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Protein

Protocadherin alpha-11

Gene

PCDHA11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: GO_Central
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • nervous system development Source: ProtInc

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protocadherin alpha-11
Short name:
PCDH-alpha-11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PCDHA11
Synonyms:CNRS7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000249158.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8665 PCDHA11

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604966 gene
606317 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y5I1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini30 – 696ExtracellularSequence analysisAdd BLAST667
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei697 – 717HelicalSequence analysisAdd BLAST21
Topological domaini718 – 949CytoplasmicSequence analysisAdd BLAST232

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000249158

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33011

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PCDHA11

Domain mapping of disease mutations (DMDM)

More...
DMDMi
13878432

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 29Sequence analysisAdd BLAST29
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000390430 – 949Protocadherin alpha-11Add BLAST920

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi265N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi304N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi547N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y5I1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y5I1

PeptideAtlas

More...
PeptideAtlasi
Q9Y5I1

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y5I1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
86406
86407 [Q9Y5I1-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y5I1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y5I1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000249158 Expressed in 60 organ(s), highest expression level in temporal lobe

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y5I1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y5I1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA077160

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121078, 11 interactors

Protein interaction database and analysis system

More...
IntActi
Q9Y5I1, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000381636

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9Y5I1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y5I1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 133Cadherin 1PROSITE-ProRule annotationAdd BLAST104
Domaini157 – 242Cadherin 2PROSITE-ProRule annotationAdd BLAST86
Domaini243 – 349Cadherin 3PROSITE-ProRule annotationAdd BLAST107
Domaini350 – 454Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini455 – 564Cadherin 5PROSITE-ProRule annotationAdd BLAST110
Domaini580 – 677Cadherin 6PROSITE-ProRule annotationAdd BLAST98
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati733 – 736PXXP 14
Repeati773 – 776PXXP 24
Repeati795 – 798PXXP 34
Repeati831 – 834PXXP 44
Repeati872 – 875PXXP 54
Repeati890 – 893PXXP 64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni733 – 8936 X 4 AA repeats of P-X-X-PAdd BLAST161

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi922 – 929Poly-Lys8

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3594 Eukaryota
ENOG410XQHI LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000164882

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000220892

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG054878

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y5I1

KEGG Orthology (KO)

More...
KOi
K16493

Identification of Orthologs from Complete Genome Data

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OMAi
KIMSTFK

Database of Orthologous Groups

More...
OrthoDBi
EOG091G00KR

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y5I1

TreeFam database of animal gene trees

More...
TreeFami
TF332299

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR031904 Cadherin_CBD
IPR020894 Cadherin_CS
IPR013164 Cadherin_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00028 Cadherin, 5 hits
PF08266 Cadherin_2, 1 hit
PF15974 Cadherin_tail, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205 CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112 CA, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49313 SSF49313, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y5I1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFGFQRRGLG TPRLQLWLLL LEFWEVGSGQ LHYSVSEEAK HGTFVGRIAQ
60 70 80 90 100
DLGLELAELV QRLFRVASKT HGDLLEVNLQ NGILFVNSRI DREELCGQSA
110 120 130 140 150
ECSIHLEVIV DRPLQVFHVN VEVKDINDNP PVFSLREQKL LIAESKQSDS
160 170 180 190 200
RFPLEGASDA DIEENALLTY RLSKNEYFSL DSPTNGKQIK RLSLILKKSL
210 220 230 240 250
DREKTPELNL LLTATDGGKP ELTGTVRLLV QVLDVNDNDP EFDKSEYKVS
260 270 280 290 300
LMENAAKETL VLKLNATDRD EGVNGEVTYS LMSIKPNGRH LFTLDQNNGE
310 320 330 340 350
VRVNGTLDYE ENKFYKIEVQ ATDKGTPPMA GHCTVWVEIL DTNDNSPEVA
360 370 380 390 400
VTSLSLPVRE DAQPSTVIAL ISVSDRDSGV NGQVTCSLTP HVPFKLVSTF
410 420 430 440 450
KNYYSLVLDS ALDRENVWAY ELVVTARDGG SPSLWATARV SVEVADVNDN
460 470 480 490 500
APAFAQPEYT VFVKENNPPG CHIFTVSARD ADAQENALVS YSLVERRLGD
510 520 530 540 550
RALSSYVSVH AESGKVYALQ PLDHEELELL QFQVSARDAG VPPLSSNVTL
560 570 580 590 600
QVFVLDENDN APALLATQAG SAGGAVNKLV PRSVGAGHVV AKVRAVDADS
610 620 630 640 650
GYNAWLSYEL QPAAGGSRIP FRVGLYTGEI STTRALDEAD SPRHRLLVLV
660 670 680 690 700
KDHGEPALTA TATVLVSLVE SGQAPKASSR TLAGAASPEA ALVDVNVYLI
710 720 730 740 750
IAICVVSSLL VLTLLLYTAL WWSATPTEGA CAPGKPTLVC SRAVGSWSYS
760 770 780 790 800
QQRRQRVCSE EGPPKTDLMA FSPSLPLGLN KEEEGERQEP GSNHPGQPRQ
810 820 830 840 850
PNPDWRYSAS LRAGMHSSVH LEEAGILRAG PGGPDQQWPT VSSATPEPEA
860 870 880 890 900
GEVSPPVGAG VNSNSWTFKY GPGNPKQSGP GELPDKFIIP GSPAIISIRQ
910 920 930 940
EPTNSQIDKS DFITFGKKEE TKKKKKKKKG NKTQEKKEKG NSTTDNSDQ
Length:949
Mass (Da):103,298
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3063589B60A125CB
GO
Isoform 2 (identifier: Q9Y5I1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     798-810: PRQPNPDWRYSAS → VSFLQIPPIRKCM
     811-949: Missing.

