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Protein

Protocadherin beta-11

Gene

PCDHB11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

  • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
  • cell adhesion Source: GO_Central
  • chemical synaptic transmission Source: UniProtKB
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • nervous system development Source: ProtInc
  • synapse assembly Source: UniProtKB

Keywordsi

Biological processCell adhesion
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin beta-11
Short name:
PCDH-beta-11
Gene namesi
Name:PCDHB11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000197479.6
HGNCiHGNC:8682 PCDHB11
MIMi604967 gene
606337 gene
neXtProtiNX_Q9Y5F2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 690ExtracellularSequence analysisAdd BLAST664
Transmembranei691 – 711HelicalSequence analysisAdd BLAST21
Topological domaini712 – 797CytoplasmicSequence analysisAdd BLAST86

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi56125
OpenTargetsiENSG00000197479
PharmGKBiPA33027

Polymorphism and mutation databases

BioMutaiPCDHB11
DMDMi13431383

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000000393427 – 797Protocadherin beta-11Add BLAST771

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi418N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi436N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi487N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi567N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9Y5F2
PeptideAtlasiQ9Y5F2
PRIDEiQ9Y5F2
ProteomicsDBi86351

PTM databases

GlyConnecti1677
iPTMnetiQ9Y5F2
PhosphoSitePlusiQ9Y5F2

Expressioni

Gene expression databases

BgeeiENSG00000197479 Expressed in 87 organ(s), highest expression level in body of pancreas
CleanExiHS_PCDHB11
GenevisibleiQ9Y5F2 HS

Organism-specific databases

HPAiHPA045042

Interactioni

Protein-protein interaction databases

BioGridi121065, 53 interactors
STRINGi9606.ENSP00000346802

Structurei

3D structure databases

ProteinModelPortaliQ9Y5F2
SMRiQ9Y5F2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 133Cadherin 1PROSITE-ProRule annotationAdd BLAST99
Domaini138 – 242Cadherin 2PROSITE-ProRule annotationAdd BLAST105
Domaini247 – 347Cadherin 3PROSITE-ProRule annotationAdd BLAST101
Domaini352 – 451Cadherin 4PROSITE-ProRule annotationAdd BLAST100
Domaini456 – 561Cadherin 5PROSITE-ProRule annotationAdd BLAST106
Domaini568 – 671Cadherin 6PROSITE-ProRule annotationAdd BLAST104

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00920000148964
HOVERGENiHBG054878
InParanoidiQ9Y5F2
KOiK16494
OMAiMRVNPDN
OrthoDBiEOG091G024L
PhylomeDBiQ9Y5F2
TreeFamiTF332299

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR032455 Cadherin_C
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
IPR030734 PCDHB11
PANTHERiPTHR24028:SF91 PTHR24028:SF91, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF08266 Cadherin_2, 1 hit
PF16492 Cadherin_C_2, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 6 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9Y5F2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MENQGTRTQQ IRQVLLLFVL LGMSQAGSET WSFSVAEEMQ SGSFVGNLAK
60 70 80 90 100
DLGLKVRELS SRGARVVSND KKQRLQLDIN TGDLLLSETL DREELCGSIE
110 120 130 140 150
PCVLHLQVLM QNPTQFLQIE LQVRDINDHS PIFSEKQMLL EIPENSPVGA
160 170 180 190 200
VFLLESAKDL DVGINAVKSY TISPNSHFHI KMRVIPDNRK YPELVLDKAL
210 220 230 240 250
DYEELPELSF ILSALDGGSP PRSGTALVRV VVVDINDNSP EFEQAFYEVK
260 270 280 290 300
IRENSILGSL ILIVSAWDLD SGTNGEICYT FSHASEDIRK TFEINQKSGE
310 320 330 340 350
ITLRAPLDFE TIESYSIIIQ ATDGGGLFGK STVIIHVIDV NDNAPEITVS
360 370 380 390 400
SITSPIPENT PETVVMVFSI QDIDSGDNGR IVCSIPEDLP FVLKSSVENY
410 420 430 440 450
YTLETERPLD RESTAEYNIT ITVTDLGIPR LKTEHNTTVL VSDVNDNAPT
460 470 480 490 500
FTQTSYTLFV RENNSPALHI GSVSATDRDS GTNAQVNYSL LPPQDLHLPL
510 520 530 540 550
ASLVSINTDN GHLFALRSLD YEALQAFDFR VGATDRGSPA LSSEALVRVL
560 570 580 590 600
VLDANDNSPF VLYPLQNGSA PCTELVPRAA EPGYLVTKVV AVDGDSGQNA
610 620 630 640 650
WLSYQLLKAT EPGLFGVWAH NGEVRTARLL SERDAAKHRL VVLVKDNGEP
660 670 680 690 700
PRSATATLQV LLVDGFSQPY LPLPEAAPAQ AQADSLTVYL VVALASVSSL
710 720 730 740 750
FLFSVLLFVA VRLCRRSRAA SVGSCSVPKG PFPGHLVDVS GTGTLSQSYQ
760 770 780 790
YEVCLTGGSE TNEFKFLKPV IPNIQAKGLG KNSEENSTFR NSFGFNF
Length:797
Mass (Da):87,088
Last modified:November 1, 1999 - v1
Checksum:i8FBA0DBCC2858504
GO
Isoform 2 (identifier: Q9Y5F2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-365: Missing.

