UniProtKB - Q9Y5H2 (PCDGB_HUMAN)
Protein
Protocadherin gamma-A11
Gene
PCDHGA11
Organism
Homo sapiens (Human)
Status
Functioni
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
GO - Molecular functioni
- calcium ion binding Source: InterPro
GO - Biological processi
- cell adhesion Source: GO_Central
- homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Keywordsi
Biological process | Cell adhesion |
Ligand | Calcium |
Enzyme and pathway databases
PathwayCommonsi | Q9Y5H2 |
Names & Taxonomyi
Protein namesi | Recommended name: Protocadherin gamma-A11Short name: PCDH-gamma-A11 |
Gene namesi | Name:PCDHGA11 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8698, PCDHGA11 |
MIMi | 604968, gene 606298, gene |
neXtProti | NX_Q9Y5H2 |
VEuPathDBi | HostDB:ENSG00000253873.5 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein By similarity
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 30 – 693 | ExtracellularSequence analysisAdd BLAST | 664 | |
Transmembranei | 694 – 714 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 715 – 935 | CytoplasmicSequence analysisAdd BLAST | 221 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 56105 |
OpenTargetsi | ENSG00000253873 |
PharmGKBi | PA33046 |
Miscellaneous databases
Pharosi | Q9Y5H2, Tdark |
Genetic variation databases
BioMutai | PCDHGA11 |
DMDMi | 37999842 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 29 | Sequence analysisAdd BLAST | 29 | |
ChainiPRO_0000003968 | 30 – 935 | Protocadherin gamma-A11Add BLAST | 906 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 48 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 255 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 266 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 420 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 546 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | Q9Y5H2 |
MassIVEi | Q9Y5H2 |
PaxDbi | Q9Y5H2 |
PeptideAtlasi | Q9Y5H2 |
PRIDEi | Q9Y5H2 |
ProteomicsDBi | 86385 [Q9Y5H2-1] 86386 [Q9Y5H2-2] 86387 [Q9Y5H2-3] |
PTM databases
GlyGeni | Q9Y5H2, 5 sites |
iPTMneti | Q9Y5H2 |
PhosphoSitePlusi | Q9Y5H2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000253873, Expressed in stromal cell of endometrium and 112 other tissues |
Genevisiblei | Q9Y5H2, HS |
Organism-specific databases
HPAi | ENSG00000253873, Tissue enhanced (brain) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 121045, 14 interactors |
IntActi | Q9Y5H2, 9 interactors |
STRINGi | 9606.ENSP00000381589 |
Miscellaneous databases
RNActi | Q9Y5H2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 30 – 134 | Cadherin 1PROSITE-ProRule annotationAdd BLAST | 105 | |
Domaini | 135 – 243 | Cadherin 2PROSITE-ProRule annotationAdd BLAST | 109 | |
Domaini | 244 – 348 | Cadherin 3PROSITE-ProRule annotationAdd BLAST | 105 | |
Domaini | 349 – 453 | Cadherin 4PROSITE-ProRule annotationAdd BLAST | 105 | |
Domaini | 454 – 563 | Cadherin 5PROSITE-ProRule annotationAdd BLAST | 110 | |
Domaini | 571 – 677 | Cadherin 6PROSITE-ProRule annotationAdd BLAST | 107 |
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3594, Eukaryota |
GeneTreei | ENSGT00940000164062 |
HOGENOMi | CLU_006480_3_0_1 |
InParanoidi | Q9Y5H2 |
OMAi | TAVSCIF |
OrthoDBi | 213724at2759 |
PhylomeDBi | Q9Y5H2 |
TreeFami | TF332299 |
