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Entry version 173 (16 Oct 2019)
Sequence version 3 (30 May 2006)
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Protein

Ubiquitin carboxyl-terminal hydrolase isozyme L5

Gene

UCHL5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). EC:3.4.19.12

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by ADRM1. Inhibited by interaction with NFRKB.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei88NucleophileCurated1
Active sitei164Proton donorBy similarity1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei179Important for enzyme activityBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processDNA damage, DNA recombination, DNA repair, Transcription, Transcription regulation, Ubl conjugation pathway

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.4.19.12 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2173788 Downregulation of TGF-beta receptor signaling
R-HSA-5689603 UCH proteinases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9Y5K5

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9Y5K5

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C12.005

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase isozyme L5 (EC:3.4.19.12)
Short name:
UCH-L5
Alternative name(s):
Ubiquitin C-terminal hydrolase UCH37
Ubiquitin thioesterase L5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UCHL5
Synonyms:UCH37
ORF Names:AD-019, CGI-70
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19678 UCHL5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610667 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y5K5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi88C → A: Abolishes enzymatic activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
51377

Open Targets

More...
OpenTargetsi
ENSG00000116750

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134916228

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9Y5K5

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3407316

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
UCHL5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
108936023

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002110661 – 329Ubiquitin carboxyl-terminal hydrolase isozyme L5Add BLAST329

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei47N6-succinyllysineBy similarity1
Modified residuei158N6-acetyllysineCombined sources1
Modified residuei289N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y5K5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Y5K5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9Y5K5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y5K5

PeptideAtlas

More...
PeptideAtlasi
Q9Y5K5

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y5K5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
86430 [Q9Y5K5-1]
86431 [Q9Y5K5-2]
86432 [Q9Y5K5-3]
86433 [Q9Y5K5-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y5K5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y5K5

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9Y5K5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000116750 Expressed in 218 organ(s), highest expression level in frontal cortex

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y5K5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y5K5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA005908
HPA006069
HPA075383

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the 19S (PA700) regulatory complex of the 26S proteasome.

Interacts with ADRM1 and NFRKB; in vitro ADRM1 and NFRKB compete for interaction with UCHL5.

Component of the INO80 complex; specifically part of a complex module associated with N-terminus of INO80.

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119509, 230 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-846 INO80 chromatin remodeling complex

Database of interacting proteins

More...
DIPi
DIP-42671N

Protein interaction database and analysis system

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IntActi
Q9Y5K5, 73 interactors

Molecular INTeraction database

More...
MINTi
Q9Y5K5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000356425

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9Y5K5

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1329
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y5K5

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9Y5K5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni313 – 329Interaction with ADRM1Add BLAST17

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C12 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2778 Eukaryota
ENOG410XP0P LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155195

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y5K5

KEGG Orthology (KO)

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KOi
K05610

Database of Orthologous Groups

More...
OrthoDBi
1363547at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y5K5

TreeFam database of animal gene trees

More...
TreeFami
TF313976

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02255 Peptidase_C12, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.532.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038765 Papain-like_cys_pep_sf
IPR001578 Peptidase_C12_UCH
IPR036959 Peptidase_C12_UCH_sf
IPR017390 Ubiquitinyl_hydrolase_UCH37
IPR033837 UCH37
IPR041507 UCH_C

The PANTHER Classification System

More...
PANTHERi
PTHR10589 PTHR10589, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01088 Peptidase_C12, 1 hit
PF18031 UCH_C, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF038120 Ubiquitinyl_hydrolase_UCH37, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00707 UBCTHYDRLASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001 SSF54001, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Experimental confirmation may be lacking for some isoforms.

This entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y5K5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTGNAGEWCL MESDPGVFTE LIKGFGCRGA QVEEIWSLEP ENFEKLKPVH
60 70 80 90 100
GLIFLFKWQP GEEPAGSVVQ DSRLDTIFFA KQVINNACAT QAIVSVLLNC
110 120 130 140 150
THQDVHLGET LSEFKEFSQS FDAAMKGLAL SNSDVIRQVH NSFARQQMFE
160 170 180 190 200
FDTKTSAKEE DAFHFVSYVP VNGRLYELDG LREGPIDLGA CNQDDWISAV
210 220 230 240 250
RPVIEKRIQK YSEGEIRFNL MAIVSDRKMI YEQKIAELQR QLAEEEPMDT
260 270 280 290 300
DQGNSMLSAI QSEVAKNQML IEEEVQKLKR YKIENIRRKH NYLPFIMELL
310 320
KTLAEHQQLI PLVEKAKEKQ NAKKAQETK
Length:329
Mass (Da):37,607
Last modified:May 30, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDF307347D48C9D0F
GO
Isoform 2 (identifier: Q9Y5K5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     246-246: Missing.
     316-329: AKEKQNAKKAQETK → GK

Show »
Length:316
Mass (Da):36,079
Checksum:i2552C52F2CFC1E9C
GO
Isoform 3 (identifier: Q9Y5K5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     246-246: Missing.

