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Protein

U3 small nucleolar RNA-associated protein 18 homolog

Gene

UTP18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in nucleolar processing of pre-18S ribosomal RNA.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processrRNA processing

Enzyme and pathway databases

ReactomeiR-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar RNA-associated protein 18 homolog
Alternative name(s):
WD repeat-containing protein 50
Gene namesi
Name:UTP18
Synonyms:WDR50
ORF Names:CDABP0061, CGI-48
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000011260.13
HGNCiHGNC:24274 UTP18
MIMi612816 gene
neXtProtiNX_Q9Y5J1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi51096
OpenTargetsiENSG00000011260
PharmGKBiPA134984104

Polymorphism and mutation databases

BioMutaiUTP18
DMDMi73920973

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000514051 – 556U3 small nucleolar RNA-associated protein 18 homologAdd BLAST556

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki84Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei121PhosphoserineCombined sources1
Modified residuei124PhosphoserineCombined sources1
Cross-linki183Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki201Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei204PhosphothreonineCombined sources1
Modified residuei205PhosphoserineCombined sources1
Modified residuei206PhosphoserineCombined sources1
Modified residuei210PhosphoserineCombined sources1
Modified residuei221PhosphothreonineCombined sources1
Cross-linki517Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9Y5J1
MaxQBiQ9Y5J1
PaxDbiQ9Y5J1
PeptideAtlasiQ9Y5J1
PRIDEiQ9Y5J1
ProteomicsDBi86417

2D gel databases

SWISS-2DPAGEiQ9Y5J1

PTM databases

iPTMnetiQ9Y5J1
PhosphoSitePlusiQ9Y5J1

Miscellaneous databases

PMAP-CutDBiQ9Y5J1

Expressioni

Gene expression databases

BgeeiENSG00000011260 Expressed in 231 organ(s), highest expression level in testis
CleanExiHS_UTP18
ExpressionAtlasiQ9Y5J1 baseline and differential
GenevisibleiQ9Y5J1 HS

Organism-specific databases

HPAiHPA052378

Interactioni

Protein-protein interaction databases

BioGridi119285, 30 interactors
IntActiQ9Y5J1, 17 interactors
MINTiQ9Y5J1
STRINGi9606.ENSP00000225298

Structurei

3D structure databases

ProteinModelPortaliQ9Y5J1
SMRiQ9Y5J1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati249 – 288WD 1Add BLAST40
Repeati293 – 333WD 2Add BLAST41
Repeati339 – 380WD 3Add BLAST42
Repeati381 – 419WD 4Add BLAST39
Repeati421 – 462WD 5Add BLAST42
Repeati471 – 512WD 6Add BLAST42

Sequence similaritiesi

Belongs to the WD repeat UTP18 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG2055 Eukaryota
ENOG410YBWP LUCA
GeneTreeiENSGT00440000033919
HOGENOMiHOG000242429
HOVERGENiHBG082494
InParanoidiQ9Y5J1
KOiK14553
OMAiQFHPTST
OrthoDBiEOG091G0BJP
PhylomeDBiQ9Y5J1
TreeFamiTF313426

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q9Y5J1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPERRRRMK LDRRTGAKPK RKPGMRPDWK AGAGPGGPPQ KPAPSSQRKP
60 70 80 90 100
PARPSAAAAA IAVAAAEEER RLRQRNRLRL EEDKPAVERC LEELVFGDVE
110 120 130 140 150
NDEDALLRRL RGPRVQEHED SGDSEVENEA KGNFPPQKKP VWVDEEDEDE
160 170 180 190 200
EMVDMMNNRF RKDMMKNASE SKLSKDNLKK RLKEEFQHAM GGVPAWAETT
210 220 230 240 250
KRKTSSDDES EEDEDDLLQR TGNFISTSTS LPRGILKMKN CQHANAERPT
260 270 280 290 300
VARISSVQFH PGAQIVMVAG LDNAVSLFQV DGKTNPKIQS IYLERFPIFK
310 320 330 340 350
ACFSANGEEV LATSTHSKVL YVYDMLAGKL IPVHQVRGLK EKIVRSFEVS
360 370 380 390 400
PDGSFLLING IAGYLHLLAM KTKELIGSMK INGRVAASTF SSDSKKVYAS
410 420 430 440 450
SGDGEVYVWD VNSRKCLNRF VDEGSLYGLS IATSRNGQYV ACGSNCGVVN
460 470 480 490 500
IYNQDSCLQE TNPKPIKAIM NLVTGVTSLT FNPTTEILAI ASEKMKEAVR
510 520 530 540 550
LVHLPSCTVF SNFPVIKNKN ISHVHTMDFS PRSGYFALGN EKGKALMYRL

HHYSDF
Length:556
Mass (Da):62,004
Last modified:August 30, 2005 - v3
Checksum:i800139F974F4EDF6
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QR85J3QR85_HUMAN
U3 small nucleolar RNA-associated p...
UTP18
143Annotation score:
J3KSR7J3KSR7_HUMAN
U3 small nucleolar RNA-associated p...
UTP18
177Annotation score:
J3QRG0J3QRG0_HUMAN
U3 small nucleolar RNA-associated p...
UTP18
123Annotation score:
J3QLD6J3QLD6_HUMAN
U3 small nucleolar RNA-associated p...
UTP18
115Annotation score:
F6VJE8F6VJE8_HUMAN
U3 small nucleolar RNA-associated p...
UTP18
43Annotation score:

Sequence cautioni

The sequence AAD34043 differs from that shown. Reason: Frameshift at position 19.Curated
The sequence AAG01999 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti543 – 556GKALM…HYSDF → ARP in AAD34043 (PubMed:10810093).CuratedAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151806 mRNA Translation: AAD34043.1 Frameshift.
BC025276 mRNA Translation: AAH25276.2
AY007138 mRNA Translation: AAG01999.1 Different initiation.
CCDSiCCDS42362.1
RefSeqiNP_057085.2, NM_016001.2
UniGeneiHs.709327

Genome annotation databases

EnsembliENST00000225298; ENSP00000225298; ENSG00000011260
GeneIDi51096
KEGGihsa:51096
UCSCiuc002its.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151806 mRNA Translation: AAD34043.1 Frameshift.
BC025276 mRNA Translation: AAH25276.2
AY007138 mRNA Translation: AAG01999.1 Different initiation.
CCDSiCCDS42362.1
RefSeqiNP_057085.2, NM_016001.2
UniGeneiHs.709327

3D structure databases

ProteinModelPortaliQ9Y5J1
SMRiQ9Y5J1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119285, 30 interactors
IntActiQ9Y5J1, 17 interactors
MINTiQ9Y5J1
STRINGi9606.ENSP00000225298

PTM databases

iPTMnetiQ9Y5J1
PhosphoSitePlusiQ9Y5J1

Polymorphism and mutation databases

BioMutaiUTP18
DMDMi73920973

2D gel databases

SWISS-2DPAGEiQ9Y5J1

Proteomic databases

EPDiQ9Y5J1
MaxQBiQ9Y5J1
PaxDbiQ9Y5J1
PeptideAtlasiQ9Y5J1
PRIDEiQ9Y5J1
ProteomicsDBi86417

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000225298; ENSP00000225298; ENSG00000011260
GeneIDi51096
KEGGihsa:51096
UCSCiuc002its.4 human

Organism-specific databases

CTDi51096
DisGeNETi51096
EuPathDBiHostDB:ENSG00000011260.13
GeneCardsiUTP18
HGNCiHGNC:24274 UTP18
HPAiHPA052378
MIMi612816 gene
neXtProtiNX_Q9Y5J1
OpenTargetsiENSG00000011260
PharmGKBiPA134984104
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2055 Eukaryota
ENOG410YBWP LUCA
GeneTreeiENSGT00440000033919
HOGENOMiHOG000242429
HOVERGENiHBG082494
InParanoidiQ9Y5J1
KOiK14553
OMAiQFHPTST
OrthoDBiEOG091G0BJP
PhylomeDBiQ9Y5J1
TreeFamiTF313426

Enzyme and pathway databases

ReactomeiR-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

ChiTaRSiUTP18 human
GeneWikiiUTP18
GenomeRNAii51096
PMAP-CutDBiQ9Y5J1
PROiPR:Q9Y5J1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000011260 Expressed in 231 organ(s), highest expression level in testis
CleanExiHS_UTP18
ExpressionAtlasiQ9Y5J1 baseline and differential
GenevisibleiQ9Y5J1 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUTP18_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5J1
Secondary accession number(s): Q9H4N6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: August 30, 2005
Last modified: November 7, 2018
This is version 174 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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