UniProtKB - Q9Y5I4 (PCDC2_HUMAN)
Protocadherin alpha-C2
PCDHAC2
Functioni
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
GO - Molecular functioni
- calcium ion binding Source: InterPro
GO - Biological processi
- cell adhesion Source: GO_Central
- homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
- nervous system development Source: ProtInc
Keywordsi
Biological process | Cell adhesion |
Ligand | Calcium |
Enzyme and pathway databases
PathwayCommonsi | Q9Y5I4 |
SignaLinki | Q9Y5I4 |
Names & Taxonomyi
Protein namesi | Recommended name: Protocadherin alpha-C2Short name: PCDH-alpha-C2 |
Gene namesi | Name:PCDHAC2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8677, PCDHAC2 |
MIMi | 604966, gene 606321, gene |
neXtProti | NX_Q9Y5I4 |
VEuPathDBi | HostDB:ENSG00000243232 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein By similarity
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 43 – 708 | ExtracellularSequence analysisAdd BLAST | 666 | |
Transmembranei | 709 – 729 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 730 – 1007 | CytoplasmicSequence analysisAdd BLAST | 278 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 56134 |
OpenTargetsi | ENSG00000243232 |
PharmGKBi | PA33023 |
Miscellaneous databases
Pharosi | Q9Y5I4, Tdark |
Genetic variation databases
BioMutai | PCDHAC2 |
DMDMi | 13878435 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 42 | Sequence analysisAdd BLAST | 42 | |
ChainiPRO_0000003912 | 43 – 1007 | Protocadherin alpha-C2Add BLAST | 965 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 280 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 436 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 586 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 657 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | Q9Y5I4 |
MassIVEi | Q9Y5I4 |
PaxDbi | Q9Y5I4 |
PeptideAtlasi | Q9Y5I4 |
PRIDEi | Q9Y5I4 |
ProteomicsDBi | 86414 [Q9Y5I4-1] 86415 [Q9Y5I4-2] |
TopDownProteomicsi | Q9Y5I4-2 [Q9Y5I4-2] |
PTM databases
GlyGeni | Q9Y5I4, 4 sites |
iPTMneti | Q9Y5I4 |
PhosphoSitePlusi | Q9Y5I4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000243232, Expressed in cerebellum and 119 other tissues |
Genevisiblei | Q9Y5I4, HS |
Organism-specific databases
HPAi | ENSG00000243232, Tissue enriched (parathyroid) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 121074, 99 interactors |
IntActi | Q9Y5I4, 37 interactors |
STRINGi | 9606.ENSP00000289269 |
Miscellaneous databases
RNActi | Q9Y5I4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 43 – 148 | Cadherin 1PROSITE-ProRule annotationAdd BLAST | 106 | |
Domaini | 149 – 257 | Cadherin 2PROSITE-ProRule annotationAdd BLAST | 109 | |
Domaini | 258 – 365 | Cadherin 3PROSITE-ProRule annotationAdd BLAST | 108 | |
Domaini | 374 – 469 | Cadherin 4PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 470 – 579 | Cadherin 5PROSITE-ProRule annotationAdd BLAST | 110 | |
Domaini | 594 – 691 | Cadherin 6PROSITE-ProRule annotationAdd BLAST | 98 | |
Repeati | 856 – 859 | PXXP 1 | 4 | |
Repeati | 889 – 892 | PXXP 2 | 4 | |
Repeati | 930 – 933 | PXXP 3 | 4 | |
Repeati | 948 – 951 | PXXP 4 | 4 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 856 – 951 | 4 X 4 AA repeats of P-X-X-PAdd BLAST | 96 | |
Regioni | 885 – 1007 | DisorderedSequence analysisAdd BLAST | 123 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 916 – 930 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 955 – 969 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 992 – 1007 | Basic and acidic residuesSequence analysisAdd BLAST | 16 |
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3594, Eukaryota |
GeneTreei | ENSGT00940000160554 |
HOGENOMi | CLU_006480_0_0_1 |
InParanoidi | Q9Y5I4 |
OMAi | AGICNWI |
OrthoDBi | 64478at2759 |
PhylomeDBi | Q9Y5I4 |
TreeFami | TF332299 |
Family and domain databases
InterProi | View protein in InterPro IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR032455, Cadherin_C IPR031904, Cadherin_CBD IPR020894, Cadherin_CS IPR013164, Cadherin_N IPR030726, PCDHAC2 |
PANTHERi | PTHR24028:SF119, PTHR24028:SF119, 1 hit |
Pfami | View protein in Pfam PF00028, Cadherin, 5 hits PF08266, Cadherin_2, 1 hit PF16492, Cadherin_C_2, 1 hit PF15974, Cadherin_tail, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 6 hits |
SUPFAMi | SSF49313, SSF49313, 6 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 5 hits PS50268, CADHERIN_2, 6 hits |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEQAGTRPAA TEHPRLRRPM PWLLLLPLLL LLLLLLPGPA ASQLRYSVPE
60 70 80 90 100
EQAPGALVGN VARALGLELR RLGPGCLRIN HLGAPSPRYL ELDLTSGALF
110 120 130 140 150
VNERIDREAL CEQRPRCLLS LEVLAHNPVA VSAVEVEILD INDNSPRFPR
160 170 180 190 200
PNYQLQVSES VAPGARFHIE SAQDPDVGAN SVQTYELSPS EHFELDLKPL
210 220 230 240 250
QENSKVLELV LRKGLDREQA ALHHLVLTAV DGGIPARSGT AQISVRVLDT
260 270 280 290 300
NDNSPAFDQS TYRVQLREDS PPGTLVVKLN ASDPDEGSNG ELRYSLSSYT
310 320 330 340 350
SDRERQLFSI DASTGEVRVI GGLDYEEASS YQIYVQATDR GPVPMAGHCK
360 370 380 390 400
VLVDIVDVND NAPEVVLTDL YSPVPENATP NTIVAVLSVN DQDSGPNRKV
410 420 430 440 450
SLGLEATLPF RLNGFGNSYT LVVSGPLDRE RVAVYNITVT ATDGGIPQLT
460 470 480 490 500
SLRTLKVEIS DINDNPPSFL EDSYSIYIQE NNLPGVLLCT VQATDPDEKE
510 520 530 540 550
NAEVTYSLLE REIQGLPVTS YVSINSASGS LYAVNSFDYE KFREFFVTVE
560 570 580 590 600
AQDKGSPPLS STVTANVYVV DMNDHAPHIL YPTSTNSSAA FEMVPRTAPA
610 620 630 640 650
GYLVTKVIAM DSDSGQNAWL FYHLAQTSDL DLFKVELHTG EIRTTRKMGD
660 670 680 690 700
ESGSTFNLTV VVRDNGEPSL SASVAITVAV VDRVSKILPD TQRHVKSPRT
710 720 730 740 750
YSEITLYLII ALSTVSFIFL LTIIILSIIK CYRYTAYGTA CCGGFCGVRE
760 770 780 790 800
RSPAELYKQA NNNIDARIPH GLKVQPHFIE VRGNGSLTKT YCYKACLTAG
810 820 830 840 850
SGSDTFMFYN TGAQTGPGPS GAQAAVTDSR NLTGQSGQNA GNLIILKNEA
860 870 880 890 900
VSQNEPRQPN PDWRYSASLR AGMHSSVHLE EAGILRAGPG GPDQQWPTVS
910 920 930 940 950
SATPEPEAGE VSPPVGAGVN SNSWTFKYGP GNPKQSGPGE LPDKFIIPGS
960 970 980 990 1000
PAIISIRQEP TNSQIDKSDF ITFGKKEETK KKKKKKKGNK TQEKKEKGNS
TTDNSDQ
The sequence of this isoform differs from the canonical sequence as follows:
856-884: PRQPNPDWRYSASLRAGMHSSVHLEEAGI → VRQWSGGLLQTHAFVTHPPISCDLALLSH
885-1007: Missing.