Show »
Length:810
Mass (Da):88,392
Checksum:iC08A31F9A9A14D4A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WZ46A0A087WZ46_HUMAN
Protocadherin alpha-11
PCDHA11
199Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048538199S → Y. Corresponds to variant dbSNP:rs10071369Ensembl.1
Natural variantiVAR_048539418W → S. Corresponds to variant dbSNP:rs17119218Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_000693798 – 810PRQPN…RYSAS → VSFLQIPPIRKCM in isoform 2. 2 PublicationsAdd BLAST13
Alternative sequenceiVSP_000694811 – 949Missing in isoform 2. 2 PublicationsAdd BLAST139

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF152307 mRNA Translation: AAD43701.1
AF152476 mRNA Translation: AAD43737.1
AJ007609 mRNA Translation: CAC22256.1
AC005609 Genomic DNA Translation: AAC34316.1
CH471062 Genomic DNA Translation: EAW61995.1
BC136706 mRNA Translation: AAI36707.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47284.1 [Q9Y5I1-1]
CCDS75326.1 [Q9Y5I1-2]

NCBI Reference Sequences

More...
RefSeqi
NP_061725.1, NM_018902.4 [Q9Y5I1-1]
NP_114067.1, NM_031861.2 [Q9Y5I1-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.199343
Hs.624176
Hs.670031

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000398640; ENSP00000381636; ENSG00000249158 [Q9Y5I1-1]
ENST00000616325; ENSP00000482503; ENSG00000249158 [Q9Y5I1-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
56138

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:56138

UCSC genome browser

More...
UCSCi
uc003lia.4 human [Q9Y5I1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152307 mRNA Translation: AAD43701.1
AF152476 mRNA Translation: AAD43737.1
AJ007609 mRNA Translation: CAC22256.1
AC005609 Genomic DNA Translation: AAC34316.1
CH471062 Genomic DNA Translation: EAW61995.1
BC136706 mRNA Translation: AAI36707.1
CCDSiCCDS47284.1 [Q9Y5I1-1]
CCDS75326.1 [Q9Y5I1-2]
RefSeqiNP_061725.1, NM_018902.4 [Q9Y5I1-1]
NP_114067.1, NM_031861.2 [Q9Y5I1-2]
UniGeneiHs.199343
Hs.624176
Hs.670031

3D structure databases

ProteinModelPortaliQ9Y5I1
SMRiQ9Y5I1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121078, 11 interactors
IntActiQ9Y5I1, 1 interactor
STRINGi9606.ENSP00000381636

PTM databases

iPTMnetiQ9Y5I1
PhosphoSitePlusiQ9Y5I1

Polymorphism and mutation databases

BioMutaiPCDHA11
DMDMi13878432

Proteomic databases

EPDiQ9Y5I1
PaxDbiQ9Y5I1
PeptideAtlasiQ9Y5I1
PRIDEiQ9Y5I1
ProteomicsDBi86406
86407 [Q9Y5I1-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398640; ENSP00000381636; ENSG00000249158 [Q9Y5I1-1]
ENST00000616325; ENSP00000482503; ENSG00000249158 [Q9Y5I1-2]
GeneIDi56138
KEGGihsa:56138
UCSCiuc003lia.4 human [Q9Y5I1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
56138
EuPathDBiHostDB:ENSG00000249158.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PCDHA11

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0032477
HGNCiHGNC:8665 PCDHA11
HPAiHPA077160
MIMi604966 gene
606317 gene
neXtProtiNX_Q9Y5I1
OpenTargetsiENSG00000249158
PharmGKBiPA33011

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00940000164882
HOGENOMiHOG000220892
HOVERGENiHBG054878
InParanoidiQ9Y5I1
KOiK16493
OMAiKIMSTFK
OrthoDBiEOG091G00KR
PhylomeDBiQ9Y5I1
TreeFamiTF332299

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
56138

Protein Ontology

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PROi
PR:Q9Y5I1

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000249158 Expressed in 60 organ(s), highest expression level in temporal lobe
ExpressionAtlasiQ9Y5I1 baseline and differential
GenevisibleiQ9Y5I1 HS

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR031904 Cadherin_CBD
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF08266 Cadherin_2, 1 hit
PF15974 Cadherin_tail, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPCDAB_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y5I1
Secondary accession number(s): B2RN58, O75279
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: December 5, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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