Note: No experimental confirmation available.
Show »
Length:432
Mass (Da):46,732
Checksum:i3EE3340AF7EE89BB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0218814Q → R. Corresponds to variant dbSNP:rs3756323Ensembl.1
Natural variantiVAR_0485537R → H. Corresponds to variant dbSNP:rs917535Ensembl.1
Natural variantiVAR_059188528D → E. Corresponds to variant dbSNP:rs799834Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0559311 – 365Missing in isoform 2. 1 PublicationAdd BLAST365

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152490 mRNA Translation: AAD43751.1
AF217747 mRNA Translation: AAK51615.1
AK299719 mRNA Translation: BAG61619.1
AC005752 Genomic DNA No translation available.
BC112132 mRNA Translation: AAI12133.1
BC113611 mRNA Translation: AAI13612.1
CCDSiCCDS4253.1 [Q9Y5F2-1]
RefSeqiNP_061754.1, NM_018931.2 [Q9Y5F2-1]
UniGeneiHs.283084

Genome annotation databases

EnsembliENST00000354757; ENSP00000346802; ENSG00000197479 [Q9Y5F2-1]
ENST00000624887; ENSP00000485553; ENSG00000197479 [Q9Y5F2-2]
GeneIDi56125
KEGGihsa:56125
UCSCiuc003liy.4 human [Q9Y5F2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152490 mRNA Translation: AAD43751.1
AF217747 mRNA Translation: AAK51615.1
AK299719 mRNA Translation: BAG61619.1
AC005752 Genomic DNA No translation available.
BC112132 mRNA Translation: AAI12133.1
BC113611 mRNA Translation: AAI13612.1
CCDSiCCDS4253.1 [Q9Y5F2-1]
RefSeqiNP_061754.1, NM_018931.2 [Q9Y5F2-1]
UniGeneiHs.283084

3D structure databases

ProteinModelPortaliQ9Y5F2
SMRiQ9Y5F2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121065, 53 interactors
STRINGi9606.ENSP00000346802

PTM databases

GlyConnecti1677
iPTMnetiQ9Y5F2
PhosphoSitePlusiQ9Y5F2

Polymorphism and mutation databases

BioMutaiPCDHB11
DMDMi13431383

Proteomic databases

PaxDbiQ9Y5F2
PeptideAtlasiQ9Y5F2
PRIDEiQ9Y5F2
ProteomicsDBi86351

Protocols and materials databases

DNASUi56125
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354757; ENSP00000346802; ENSG00000197479 [Q9Y5F2-1]
ENST00000624887; ENSP00000485553; ENSG00000197479 [Q9Y5F2-2]
GeneIDi56125
KEGGihsa:56125
UCSCiuc003liy.4 human [Q9Y5F2-1]

Organism-specific databases

CTDi56125
DisGeNETi56125
EuPathDBiHostDB:ENSG00000197479.6
GeneCardsiPCDHB11
HGNCiHGNC:8682 PCDHB11
HPAiHPA045042
MIMi604967 gene
606337 gene
neXtProtiNX_Q9Y5F2
OpenTargetsiENSG00000197479
PharmGKBiPA33027
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00920000148964
HOVERGENiHBG054878
InParanoidiQ9Y5F2
KOiK16494
OMAiMRVNPDN
OrthoDBiEOG091G024L
PhylomeDBiQ9Y5F2
TreeFamiTF332299

Miscellaneous databases

GeneWikiiPCDHB11
GenomeRNAii56125
PROiPR:Q9Y5F2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197479 Expressed in 87 organ(s), highest expression level in body of pancreas
CleanExiHS_PCDHB11
GenevisibleiQ9Y5F2 HS

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR032455 Cadherin_C
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
IPR030734 PCDHB11
PANTHERiPTHR24028:SF91 PTHR24028:SF91, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF08266 Cadherin_2, 1 hit
PF16492 Cadherin_C_2, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPCDBB_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5F2
Secondary accession number(s): B4DSF7, Q2M223
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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