Family and domain databases
InterProi | View protein in InterPro IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR032455, Cadherin_C IPR031904, Cadherin_CBD IPR020894, Cadherin_CS IPR013164, Cadherin_N |
Pfami | View protein in Pfam PF00028, Cadherin, 4 hits PF08266, Cadherin_2, 1 hit PF16492, Cadherin_C_2, 1 hit PF15974, Cadherin_tail, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 6 hits |
SUPFAMi | SSF49313, SSF49313, 6 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 5 hits PS50268, CADHERIN_2, 6 hits |
s (3)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q9Y5H2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MANRLQRGDR SRLLLLLCIF LGTLRGFRAR QIRYSVPEET EKGSFVGNIS
60 70 80 90 100
KDLGLEPREL AKRGVRIVSR GKTQLFAVNP RSGSLITAGR IDREELCETV
110 120 130 140 150
SSCFLNMELL VEDTLKIYGV EVEIIDINDN APSFQEDEVE IKVSEHAIPG
160 170 180 190 200
ARFALPNARD PDVGVNSLQS YQLSPNNYFS LQLRGRTDGA KNPELVLEGS
210 220 230 240 250
LDREKEAAHL LLLTALDGGD PIRKGAVPIR VVVLDVNDHI PMFTQSVYRV
260 270 280 290 300
SVPENISSGT RVLMVNATDP DEGINGEVMY SFRNMESKAS EIFQLDSQTG
310 320 330 340 350
EVQVRGSLDF EKYRFYEMEI QGQDGGGLFT TTTMLITVVD VNDNAPEITI
360 370 380 390 400
TSSINSILEN SPPGTVIALL NVQDQDSGEN GQVSCFIPNH LPFKLEKTYG
410 420 430 440 450
NYYKLITSRV LDRELVQSYN ITLTATDQGS PPLSAETHVW LNVADDNDNP
460 470 480 490 500
PVFPHSSYSA YIPENNPRGA SIFSVTALDP DSKQNALVTY SLTDDTVQGV
510 520 530 540 550
PLSSYVSINS NTGVLYALQS FDYEQFRDLE LRVIARDSGD PPLSSNVSLS
560 570 580 590 600
LFVLDQNDNA PEILYPALPT DGSTGVELAP RSAEPGYLVT KVVAVDKDSG
610 620 630 640 650
QNAWLSYRLL KASEPGLFAV GEHTGEVRTA RALLDRDALK QSLVVAVQDH
660 670 680 690 700
GQPPLSATVT LTVAVADSIP EVLADLGSLE SLANSETSDL SLYLVVAVAA
710 720 730 740 750
VSCIFLVFVI VLLALRLWRW HKSRLLQASE GGLAGMPTSH FVGVDGVQAF
760 770 780 790 800
LQTYSHEVSL IADSQKSHLI FPQPNYGDTL ISQESCEKSE PLLIAEDSAI
810 820 830 840 850
ILGKCDPTSN QQAPPNTDWR FSQAQRPGTS GSQNGDDTGT WPNNQFDTEM
860 870 880 890 900
LQAMILASAS EAADGSSTLG GGAGTMGLSA RYGPQFTLQH VPDYRQNVYI
910 920 930
PGSNATLTNA AGKRDGKAPA GGNGNKKKSG KKEKK
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_033711 | 104 | F → L. Corresponds to variant dbSNP:rs11167744Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_008679 | 627 – 811 | Missing in isoform 3. 1 PublicationAdd BLAST | 185 | |
Alternative sequenceiVSP_008680 | 812 – 837 | QAPPN…QNGDD → VRFISLPPNCWCLGTSLLRR CFLSLL in isoform 2. 1 PublicationAdd BLAST | 26 | |
Alternative sequenceiVSP_008681 | 838 – 935 | Missing in isoform 2. 1 PublicationAdd BLAST | 98 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF152320 mRNA Translation: AAD43714.1 AF152505 mRNA Translation: AAD43766.1 AF152504 mRNA Translation: AAD43765.1 CH471062 Genomic DNA Translation: EAW61934.1 BC136781 mRNA Translation: AAI36782.1 BC171774 mRNA Translation: AAI71774.1 |
CCDSi | CCDS47294.1 [Q9Y5H2-1] CCDS54930.1 [Q9Y5H2-3] CCDS75345.1 [Q9Y5H2-2] |
RefSeqi | NP_061737.1, NM_018914.2 [Q9Y5H2-1] NP_114480.1, NM_032091.1 [Q9Y5H2-2] NP_114481.1, NM_032092.1 [Q9Y5H2-3] |
Genome annotation databases
Ensembli | ENST00000398587; ENSP00000381589; ENSG00000253873 [Q9Y5H2-1] ENST00000518882; ENSP00000428333; ENSG00000253873 [Q9Y5H2-3] ENST00000622044; ENSP00000480917; ENSG00000253873 [Q9Y5H2-2] |
GeneIDi | 56105 |
KEGGi | hsa:56105 |
