Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protocadherin beta-3

Gene

PCDHB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

  • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
  • cell adhesion Source: GO_Central
  • chemical synaptic transmission Source: UniProtKB
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • nervous system development Source: ProtInc
  • synapse assembly Source: UniProtKB

Keywordsi

Biological processCell adhesion
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin beta-3
Short name:
PCDH-beta-3
Gene namesi
Name:PCDHB3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000113205.5
HGNCiHGNC:8688 PCDHB3
MIMi604967 gene
606329 gene
neXtProtiNX_Q9Y5E6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 690ExtracellularSequence analysisAdd BLAST664
Transmembranei691 – 711HelicalSequence analysisAdd BLAST21
Topological domaini712 – 796CytoplasmicSequence analysisAdd BLAST85

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33037

Polymorphism and mutation databases

BioMutaiPCDHB3
DMDMi13431377

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000000391827 – 796Protocadherin beta-3Add BLAST770

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi418N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi436N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi567N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9Y5E6
PaxDbiQ9Y5E6
PeptideAtlasiQ9Y5E6
PRIDEiQ9Y5E6
ProteomicsDBi86345

PTM databases

GlyConnecti1682
iPTMnetiQ9Y5E6
PhosphoSitePlusiQ9Y5E6

Expressioni

Gene expression databases

BgeeiENSG00000113205 Expressed in 96 organ(s), highest expression level in testis
CleanExiHS_PCDHB3
ExpressionAtlasiQ9Y5E6 baseline and differential
GenevisibleiQ9Y5E6 HS

Organism-specific databases

HPAiHPA050296

Interactioni

Protein-protein interaction databases

BioGridi121072, 19 interactors
STRINGi9606.ENSP00000231130

Structurei

3D structure databases

ProteinModelPortaliQ9Y5E6
SMRiQ9Y5E6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 133Cadherin 1PROSITE-ProRule annotationAdd BLAST99
Domaini138 – 242Cadherin 2PROSITE-ProRule annotationAdd BLAST105
Domaini247 – 347Cadherin 3PROSITE-ProRule annotationAdd BLAST101
Domaini352 – 451Cadherin 4PROSITE-ProRule annotationAdd BLAST100
Domaini456 – 561Cadherin 5PROSITE-ProRule annotationAdd BLAST106
Domaini568 – 671Cadherin 6PROSITE-ProRule annotationAdd BLAST104

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
HOGENOMiHOG000220892
HOVERGENiHBG054878
InParanoidiQ9Y5E6
KOiK16494
OrthoDBiEOG091G024L
PhylomeDBiQ9Y5E6
TreeFamiTF332299

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR032455 Cadherin_C
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
IPR030735 PCDHB2/3
PANTHERiPTHR24028:SF77 PTHR24028:SF77, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF08266 Cadherin_2, 1 hit
PF16492 Cadherin_C_2, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 6 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y5E6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAGGERFLR QRQVLLLFVF LGGSLAGSES RRYSVAEEKE KGFLIANLAK
60 70 80 90 100
DLGLRVEELA ARGAQVVSKG NKQHFQLSHQ TGDLLLNEKL DREELCGPTE
110 120 130 140 150
PCILHFQILL QNPLQFVTNE LRIIDVNDHS PVFFENEMHL KILESTLPGT
160 170 180 190 200
VIPLGNAEDL DVGRNSLQNY TITPNSHFHV LTRSRRDGRK YPELVLDKAL
210 220 230 240 250
DREEQPELSL TLTALDGGSP PRSGTAQINI QVLDINDNAP EFAQPLYEVA
260 270 280 290 300
VLENTPVNSV IVTVSASDLD TGSFGTISYA FFHASEEIRK TFQLNPITGD
310 320 330 340 350
MQLVKYLNFE AINSYEVDIE AKDGGGLSGK STVIVQVVDV NDNPPELTLS
360 370 380 390 400
SVNSPIPENS GETVLAVFSV SDLDSGDNGR VMCSIENNLP FFLKPSVENF
410 420 430 440 450
YTLVSEGALD RETRSEYNIT ITITDLGTPR LKTKYNITVL VSDVNDNAPA
460 470 480 490 500
FTQISYTLFV RENNSPALHI GSVSATDRDS GTNAQVTYSL LPPQDPHLPL
510 520 530 540 550
SSLVSINADN GHLFALRSLD YEALQAFEFR VGATDRGSPA LSSEALVRVL
560 570 580 590 600
VLDANDNSPF VLYPLQNGSA PCTELVPRAA EPGYLVTKVV AVDGDSGQNA
610 620 630 640 650
WLSYQLLKAT EPGLFGVWAH NGEVRTARLL SERDAAKHRL VVLVKDNGEP
660 670 680 690 700
PRSATATLHV LLVDGFSQPY LPLPEAAPAQ AQADLLTVYL VVALASVSSL
710 720 730 740 750
FLFSVLLFVA VRLCRRSRAA SVGRCSVPEG PFPGQMVDVS GTGTLSQSYQ
760 770 780 790
YEVCLTGGSG TNEFKFLKPI IPNFVAQGAE RVSEANPSFR KSFEFS
Length:796
Mass (Da):86,773
Last modified:November 1, 1999 - v1
Checksum:iF586CF1BC3A2B0D2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02439141K → R. Corresponds to variant dbSNP:rs31849Ensembl.1
Natural variantiVAR_033703207E → K. Corresponds to variant dbSNP:rs12515688Ensembl.1
Natural variantiVAR_020366414R → S. Corresponds to variant dbSNP:rs3733699Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152496 mRNA Translation: AAD43757.1
AF217755 mRNA Translation: AAK51622.1
AK313451 mRNA Translation: BAG36239.1
CH471062 Genomic DNA Translation: EAW61981.1
CCDSiCCDS4245.1
RefSeqiNP_061760.1, NM_018937.4
UniGeneiHs.508987
Hs.674730
Hs.708778

Genome annotation databases

EnsembliENST00000231130; ENSP00000231130; ENSG00000113205
GeneIDi56132
KEGGihsa:56132
UCSCiuc003lio.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152496 mRNA Translation: AAD43757.1
AF217755 mRNA Translation: AAK51622.1
AK313451 mRNA Translation: BAG36239.1
CH471062 Genomic DNA Translation: EAW61981.1
CCDSiCCDS4245.1
RefSeqiNP_061760.1, NM_018937.4
UniGeneiHs.508987
Hs.674730
Hs.708778

3D structure databases

ProteinModelPortaliQ9Y5E6
SMRiQ9Y5E6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121072, 19 interactors
STRINGi9606.ENSP00000231130

PTM databases

GlyConnecti1682
iPTMnetiQ9Y5E6
PhosphoSitePlusiQ9Y5E6

Polymorphism and mutation databases

BioMutaiPCDHB3
DMDMi13431377

Proteomic databases

EPDiQ9Y5E6
PaxDbiQ9Y5E6
PeptideAtlasiQ9Y5E6
PRIDEiQ9Y5E6
ProteomicsDBi86345

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000231130; ENSP00000231130; ENSG00000113205
GeneIDi56132
KEGGihsa:56132
UCSCiuc003lio.5 human

Organism-specific databases

CTDi56132
EuPathDBiHostDB:ENSG00000113205.5
GeneCardsiPCDHB3
H-InvDBiHIX0032374
HGNCiHGNC:8688 PCDHB3
HPAiHPA050296
MIMi604967 gene
606329 gene
neXtProtiNX_Q9Y5E6
PharmGKBiPA33037
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
HOGENOMiHOG000220892
HOVERGENiHBG054878
InParanoidiQ9Y5E6
KOiK16494
OrthoDBiEOG091G024L
PhylomeDBiQ9Y5E6
TreeFamiTF332299

Miscellaneous databases

GeneWikiiPCDHB3
GenomeRNAii56132
PROiPR:Q9Y5E6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000113205 Expressed in 96 organ(s), highest expression level in testis
CleanExiHS_PCDHB3
ExpressionAtlasiQ9Y5E6 baseline and differential
GenevisibleiQ9Y5E6 HS

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR032455 Cadherin_C
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
IPR030735 PCDHB2/3
PANTHERiPTHR24028:SF77 PTHR24028:SF77, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF08266 Cadherin_2, 1 hit
PF16492 Cadherin_C_2, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPCDB3_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5E6
Secondary accession number(s): B2R8P2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again