Show »
Length:328
Mass (Da):37,478
Checksum:i2ECFB3AB11D07E72
GO
Isoform 4 (identifier: Q9Y5K5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     246-246: Missing.
     316-329: AKEKQNAKKAQETK → FEKHFEKTLLGK

Note: No experimental confirmation available.
Show »
Length:326
Mass (Da):37,353
Checksum:iA3570094A7EC96CB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5LJA5Q5LJA5_HUMAN
Ubiquitin carboxyl-terminal hydrola...
UCHL5
355Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5LJA9Q5LJA9_HUMAN
Ubiquitin carboxyl-terminal hydrola...
UCHL5
368Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5LJB0Q5LJB0_HUMAN
Ubiquitin carboxyl-terminal hydrola...
UCHL5
258Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y4E0H0Y4E0_HUMAN
Ubiquitin carboxyl-terminal hydrola...
UCHL5
183Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y6Y4H0Y6Y4_HUMAN
Ubiquitin carboxyl-terminal hydrola...
UCHL5
218Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y4K0H0Y4K0_HUMAN
Ubiquitin carboxyl-terminal hydrola...
UCHL5
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y636H0Y636_HUMAN
Ubiquitin carboxyl-terminal hydrola...
UCHL5
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5LJB1Q5LJB1_HUMAN
Ubiquitin carboxyl-terminal hydrola...
UCHL5
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti6G → V in AAD34065 (PubMed:10810093).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_011613197I → F2 Publications1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_005253246Missing in isoform 2, isoform 3 and isoform 4. 4 Publications1
Alternative sequenceiVSP_005254316 – 329AKEKQ…AQETK → GK in isoform 2. 2 PublicationsAdd BLAST14
Alternative sequenceiVSP_017062316 – 329AKEKQ…AQETK → FEKHFEKTLLGK in isoform 4. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF147717 mRNA Translation: AAD31528.1
AF151828 mRNA Translation: AAD34065.1
AF157320 mRNA Translation: AAF67486.1
BT006790 mRNA Translation: AAP35436.1
AL136370 Genomic DNA No translation available.
BC015521 mRNA Translation: AAH15521.1
BC025369 mRNA Translation: AAH25369.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1378.1 [Q9Y5K5-1]
CCDS55668.1 [Q9Y5K5-3]
CCDS55669.1 [Q9Y5K5-2]
CCDS55670.1 [Q9Y5K5-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001186190.1, NM_001199261.1 [Q9Y5K5-3]
NP_001186191.1, NM_001199262.1 [Q9Y5K5-4]
NP_001186192.1, NM_001199263.1 [Q9Y5K5-2]
NP_057068.1, NM_015984.3 [Q9Y5K5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000367448; ENSP00000356418; ENSG00000116750 [Q9Y5K5-4]
ENST00000367449; ENSP00000356419; ENSG00000116750 [Q9Y5K5-2]
ENST00000367454; ENSP00000356424; ENSG00000116750 [Q9Y5K5-3]
ENST00000367455; ENSP00000356425; ENSG00000116750 [Q9Y5K5-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
51377

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:51377

UCSC genome browser

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UCSCi
uc001gsm.4 human [Q9Y5K5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF147717 mRNA Translation: AAD31528.1
AF151828 mRNA Translation: AAD34065.1
AF157320 mRNA Translation: AAF67486.1
BT006790 mRNA Translation: AAP35436.1
AL136370 Genomic DNA No translation available.
BC015521 mRNA Translation: AAH15521.1
BC025369 mRNA Translation: AAH25369.1
CCDSiCCDS1378.1 [Q9Y5K5-1]
CCDS55668.1 [Q9Y5K5-3]
CCDS55669.1 [Q9Y5K5-2]
CCDS55670.1 [Q9Y5K5-4]
RefSeqiNP_001186190.1, NM_001199261.1 [Q9Y5K5-3]
NP_001186191.1, NM_001199262.1 [Q9Y5K5-4]
NP_001186192.1, NM_001199263.1 [Q9Y5K5-2]
NP_057068.1, NM_015984.3 [Q9Y5K5-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3A7SX-ray2.20A1-228[»]
3IHRX-ray2.95A1-329[»]
3RIIX-ray2.00A/B1-228[»]
3RISX-ray2.40A/B/C/D1-240[»]
3TB3X-ray2.30A/B1-227[»]
4UELX-ray2.30A1-329[»]
4UEMX-ray2.82A1-329[»]
4UF5X-ray3.70A1-329[»]
4UF6X-ray3.69A/D/G/J1-329[»]
4WLPX-ray3.10A5-322[»]
SMRiQ9Y5K5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi119509, 230 interactors
ComplexPortaliCPX-846 INO80 chromatin remodeling complex
DIPiDIP-42671N
IntActiQ9Y5K5, 73 interactors
MINTiQ9Y5K5
STRINGi9606.ENSP00000356425