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_000701 | 856 – 884 | PRQPN…EEAGI → VRQWSGGLLQTHAFVTHPPI SCDLALLSH in isoform Short. 2 PublicationsAdd BLAST | 29 | |
Alternative sequenceiVSP_000702 | 885 – 1007 | Missing in isoform Short. 2 PublicationsAdd BLAST | 123 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF152304 mRNA Translation: AAD43698.1 AF152474 mRNA Translation: AAD43735.1 CH471062 Genomic DNA Translation: EAW62000.1 BC104776 mRNA Translation: AAI04777.1 BC105111 mRNA Translation: AAI05112.1 |
CCDSi | CCDS4242.1 [Q9Y5I4-1] |
RefSeqi | NP_061722.1, NM_018899.5 [Q9Y5I4-1] NP_114089.1, NM_031883.2 [Q9Y5I4-2] |
Genome annotation databases
Ensembli | ENST00000289269.7; ENSP00000289269.5; ENSG00000243232.6 ENST00000615316.1; ENSP00000478629.1; ENSG00000243232.6 [Q9Y5I4-2] |
GeneIDi | 56134 |
KEGGi | hsa:56134 |
MANE-Selecti | ENST00000289269.7; ENSP00000289269.5; NM_018899.6; NP_061722.1 |
UCSCi | uc003lii.4, human [Q9Y5I4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF152304 mRNA Translation: AAD43698.1 AF152474 mRNA Translation: AAD43735.1 CH471062 Genomic DNA Translation: EAW62000.1 BC104776 mRNA Translation: AAI04777.1 BC105111 mRNA Translation: AAI05112.1 |
CCDSi | CCDS4242.1 [Q9Y5I4-1] |
RefSeqi | NP_061722.1, NM_018899.5 [Q9Y5I4-1] NP_114089.1, NM_031883.2 [Q9Y5I4-2] |
3D structure databases
AlphaFoldDBi | Q9Y5I4 |
SMRi | Q9Y5I4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121074, 99 interactors |
IntActi | Q9Y5I4, 37 interactors |
STRINGi | 9606.ENSP00000289269 |
PTM databases
GlyGeni | Q9Y5I4, 4 sites |
iPTMneti | Q9Y5I4 |
PhosphoSitePlusi | Q9Y5I4 |
Genetic variation databases
BioMutai | PCDHAC2 |
DMDMi | 13878435 |
Proteomic databases
EPDi | Q9Y5I4 |
MassIVEi | Q9Y5I4 |
PaxDbi | Q9Y5I4 |
PeptideAtlasi | Q9Y5I4 |
PRIDEi | Q9Y5I4 |
ProteomicsDBi | 86414 [Q9Y5I4-1] 86415 [Q9Y5I4-2] |
TopDownProteomicsi | Q9Y5I4-2 [Q9Y5I4-2] |
Protocols and materials databases
Antibodypediai | 35019, 160 antibodies from 23 providers |
DNASUi | 56134 |
Genome annotation databases
Ensembli | ENST00000289269.7; ENSP00000289269.5; ENSG00000243232.6 ENST00000615316.1; ENSP00000478629.1; ENSG00000243232.6 [Q9Y5I4-2] |
GeneIDi | 56134 |
KEGGi | hsa:56134 |
MANE-Selecti | ENST00000289269.7; ENSP00000289269.5; NM_018899.6; NP_061722.1 |
UCSCi | uc003lii.4, human [Q9Y5I4-1] |
Organism-specific databases
CTDi | 56134 |
DisGeNETi | 56134 |
GeneCardsi | PCDHAC2 |
HGNCi | HGNC:8677, PCDHAC2 |
HPAi | ENSG00000243232, Tissue enriched (parathyroid) |
MIMi | 604966, gene 606321, gene |
neXtProti | NX_Q9Y5I4 |
OpenTargetsi | ENSG00000243232 |
PharmGKBi | PA33023 |
VEuPathDBi | HostDB:ENSG00000243232 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3594, Eukaryota |
GeneTreei | ENSGT00940000160554 |
HOGENOMi | CLU_006480_0_0_1 |
InParanoidi | Q9Y5I4 |
OMAi | AGICNWI |
OrthoDBi | 64478at2759 |
PhylomeDBi | Q9Y5I4 |
TreeFami | TF332299 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y5I4 |
SignaLinki | Q9Y5I4 |
Miscellaneous databases
BioGRID-ORCSi | 56134, 9 hits in 1020 CRISPR screens |
GeneWikii | PCDHAC2 |
GenomeRNAii | 56134 |
Pharosi | Q9Y5I4, Tdark |
PROi | PR:Q9Y5I4 |
RNActi | Q9Y5I4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000243232, Expressed in cerebellum and 119 other tissues |
Genevisiblei | Q9Y5I4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR032455, Cadherin_C IPR031904, Cadherin_CBD IPR020894, Cadherin_CS IPR013164, Cadherin_N IPR030726, PCDHAC2 |
PANTHERi | PTHR24028:SF119, PTHR24028:SF119, 1 hit |
Pfami | View protein in Pfam PF00028, Cadherin, 5 hits PF08266, Cadherin_2, 1 hit PF16492, Cadherin_C_2, 1 hit PF15974, Cadherin_tail, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 6 hits |
SUPFAMi | SSF49313, SSF49313, 6 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 5 hits PS50268, CADHERIN_2, 6 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | PCDC2_HUMAN | |
Accessioni | Q9Y5I4Primary (citable) accession number: Q9Y5I4 Secondary accession number(s): Q2M3V1, Q9Y5F4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 27, 2001 |
Last sequence update: | November 1, 1999 | |
Last modified: | May 25, 2022 | |
This is version 171 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot