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UniProtKB - Q9Y5B9 (SP16H_HUMAN)

Entry version 182 (25 May 2022)
Sequence version 1 (01 Nov 1999)
Previous versions | rss
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Protein

FACT complex subunit SPT16

Gene

SUPT16H

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II).

6 Publications

Caution

Although related to the peptidase M24 family, this protein lacks conserved active site residues suggesting that it may lack peptidase activity.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA damage, DNA repair, DNA replication, Host-virus interaction, Transcription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9Y5B9

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-112382, Formation of RNA Pol II elongation complex
R-HSA-167152, Formation of HIV elongation complex in the absence of HIV Tat
R-HSA-167200, Formation of HIV-1 elongation complex containing HIV-1 Tat
R-HSA-167238, Pausing and recovery of Tat-mediated HIV elongation
R-HSA-167243, Tat-mediated HIV elongation arrest and recovery
R-HSA-167246, Tat-mediated elongation of the HIV-1 transcript
R-HSA-167287, HIV elongation arrest and recovery
R-HSA-167290, Pausing and recovery of HIV elongation
R-HSA-674695, RNA Polymerase II Pre-transcription Events
R-HSA-6796648, TP53 Regulates Transcription of DNA Repair Genes
R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation
R-HSA-75955, RNA Polymerase II Transcription Elongation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9Y5B9

Protein family/group databases

MEROPS protease database

More...MEROPSi		M24.974

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
FACT complex subunit SPT16
Alternative name(s):
Chromatin-specific transcription elongation factor 140 kDa subunit
FACT 140 kDa subunit
FACTp140
Facilitates chromatin transcription complex subunit SPT16
Short name:
hSPT16
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SUPT16H
Synonyms:FACT140, FACTP140
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11465, SUPT16H

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605012, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y5B9

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000092201

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		11198

Open Targets

More...OpenTargetsi		ENSG00000092201

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36251

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y5B9, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SUPT16H

Domain mapping of disease mutations (DMDM)

More...DMDMi		74753511

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources2 Publications
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002451692 – 1047FACT complex subunit SPT16Add BLAST1046

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources2 Publications1
Modified residuei139N6-acetyllysineCombined sources1
Modified residuei188PhosphoserineCombined sources1
Modified residuei196N6-acetyllysineCombined sources1
Modified residuei223N6-acetyllysineCombined sources1
Modified residuei455PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki497Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei508PhosphoserineCombined sources1
Modified residuei513N6-acetyllysine; alternateCombined sources1
Cross-linki513Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki647Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei650PhosphoserineCombined sources1
Modified residuei658PhosphoserineCombined sources1
Modified residuei732N6-acetyllysineCombined sources1
Modified residuei786N6-acetyllysineCombined sources1
Modified residuei903PhosphothreonineCombined sources1
Modified residuei904N6-acetyllysineCombined sources1
Modified residuei979PhosphoserineCombined sources1
Modified residuei982PhosphoserineCombined sources1
Modified residuei986PhosphoserineCombined sources1
Modified residuei1015PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

ADP-ribosylated. ADP-ribosylation by PARP1 is induced by genotoxic stress and correlates with dissociation of FACT from chromatin.

Keywords - PTMi

Acetylation, ADP-ribosylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9Y5B9

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9Y5B9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9Y5B9

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9Y5B9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y5B9

PeptideAtlas

More...PeptideAtlasi		Q9Y5B9

PRoteomics IDEntifications database

More...PRIDEi		Q9Y5B9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		86338

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9Y5B9, 1 site, 2 O-linked glycans (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y5B9

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9Y5B9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y5B9

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9Y5B9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000092201, Expressed in ventricular zone and 173 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9Y5B9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Y5B9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000092201, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MYOG (via C-terminal region) (By similarity).

Component of the FACT complex, a stable heterodimer of SSRP1 and SUPT16H (PubMed:10421373). Also component of a CK2-SPT16-SSRP1 complex which forms following UV irradiation, composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B (PubMed:11239457, PubMed:12393879).

Interacts with NEK9 (PubMed:14660563). Binds to histone H2A-H2B (PubMed:10421373).

Identified in a centromere complex containing histones H2A, H2B and H4, and at least CENPA, CENPB, CENPC, CENPT, CENPN, HJURP, SUPT16H, SSRP1 and RSF1 (PubMed:27499292).

Interacts with GTF2E2 (PubMed:10792464).

By similarity6 Publications

(Microbial infection) Interacts with Herpes simplex virus 1 (HHV-1) protein ICP22; this interaction relocalizes the FACT complex to viral genomes in infected cells.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116367, 331 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-419, FACT complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9Y5B9

Database of interacting proteins

More...DIPi		DIP-42757N

Protein interaction database and analysis system

More...IntActi		Q9Y5B9, 111 interactors

Molecular INTeraction database

More...MINTi		Q9Y5B9

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000216297

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Y5B9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11047
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9Y5B9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Y5B9

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni492 – 518DisorderedSequence analysisAdd BLAST27
Regioni918 – 1047DisorderedSequence analysisAdd BLAST130

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili432 – 507Sequence analysisAdd BLAST76

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi929 – 971Acidic residuesSequence analysisAdd BLAST43
Compositional biasi972 – 1018Basic and acidic residuesSequence analysisAdd BLAST47

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal Glu-rich acidic region is essential for FACT activity.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M24 family. SPT16 subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1189, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000014495

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004627_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y5B9

Identification of Orthologs from Complete Genome Data

More...OMAi		HQFFLDG

Database of Orthologous Groups

More...OrthoDBi		145488at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y5B9

TreeFam database of animal gene trees

More...TreeFami		TF300341

Family and domain databases

Conserved Domains Database

More...CDDi		cd01091, CDC68-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.29.30, 1 hit
3.40.350.10, 1 hit
3.90.230.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029149, Creatin/AminoP/Spt16_NTD
IPR036005, Creatinase/aminopeptidase-like
IPR013719, DUF1747
IPR029148, FACT-Spt16_Nlobe
IPR013953, FACT_Spt16
IPR000994, Pept_M24
IPR011993, PH-like_dom_sf
IPR040258, Spt16
IPR033825, Spt16_M24

The PANTHER Classification System

More...PANTHERi		PTHR13980, PTHR13980, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF14826, FACT-Spt16_Nlob, 1 hit
PF00557, Peptidase_M24, 1 hit
PF08512, Rtt106, 1 hit
PF08644, SPT16, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01285, FACT-Spt16_Nlob, 1 hit
SM01287, Rtt106, 1 hit
SM01286, SPT16, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF55920, SSF55920, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9Y5B9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVTLDKDAY YRRVKRLYSN WRKGEDEYAN VDAIVVSVGV DEEIVYAKST 
        60         70         80         90        100
ALQTWLFGYE LTDTIMVFCD DKIIFMASKK KVEFLKQIAN TKGNENANGA 
       110        120        130        140        150
PAITLLIREK NESNKSSFDK MIEAIKESKN GKKIGVFSKD KFPGEFMKSW 
       160        170        180        190        200
NDCLNKEGFD KIDISAVVAY TIAVKEDGEL NLMKKAASIT SEVFNKFFKE 
       210        220        230        240        250
RVMEIVDADE KVRHSKLAES VEKAIEEKKY LAGADPSTVE MCYPPIIQSG 
       260        270        280        290        300
GNYNLKFSVV SDKNHMHFGA ITCAMGIRFK SYCSNLVRTL MVDPSQEVQE 
       310        320        330        340        350
NYNFLLQLQE ELLKELRHGV KICDVYNAVM DVVKKQKPEL LNKITKNLGF 
       360        370        380        390        400
GMGIEFREGS LVINSKNQYK LKKGMVFSIN LGFSDLTNKE GKKPEEKTYA 
       410        420        430        440        450
LFIGDTVLVD EDGPATVLTS VKKKVKNVGI FLKNEDEEEE EEEKDEAEDL 
       460        470        480        490        500
LGRGSRAALL TERTRNEMTA EEKRRAHQKE LAAQLNEEAK RRLTEQKGEQ 
       510        520        530        540        550
QIQKARKSNV SYKNPSLMPK EPHIREMKIY IDKKYETVIM PVFGIATPFH 
       560        570        580        590        600
IATIKNISMS VEGDYTYLRI NFYCPGSALG RNEGNIFPNP EATFVKEITY 
       610        620        630        640        650
RASNIKAPGE QTVPALNLQN AFRIIKEVQK RYKTREAEEK EKEGIVKQDS 
       660        670        680        690        700
LVINLNRSNP KLKDLYIRPN IAQKRMQGSL EAHVNGFRFT SVRGDKVDIL 
       710        720        730        740        750
YNNIKHALFQ PCDGEMIIVL HFHLKNAIMF GKKRHTDVQF YTEVGEITTD 
       760        770        780        790        800
LGKHQHMHDR DDLYAEQMER EMRHKLKTAF KNFIEKVEAL TKEELEFEVP 
       810        820        830        840        850
FRDLGFNGAP YRSTCLLQPT SSALVNATEW PPFVVTLDEV ELIHFERVQF 
       860        870        880        890        900
HLKNFDMVIV YKDYSKKVTM INAIPVASLD PIKEWLNSCD LKYTEGVQSL 
       910        920        930        940        950
NWTKIMKTIV DDPEGFFEQG GWSFLEPEGE GSDAEEGDSE SEIEDETFNP 
       960        970        980        990       1000
SEDDYEEEEE DSDEDYSSEA EESDYSKESL GSEEESGKDW DELEEEARKA 
      1010       1020       1030       1040 
DRESRYEEEE EQSRSMSRKR KASVHSSGRG SNRGSRHSSA PPKKKRK
Length:1,047
Mass (Da):119,914
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3E1B23C45BDC61C2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V5A4G3V5A4_HUMAN
FACT complex subunit
SUPT16H
66Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V401G3V401_HUMAN
FACT complex subunit
SUPT16H
81Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V2X0G3V2X0_HUMAN
FACT complex subunit SPT16
SUPT16H
83Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH64561 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH73849 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF152961 mRNA Translation: AAD43978.1
BC000565 mRNA Translation: AAH00565.1
BC014046 mRNA Translation: AAH14046.1
BC064561 mRNA Translation: AAH64561.1 Sequence problems.
BC073849 mRNA Translation: AAH73849.1 Sequence problems.
AF164924 mRNA Translation: AAF28231.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS9569.1

NCBI Reference Sequences

More...RefSeqi		NP_009123.1, NM_007192.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000216297.7; ENSP00000216297.2; ENSG00000092201.10

Database of genes from NCBI RefSeq genomes

More...GeneIDi		11198

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:11198

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000216297.7; ENSP00000216297.2; NM_007192.4; NP_009123.1

UCSC genome browser

More...UCSCi		uc001wao.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152961 mRNA Translation: AAD43978.1
BC000565 mRNA Translation: AAH00565.1
BC014046 mRNA Translation: AAH14046.1
BC064561 mRNA Translation: AAH64561.1 Sequence problems.
BC073849 mRNA Translation: AAH73849.1 Sequence problems.
AF164924 mRNA Translation: AAF28231.1
CCDSiCCDS9569.1
RefSeqiNP_009123.1, NM_007192.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4Z2MX-ray2.98B644-930[»]
4Z2NX-ray1.92A644-930[»]
5E5BX-ray1.84A2-432[»]
5UMTX-ray2.09A1-434[»]
5UMUX-ray1.90A/B649-926[»]
5XM2X-ray2.19A/B1-437[»]
6UPKelectron microscopy4.90G2-925[»]
6UPLelectron microscopy7.40G2-925[»]
AlphaFoldDBiQ9Y5B9
SMRiQ9Y5B9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116367, 331 interactors
ComplexPortaliCPX-419, FACT complex
CORUMiQ9Y5B9
DIPiDIP-42757N
IntActiQ9Y5B9, 111 interactors
MINTiQ9Y5B9
STRINGi9606.ENSP00000216297

Protein family/group databases

MEROPSiM24.974

PTM databases

GlyGeniQ9Y5B9, 1 site, 2 O-linked glycans (1 site)
iPTMnetiQ9Y5B9
MetOSiteiQ9Y5B9
PhosphoSitePlusiQ9Y5B9
SwissPalmiQ9Y5B9

Genetic variation databases

BioMutaiSUPT16H
DMDMi74753511

Proteomic databases

EPDiQ9Y5B9
jPOSTiQ9Y5B9
MassIVEiQ9Y5B9
MaxQBiQ9Y5B9
PaxDbiQ9Y5B9
PeptideAtlasiQ9Y5B9
PRIDEiQ9Y5B9
ProteomicsDBi86338

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		22129, 427 antibodies from 40 providers

The DNASU plasmid repository

More...DNASUi		11198

Genome annotation databases

EnsembliENST00000216297.7; ENSP00000216297.2; ENSG00000092201.10
GeneIDi11198
KEGGihsa:11198
MANE-SelectiENST00000216297.7; ENSP00000216297.2; NM_007192.4; NP_009123.1
UCSCiuc001wao.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		11198
DisGeNETi11198

GeneCards: human genes, protein and diseases

More...GeneCardsi		SUPT16H
HGNCiHGNC:11465, SUPT16H
HPAiENSG00000092201, Low tissue specificity
MIMi605012, gene
neXtProtiNX_Q9Y5B9
OpenTargetsiENSG00000092201
PharmGKBiPA36251
VEuPathDBiHostDB:ENSG00000092201

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1189, Eukaryota
GeneTreeiENSGT00390000014495
HOGENOMiCLU_004627_0_0_1
InParanoidiQ9Y5B9
OMAiHQFFLDG
OrthoDBi145488at2759
PhylomeDBiQ9Y5B9
TreeFamiTF300341

Enzyme and pathway databases

PathwayCommonsiQ9Y5B9
ReactomeiR-HSA-112382, Formation of RNA Pol II elongation complex
R-HSA-167152, Formation of HIV elongation complex in the absence of HIV Tat
R-HSA-167200, Formation of HIV-1 elongation complex containing HIV-1 Tat
R-HSA-167238, Pausing and recovery of Tat-mediated HIV elongation
R-HSA-167243, Tat-mediated HIV elongation arrest and recovery
R-HSA-167246, Tat-mediated elongation of the HIV-1 transcript
R-HSA-167287, HIV elongation arrest and recovery
R-HSA-167290, Pausing and recovery of HIV elongation
R-HSA-674695, RNA Polymerase II Pre-transcription Events
R-HSA-6796648, TP53 Regulates Transcription of DNA Repair Genes
R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation
R-HSA-75955, RNA Polymerase II Transcription Elongation
SignaLinkiQ9Y5B9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		11198, 766 hits in 1063 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SUPT16H, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SUPT16H

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		11198
PharosiQ9Y5B9, Tbio

Protein Ontology

More...PROi		PR:Q9Y5B9
RNActiQ9Y5B9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000092201, Expressed in ventricular zone and 173 other tissues
ExpressionAtlasiQ9Y5B9, baseline and differential
GenevisibleiQ9Y5B9, HS

Family and domain databases

CDDicd01091, CDC68-like, 1 hit
Gene3Di2.30.29.30, 1 hit
3.40.350.10, 1 hit
3.90.230.10, 1 hit
InterProiView protein in InterPro
IPR029149, Creatin/AminoP/Spt16_NTD
IPR036005, Creatinase/aminopeptidase-like
IPR013719, DUF1747
IPR029148, FACT-Spt16_Nlobe
IPR013953, FACT_Spt16
IPR000994, Pept_M24
IPR011993, PH-like_dom_sf
IPR040258, Spt16
IPR033825, Spt16_M24
PANTHERiPTHR13980, PTHR13980, 1 hit
PfamiView protein in Pfam
PF14826, FACT-Spt16_Nlob, 1 hit
PF00557, Peptidase_M24, 1 hit
PF08512, Rtt106, 1 hit
PF08644, SPT16, 1 hit
SMARTiView protein in SMART
SM01285, FACT-Spt16_Nlob, 1 hit
SM01287, Rtt106, 1 hit
SM01286, SPT16, 1 hit
SUPFAMiSSF55920, SSF55920, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSP16H_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y5B9
Secondary accession number(s): Q6GMT8
, Q6P2F1, Q6PJM1, Q9NRX0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: November 1, 1999
Last modified: May 25, 2022
This is version 182 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
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