UniProtKB - Q9Y5H7 (PCDA5_HUMAN)
Protein
Protocadherin alpha-5
Gene
PCDHA5
Organism
Homo sapiens (Human)
Status
Functioni
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
GO - Molecular functioni
- calcium ion binding Source: InterPro
GO - Biological processi
- cell adhesion Source: GO_Central
- homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
- nervous system development Source: ProtInc
Keywordsi
Biological process | Cell adhesion |
Ligand | Calcium |
Enzyme and pathway databases
PathwayCommonsi | Q9Y5H7 |
Names & Taxonomyi
Protein namesi | Recommended name: Protocadherin alpha-5Short name: PCDH-alpha-5 |
Gene namesi | Name:PCDHA5 Synonyms:CNRS6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8671, PCDHA5 |
MIMi | 604966, gene 606311, gene |
neXtProti | NX_Q9Y5H7 |
VEuPathDBi | HostDB:ENSG00000204965.8 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein By similarity
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 29 – 696 | ExtracellularSequence analysisAdd BLAST | 668 | |
Transmembranei | 697 – 717 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 718 – 936 | CytoplasmicSequence analysisAdd BLAST | 219 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 56143 |
OpenTargetsi | ENSG00000204965 |
PharmGKBi | PA33017 |
Miscellaneous databases
Pharosi | Q9Y5H7, Tdark |
Genetic variation databases
BioMutai | PCDHA5 |
DMDMi | 13878428 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 28 | Sequence analysisAdd BLAST | 28 | |
ChainiPRO_0000003892 | 29 – 936 | Protocadherin alpha-5Add BLAST | 908 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 264 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 547 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | Q9Y5H7 |
jPOSTi | Q9Y5H7 |
MassIVEi | Q9Y5H7 |
PaxDbi | Q9Y5H7 |
PeptideAtlasi | Q9Y5H7 |
PRIDEi | Q9Y5H7 |
ProteomicsDBi | 86396 [Q9Y5H7-1] 86397 [Q9Y5H7-2] 86398 [Q9Y5H7-3] |
PTM databases
GlyGeni | Q9Y5H7, 2 sites |
iPTMneti | Q9Y5H7 |
PhosphoSitePlusi | Q9Y5H7 |
Expressioni
Gene expression databases
Bgeei | ENSG00000204965, Expressed in prefrontal cortex and 54 other tissues |
Genevisiblei | Q9Y5H7, HS |
Organism-specific databases
HPAi | ENSG00000204965, Tissue enriched (brain) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 121083, 3 interactors |
IntActi | Q9Y5H7, 2 interactors |
STRINGi | 9606.ENSP00000436557 |
Miscellaneous databases
RNActi | Q9Y5H7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 33 – 132 | Cadherin 1PROSITE-ProRule annotationAdd BLAST | 100 | |
Domaini | 156 – 241 | Cadherin 2PROSITE-ProRule annotationAdd BLAST | 86 | |
Domaini | 242 – 349 | Cadherin 3PROSITE-ProRule annotationAdd BLAST | 108 | |
Domaini | 350 – 454 | Cadherin 4PROSITE-ProRule annotationAdd BLAST | 105 | |
Domaini | 455 – 564 | Cadherin 5PROSITE-ProRule annotationAdd BLAST | 110 | |
Domaini | 580 – 677 | Cadherin 6PROSITE-ProRule annotationAdd BLAST | 98 | |
Repeati | 773 – 776 | PXXP 1 | 4 | |
Repeati | 785 – 788 | PXXP 2 | 4 | |
Repeati | 818 – 821 | PXXP 3 | 4 | |
Repeati | 873 – 876 | PXXP 4 | 4 | |
Repeati | 877 – 890 | PXXP 5Add BLAST | 14 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 773 – 890 | 5 X 4 AA repeats of P-X-X-PAdd BLAST | 118 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 909 – 916 | Poly-Lys | 8 |