Chemistry databases

BindingDBiQ9Y5K5
ChEMBLiCHEMBL3407316

Protein family/group databases

MEROPSiC12.005

PTM databases

iPTMnetiQ9Y5K5
PhosphoSitePlusiQ9Y5K5
SwissPalmiQ9Y5K5

Polymorphism and mutation databases

BioMutaiUCHL5
DMDMi108936023

Proteomic databases

EPDiQ9Y5K5
jPOSTiQ9Y5K5
MassIVEiQ9Y5K5
PaxDbiQ9Y5K5
PeptideAtlasiQ9Y5K5
PRIDEiQ9Y5K5
ProteomicsDBi86430 [Q9Y5K5-1]
86431 [Q9Y5K5-2]
86432 [Q9Y5K5-3]
86433 [Q9Y5K5-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
51377

Genome annotation databases

EnsembliENST00000367448; ENSP00000356418; ENSG00000116750 [Q9Y5K5-4]
ENST00000367449; ENSP00000356419; ENSG00000116750 [Q9Y5K5-2]
ENST00000367454; ENSP00000356424; ENSG00000116750 [Q9Y5K5-3]
ENST00000367455; ENSP00000356425; ENSG00000116750 [Q9Y5K5-1]
GeneIDi51377
KEGGihsa:51377
UCSCiuc001gsm.4 human [Q9Y5K5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51377
DisGeNETi51377

GeneCards: human genes, protein and diseases

More...
GeneCardsi
UCHL5
HGNCiHGNC:19678 UCHL5
HPAiHPA005908
HPA006069
HPA075383
MIMi610667 gene
neXtProtiNX_Q9Y5K5
OpenTargetsiENSG00000116750
PharmGKBiPA134916228

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2778 Eukaryota
ENOG410XP0P LUCA
GeneTreeiENSGT00940000155195
InParanoidiQ9Y5K5
KOiK05610
OrthoDBi1363547at2759
PhylomeDBiQ9Y5K5
TreeFamiTF313976

Enzyme and pathway databases

BRENDAi3.4.19.12 2681
ReactomeiR-HSA-2173788 Downregulation of TGF-beta receptor signaling
R-HSA-5689603 UCH proteinases
SignaLinkiQ9Y5K5
SIGNORiQ9Y5K5

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
UCHL5 human
EvolutionaryTraceiQ9Y5K5

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Ubiquitin_carboxyl-terminal_hydrolase_L5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
51377
PharosiQ9Y5K5

Protein Ontology

More...
PROi
PR:Q9Y5K5

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000116750 Expressed in 218 organ(s), highest expression level in frontal cortex
ExpressionAtlasiQ9Y5K5 baseline and differential
GenevisibleiQ9Y5K5 HS

Family and domain databases

CDDicd02255 Peptidase_C12, 1 hit
Gene3Di3.40.532.10, 1 hit
InterProiView protein in InterPro
IPR038765 Papain-like_cys_pep_sf
IPR001578 Peptidase_C12_UCH
IPR036959 Peptidase_C12_UCH_sf
IPR017390 Ubiquitinyl_hydrolase_UCH37
IPR033837 UCH37
IPR041507 UCH_C
PANTHERiPTHR10589 PTHR10589, 1 hit
PfamiView protein in Pfam
PF01088 Peptidase_C12, 1 hit
PF18031 UCH_C, 1 hit
PIRSFiPIRSF038120 Ubiquitinyl_hydrolase_UCH37, 1 hit
PRINTSiPR00707 UBCTHYDRLASE
SUPFAMiSSF54001 SSF54001, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUCHL5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y5K5
Secondary accession number(s): Q5LJA6
, Q5LJA7, Q8TBS4, Q96BJ9, Q9H1W5, Q9P0I3, Q9UQN2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 30, 2006
Last modified: October 16, 2019
This is version 173 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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