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UniProtKB - Q9Y5H2 (PCDGB_HUMAN)

Protein

Protocadherin gamma-A11

Gene

PCDHGA11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Biological processCell adhesion
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin gamma-A11
Short name:
PCDH-gamma-A11
Gene namesi
Name:PCDHGA11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000253873.5
HGNCiHGNC:8698 PCDHGA11
MIMi604968 gene
606298 gene
neXtProtiNX_Q9Y5H2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 693ExtracellularSequence analysisAdd BLAST664
Transmembranei694 – 714HelicalSequence analysisAdd BLAST21
Topological domaini715 – 935CytoplasmicSequence analysisAdd BLAST221

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi56105
OpenTargetsiENSG00000253873
PharmGKBiPA33046

Polymorphism and mutation databases

BioMutaiPCDHGA11
DMDMi37999842

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000000396830 – 935Protocadherin gamma-A11Add BLAST906

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi48N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi255N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi266N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi420N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi546N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9Y5H2
PaxDbiQ9Y5H2
PeptideAtlasiQ9Y5H2
PRIDEiQ9Y5H2
ProteomicsDBi86385
86386 [Q9Y5H2-2]
86387 [Q9Y5H2-3]

PTM databases

iPTMnetiQ9Y5H2
PhosphoSitePlusiQ9Y5H2

Expressioni

Gene expression databases

BgeeiENSG00000253873 Expressed in 90 organ(s), highest expression level in heart left ventricle
GenevisibleiQ9Y5H2 HS

Organism-specific databases

HPAiHPA008755
HPA010580

Interactioni

Protein-protein interaction databases

BioGridi121045, 13 interactors

Structurei

3D structure databases

ProteinModelPortaliQ9Y5H2
SMRiQ9Y5H2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 134Cadherin 1PROSITE-ProRule annotationAdd BLAST105
Domaini135 – 243Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini244 – 348Cadherin 3PROSITE-ProRule annotationAdd BLAST105
Domaini349 – 453Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini454 – 563Cadherin 5PROSITE-ProRule annotationAdd BLAST110
Domaini571 – 677Cadherin 6PROSITE-ProRule annotationAdd BLAST107

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00900000140770
HOGENOMiHOG000220892
HOVERGENiHBG054878
InParanoidiQ9Y5H2
KOiK16495
OMAiTAVSCIF
OrthoDBiEOG091G00SP
PhylomeDBiQ9Y5H2
TreeFamiTF332299

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin
IPR015919 Cadherin-like
IPR032455 Cadherin_C
IPR031904 Cadherin_CBD
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
PfamiView protein in Pfam
PF00028 Cadherin, 4 hits
PF08266 Cadherin_2, 1 hit
PF16492 Cadherin_C_2, 1 hit
PF15974 Cadherin_tail, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 6 hits

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9Y5H2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MANRLQRGDR SRLLLLLCIF LGTLRGFRAR QIRYSVPEET EKGSFVGNIS 
        60         70         80         90        100
KDLGLEPREL AKRGVRIVSR GKTQLFAVNP RSGSLITAGR IDREELCETV 
       110        120        130        140        150
SSCFLNMELL VEDTLKIYGV EVEIIDINDN APSFQEDEVE IKVSEHAIPG 
       160        170        180        190        200
ARFALPNARD PDVGVNSLQS YQLSPNNYFS LQLRGRTDGA KNPELVLEGS 
       210        220        230        240        250
LDREKEAAHL LLLTALDGGD PIRKGAVPIR VVVLDVNDHI PMFTQSVYRV 
       260        270        280        290        300
SVPENISSGT RVLMVNATDP DEGINGEVMY SFRNMESKAS EIFQLDSQTG 
       310        320        330        340        350
EVQVRGSLDF EKYRFYEMEI QGQDGGGLFT TTTMLITVVD VNDNAPEITI 
       360        370        380        390        400
TSSINSILEN SPPGTVIALL NVQDQDSGEN GQVSCFIPNH LPFKLEKTYG 
       410        420        430        440        450
NYYKLITSRV LDRELVQSYN ITLTATDQGS PPLSAETHVW LNVADDNDNP 
       460        470        480        490        500
PVFPHSSYSA YIPENNPRGA SIFSVTALDP DSKQNALVTY SLTDDTVQGV 
       510        520        530        540        550
PLSSYVSINS NTGVLYALQS FDYEQFRDLE LRVIARDSGD PPLSSNVSLS 
       560        570        580        590        600
LFVLDQNDNA PEILYPALPT DGSTGVELAP RSAEPGYLVT KVVAVDKDSG 
       610        620        630        640        650
QNAWLSYRLL KASEPGLFAV GEHTGEVRTA RALLDRDALK QSLVVAVQDH 
       660        670        680        690        700
GQPPLSATVT LTVAVADSIP EVLADLGSLE SLANSETSDL SLYLVVAVAA 
       710        720        730        740        750
VSCIFLVFVI VLLALRLWRW HKSRLLQASE GGLAGMPTSH FVGVDGVQAF 
       760        770        780        790        800
LQTYSHEVSL IADSQKSHLI FPQPNYGDTL ISQESCEKSE PLLIAEDSAI 
       810        820        830        840        850
ILGKCDPTSN QQAPPNTDWR FSQAQRPGTS GSQNGDDTGT WPNNQFDTEM 
       860        870        880        890        900
LQAMILASAS EAADGSSTLG GGAGTMGLSA RYGPQFTLQH VPDYRQNVYI 
       910        920        930 
PGSNATLTNA AGKRDGKAPA GGNGNKKKSG KKEKK
Length:935
Mass (Da):101,543
Last modified:November 1, 1999 - v1
Checksum:i51296C167D62480B
GO
Isoform 2 (identifier: Q9Y5H2-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     812-837: QAPPNTDWRFSQAQRPGTSGSQNGDD → VRFISLPPNCWCLGTSLLRRCFLSLL
     838-935: Missing.

Show »
Length:837
Mass (Da):91,608
Checksum:i8A5EABB07F5794B7
GO
Isoform 3 (identifier: Q9Y5H2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     627-811: Missing.

Show »
Length:750
Mass (Da):81,739
Checksum:i817DB54A0F1A446B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033711104F → L. Corresponds to variant dbSNP:rs11167744Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008679627 – 811Missing in isoform 3. 1 PublicationAdd BLAST185
Alternative sequenceiVSP_008680812 – 837QAPPN…QNGDD → VRFISLPPNCWCLGTSLLRR CFLSLL in isoform 2. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_008681838 – 935Missing in isoform 2. 1 PublicationAdd BLAST98

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152320 mRNA Translation: AAD43714.1
AF152505 mRNA Translation: AAD43766.1
AF152504 mRNA Translation: AAD43765.1
CH471062 Genomic DNA Translation: EAW61934.1
BC136781 mRNA Translation: AAI36782.1
BC171774 mRNA Translation: AAI71774.1
CCDSiCCDS47294.1 [Q9Y5H2-1]
CCDS54930.1 [Q9Y5H2-3]
CCDS75345.1 [Q9Y5H2-2]
RefSeqiNP_061737.1, NM_018914.2 [Q9Y5H2-1]
NP_114480.1, NM_032091.1 [Q9Y5H2-2]
NP_114481.1, NM_032092.1 [Q9Y5H2-3]
UniGeneiHs.368160

Genome annotation databases

EnsembliENST00000398587; ENSP00000381589; ENSG00000253873 [Q9Y5H2-1]
ENST00000518882; ENSP00000428333; ENSG00000253873 [Q9Y5H2-3]
ENST00000622044; ENSP00000480917; ENSG00000253873 [Q9Y5H2-2]
GeneIDi56105
KEGGihsa:56105
UCSCiuc003lko.2 human [Q9Y5H2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152320 mRNA Translation: AAD43714.1
AF152505 mRNA Translation: AAD43766.1
AF152504 mRNA Translation: AAD43765.1
CH471062 Genomic DNA Translation: EAW61934.1
BC136781 mRNA Translation: AAI36782.1
BC171774 mRNA Translation: AAI71774.1
CCDSiCCDS47294.1 [Q9Y5H2-1]
CCDS54930.1 [Q9Y5H2-3]
CCDS75345.1 [Q9Y5H2-2]
RefSeqiNP_061737.1, NM_018914.2 [Q9Y5H2-1]
NP_114480.1, NM_032091.1 [Q9Y5H2-2]
NP_114481.1, NM_032092.1 [Q9Y5H2-3]
UniGeneiHs.368160

3D structure databases

ProteinModelPortaliQ9Y5H2
SMRiQ9Y5H2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121045, 13 interactors

PTM databases

iPTMnetiQ9Y5H2
PhosphoSitePlusiQ9Y5H2

Polymorphism and mutation databases

BioMutaiPCDHGA11
DMDMi37999842

Proteomic databases

EPDiQ9Y5H2
PaxDbiQ9Y5H2
PeptideAtlasiQ9Y5H2
PRIDEiQ9Y5H2
ProteomicsDBi86385
86386 [Q9Y5H2-2]
86387 [Q9Y5H2-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398587; ENSP00000381589; ENSG00000253873 [Q9Y5H2-1]
ENST00000518882; ENSP00000428333; ENSG00000253873 [Q9Y5H2-3]
ENST00000622044; ENSP00000480917; ENSG00000253873 [Q9Y5H2-2]
GeneIDi56105
KEGGihsa:56105
UCSCiuc003lko.2 human [Q9Y5H2-1]

Organism-specific databases

CTDi56105
DisGeNETi56105
EuPathDBiHostDB:ENSG00000253873.5
GeneCardsiPCDHGA11
HGNCiHGNC:8698 PCDHGA11
HPAiHPA008755
HPA010580
MIMi604968 gene
606298 gene
neXtProtiNX_Q9Y5H2
OpenTargetsiENSG00000253873
PharmGKBiPA33046
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00900000140770
HOGENOMiHOG000220892
HOVERGENiHBG054878
InParanoidiQ9Y5H2
KOiK16495
OMAiTAVSCIF
OrthoDBiEOG091G00SP
PhylomeDBiQ9Y5H2
TreeFamiTF332299

Miscellaneous databases

GeneWikiiPCDHGA11
GenomeRNAii56105
PROiPR:Q9Y5H2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000253873 Expressed in 90 organ(s), highest expression level in heart left ventricle
GenevisibleiQ9Y5H2 HS

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin
IPR015919 Cadherin-like
IPR032455 Cadherin_C
IPR031904 Cadherin_CBD
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
PfamiView protein in Pfam
PF00028 Cadherin, 4 hits
PF08266 Cadherin_2, 1 hit
PF16492 Cadherin_C_2, 1 hit
PF15974 Cadherin_tail, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPCDGB_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5H2
Secondary accession number(s): B7ZVY8, Q9Y5D8, Q9Y5D9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: November 1, 1999
Last modified: September 12, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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