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Protein

Protocadherin alpha-2

Gene

PCDHA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: GO_Central
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • nervous system development Source: ProtInc

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protocadherin alpha-2
Short name:
PCDH-alpha-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PCDHA2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000204969.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8668 PCDHA2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604966 gene
606308 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y5H9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini23 – 697ExtracellularSequence analysisAdd BLAST675
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei698 – 718HelicalSequence analysisAdd BLAST21
Topological domaini719 – 948CytoplasmicSequence analysisAdd BLAST230

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000204969

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33014

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PCDHA2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
13878430

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 221 PublicationAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000388623 – 948Protocadherin alpha-2Add BLAST926

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi257N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi265N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi362N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi548N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y5H9

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9Y5H9

PeptideAtlas

More...
PeptideAtlasi
Q9Y5H9

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y5H9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
86401
86402 [Q9Y5H9-2]
86403 [Q9Y5H9-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y5H9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y5H9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000204969 Expressed in 51 organ(s), highest expression level in cerebellar hemisphere

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9Y5H9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA035653

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121086, 11 interactors

Protein interaction database and analysis system

More...
IntActi
Q9Y5H9, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000431748

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9Y5H9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y5H9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 133Cadherin 1PROSITE-ProRule annotationAdd BLAST104
Domaini157 – 242Cadherin 2PROSITE-ProRule annotationAdd BLAST86
Domaini243 – 350Cadherin 3PROSITE-ProRule annotationAdd BLAST108
Domaini351 – 455Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini456 – 565Cadherin 5PROSITE-ProRule annotationAdd BLAST110
Domaini588 – 678Cadherin 6PROSITE-ProRule annotationAdd BLAST91
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati734 – 737PXXP 14
Repeati797 – 800PXXP 24
Repeati830 – 833PXXP 34
Repeati871 – 874PXXP 44
Repeati889 – 892PXXP 54

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni734 – 8925 X 4 AA repeats of P-X-X-PAdd BLAST159

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi921 – 928Poly-Lys8

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3594 Eukaryota
ENOG410XQHI LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000164747

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000220892

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG054878

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9Y5H9

KEGG Orthology (KO)

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KOi
K16493

Identification of Orthologs from Complete Genome Data

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OMAi
TIRFHES

Database of Orthologous Groups

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OrthoDBi
EOG091G00KR

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y5H9

TreeFam database of animal gene trees

More...
TreeFami
TF332299

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR031904 Cadherin_CBD
IPR020894 Cadherin_CS
IPR013164 Cadherin_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00028 Cadherin, 5 hits
PF08266 Cadherin_2, 1 hit
PF15974 Cadherin_tail, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205 CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00112 CA, 6 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF49313 SSF49313, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9Y5H9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASSIRRGRG AWTRLLSLLL LAAWEVGSGQ LRYSVPEEAK HGTFVGRIAQ
60 70 80 90 100
DLGLELEELV PRLFRVASKR HGDLLEVNLQ NGILFVNSRI DREELCGRSA
110 120 130 140 150
ECSIHVEVIV DRPLQVFHVE VEVKDINDNP PIFPMTVKTI RFPESRLLDS
160 170 180 190 200
RFPLEGASDA DIGVNALLSY KLSSSEFFFL DIQANDELSE SLSLVLGKSL
210 220 230 240 250
DREETAEVNL LLVATDGGKP ELTGTVQILI KVLDVNDNEP TFAQSVYKVK
260 270 280 290 300
LLENTANGTL VVKLNASDAD EGPNSEIVYS LGSDVSSTIQ TKFTIDPISG
310 320 330 340 350
EIRTKGKLDY EEAKSYEIQV TATDKGTPSM SGHCKISLKL VDINDNTPEV
360 370 380 390 400
SITSLSLPIS ENASLGTVIA LITVSDRDSG TNGHVTCSLT PHVPFKLVST
410 420 430 440 450
FKNYYSLVLD SALDRESVSA YELVVTARDG GSPSLWATTS VSIEVADVND
460 470 480 490 500
NAPAFAQPEY TVFVKENNPP GCHIFTVSAW DADAQENALV SYSLVERRVG
510 520 530 540 550
ERALSSYVSV HAESGKVYAL QPLDHEEVEL LQFQVSARDA GVPPLGSNVT
560 570 580 590 600
LQVFVLDEND NAPALLAPRA GTAAGAVSEL VPWSVGAGHV VAKVRAVDAD
610 620 630 640 650
SGYNAWLSYE LQLGTGSARI PFRVGLYTGE ISTTRALDEA DSPRHRLLVL
660 670 680 690 700
VKDHGEPALT ATATVLVSLV ESGQAPKASS RAWVGAAGSE ATLVDVNVYL
710 720 730 740 750
IIAICAVSSL LVLTVLLYTA LRCSVPPTEG ARAPGKPTLV CSSAVGSWSY
760 770 780 790 800
SQQRRQRVCS GEDPPKTDLM AFSPSLSQGP DSAEEKQLSE SEYVGKPRQP
810 820 830 840 850
NPDWRYSASL RAGMHSSVHL EEAGILRAGP GGPDQQWPTV SSATPEPEAG
860 870 880 890 900
EVSPPVGAGV NSNSWTFKYG PGNPKQSGPG ELPDKFIIPG SPAIISIRQE
910 920 930 940
PTNSQIDKSD FITFGKKEET KKKKKKKKGN KTQEKKEKGN STTDNSDQ
Length:948
Mass (Da):102,063
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8D2E9644982AE59E
GO
Isoform 2 (identifier: Q9Y5H9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     797-824: PRQPNPDWRYSASLRAGMHSSVHLEEAG → VSLLLFLANSKIVLFKKFYMISTSYLDS
     825-948: Missing.

