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Protein

Protocadherin beta-2

Gene

PCDHB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

  • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
  • cell adhesion Source: GO_Central
  • chemical synaptic transmission Source: UniProtKB
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • nervous system development Source: ProtInc
  • synapse assembly Source: UniProtKB

Keywordsi

Biological processCell adhesion
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin beta-2
Short name:
PCDH-beta-2
Gene namesi
Name:PCDHB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000112852.6
HGNCiHGNC:8687 PCDHB2
MIMi604967 gene
606328 gene
neXtProtiNX_Q9Y5E7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 692ExtracellularSequence analysisAdd BLAST662
Transmembranei693 – 713HelicalSequence analysisAdd BLAST21
Topological domaini714 – 798CytoplasmicSequence analysisAdd BLAST85

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000112852
PharmGKBiPA33036

Polymorphism and mutation databases

BioMutaiPCDHB2
DMDMi13431378

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000000391631 – 798Protocadherin beta-2Add BLAST768

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi171N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei299N6-acetyllysineCombined sources1
Glycosylationi420N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi438N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi569N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Acetylation, Glycoprotein

Proteomic databases

EPDiQ9Y5E7
PaxDbiQ9Y5E7
PeptideAtlasiQ9Y5E7
PRIDEiQ9Y5E7
ProteomicsDBi86346

PTM databases

GlyConnecti1681
iPTMnetiQ9Y5E7
PhosphoSitePlusiQ9Y5E7

Expressioni

Gene expression databases

BgeeiENSG00000112852 Expressed in 112 organ(s), highest expression level in testis
CleanExiHS_PCDHB2
ExpressionAtlasiQ9Y5E7 baseline and differential
GenevisibleiQ9Y5E7 HS

Organism-specific databases

HPAiHPA007548

Interactioni

Protein-protein interaction databases

BioGridi121073, 3 interactors
STRINGi9606.ENSP00000194155

Structurei

3D structure databases

ProteinModelPortaliQ9Y5E7
SMRiQ9Y5E7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 135Cadherin 1PROSITE-ProRule annotationAdd BLAST99
Domaini136 – 244Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini249 – 349Cadherin 3PROSITE-ProRule annotationAdd BLAST101
Domaini354 – 453Cadherin 4PROSITE-ProRule annotationAdd BLAST100
Domaini458 – 563Cadherin 5PROSITE-ProRule annotationAdd BLAST106
Domaini570 – 673Cadherin 6PROSITE-ProRule annotationAdd BLAST104

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00920000148964
HOGENOMiHOG000220892
HOVERGENiHBG054878
InParanoidiQ9Y5E7
KOiK16494
OMAiVVFVQVM
OrthoDBiEOG091G024L
PhylomeDBiQ9Y5E7
TreeFamiTF332299

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR032455 Cadherin_C
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
IPR030735 PCDHB2/3
PANTHERiPTHR24028:SF77 PTHR24028:SF77, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF08266 Cadherin_2, 1 hit
PF16492 Cadherin_C_2, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 5 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 6 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9Y5E7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAGEGKERV PKQRQVLIFF VLLGIAQASC QPRHYSVAEE TESGSFVANL
60 70 80 90 100
LKDLGLEIGE LAVRGARVVS KGKKMHLQFD RQTGDLLLNE KLDREELCGP
110 120 130 140 150
TEPCVLPFQV LLENPLQFFQ AELRIRDVND HSPVFLDKEI LLKIPESITP
160 170 180 190 200
GTTFLIERAQ DLDVGTNSLQ NYTISPNFHF HLNLQDSLDG IILPQLVLNR
210 220 230 240 250
ALDREEQPEI RLTLTALDGG SPPRSGTALV RIEVVDINDN VPEFAKLLYE
260 270 280 290 300
VQIPEDSPVG SQVAIVSARD LDIGTNGEIS YAFSQASEDI RKTFRLSAKS
310 320 330 340 350
GELLLRQKLD FESIQTYTVN IQATDGGGLS GTCVVFVQVM DLNDNPPELT
360 370 380 390 400
MSTLINQIPE NLQDTLIAVF SVSDPDSGDN GRMVCSIQDD LPFFLKPSVE
410 420 430 440 450
NFYTLVISTA LDRETRSEYN ITITVTDFGT PRLKTEHNIT VLVSDVNDNA
460 470 480 490 500
PAFTQTSYTL FVRENNSPAL HIGSVSATDR DSGTNAQVTY SLLPPQDPHL
510 520 530 540 550
PLASLVSINA DNGHLFALQS LDYEALQAFE FRVGAADRGS PALSSEALVR
560 570 580 590 600
VLVLDANDNS PFVLYPLQNG SAPCTELVPR AAEPGYLVTK VVAVDGDSGQ
610 620 630 640 650
NAWLSYQLLK ATEPGLFGVW AHNGEVRTAR LLRERDAAKQ RLVVLVKDNG
660 670 680 690 700
EPPRSATATL HVLLVDGFSQ PYLLLPEAAP AQAQADLLTV YLVVALASVS
710 720 730 740 750
SLFLFSVLLF VAVRLCRRSR AASVGRCSVP EGPFPGQMVD VSGTGTLSQS
760 770 780 790
YQYEVCLTGG SGTNEFKFLK PIIPNFVAQG AERVSEANPS FRKSFEFT
Length:798
Mass (Da):87,254
Last modified:November 1, 1999 - v1
Checksum:iB2602E865378CB27
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A096LPA4A0A096LPA4_HUMAN
Protocadherin beta-2
PCDHB2 PCDHB3
54Annotation score:
A0A096LNX2A0A096LNX2_HUMAN
Protocadherin beta-2
PCDHB2
50Annotation score:
A0A096LP37A0A096LP37_HUMAN
Protocadherin beta-2
PCDHB2
36Annotation score:
A0A096LNI2A0A096LNI2_HUMAN
Protocadherin beta-2
PCDHB2
39Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020365128V → I. Corresponds to variant dbSNP:rs31853Ensembl.1
Natural variantiVAR_033701674L → P. Corresponds to variant dbSNP:rs384081Ensembl.1
Natural variantiVAR_033702760G → D. Corresponds to variant dbSNP:rs1047372Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152495 mRNA Translation: AAD43756.1
AF217756 mRNA Translation: AAK51623.1
BC098347 mRNA Translation: AAH98347.1
CCDSiCCDS4244.1
RefSeqiNP_061759.1, NM_018936.3
UniGeneiHs.533023

Genome annotation databases

EnsembliENST00000194155; ENSP00000194155; ENSG00000112852
GeneIDi56133
KEGGihsa:56133
UCSCiuc003lil.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152495 mRNA Translation: AAD43756.1
AF217756 mRNA Translation: AAK51623.1
BC098347 mRNA Translation: AAH98347.1
CCDSiCCDS4244.1
RefSeqiNP_061759.1, NM_018936.3
UniGeneiHs.533023

3D structure databases

ProteinModelPortaliQ9Y5E7
SMRiQ9Y5E7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121073, 3 interactors
STRINGi9606.ENSP00000194155

PTM databases

GlyConnecti1681
iPTMnetiQ9Y5E7
PhosphoSitePlusiQ9Y5E7

Polymorphism and mutation databases

BioMutaiPCDHB2
DMDMi13431378

Proteomic databases

EPDiQ9Y5E7
PaxDbiQ9Y5E7
PeptideAtlasiQ9Y5E7
PRIDEiQ9Y5E7
ProteomicsDBi86346

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000194155; ENSP00000194155; ENSG00000112852
GeneIDi56133
KEGGihsa:56133
UCSCiuc003lil.5 human

Organism-specific databases

CTDi56133
EuPathDBiHostDB:ENSG00000112852.6
GeneCardsiPCDHB2
HGNCiHGNC:8687 PCDHB2
HPAiHPA007548
MIMi604967 gene
606328 gene
neXtProtiNX_Q9Y5E7
OpenTargetsiENSG00000112852
PharmGKBiPA33036
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00920000148964
HOGENOMiHOG000220892
HOVERGENiHBG054878
InParanoidiQ9Y5E7
KOiK16494
OMAiVVFVQVM
OrthoDBiEOG091G024L
PhylomeDBiQ9Y5E7
TreeFamiTF332299

Miscellaneous databases

GeneWikiiPCDHB2
GenomeRNAii56133
PROiPR:Q9Y5E7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000112852 Expressed in 112 organ(s), highest expression level in testis
CleanExiHS_PCDHB2
ExpressionAtlasiQ9Y5E7 baseline and differential
GenevisibleiQ9Y5E7 HS

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR032455 Cadherin_C
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
IPR030735 PCDHB2/3
PANTHERiPTHR24028:SF77 PTHR24028:SF77, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF08266 Cadherin_2, 1 hit
PF16492 Cadherin_C_2, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 5 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPCDB2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5E7
Secondary accession number(s): Q4KMU1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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