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Protein

Protocadherin beta-14

Gene

PCDHB14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin beta-14
Short name:
PCDH-beta-14
Gene namesi
Name:PCDHB14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000120327.6
HGNCiHGNC:8685 PCDHB14
MIMi604967 gene
606340 gene
neXtProtiNX_Q9Y5E9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 686ExtracellularSequence analysisAdd BLAST660
Transmembranei687 – 711HelicalSequence analysisAdd BLAST25
Topological domaini712 – 798CytoplasmicSequence analysisAdd BLAST87

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000120327
PharmGKBiPA33030

Polymorphism and mutation databases

BioMutaiPCDHB14
DMDMi13431380

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000000394027 – 798Protocadherin beta-14Add BLAST772

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi96 ↔ 102By similarity
Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi359N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi418N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi436N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi487N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi567N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9Y5E9
PaxDbiQ9Y5E9
PeptideAtlasiQ9Y5E9
PRIDEiQ9Y5E9
ProteomicsDBi86348

PTM databases

GlyConnecti1678
iPTMnetiQ9Y5E9
PhosphoSitePlusiQ9Y5E9

Expressioni

Gene expression databases

BgeeiENSG00000120327 Expressed in 168 organ(s), highest expression level in forebrain
CleanExiHS_PCDHB14
GenevisibleiQ9Y5E9 HS

Organism-specific databases

HPAiHPA007692
HPA045248

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi121062, 4 interactors
IntActiQ9Y5E9, 14 interactors
STRINGi9606.ENSP00000239449

Structurei

3D structure databases

ProteinModelPortaliQ9Y5E9
SMRiQ9Y5E9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 133Cadherin 1PROSITE-ProRule annotationAdd BLAST99
Domaini138 – 242Cadherin 2PROSITE-ProRule annotationAdd BLAST105
Domaini247 – 347Cadherin 3PROSITE-ProRule annotationAdd BLAST101
Domaini352 – 451Cadherin 4PROSITE-ProRule annotationAdd BLAST100
Domaini456 – 561Cadherin 5PROSITE-ProRule annotationAdd BLAST106
Domaini568 – 671Cadherin 6PROSITE-ProRule annotationAdd BLAST104

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00920000148964
HOGENOMiHOG000220892
HOVERGENiHBG054878
InParanoidiQ9Y5E9
KOiK16494
OMAiTFFHASE
OrthoDBiEOG091G024L
PhylomeDBiQ9Y5E9
TreeFamiTF332299

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin
IPR015919 Cadherin-like
IPR032455 Cadherin_C
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF08266 Cadherin_2, 1 hit
PF16492 Cadherin_C_2, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 5 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 5 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9Y5E9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEIRGALDLR KRQVLIFLVL LGLSRAGTES AHYSVAEETE IGSFVANLAR
60 70 80 90 100
DLGLGVEELS SREARVVSDD NKKYLHLDLL TGNLLLNEKL DRDELCGSTE
110 120 130 140 150
PCVLHFQVVL ENPLQFFRFE LCVKDINDHS PTFLDKEILI KISEGTTVGA
160 170 180 190 200
TFLMESAQDL DVGSNSLQNY TISPNSHFYI KIPDSSDRKI YPELVLDRAL
210 220 230 240 250
DYEQEAELRL TLTAVDGGSP PKSGTTLVLI KVLDINDNAP EFPQSLYEVQ
260 270 280 290 300
VPEDRPLGSW IATISAKDLD AGNYGKISYT FFHASEDIRK TFEINPISGE
310 320 330 340 350
VNLRSPLDFE VIQSYTINIQ ATDGGGLSGK CTLLVKVMDI NDNPPEVTIS
360 370 380 390 400
SITKRIPENA SETLVALFSI LDQDSGDNGR MICSIQDNLP FFLKPTFKNF
410 420 430 440 450
FTLVSEKALD RESQAEYNIT ITVTDLGTPR LKTEYNITVL LSDVNDNAPT
460 470 480 490 500
FTQTSYTLFV RENNSPALHI GSVSATDRDS GTNAQVNYSL LPPQDRHLPL
510 520 530 540 550
ASLVSINADN GHLFALRSLD YEALQEFEFR VGATDRGSPA LSSEALVRVL
560 570 580 590 600
VLDANDNSPF VLYPLQNGSA PCTELVPRAA EPGYLVTKVV AVDGDSGQNA
610 620 630 640 650
WLSYQLLKAT EPGLFGVWAH NGEVRTARLL SERDAAKHRL VVLVKDNGEP
660 670 680 690 700
PRSATATLHV LLVDGFSQPY LPLPEAAPAQ AQADSLTVYL VVALASVSSL
710 720 730 740 750
FLFSVLLFVA VRLCRRSRAA SVGRCSVPEG PFPGHLVDVS GTGTLSQSYQ
760 770 780 790
YEVCLTGGSG TNEFKFLKPI IPNFQVHDTG RNMGEIENFR NSFGLNIQ
Length:798
Mass (Da):87,548
Last modified:November 1, 1999 - v1
Checksum:i65151C1A423BB52E
GO
Isoform 2 (identifier: Q9Y5E9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-153: Missing.

Note: No experimental confirmation available.
Show »
Length:645
Mass (Da):70,448
Checksum:i9F771EFF7BB91B1A
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0559321 – 153Missing in isoform 2. 1 PublicationAdd BLAST153

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152493 mRNA Translation: AAD43754.1
AF217744 mRNA Translation: AAK51612.1
AK298296 mRNA Translation: BAG60554.1
AC005752 Genomic DNA No translation available.
BC098144 mRNA Translation: AAH98144.1
BC099728 mRNA Translation: AAH99728.1
CCDSiCCDS4256.1 [Q9Y5E9-1]
RefSeqiNP_061757.1, NM_018934.3 [Q9Y5E9-1]
UniGeneiHs.658497

Genome annotation databases

EnsembliENST00000239449; ENSP00000239449; ENSG00000120327 [Q9Y5E9-1]
ENST00000624896; ENSP00000485055; ENSG00000120327 [Q9Y5E9-2]
GeneIDi56122
KEGGihsa:56122
UCSCiuc003ljb.5 human [Q9Y5E9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152493 mRNA Translation: AAD43754.1
AF217744 mRNA Translation: AAK51612.1
AK298296 mRNA Translation: BAG60554.1
AC005752 Genomic DNA No translation available.
BC098144 mRNA Translation: AAH98144.1
BC099728 mRNA Translation: AAH99728.1
CCDSiCCDS4256.1 [Q9Y5E9-1]
RefSeqiNP_061757.1, NM_018934.3 [Q9Y5E9-1]
UniGeneiHs.658497

3D structure databases

ProteinModelPortaliQ9Y5E9
SMRiQ9Y5E9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121062, 4 interactors
IntActiQ9Y5E9, 14 interactors
STRINGi9606.ENSP00000239449

PTM databases

GlyConnecti1678
iPTMnetiQ9Y5E9
PhosphoSitePlusiQ9Y5E9

Polymorphism and mutation databases

BioMutaiPCDHB14
DMDMi13431380

Proteomic databases

EPDiQ9Y5E9
PaxDbiQ9Y5E9
PeptideAtlasiQ9Y5E9
PRIDEiQ9Y5E9
ProteomicsDBi86348

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000239449; ENSP00000239449; ENSG00000120327 [Q9Y5E9-1]
ENST00000624896; ENSP00000485055; ENSG00000120327 [Q9Y5E9-2]
GeneIDi56122
KEGGihsa:56122
UCSCiuc003ljb.5 human [Q9Y5E9-1]

Organism-specific databases

CTDi56122
EuPathDBiHostDB:ENSG00000120327.6
GeneCardsiPCDHB14
HGNCiHGNC:8685 PCDHB14
HPAiHPA007692
HPA045248
MIMi604967 gene
606340 gene
neXtProtiNX_Q9Y5E9
OpenTargetsiENSG00000120327
PharmGKBiPA33030
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00920000148964
HOGENOMiHOG000220892
HOVERGENiHBG054878
InParanoidiQ9Y5E9
KOiK16494
OMAiTFFHASE
OrthoDBiEOG091G024L
PhylomeDBiQ9Y5E9
TreeFamiTF332299

Miscellaneous databases

ChiTaRSiPCDHB14 human
GeneWikiiPCDHB14
GenomeRNAii56122
PROiPR:Q9Y5E9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000120327 Expressed in 168 organ(s), highest expression level in forebrain
CleanExiHS_PCDHB14
GenevisibleiQ9Y5E9 HS

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin
IPR015919 Cadherin-like
IPR032455 Cadherin_C
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF08266 Cadherin_2, 1 hit
PF16492 Cadherin_C_2, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 5 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPCDBE_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5E9
Secondary accession number(s): B4DPE2, Q4FZA4, Q4KN11
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: October 10, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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