Show »
Length:824
Mass (Da):88,867
Checksum:iDF8CEA0DE1ACA25D
GO
Isoform 3 (identifier: Q9Y5H9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     797-808: PRQPNPDWRYSA → IWNFNLQIQLAS
     809-948: Missing.

Note: No experimental confirmation available.
Show »
Length:808
Mass (Da):87,071
Checksum:iD24E04FEE1207EA1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05917925E → K. Corresponds to variant dbSNP:rs9686540Ensembl.1
Natural variantiVAR_024389106V → L. Corresponds to variant dbSNP:rs11167600Ensembl.1
Natural variantiVAR_048523764P → L. Corresponds to variant dbSNP:rs6858913Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_000673797 – 824PRQPN…LEEAG → VSLLLFLANSKIVLFKKFYM ISTSYLDS in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_008040797 – 808PRQPN…WRYSA → IWNFNLQIQLAS in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_008041809 – 948Missing in isoform 3. 1 PublicationAdd BLAST140
Alternative sequenceiVSP_000674825 – 948Missing in isoform 2. 1 PublicationAdd BLAST124

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF152310 mRNA Translation: AAD43704.1
AF152480 mRNA Translation: AAD43741.1
AC005609 Genomic DNA Translation: AAC34324.1
BC003126 mRNA Translation: AAH03126.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS54914.1 [Q9Y5H9-1]
CCDS64269.1 [Q9Y5H9-3]

NCBI Reference Sequences

More...
RefSeqi
NP_061728.1, NM_018905.2 [Q9Y5H9-1]
NP_113683.1, NM_031495.1 [Q9Y5H9-2]
NP_113684.1, NM_031496.1 [Q9Y5H9-3]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.199343

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000378132; ENSP00000367372; ENSG00000204969 [Q9Y5H9-2]
ENST00000520672; ENSP00000430584; ENSG00000204969 [Q9Y5H9-3]
ENST00000526136; ENSP00000431748; ENSG00000204969 [Q9Y5H9-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
56146

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:56146

UCSC genome browser

More...
UCSCi
uc003lhc.2 human [Q9Y5H9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152310 mRNA Translation: AAD43704.1
AF152480 mRNA Translation: AAD43741.1
AC005609 Genomic DNA Translation: AAC34324.1
BC003126 mRNA Translation: AAH03126.1
CCDSiCCDS54914.1 [Q9Y5H9-1]
CCDS64269.1 [Q9Y5H9-3]
RefSeqiNP_061728.1, NM_018905.2 [Q9Y5H9-1]
NP_113683.1, NM_031495.1 [Q9Y5H9-2]
NP_113684.1, NM_031496.1 [Q9Y5H9-3]
UniGeneiHs.199343

3D structure databases

ProteinModelPortaliQ9Y5H9
SMRiQ9Y5H9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121086, 11 interactors
IntActiQ9Y5H9, 1 interactor
STRINGi9606.ENSP00000431748

PTM databases

iPTMnetiQ9Y5H9
PhosphoSitePlusiQ9Y5H9

Polymorphism and mutation databases

BioMutaiPCDHA2
DMDMi13878430

Proteomic databases

EPDiQ9Y5H9
PaxDbiQ9Y5H9
PeptideAtlasiQ9Y5H9
PRIDEiQ9Y5H9
ProteomicsDBi86401
86402 [Q9Y5H9-2]
86403 [Q9Y5H9-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378132; ENSP00000367372; ENSG00000204969 [Q9Y5H9-2]
ENST00000520672; ENSP00000430584; ENSG00000204969 [Q9Y5H9-3]
ENST00000526136; ENSP00000431748; ENSG00000204969 [Q9Y5H9-1]
GeneIDi56146
KEGGihsa:56146
UCSCiuc003lhc.2 human [Q9Y5H9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
56146
EuPathDBiHostDB:ENSG00000204969.6

GeneCards: human genes, protein and diseases

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GeneCardsi
PCDHA2
HGNCiHGNC:8668 PCDHA2
HPAiHPA035653
MIMi604966 gene
606308 gene
neXtProtiNX_Q9Y5H9
OpenTargetsiENSG00000204969
PharmGKBiPA33014

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00940000164747
HOGENOMiHOG000220892
HOVERGENiHBG054878
InParanoidiQ9Y5H9
KOiK16493
OMAiTIRFHES
OrthoDBiEOG091G00KR
PhylomeDBiQ9Y5H9
TreeFamiTF332299

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PCDHA2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
56146

Protein Ontology

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PROi
PR:Q9Y5H9

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000204969 Expressed in 51 organ(s), highest expression level in cerebellar hemisphere
GenevisibleiQ9Y5H9 HS

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR031904 Cadherin_CBD
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF08266 Cadherin_2, 1 hit
PF15974 Cadherin_tail, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPCDA2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y5H9
Secondary accession number(s): O75287, Q9BTV3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: December 5, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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