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UniProtKB - Q9Y5B8 (NDK7_HUMAN)

Entry version 174 (17 Jun 2020)
Sequence version 1 (01 Nov 1999)
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Protein

Nucleoside diphosphate kinase 7

Gene

NME7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei99ATPBy similarity1
Binding sitei145ATPBy similarity1
Binding sitei193ATPBy similarity1
Binding sitei203ATPBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei206Pros-phosphohistidine intermediateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
Biological processNucleotide metabolism
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nucleoside diphosphate kinase 7 (EC:2.7.4.6)
Short name:
NDK 7
Short name:
NDP kinase 7
Alternative name(s):
nm23-H7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NME7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000143156.13

Human Gene Nomenclature Database

More...HGNCi		HGNC:20461 NME7

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613465 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y5B8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		29922

MalaCards human disease database

More...MalaCardsi		NME7

Open Targets

More...OpenTargetsi		ENSG00000143156

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		101063 Situs inversus totalis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134962167

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y5B8 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NME7

Domain mapping of disease mutations (DMDM)

More...DMDMi		12230353

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001371301 – 376Nucleoside diphosphate kinase 7Add BLAST376

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9Y5B8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9Y5B8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9Y5B8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y5B8

PeptideAtlas

More...PeptideAtlasi		Q9Y5B8

PRoteomics IDEntifications database

More...PRIDEi		Q9Y5B8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		86336 [Q9Y5B8-1]
86337 [Q9Y5B8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y5B8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y5B8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000143156 Expressed in cerebellar vermis and 229 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9Y5B8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Y5B8 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000143156 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9Y5B8
With#Exp.IntAct
AMOTL2 [Q9Y2J4]3EBI-744782,EBI-746752
ARHGAP9 [Q9BRR9]3EBI-744782,EBI-750254
BTBD6 - isoform 2 [Q96KE9-2]5EBI-744782,EBI-12012762
C1orf189 [Q5VU69]10EBI-744782,EBI-10247920
CARD10 [Q9BWT7]3EBI-744782,EBI-3866279
CASC1 [Q6TDU7]3EBI-744782,EBI-5235378
CBY2 - isoform 2 [Q8NA61-2]3EBI-744782,EBI-11524851
CCDC88B [A6NC98]3EBI-744782,EBI-347573
CCHCR1 - isoform 3 [Q8TD31-3]6EBI-744782,EBI-10175300
CDC42EP2 [O14613]6EBI-744782,EBI-3438291
CEP72 [Q9P209]12EBI-744782,EBI-739498
DDIT4L [Q96D03]3EBI-744782,EBI-742054
DISC1 - isoform 2 [Q9NRI5-2]3EBI-744782,EBI-11988027
EFHC2 [Q5JST6]3EBI-744782,EBI-2349927
FKBP6 [O75344]4EBI-744782,EBI-744771
FLOT1 [O75955]3EBI-744782,EBI-603643
FOSL1 [P15407]9EBI-744782,EBI-744510
FOSL2 [P15408]3EBI-744782,EBI-3893419
GATAD2B [Q8WXI9]3EBI-744782,EBI-923440
GLIS2 [Q9BZE0]3EBI-744782,EBI-7251368
GOLGA2 [Q08379]6EBI-744782,EBI-618309
GSC2 [O15499]3EBI-744782,EBI-19954058
HAUS8 [Q9BT25]3EBI-744782,EBI-2558143
IKZF1 - isoform Ik7 [Q13422-7]6EBI-744782,EBI-11522367
IKZF3 [Q9UKT9]3EBI-744782,EBI-747204
INCA1 [Q0VD86]5EBI-744782,EBI-6509505
ISY1 - isoform 2 [Q9ULR0-1]3EBI-744782,EBI-18398632
KRT18 [P05783]4EBI-744782,EBI-297888
KRT75 [O95678]3EBI-744782,EBI-2949715
LNX1 [Q8TBB1]9EBI-744782,EBI-739832
MED11 [Q9P086]3EBI-744782,EBI-394704
MED30 [Q96HR3]5EBI-744782,EBI-394659
MEI4 [A8MW99]3EBI-744782,EBI-19944212
MEOX2 [Q6FHY5]3EBI-744782,EBI-16439278
MYOT [Q9UBF9]3EBI-744782,EBI-296701
NAB2 [Q15742]6EBI-744782,EBI-8641936
NEFL [I6L9F6]3EBI-744782,EBI-10178578
NEFL [P07196]3EBI-744782,EBI-475646
NFKBIL1 [Q9UBC1]3EBI-744782,EBI-1043728
NIF3L1 [Q9GZT8]3EBI-744782,EBI-740897
NME4 [O00746]3EBI-744782,EBI-744871
NT5C2 [P49902]4EBI-744782,EBI-742084
OFD1 [O75665]3EBI-744782,EBI-716327
PAX4 [Q3KNR5]3EBI-744782,EBI-10240813
PIAS2 - isoform PIAS2-alpha [O75928-2]3EBI-744782,EBI-348567
PICK1 [Q9NRD5]3EBI-744782,EBI-79165
POU6F2 [P78424]3EBI-744782,EBI-12029004
PROSER3 [Q2NL68]5EBI-744782,EBI-11336487
PSMA1 [P25786]3EBI-744782,EBI-359352
REL [Q04864]3EBI-744782,EBI-307352
RUBCN [Q92622]3EBI-744782,EBI-2952709
SHTN1 [A0MZ66]3EBI-744782,EBI-308778
SHTN1 - isoform 4 [A0MZ66-4]3EBI-744782,EBI-12097232
SNAPIN [O95295]3EBI-744782,EBI-296723
SNX32 [Q86XE0]5EBI-744782,EBI-8099743
SYCE1 [Q8N0S2]6EBI-744782,EBI-6872807
TCF4 [P15884]3EBI-744782,EBI-533224
TCF4 - isoform SEF2-1D [P15884-3]3EBI-744782,EBI-13636688
TCHP [Q9BT92]12EBI-744782,EBI-740781
TEKT1 [Q969V4]5EBI-744782,EBI-10180409
TEPSIN [Q96N21]3EBI-744782,EBI-11139477
THAP10 [Q9P2Z0]3EBI-744782,EBI-745404
TNIP1 [Q15025]8EBI-744782,EBI-357849
TNNI2 [P48788]3EBI-744782,EBI-7746394
TRIM27 [P14373]3EBI-744782,EBI-719493
TRIM48 [Q8IWZ4]3EBI-744782,EBI-17555779
ZBTB48 [P10074]6EBI-744782,EBI-744864
ZNF23 [P17027]3EBI-744782,EBI-5657766
ZNF343 [Q6P1L6]3EBI-744782,EBI-10252492
ZNF526 [Q8TF50]3EBI-744782,EBI-11035148
ZNF620 [Q6ZNG0]3EBI-744782,EBI-4395669

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		118963, 78 interactors

Protein interaction database and analysis system

More...IntActi		Q9Y5B8, 118 interactors

Molecular INTeraction database

More...MINTi		Q9Y5B8

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000356785

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Y5B8 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Y5B8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 91DM10PROSITE-ProRule annotationAdd BLAST89

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NDK family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0888 Eukaryota
COG0105 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158946

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_060216_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y5B8

KEGG Orthology (KO)

More...KOi		K00940

Identification of Orthologs from Complete Genome Data

More...OMAi		NLELQYM

Database of Orthologous Groups

More...OrthoDBi		1230088at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y5B8

TreeFam database of animal gene trees

More...TreeFami		TF106374

Family and domain databases

Conserved Domains Database

More...CDDi		cd04415 NDPk7A, 1 hit
cd04412 NDPk7B, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.70.141, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR034907 NDK-like_dom
IPR036850 NDK-like_dom_sf
IPR011410 NDPK7
IPR035525 NDPk7A
IPR037993 NDPk7B
IPR001564 Nucleoside_diP_kinase
IPR006602 Uncharacterised_DM10

The PANTHER Classification System

More...PANTHERi		PTHR43109 PTHR43109, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00334 NDK, 2 hits

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF036503 NDK7, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01243 NUCDPKINASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00676 DM10, 1 hit
SM00562 NDK, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54919 SSF54919, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51336 DM10, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y5B8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNHSERFVFI AEWYDPNASL LRRYELLFYP GDGSVEMHDV KNHRTFLKRT 
        60         70         80         90        100
KYDNLHLEDL FIGNKVNVFS RQLVLIDYGD QYTARQLGSR KEKTLALIKP 
       110        120        130        140        150
DAISKAGEII EIINKAGFTI TKLKMMMLSR KEALDFHVDH QSRPFFNELI 
       160        170        180        190        200
QFITTGPIIA MEILRDDAIC EWKRLLGPAN SGVARTDASE SIRALFGTDG 
       210        220        230        240        250
IRNAAHGPDS FASAAREMEL FFPSSGGCGP ANTAKFTNCT CCIVKPHAVS 
       260        270        280        290        300
EGLLGKILMA IRDAGFEISA MQMFNMDRVN VEEFYEVYKG VVTEYHDMVT 
       310        320        330        340        350
EMYSGPCVAM EIQQNNATKT FREFCGPADP EIARHLRPGT LRAIFGKTKI 
       360        370 
QNAVHCTDLP EDGLLEVQYF FKILDN
Length:376
Mass (Da):42,492
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i67C121D6C36E7012
GO
Isoform 2 (identifier: Q9Y5B8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.

Show »
Length:340
Mass (Da):38,187
Checksum:i2FA9FE0342B05737
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DXC8B4DXC8_HUMAN
Nucleoside diphosphate kinase 7
NME7
339Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PNU1E9PNU1_HUMAN
Nucleoside diphosphate kinase 7
NME7
256Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0409961 – 36Missing in isoform 2. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF153191 mRNA Translation: AAD34622.1
AK094513 mRNA Translation: BAG52881.1
AK290701 mRNA Translation: BAF83390.1
AL031726 Genomic DNA No translation available.
Z99758 Genomic DNA No translation available.
AL356852 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90834.1
CH471067 Genomic DNA Translation: EAW90835.1
BC006983 mRNA Translation: AAH06983.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1277.1 [Q9Y5B8-1]
CCDS44274.1 [Q9Y5B8-2]

NCBI Reference Sequences

More...RefSeqi		NP_037462.1, NM_013330.4 [Q9Y5B8-1]
NP_932076.1, NM_197972.2 [Q9Y5B8-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000367811; ENSP00000356785; ENSG00000143156 [Q9Y5B8-1]
ENST00000472647; ENSP00000433341; ENSG00000143156 [Q9Y5B8-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		29922

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:29922

UCSC genome browser

More...UCSCi		uc001gft.5 human [Q9Y5B8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF153191 mRNA Translation: AAD34622.1
AK094513 mRNA Translation: BAG52881.1
AK290701 mRNA Translation: BAF83390.1
AL031726 Genomic DNA No translation available.
Z99758 Genomic DNA No translation available.
AL356852 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90834.1
CH471067 Genomic DNA Translation: EAW90835.1
BC006983 mRNA Translation: AAH06983.1
CCDSiCCDS1277.1 [Q9Y5B8-1]
CCDS44274.1 [Q9Y5B8-2]
RefSeqiNP_037462.1, NM_013330.4 [Q9Y5B8-1]
NP_932076.1, NM_197972.2 [Q9Y5B8-2]

3D structure databases

SMRiQ9Y5B8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi118963, 78 interactors
IntActiQ9Y5B8, 118 interactors
MINTiQ9Y5B8
STRINGi9606.ENSP00000356785

PTM databases

iPTMnetiQ9Y5B8
PhosphoSitePlusiQ9Y5B8

Polymorphism and mutation databases

BioMutaiNME7
DMDMi12230353

Proteomic databases

EPDiQ9Y5B8
jPOSTiQ9Y5B8
MassIVEiQ9Y5B8
PaxDbiQ9Y5B8
PeptideAtlasiQ9Y5B8
PRIDEiQ9Y5B8
ProteomicsDBi86336 [Q9Y5B8-1]
86337 [Q9Y5B8-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		34356 149 antibodies

The DNASU plasmid repository

More...DNASUi		29922

Genome annotation databases

EnsembliENST00000367811; ENSP00000356785; ENSG00000143156 [Q9Y5B8-1]
ENST00000472647; ENSP00000433341; ENSG00000143156 [Q9Y5B8-2]
GeneIDi29922
KEGGihsa:29922
UCSCiuc001gft.5 human [Q9Y5B8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		29922
DisGeNETi29922
EuPathDBiHostDB:ENSG00000143156.13

GeneCards: human genes, protein and diseases

More...GeneCardsi		NME7
HGNCiHGNC:20461 NME7
HPAiENSG00000143156 Low tissue specificity
MalaCardsiNME7
MIMi613465 gene
neXtProtiNX_Q9Y5B8
OpenTargetsiENSG00000143156
Orphaneti101063 Situs inversus totalis
PharmGKBiPA134962167

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0888 Eukaryota
COG0105 LUCA
GeneTreeiENSGT00940000158946
HOGENOMiCLU_060216_3_1_1
InParanoidiQ9Y5B8
KOiK00940
OMAiNLELQYM
OrthoDBi1230088at2759
PhylomeDBiQ9Y5B8
TreeFamiTF106374

Enzyme and pathway databases

ReactomeiR-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		29922 0 hits in 785 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NME7 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		29922
PharosiQ9Y5B8 Tbio

Protein Ontology

More...PROi		PR:Q9Y5B8
RNActiQ9Y5B8 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000143156 Expressed in cerebellar vermis and 229 other tissues
ExpressionAtlasiQ9Y5B8 baseline and differential
GenevisibleiQ9Y5B8 HS

Family and domain databases

CDDicd04415 NDPk7A, 1 hit
cd04412 NDPk7B, 1 hit
Gene3Di3.30.70.141, 2 hits
InterProiView protein in InterPro
IPR034907 NDK-like_dom
IPR036850 NDK-like_dom_sf
IPR011410 NDPK7
IPR035525 NDPk7A
IPR037993 NDPk7B
IPR001564 Nucleoside_diP_kinase
IPR006602 Uncharacterised_DM10
PANTHERiPTHR43109 PTHR43109, 1 hit
PfamiView protein in Pfam
PF00334 NDK, 2 hits
PIRSFiPIRSF036503 NDK7, 1 hit
PRINTSiPR01243 NUCDPKINASE
SMARTiView protein in SMART
SM00676 DM10, 1 hit
SM00562 NDK, 2 hits
SUPFAMiSSF54919 SSF54919, 2 hits
PROSITEiView protein in PROSITE
PS51336 DM10, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNDK7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y5B8
Secondary accession number(s): A8K3T6
, A8MY09, B3KSW9, Q5TGZ4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1999
Last modified: June 17, 2020
This is version 174 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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