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UniProtKB - Q9Y5H7 (PCDA5_HUMAN)

Protein

Protocadherin alpha-5

Gene

PCDHA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

  • cell adhesion Source: GO_Central
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • nervous system development Source: ProtInc
View the complete GO annotation on QuickGO ...

Keywordsi

Biological processCell adhesion
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin alpha-5
Short name:
PCDH-alpha-5
Gene namesi
Name:PCDHA5
Synonyms:CNRS6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000204965.8
HGNCiHGNC:8671 PCDHA5
MIMi604966 gene
606311 gene
neXtProtiNX_Q9Y5H7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 696ExtracellularSequence analysisAdd BLAST668
Transmembranei697 – 717HelicalSequence analysisAdd BLAST21
Topological domaini718 – 936CytoplasmicSequence analysisAdd BLAST219

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204965
PharmGKBiPA33017

Polymorphism and mutation databases

BioMutaiPCDHA5
DMDMi13878428

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000000389229 – 936Protocadherin alpha-5Add BLAST908

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi264N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi547N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9Y5H7
PaxDbiQ9Y5H7
PeptideAtlasiQ9Y5H7
PRIDEiQ9Y5H7
ProteomicsDBi86396
86397 [Q9Y5H7-2]
86398 [Q9Y5H7-3]

PTM databases

iPTMnetiQ9Y5H7
PhosphoSitePlusiQ9Y5H7

Expressioni

Gene expression databases

BgeeiENSG00000204965 Expressed in 37 organ(s), highest expression level in anterior cingulate cortex
GenevisibleiQ9Y5H7 HS

Organism-specific databases

HPAiHPA044557

Interactioni

Protein-protein interaction databases

BioGridi121083, 1 interactor
IntActiQ9Y5H7, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ9Y5H7
SMRiQ9Y5H7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 132Cadherin 1PROSITE-ProRule annotationAdd BLAST100
Domaini156 – 241Cadherin 2PROSITE-ProRule annotationAdd BLAST86
Domaini242 – 349Cadherin 3PROSITE-ProRule annotationAdd BLAST108
Domaini350 – 454Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini455 – 564Cadherin 5PROSITE-ProRule annotationAdd BLAST110
Domaini580 – 677Cadherin 6PROSITE-ProRule annotationAdd BLAST98
Repeati773 – 776PXXP 14
Repeati785 – 788PXXP 24
Repeati818 – 821PXXP 34
Repeati873 – 876PXXP 44
Repeati877 – 890PXXP 5Add BLAST14

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni773 – 8905 X 4 AA repeats of P-X-X-PAdd BLAST118

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi909 – 916Poly-Lys8

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00920000148964
HOGENOMiHOG000220892
HOVERGENiHBG054878
InParanoidiQ9Y5H7
KOiK16493
OMAiLDYEDCK
OrthoDBiEOG091G00KR
PhylomeDBiQ9Y5H7
TreeFamiTF332299

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR031904 Cadherin_CBD
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF08266 Cadherin_2, 1 hit
PF15974 Cadherin_tail, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 6 hits

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9Y5H7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVYSRRGSLG SRLLLLWLLL AYWKAGSGQL HYSIPEEAKH GTFVGRIAQD 
        60         70         80         90        100
LGLELAELVP RLFRVASKGR GDLLEVNLQN GILFVNSRID REELCRRRAE 
       110        120        130        140        150
CSIHLEVIVD RPLQVFHVEV AVKDINDNPP RFSRQEQRLF ILESRMPDSR 
       160        170        180        190        200
FPLEGASDLD IGANAQLRYR LNPNEYFDLD VKTNEEETNF LELVLRKSLD 
       210        220        230        240        250
REETQEHRLL VIATDGGKPE LTGTVQLLIN VLDANDNAPE FDKSIYNVRL 
       260        270        280        290        300
LENAPSGTLV IKLNASDADE GINKEIVYFF SNLVLDDVKS KFIINSNTGE 
       310        320        330        340        350
IKVNGELDYE DYNSYEINID AMDKSTFPLS GHCKVVVKLL DVNDNTPEMA 
       360        370        380        390        400
ITTLFLPVKE DAPLSTVIAL ISVSDRDSGA NGQVTCSLMP HVPFKLVSTF 
       410        420        430        440        450
KNYYSLVLDS ALDRESVSVY ELVVTARDGG SPSLWATASV SVEVADVNDN 
       460        470        480        490        500
APAFAQPQYT VFVKENNPPG CHIFTVSARD ADAQENALVS YSLVERRVGE 
       510        520        530        540        550
RPLSSYVSVH AESGKVYALQ PLDHEEVELL QFQVSARDAG VPPLGSNVTL 
       560        570        580        590        600
QVFVLDENDN APALLVPRVG GTGGAVSELV PRSVGAGHVV AKVRAVDPDS 
       610        620        630        640        650
GYNAWLSYEL QPAPGSARIP FRVGLYTGEI STTRSLDETE APRHRLLVLV 
       660        670        680        690        700
KDHGEPPLTA TATVLVSLVE SGQAPKASSR ASAGAVGPEA ALVDVNVYLI 
       710        720        730        740        750
IAICAVSSLL VLTLLLYTAL RCSAQPTEAV CTRGKPTLLC SSAVGSWSYS 
       760        770        780        790        800
QQRRQRVCSG EAPPKTDLMA FSPSLPQGPT STDNPRQPNP DWRYSASLRA 
       810        820        830        840        850
GMHSSVHLEE AGILRAGPGG PDQQWPTVSS ATPEPEAGEV SPPVGAGVNS 
       860        870        880        890        900
NSWTFKYGPG NPKQSGPGEL PDKFIIPGSP AIISIRQEPT NSQIDKSDFI 
       910        920        930 
TFGKKEETKK KKKKKKGNKT QEKKEKGNST TDNSDQ
Length:936
Mass (Da):102,048
Last modified:November 1, 1999 - v1
Checksum:i7143EECE1A357CD6
GO
Isoform 2 (identifier: Q9Y5H7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     785-816: PRQPNPDWRYSASLRAGMHSSVHLEEAGILRA → VSFLILTSIFPSQFSNIKCHIHPLFLYLKIMS
     817-936: Missing.

Show »
Length:816
Mass (Da):89,349
Checksum:i3866970F5657BF16
GO
Isoform 3 (identifier: Q9Y5H7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     868-890: GELPDKFIIPGSPAIISIRQEPT → EPKKQTQVSFLLRRKGEASQPRQ
     891-936: Missing.

Note: No experimental confirmation available.
Show »
Length:890
Mass (Da):96,996
Checksum:iFD9B5EA33572A7E3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti237N → S in AAH33735 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048526691A → V. Corresponds to variant dbSNP:rs4141841Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000679785 – 816PRQPN…GILRA → VSFLILTSIFPSQFSNIKCH IHPLFLYLKIMS in isoform 2. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_000680817 – 936Missing in isoform 2. 1 PublicationAdd BLAST120
Alternative sequenceiVSP_008704868 – 890GELPD…RQEPT → EPKKQTQVSFLLRRKGEASQ PRQ in isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_008705891 – 936Missing in isoform 3. 1 PublicationAdd BLAST46

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152313 mRNA Translation: AAD43707.1
AF152483 mRNA Translation: AAD43744.1
AC005609 Genomic DNA Translation: AAC34321.1
BC033735 mRNA Translation: AAH33735.1
CCDSiCCDS54917.1 [Q9Y5H7-1]
RefSeqiNP_061731.1, NM_018908.2 [Q9Y5H7-1]
NP_113689.1, NM_031501.1 [Q9Y5H7-2]
UniGeneiHs.199343

Genome annotation databases

EnsembliENST00000529619; ENSP00000433416; ENSG00000204965 [Q9Y5H7-3]
ENST00000529859; ENSP00000436557; ENSG00000204965 [Q9Y5H7-1]
ENST00000614258; ENSP00000484128; ENSG00000204965 [Q9Y5H7-2]
GeneIDi56143
KEGGihsa:56143
UCSCiuc003lhj.2 human [Q9Y5H7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152313 mRNA Translation: AAD43707.1
AF152483 mRNA Translation: AAD43744.1
AC005609 Genomic DNA Translation: AAC34321.1
BC033735 mRNA Translation: AAH33735.1
CCDSiCCDS54917.1 [Q9Y5H7-1]
RefSeqiNP_061731.1, NM_018908.2 [Q9Y5H7-1]
NP_113689.1, NM_031501.1 [Q9Y5H7-2]
UniGeneiHs.199343

3D structure databases

ProteinModelPortaliQ9Y5H7
SMRiQ9Y5H7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121083, 1 interactor
IntActiQ9Y5H7, 1 interactor

PTM databases

iPTMnetiQ9Y5H7
PhosphoSitePlusiQ9Y5H7

Polymorphism and mutation databases

BioMutaiPCDHA5
DMDMi13878428

Proteomic databases

EPDiQ9Y5H7
PaxDbiQ9Y5H7
PeptideAtlasiQ9Y5H7
PRIDEiQ9Y5H7
ProteomicsDBi86396
86397 [Q9Y5H7-2]
86398 [Q9Y5H7-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000529619; ENSP00000433416; ENSG00000204965 [Q9Y5H7-3]
ENST00000529859; ENSP00000436557; ENSG00000204965 [Q9Y5H7-1]
ENST00000614258; ENSP00000484128; ENSG00000204965 [Q9Y5H7-2]
GeneIDi56143
KEGGihsa:56143
UCSCiuc003lhj.2 human [Q9Y5H7-1]

Organism-specific databases

CTDi56143
EuPathDBiHostDB:ENSG00000204965.8
GeneCardsiPCDHA5
H-InvDBiHIX0164437
HGNCiHGNC:8671 PCDHA5
HPAiHPA044557
MIMi604966 gene
606311 gene
neXtProtiNX_Q9Y5H7
OpenTargetsiENSG00000204965
PharmGKBiPA33017
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00920000148964
HOGENOMiHOG000220892
HOVERGENiHBG054878
InParanoidiQ9Y5H7
KOiK16493
OMAiLDYEDCK
OrthoDBiEOG091G00KR
PhylomeDBiQ9Y5H7
TreeFamiTF332299

Miscellaneous databases

GeneWikiiPCDHA5
GenomeRNAii56143
PROiPR:Q9Y5H7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204965 Expressed in 37 organ(s), highest expression level in anterior cingulate cortex
GenevisibleiQ9Y5H7 HS

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR031904 Cadherin_CBD
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF08266 Cadherin_2, 1 hit
PF15974 Cadherin_tail, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPCDA5_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5H7
Secondary accession number(s): O75284, Q8N4R3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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