 | H0YJS0_HUMAN | V-type proton ATPase subunit D | ATP6V1D | 119 | Annotation score: | ||
G3V5S7 | G3V5S7_HUMAN | V-type proton ATPase subunit D | ATP6V1D | 59 | Annotation score: | ||
G3V341 | G3V341_HUMAN | V-type proton ATPase subunit D | ATP6V1D | 72 | Annotation score: | ||
G3V3T8 | G3V3T8_HUMAN | V-type proton ATPase subunit D | ATP6V1D | 86 | Annotation score: | ||
H0YJ55 | H0YJ55_HUMAN | V-type proton ATPase subunit D | ATP6V1D | 44 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 228 – 235 | EVLEPANL → RCWSLLIF in AAD40384 (PubMed:10931946).Curated | 8 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF145316 mRNA Translation: AAD33953.1 AF100741 mRNA Translation: AAD40384.1 AF104629 mRNA Translation: AAG30726.1 AK315784 mRNA Translation: BAG38130.1 CH471061 Genomic DNA Translation: EAW80931.1 BC001411 mRNA Translation: AAH01411.1 |
CCDSi | CCDS9780.1 |
RefSeqi | NP_057078.1, NM_015994.3 |
Genome annotation databases
Ensembli | ENST00000216442; ENSP00000216442; ENSG00000100554 ENST00000554087; ENSP00000451167; ENSG00000100554 |
GeneIDi | 51382 |
KEGGi | hsa:51382 |
UCSCi | uc001xjf.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF145316 mRNA Translation: AAD33953.1 AF100741 mRNA Translation: AAD40384.1 AF104629 mRNA Translation: AAG30726.1 AK315784 mRNA Translation: BAG38130.1 CH471061 Genomic DNA Translation: EAW80931.1 BC001411 mRNA Translation: AAH01411.1 |
CCDSi | CCDS9780.1 |
RefSeqi | NP_057078.1, NM_015994.3 |
3D structure databases
SMRi | Q9Y5K8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119513, 72 interactors |
IntActi | Q9Y5K8, 36 interactors |
MINTi | Q9Y5K8 |
STRINGi | 9606.ENSP00000216442 |
Chemistry databases
DrugBanki | DB01133, Tiludronic acid |
PTM databases
iPTMneti | Q9Y5K8 |
PhosphoSitePlusi | Q9Y5K8 |
SwissPalmi | Q9Y5K8 |
Genetic variation databases
BioMutai | ATP6V1D |
DMDMi | 10720351 |
Proteomic databases
EPDi | Q9Y5K8 |
jPOSTi | Q9Y5K8 |
MassIVEi | Q9Y5K8 |
MaxQBi | Q9Y5K8 |
PaxDbi | Q9Y5K8 |
PeptideAtlasi | Q9Y5K8 |
PRIDEi | Q9Y5K8 |
ProteomicsDBi | 86435 |
Protocols and materials databases
Antibodypediai | 24797, 92 antibodies |
DNASUi | 51382 |
Genome annotation databases
Ensembli | ENST00000216442; ENSP00000216442; ENSG00000100554 ENST00000554087; ENSP00000451167; ENSG00000100554 |
GeneIDi | 51382 |
KEGGi | hsa:51382 |
UCSCi | uc001xjf.4, human |
Organism-specific databases
CTDi | 51382 |
DisGeNETi | 51382 |
GeneCardsi | ATP6V1D |
HGNCi | HGNC:13527, ATP6V1D |
HPAi | ENSG00000100554, Low tissue specificity |
MIMi | 609398, gene |
neXtProti | NX_Q9Y5K8 |
OpenTargetsi | ENSG00000100554 |
PharmGKBi | PA25157 |
VEuPathDBi | HostDB:ENSG00000100554.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1647, Eukaryota |
GeneTreei | ENSGT00390000010770 |
HOGENOMi | CLU_069688_0_0_1 |
InParanoidi | Q9Y5K8 |
OMAi | SKNIMGV |
OrthoDBi | 1313938at2759 |
PhylomeDBi | Q9Y5K8 |
TreeFami | TF300160 |
Enzyme and pathway databases
BioCyci | MetaCyc:HS02107-MONOMER |
PathwayCommonsi | Q9Y5K8 |
Reactomei | R-HSA-1222556, ROS and RNS production in phagocytes R-HSA-6798695, Neutrophil degranulation R-HSA-77387, Insulin receptor recycling R-HSA-917977, Transferrin endocytosis and recycling R-HSA-9639288, Amino acids regulate mTORC1 R-HSA-983712, Ion channel transport |
Miscellaneous databases
BioGRID-ORCSi | 51382, 621 hits in 882 CRISPR screens |
ChiTaRSi | ATP6V1D, human |
GeneWikii | ATP6V1D |
GenomeRNAii | 51382 |
Pharosi | Q9Y5K8, Tbio |
PROi | PR:Q9Y5K8 |
RNActi | Q9Y5K8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000100554, Expressed in caudate nucleus and 245 other tissues |
ExpressionAtlasi | Q9Y5K8, baseline and differential |
Genevisiblei | Q9Y5K8, HS |
Family and domain databases
InterProi | View protein in InterPro IPR002699, V_ATPase_D |
PANTHERi | PTHR11671, PTHR11671, 1 hit |
Pfami | View protein in Pfam PF01813, ATP-synt_D, 1 hit |
TIGRFAMsi | TIGR00309, V_ATPase_subD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VATD_HUMAN | |
Accessioni | Q9Y5K8Primary (citable) accession number: Q9Y5K8 Secondary accession number(s): B2RE33, Q9Y688 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | November 1, 1999 | |
Last modified: | February 10, 2021 | |
This is version 181 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families