UCSCi | uc003lko.2, human [Q9Y5H2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF152320 mRNA Translation: AAD43714.1 AF152505 mRNA Translation: AAD43766.1 AF152504 mRNA Translation: AAD43765.1 CH471062 Genomic DNA Translation: EAW61934.1 BC136781 mRNA Translation: AAI36782.1 BC171774 mRNA Translation: AAI71774.1 |
CCDSi | CCDS47294.1 [Q9Y5H2-1] CCDS54930.1 [Q9Y5H2-3] CCDS75345.1 [Q9Y5H2-2] |
RefSeqi | NP_061737.1, NM_018914.2 [Q9Y5H2-1] NP_114480.1, NM_032091.1 [Q9Y5H2-2] NP_114481.1, NM_032092.1 [Q9Y5H2-3] |
3D structure databases
SMRi | Q9Y5H2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121045, 14 interactors |
IntActi | Q9Y5H2, 9 interactors |
STRINGi | 9606.ENSP00000381589 |
PTM databases
GlyGeni | Q9Y5H2, 5 sites |
iPTMneti | Q9Y5H2 |
PhosphoSitePlusi | Q9Y5H2 |
Genetic variation databases
BioMutai | PCDHGA11 |
DMDMi | 37999842 |
Proteomic databases
jPOSTi | Q9Y5H2 |
MassIVEi | Q9Y5H2 |
PaxDbi | Q9Y5H2 |
PeptideAtlasi | Q9Y5H2 |
PRIDEi | Q9Y5H2 |
ProteomicsDBi | 86385 [Q9Y5H2-1] 86386 [Q9Y5H2-2] 86387 [Q9Y5H2-3] |
Protocols and materials databases
Antibodypediai | 57509, 10 antibodies |
Genome annotation databases
Ensembli | ENST00000398587; ENSP00000381589; ENSG00000253873 [Q9Y5H2-1] ENST00000518882; ENSP00000428333; ENSG00000253873 [Q9Y5H2-3] ENST00000622044; ENSP00000480917; ENSG00000253873 [Q9Y5H2-2] |
GeneIDi | 56105 |
KEGGi | hsa:56105 |
UCSCi | uc003lko.2, human [Q9Y5H2-1] |
Organism-specific databases
CTDi | 56105 |
DisGeNETi | 56105 |
GeneCardsi | PCDHGA11 |
HGNCi | HGNC:8698, PCDHGA11 |
HPAi | ENSG00000253873, Tissue enhanced (brain) |
MIMi | 604968, gene 606298, gene |
neXtProti | NX_Q9Y5H2 |
OpenTargetsi | ENSG00000253873 |
PharmGKBi | PA33046 |
VEuPathDBi | HostDB:ENSG00000253873.5 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3594, Eukaryota |
GeneTreei | ENSGT00940000164062 |
HOGENOMi | CLU_006480_3_0_1 |
InParanoidi | Q9Y5H2 |
OMAi | TAVSCIF |
OrthoDBi | 213724at2759 |
PhylomeDBi | Q9Y5H2 |
TreeFami | TF332299 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y5H2 |
Miscellaneous databases
BioGRID-ORCSi | 56105, 3 hits in 935 CRISPR screens |
GeneWikii | PCDHGA11 |
GenomeRNAii | 56105 |
Pharosi | Q9Y5H2, Tdark |
PROi | PR:Q9Y5H2 |
RNActi | Q9Y5H2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000253873, Expressed in stromal cell of endometrium and 112 other tissues |
Genevisiblei | Q9Y5H2, HS |
Family and domain databases
InterProi | View protein in InterPro IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR032455, Cadherin_C IPR031904, Cadherin_CBD IPR020894, Cadherin_CS IPR013164, Cadherin_N |
Pfami | View protein in Pfam PF00028, Cadherin, 4 hits PF08266, Cadherin_2, 1 hit PF16492, Cadherin_C_2, 1 hit PF15974, Cadherin_tail, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 6 hits |
SUPFAMi | SSF49313, SSF49313, 6 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 5 hits PS50268, CADHERIN_2, 6 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PCDGB_HUMAN | |
Accessioni | Q9Y5H2Primary (citable) accession number: Q9Y5H2 Secondary accession number(s): B7ZVY8, Q9Y5D8, Q9Y5D9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 24, 2003 |
Last sequence update: | November 1, 1999 | |
Last modified: | April 7, 2021 | |
This is version 156 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot