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Protein

Protocadherin beta-5

Gene

PCDHB5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

  • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
  • cell adhesion Source: GO_Central
  • chemical synaptic transmission Source: UniProtKB
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • synapse assembly Source: UniProtKB

Keywordsi

Biological processCell adhesion
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin beta-5
Short name:
PCDH-beta-5
Gene namesi
Name:PCDHB5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000113209.8
HGNCiHGNC:8690 PCDHB5
MIMi604967 gene
606331 gene
neXtProtiNX_Q9Y5E4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 689ExtracellularSequence analysisAdd BLAST659
Transmembranei690 – 710HelicalSequence analysisAdd BLAST21
Topological domaini711 – 795CytoplasmicSequence analysisAdd BLAST85

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33039

Polymorphism and mutation databases

BioMutaiPCDHB5
DMDMi13431375

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000000392231 – 795Protocadherin beta-5Add BLAST765

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei296N6-acetyllysineBy similarity1
Glycosylationi417N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi435N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi566N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Acetylation, Glycoprotein

Proteomic databases

EPDiQ9Y5E4
PaxDbiQ9Y5E4
PeptideAtlasiQ9Y5E4
PRIDEiQ9Y5E4
ProteomicsDBi86343

PTM databases

GlyConnecti1683
iPTMnetiQ9Y5E4
PhosphoSitePlusiQ9Y5E4

Expressioni

Gene expression databases

BgeeiENSG00000113209 Expressed in 127 organ(s), highest expression level in parietal pleura
CleanExiHS_PCDHB5
ExpressionAtlasiQ9Y5E4 baseline and differential
GenevisibleiQ9Y5E4 HS

Organism-specific databases

HPAiHPA013191

Interactioni

Protein-protein interaction databases

BioGridi117593, 10 interactors
IntActiQ9Y5E4, 2 interactors
STRINGi9606.ENSP00000231134

Structurei

3D structure databases

ProteinModelPortaliQ9Y5E4
SMRiQ9Y5E4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 133Cadherin 1PROSITE-ProRule annotationAdd BLAST99
Domaini138 – 242Cadherin 2PROSITE-ProRule annotationAdd BLAST105
Domaini247 – 346Cadherin 3PROSITE-ProRule annotationAdd BLAST100
Domaini351 – 450Cadherin 4PROSITE-ProRule annotationAdd BLAST100
Domaini455 – 560Cadherin 5PROSITE-ProRule annotationAdd BLAST106
Domaini567 – 670Cadherin 6PROSITE-ProRule annotationAdd BLAST104

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
HOVERGENiHBG054878
InParanoidiQ9Y5E4
KOiK16494
OrthoDBiEOG091G024L
PhylomeDBiQ9Y5E4
TreeFamiTF332299

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR032455 Cadherin_C
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
IPR030730 PCDHB5
PANTHERiPTHR24028:SF90 PTHR24028:SF90, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF08266 Cadherin_2, 1 hit
PF16492 Cadherin_C_2, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 5 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 6 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9Y5E4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METALAKTPQ KRQVMFLAIL LLLWEAGSEA VRYSIPEETE SGYSVANLAK
60 70 80 90 100
DLGLGVGELA TRGARMHYKG NKELLQLDIK TGNLLLYEKL DREVMCGATE
110 120 130 140 150
PCILHFQLLL ENPVQFFQTD LQLTDINDHA PEFPEKEMLL KIPESTQPGT
160 170 180 190 200
VFPLKIAQDF DIGSNTVQNY TISPNSHFHV ATHNRGDGRK YPELVLDKAL
210 220 230 240 250
DREERPELSL TLTALDGGAP PRSGTTTIRI VVLDNNDNAP EFLQSFYEVQ
260 270 280 290 300
VPENSPLNSL VVVVSARDLD AGAYGSVAYA LFQGDEVTQP FVIDEKTAEI
310 320 330 340 350
RLKRALDFEA TPYYNVEIVA TDGGGLSGKC TVAIEVVDVN DNAPELTMST
360 370 380 390 400
LSSPTPENAP ETVVAVFSVS DPDSGDNGRM ICSIQNDLPF LLKPTLKNFY
410 420 430 440 450
TLVTQRTLDR ESQAEYNITI TVTDMGTPRL KTEHNITVLV SDVNDNAPAF
460 470 480 490 500
TQTSYTLFVR ENNSPALHIG SVSATDRDSG TNAQVTYSLL PPQNPHLRLA
510 520 530 540 550
SLVSINADNG HLFALRSLDY EALQAFEFRV GATDRGSPAL SSEALVRVLV
560 570 580 590 600
LDANDNSPFV LYPLQNGSAP CTELVPRAAE PGYLVTKVVA VDGDSGQNAW
610 620 630 640 650
LSYQLLKATE PGLFSMWAHN GEVRTARLLS ERDAAKHRLV VLVKDNGEPP
660 670 680 690 700
RSATATLHVL LVDGFSQPYL PLPEAAPAQA QADSLTVYLV VALASVSSLF
710 720 730 740 750
LFSVLLFVAV RLCRRSRAAS VGRCSVPEGP FPGHLVDVSG TGTLSQSYHY
760 770 780 790
EVCLTGDSGA GEFKFLKPII PNLLPQGAGE EIGKTAAFRN SFGLN
Length:795
Mass (Da):86,423
Last modified:November 1, 1999 - v1
Checksum:i06F743580DC65B64
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A096LP94A0A096LP94_HUMAN
Protocadherin beta-5
PCDHB5
247Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033704156I → T. Corresponds to variant dbSNP:rs17096901Ensembl.1
Natural variantiVAR_048552720S → P2 PublicationsCorresponds to variant dbSNP:rs400562Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152498 mRNA Translation: AAD43759.1
AF134474 mRNA Translation: AAP97251.1
AF217753 mRNA Translation: AAK51620.1
BC001186 mRNA Translation: AAH01186.1
AL117449 mRNA Translation: CAB55933.1
CCDSiCCDS4247.1
PIRiT17243
RefSeqiNP_056484.2, NM_015669.4
UniGeneiHs.119693

Genome annotation databases

EnsembliENST00000231134; ENSP00000231134; ENSG00000113209
GeneIDi26167
KEGGihsa:26167
UCSCiuc003liq.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152498 mRNA Translation: AAD43759.1
AF134474 mRNA Translation: AAP97251.1
AF217753 mRNA Translation: AAK51620.1
BC001186 mRNA Translation: AAH01186.1
AL117449 mRNA Translation: CAB55933.1
CCDSiCCDS4247.1
PIRiT17243
RefSeqiNP_056484.2, NM_015669.4
UniGeneiHs.119693

3D structure databases

ProteinModelPortaliQ9Y5E4
SMRiQ9Y5E4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117593, 10 interactors
IntActiQ9Y5E4, 2 interactors
STRINGi9606.ENSP00000231134

PTM databases

GlyConnecti1683
iPTMnetiQ9Y5E4
PhosphoSitePlusiQ9Y5E4

Polymorphism and mutation databases

BioMutaiPCDHB5
DMDMi13431375

Proteomic databases

EPDiQ9Y5E4
PaxDbiQ9Y5E4
PeptideAtlasiQ9Y5E4
PRIDEiQ9Y5E4
ProteomicsDBi86343

Protocols and materials databases

DNASUi26167
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000231134; ENSP00000231134; ENSG00000113209
GeneIDi26167
KEGGihsa:26167
UCSCiuc003liq.5 human

Organism-specific databases

CTDi26167
EuPathDBiHostDB:ENSG00000113209.8
GeneCardsiPCDHB5
HGNCiHGNC:8690 PCDHB5
HPAiHPA013191
MIMi604967 gene
606331 gene
neXtProtiNX_Q9Y5E4
PharmGKBiPA33039
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
HOVERGENiHBG054878
InParanoidiQ9Y5E4
KOiK16494
OrthoDBiEOG091G024L
PhylomeDBiQ9Y5E4
TreeFamiTF332299

Miscellaneous databases

ChiTaRSiPCDHB5 human
GeneWikiiPCDHB5
GenomeRNAii26167
PROiPR:Q9Y5E4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000113209 Expressed in 127 organ(s), highest expression level in parietal pleura
CleanExiHS_PCDHB5
ExpressionAtlasiQ9Y5E4 baseline and differential
GenevisibleiQ9Y5E4 HS

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR032455 Cadherin_C
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
IPR030730 PCDHB5
PANTHERiPTHR24028:SF90 PTHR24028:SF90, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF08266 Cadherin_2, 1 hit
PF16492 Cadherin_C_2, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 5 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPCDB5_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5E4
Secondary accession number(s): Q549F4, Q9UFU9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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