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3594, Eukaryota |
GeneTreei | ENSGT00940000164408 |
HOGENOMi | CLU_006480_3_0_1 |
InParanoidi | Q9Y5H7 |
OMAi | LDYEDCK |
OrthoDBi | 184745at2759 |
PhylomeDBi | Q9Y5H7 |
TreeFami | TF332299 |
Family and domain databases
InterProi | View protein in InterPro IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR031904, Cadherin_CBD IPR020894, Cadherin_CS IPR013164, Cadherin_N |
Pfami | View protein in Pfam PF00028, Cadherin, 5 hits PF08266, Cadherin_2, 1 hit PF15974, Cadherin_tail, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 6 hits |
SUPFAMi | SSF49313, SSF49313, 6 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 5 hits PS50268, CADHERIN_2, 6 hits |
s (3)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q9Y5H7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVYSRRGSLG SRLLLLWLLL AYWKAGSGQL HYSIPEEAKH GTFVGRIAQD
60 70 80 90 100
LGLELAELVP RLFRVASKGR GDLLEVNLQN GILFVNSRID REELCRRRAE
110 120 130 140 150
CSIHLEVIVD RPLQVFHVEV AVKDINDNPP RFSRQEQRLF ILESRMPDSR
160 170 180 190 200
FPLEGASDLD IGANAQLRYR LNPNEYFDLD VKTNEEETNF LELVLRKSLD
210 220 230 240 250
REETQEHRLL VIATDGGKPE LTGTVQLLIN VLDANDNAPE FDKSIYNVRL
260 270 280 290 300
LENAPSGTLV IKLNASDADE GINKEIVYFF SNLVLDDVKS KFIINSNTGE
310 320 330 340 350
IKVNGELDYE DYNSYEINID AMDKSTFPLS GHCKVVVKLL DVNDNTPEMA
360 370 380 390 400
ITTLFLPVKE DAPLSTVIAL ISVSDRDSGA NGQVTCSLMP HVPFKLVSTF
410 420 430 440 450
KNYYSLVLDS ALDRESVSVY ELVVTARDGG SPSLWATASV SVEVADVNDN
460 470 480 490 500
APAFAQPQYT VFVKENNPPG CHIFTVSARD ADAQENALVS YSLVERRVGE
510 520 530 540 550
RPLSSYVSVH AESGKVYALQ PLDHEEVELL QFQVSARDAG VPPLGSNVTL
560 570 580 590 600
QVFVLDENDN APALLVPRVG GTGGAVSELV PRSVGAGHVV AKVRAVDPDS
610 620 630 640 650
GYNAWLSYEL QPAPGSARIP FRVGLYTGEI STTRSLDETE APRHRLLVLV
660 670 680 690 700
KDHGEPPLTA TATVLVSLVE SGQAPKASSR ASAGAVGPEA ALVDVNVYLI
710 720 730 740 750
IAICAVSSLL VLTLLLYTAL RCSAQPTEAV CTRGKPTLLC SSAVGSWSYS
760 770 780 790 800
QQRRQRVCSG EAPPKTDLMA FSPSLPQGPT STDNPRQPNP DWRYSASLRA
810 820 830 840 850
GMHSSVHLEE AGILRAGPGG PDQQWPTVSS ATPEPEAGEV SPPVGAGVNS
860 870 880 890 900
NSWTFKYGPG NPKQSGPGEL PDKFIIPGSP AIISIRQEPT NSQIDKSDFI
910 920 930
TFGKKEETKK KKKKKKGNKT QEKKEKGNST TDNSDQ
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 237 | N → S in AAH33735 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048526 | 691 | A → V. Corresponds to variant dbSNP:rs4141841Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_000679 | 785 – 816 | PRQPN…GILRA → VSFLILTSIFPSQFSNIKCH IHPLFLYLKIMS in isoform 2. 1 PublicationAdd BLAST | 32 | |
Alternative sequenceiVSP_000680 | 817 – 936 | Missing in isoform 2. 1 PublicationAdd BLAST | 120 | |
Alternative sequenceiVSP_008704 | 868 – 890 | GELPD…RQEPT → EPKKQTQVSFLLRRKGEASQ PRQ in isoform 3. 1 PublicationAdd BLAST | 23 | |
Alternative sequenceiVSP_008705 | 891 – 936 | Missing in isoform 3. 1 PublicationAdd BLAST | 46 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF152313 mRNA Translation: AAD43707.1 AF152483 mRNA Translation: AAD43744.1 AC005609 Genomic DNA Translation: AAC34321.1 BC033735 mRNA Translation: AAH33735.1 |
CCDSi | CCDS54917.1 [Q9Y5H7-1] |
RefSeqi | NP_061731.1, NM_018908.2 [Q9Y5H7-1] NP_113689.1, NM_031501.1 [Q9Y5H7-2] |
Genome annotation databases
Ensembli | ENST00000529619; ENSP00000433416; ENSG00000204965 [Q9Y5H7-3] ENST00000529859; ENSP00000436557; ENSG00000204965 [Q9Y5H7-1] ENST00000614258; ENSP00000484128; ENSG00000204965 [Q9Y5H7-2] |
GeneIDi | 56143 |
KEGGi | hsa:56143 |
UCSCi | uc003lhj.2, human [Q9Y5H7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF152313 mRNA Translation: AAD43707.1 AF152483 mRNA Translation: AAD43744.1 AC005609 Genomic DNA Translation: AAC34321.1 BC033735 mRNA Translation: AAH33735.1 |
CCDSi | CCDS54917.1 [Q9Y5H7-1] |
RefSeqi | NP_061731.1, NM_018908.2 [Q9Y5H7-1] NP_113689.1, NM_031501.1 [Q9Y5H7-2] |
3D structure databases
SMRi | Q9Y5H7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121083, 3 interactors |
IntActi | Q9Y5H7, 2 interactors |
STRINGi | 9606.ENSP00000436557 |
PTM databases
GlyGeni | Q9Y5H7, 2 sites |
iPTMneti | Q9Y5H7 |
PhosphoSitePlusi | Q9Y5H7 |
Genetic variation databases
BioMutai | PCDHA5 |
DMDMi | 13878428 |
Proteomic databases
EPDi | Q9Y5H7 |
jPOSTi | Q9Y5H7 |
MassIVEi | Q9Y5H7 |
PaxDbi | Q9Y5H7 |
PeptideAtlasi | Q9Y5H7 |
PRIDEi | Q9Y5H7 |
ProteomicsDBi | 86396 [Q9Y5H7-1] 86397 [Q9Y5H7-2] 86398 [Q9Y5H7-3] |
Protocols and materials databases
Antibodypediai | 27127, 135 antibodies |
Genome annotation databases
Ensembli | ENST00000529619; ENSP00000433416; ENSG00000204965 [Q9Y5H7-3] ENST00000529859; ENSP00000436557; ENSG00000204965 [Q9Y5H7-1] ENST00000614258; ENSP00000484128; ENSG00000204965 [Q9Y5H7-2] |
GeneIDi | 56143 |
KEGGi | hsa:56143 |
UCSCi | uc003lhj.2, human [Q9Y5H7-1] |
Organism-specific databases
CTDi | 56143 |
DisGeNETi | 56143 |
GeneCardsi | PCDHA5 |
HGNCi | HGNC:8671, PCDHA5 |
HPAi | ENSG00000204965, Tissue enriched (brain) |
MIMi | 604966, gene 606311, gene |
neXtProti | NX_Q9Y5H7 |
OpenTargetsi | ENSG00000204965 |
PharmGKBi | PA33017 |
VEuPathDBi | HostDB:ENSG00000204965.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3594, Eukaryota |
GeneTreei | ENSGT00940000164408 |
HOGENOMi | CLU_006480_3_0_1 |
InParanoidi | Q9Y5H7 |
OMAi | LDYEDCK |
OrthoDBi | 184745at2759 |
PhylomeDBi | Q9Y5H7 |
TreeFami | TF332299 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y5H7 |
Miscellaneous databases
BioGRID-ORCSi | 56143, 1 hit in 842 CRISPR screens |
GeneWikii | PCDHA5 |
GenomeRNAii | 56143 |
Pharosi | Q9Y5H7, Tdark |
PROi | PR:Q9Y5H7 |
RNActi | Q9Y5H7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000204965, Expressed in prefrontal cortex and 54 other tissues |
Genevisiblei | Q9Y5H7, HS |
Family and domain databases
InterProi | View protein in InterPro IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR031904, Cadherin_CBD IPR020894, Cadherin_CS IPR013164, Cadherin_N |
Pfami | View protein in Pfam PF00028, Cadherin, 5 hits PF08266, Cadherin_2, 1 hit PF15974, Cadherin_tail, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 6 hits |
SUPFAMi | SSF49313, SSF49313, 6 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 5 hits PS50268, CADHERIN_2, 6 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PCDA5_HUMAN | |
Accessioni | Q9Y5H7Primary (citable) accession number: Q9Y5H7 Secondary accession number(s): O75284, Q8N4R3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 27, 2001 |
Last sequence update: | November 1, 1999 | |
Last modified: | February 10, 2021 | |
This is version 175 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants