UniProtKB - Q9Y5J1 (UTP18_HUMAN)
Protein
U3 small nucleolar RNA-associated protein 18 homolog
Gene
UTP18
Organism
Homo sapiens (Human)
Status
Functioni
Involved in nucleolar processing of pre-18S ribosomal RNA.By similarity
GO - Molecular functioni
- RNA binding Source: UniProtKB
GO - Biological processi
- rRNA processing Source: Reactome
Keywordsi
Biological process | rRNA processing |
Enzyme and pathway databases
PathwayCommonsi | Q9Y5J1 |
Reactomei | R-HSA-6790901, rRNA modification in the nucleus and cytosol R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
Names & Taxonomyi
Protein namesi | Recommended name: U3 small nucleolar RNA-associated protein 18 homologAlternative name(s): WD repeat-containing protein 50 |
Gene namesi | Name:UTP18 Synonyms:WDR50 ORF Names:CDABP0061, CGI-48 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24274, UTP18 |
MIMi | 612816, gene |
neXtProti | NX_Q9Y5J1 |
VEuPathDBi | HostDB:ENSG00000011260.13 |
Subcellular locationi
Nucleus
- nucleolus 1 Publication
Nucleus
- nuclear membrane Source: HPA
- nucleolus Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
- Pwp2p-containing subcomplex of 90S preribosome Source: GO_Central
Other locations
- small-subunit processome Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 51096 |
OpenTargetsi | ENSG00000011260 |
PharmGKBi | PA134984104 |
Miscellaneous databases
Pharosi | Q9Y5J1, Tdark |
Genetic variation databases
BioMutai | UTP18 |
DMDMi | 73920973 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051405 | 1 – 556 | U3 small nucleolar RNA-associated protein 18 homologAdd BLAST | 556 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 84 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 121 | PhosphoserineCombined sources | 1 | |
Modified residuei | 124 | PhosphoserineCombined sources | 1 | |
Cross-linki | 183 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 201 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 204 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 205 | PhosphoserineCombined sources | 1 | |
Modified residuei | 206 | PhosphoserineCombined sources | 1 | |
Modified residuei | 210 | PhosphoserineCombined sources | 1 | |
Modified residuei | 221 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 517 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9Y5J1 |
jPOSTi | Q9Y5J1 |
MassIVEi | Q9Y5J1 |
MaxQBi | Q9Y5J1 |
PaxDbi | Q9Y5J1 |
PeptideAtlasi | Q9Y5J1 |
PRIDEi | Q9Y5J1 |
ProteomicsDBi | 86417 |
2D gel databases
SWISS-2DPAGEi | Q9Y5J1 |
PTM databases
iPTMneti | Q9Y5J1 |
PhosphoSitePlusi | Q9Y5J1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000011260, Expressed in testis and 243 other tissues |
ExpressionAtlasi | Q9Y5J1, baseline and differential |
Genevisiblei | Q9Y5J1, HS |
Organism-specific databases
HPAi | ENSG00000011260, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 119285, 49 interactors |
IntActi | Q9Y5J1, 26 interactors |
MINTi | Q9Y5J1 |
STRINGi | 9606.ENSP00000225298 |
Miscellaneous databases
RNActi | Q9Y5J1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 249 – 288 | WD 1Add BLAST | 40 | |
Repeati | 293 – 333 | WD 2Add BLAST | 41 | |
Repeati | 339 – 380 | WD 3Add BLAST | 42 | |
Repeati | 381 – 419 | WD 4Add BLAST | 39 | |
Repeati | 421 – 462 | WD 5Add BLAST | 42 | |
Repeati | 471 – 512 | WD 6Add BLAST | 42 |
Sequence similaritiesi
Belongs to the WD repeat UTP18 family.Curated
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG2055, Eukaryota |
GeneTreei | ENSGT00440000033919 |
HOGENOMi | CLU_011055_3_1_1 |
InParanoidi | Q9Y5J1 |
OMAi | QFHPTST |
OrthoDBi | 462558at2759 |
PhylomeDBi | Q9Y5J1 |
TreeFami | TF313426 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
SMARTi | View protein in SMART SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 1 hit PS50082, WD_REPEATS_2, 1 hit PS50294, WD_REPEATS_REGION, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
Q9Y5J1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPPERRRRMK LDRRTGAKPK RKPGMRPDWK AGAGPGGPPQ KPAPSSQRKP
60 70 80 90 100
PARPSAAAAA IAVAAAEEER RLRQRNRLRL EEDKPAVERC LEELVFGDVE
110 120 130 140 150
NDEDALLRRL RGPRVQEHED SGDSEVENEA KGNFPPQKKP VWVDEEDEDE
160 170 180 190 200
EMVDMMNNRF RKDMMKNASE SKLSKDNLKK RLKEEFQHAM GGVPAWAETT
210 220 230 240 250
KRKTSSDDES EEDEDDLLQR TGNFISTSTS LPRGILKMKN CQHANAERPT
260 270 280 290 300
VARISSVQFH PGAQIVMVAG LDNAVSLFQV DGKTNPKIQS IYLERFPIFK
310 320 330 340 350
ACFSANGEEV LATSTHSKVL YVYDMLAGKL IPVHQVRGLK EKIVRSFEVS
360 370 380 390 400
PDGSFLLING IAGYLHLLAM KTKELIGSMK INGRVAASTF SSDSKKVYAS
410 420 430 440 450
SGDGEVYVWD VNSRKCLNRF VDEGSLYGLS IATSRNGQYV ACGSNCGVVN
460 470 480 490 500
IYNQDSCLQE TNPKPIKAIM NLVTGVTSLT FNPTTEILAI ASEKMKEAVR
510 520 530 540 550
LVHLPSCTVF SNFPVIKNKN ISHVHTMDFS PRSGYFALGN EKGKALMYRL
HHYSDF
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3QR85 | J3QR85_HUMAN | U3 small nucleolar RNA-associated p... | UTP18 | 143 | Annotation score: | ||
J3KSR7 | J3KSR7_HUMAN | U3 small nucleolar RNA-associated p... | UTP18 | 177 | Annotation score: | ||
J3QRG0 | J3QRG0_HUMAN | U3 small nucleolar RNA-associated p... | UTP18 | 123 | Annotation score: | ||
J3QLD6 | J3QLD6_HUMAN | U3 small nucleolar RNA-associated p... | UTP18 | 115 | Annotation score: | ||
F6VJE8 | F6VJE8_HUMAN | U3 small nucleolar RNA-associated p... | UTP18 | 43 | Annotation score: |
Sequence cautioni
The sequence AAD34043 differs from that shown. Reason: Frameshift.Curated
The sequence AAG01999 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 543 – 556 | GKALM…HYSDF → ARP in AAD34043 (PubMed:10810093).CuratedAdd BLAST | 14 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF151806 mRNA Translation: AAD34043.1 Frameshift. BC025276 mRNA Translation: AAH25276.2 AY007138 mRNA Translation: AAG01999.1 Different initiation. |
CCDSi | CCDS42362.1 |
RefSeqi | NP_057085.2, NM_016001.2 |
Genome annotation databases
Ensembli | ENST00000225298; ENSP00000225298; ENSG00000011260 |
GeneIDi | 51096 |
KEGGi | hsa:51096 |
UCSCi | uc002its.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF151806 mRNA Translation: AAD34043.1 Frameshift. BC025276 mRNA Translation: AAH25276.2 AY007138 mRNA Translation: AAG01999.1 Different initiation. |
CCDSi | CCDS42362.1 |
RefSeqi | NP_057085.2, NM_016001.2 |
3D structure databases
SMRi | Q9Y5J1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119285, 49 interactors |
IntActi | Q9Y5J1, 26 interactors |
MINTi | Q9Y5J1 |
STRINGi | 9606.ENSP00000225298 |
PTM databases
iPTMneti | Q9Y5J1 |
PhosphoSitePlusi | Q9Y5J1 |
Genetic variation databases
BioMutai | UTP18 |
DMDMi | 73920973 |
2D gel databases
SWISS-2DPAGEi | Q9Y5J1 |
Proteomic databases
EPDi | Q9Y5J1 |
jPOSTi | Q9Y5J1 |
MassIVEi | Q9Y5J1 |
MaxQBi | Q9Y5J1 |
PaxDbi | Q9Y5J1 |
PeptideAtlasi | Q9Y5J1 |
PRIDEi | Q9Y5J1 |
ProteomicsDBi | 86417 |
Protocols and materials databases
Antibodypediai | 30799, 65 antibodies |
Genome annotation databases
Ensembli | ENST00000225298; ENSP00000225298; ENSG00000011260 |
GeneIDi | 51096 |
KEGGi | hsa:51096 |
UCSCi | uc002its.4, human |
Organism-specific databases
CTDi | 51096 |
DisGeNETi | 51096 |
GeneCardsi | UTP18 |
HGNCi | HGNC:24274, UTP18 |
HPAi | ENSG00000011260, Low tissue specificity |
MIMi | 612816, gene |
neXtProti | NX_Q9Y5J1 |
OpenTargetsi | ENSG00000011260 |
PharmGKBi | PA134984104 |
VEuPathDBi | HostDB:ENSG00000011260.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2055, Eukaryota |
GeneTreei | ENSGT00440000033919 |
HOGENOMi | CLU_011055_3_1_1 |
InParanoidi | Q9Y5J1 |
OMAi | QFHPTST |
OrthoDBi | 462558at2759 |
PhylomeDBi | Q9Y5J1 |
TreeFami | TF313426 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y5J1 |
Reactomei | R-HSA-6790901, rRNA modification in the nucleus and cytosol R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
Miscellaneous databases
BioGRID-ORCSi | 51096, 613 hits in 886 CRISPR screens |
ChiTaRSi | UTP18, human |
GeneWikii | UTP18 |
GenomeRNAii | 51096 |
Pharosi | Q9Y5J1, Tdark |
PROi | PR:Q9Y5J1 |
RNActi | Q9Y5J1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000011260, Expressed in testis and 243 other tissues |
ExpressionAtlasi | Q9Y5J1, baseline and differential |
Genevisiblei | Q9Y5J1, HS |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
SMARTi | View protein in SMART SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 1 hit PS50082, WD_REPEATS_2, 1 hit PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UTP18_HUMAN | |
Accessioni | Q9Y5J1Primary (citable) accession number: Q9Y5J1 Secondary accession number(s): Q9H4N6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 16, 2001 |
Last sequence update: | August 30, 2005 | |
Last modified: | February 10, 2021 | |
This is version 189 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM