UniProtKB - Q9Y5B8 (NDK7_HUMAN)
Protein
Nucleoside diphosphate kinase 7
Gene
NME7
Organism
Homo sapiens (Human)
Status
Functioni
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
Catalytic activityi
Cofactori
Mg2+By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 99 | ATPBy similarity | 1 | |
Binding sitei | 145 | ATPBy similarity | 1 | |
Binding sitei | 193 | ATPBy similarity | 1 | |
Binding sitei | 203 | ATPBy similarity | 1 | |
Active sitei | 206 | Pros-phosphohistidine intermediateBy similarity | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- nucleoside diphosphate kinase activity Source: UniProtKB-EC
GO - Biological processi
- CTP biosynthetic process Source: InterPro
- GTP biosynthetic process Source: InterPro
- UTP biosynthetic process Source: InterPro
Keywordsi
Molecular function | Kinase, Transferase |
Biological process | Nucleotide metabolism |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9Y5B8 |
Reactomei | R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes R-HSA-380320, Recruitment of NuMA to mitotic centrosomes |
Names & Taxonomyi
Protein namesi | Recommended name: Nucleoside diphosphate kinase 7 (EC:2.7.4.6)Short name: NDK 7 Short name: NDP kinase 7 Alternative name(s): nm23-H7 |
Gene namesi | Name:NME7 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20461, NME7 |
MIMi | 613465, gene |
neXtProti | NX_Q9Y5B8 |
VEuPathDBi | HostDB:ENSG00000143156.13 |
Subcellular locationi
Cytoskeleton
- centrosome Source: UniProtKB
Cytosol
- cytosol Source: Reactome
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 29922 |
MalaCardsi | NME7 |
OpenTargetsi | ENSG00000143156 |
Orphaneti | 101063, Situs inversus totalis |
PharmGKBi | PA134962167 |
Miscellaneous databases
Pharosi | Q9Y5B8, Tbio |
Genetic variation databases
BioMutai | NME7 |
DMDMi | 12230353 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000137130 | 1 – 376 | Nucleoside diphosphate kinase 7Add BLAST | 376 |
Proteomic databases
EPDi | Q9Y5B8 |
jPOSTi | Q9Y5B8 |
MassIVEi | Q9Y5B8 |
PaxDbi | Q9Y5B8 |
PeptideAtlasi | Q9Y5B8 |
PRIDEi | Q9Y5B8 |
ProteomicsDBi | 86336 [Q9Y5B8-1] 86337 [Q9Y5B8-2] |
PTM databases
iPTMneti | Q9Y5B8 |
PhosphoSitePlusi | Q9Y5B8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000143156, Expressed in cerebellar vermis and 241 other tissues |
ExpressionAtlasi | Q9Y5B8, baseline and differential |
Genevisiblei | Q9Y5B8, HS |
Organism-specific databases
HPAi | ENSG00000143156, Low tissue specificity |
Interactioni
Binary interactionsi
Q9Y5B8
Protein-protein interaction databases
BioGRIDi | 118963, 128 interactors |
IntActi | Q9Y5B8, 118 interactors |
MINTi | Q9Y5B8 |
STRINGi | 9606.ENSP00000356785 |
Miscellaneous databases
RNActi | Q9Y5B8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 3 – 91 | DM10PROSITE-ProRule annotationAdd BLAST | 89 |
Sequence similaritiesi
Belongs to the NDK family.Curated
Phylogenomic databases
eggNOGi | KOG0888, Eukaryota |
GeneTreei | ENSGT00940000158946 |
HOGENOMi | CLU_060216_3_1_1 |
InParanoidi | Q9Y5B8 |
OMAi | NLELQYM |
OrthoDBi | 1230088at2759 |
PhylomeDBi | Q9Y5B8 |
TreeFami | TF106374 |
Family and domain databases
CDDi | cd04415, NDPk7A, 1 hit cd04412, NDPk7B, 1 hit |
Gene3Di | 3.30.70.141, 2 hits |
InterProi | View protein in InterPro IPR034907, NDK-like_dom IPR036850, NDK-like_dom_sf IPR011410, NDPK7 IPR035525, NDPk7A IPR037993, NDPk7B IPR001564, Nucleoside_diP_kinase IPR006602, Uncharacterised_DM10 |
PANTHERi | PTHR43109, PTHR43109, 1 hit |
Pfami | View protein in Pfam PF00334, NDK, 2 hits |
PIRSFi | PIRSF036503, NDK7, 1 hit |
PRINTSi | PR01243, NUCDPKINASE |
SMARTi | View protein in SMART SM00676, DM10, 1 hit SM00562, NDK, 2 hits |
SUPFAMi | SSF54919, SSF54919, 2 hits |
PROSITEi | View protein in PROSITE PS51336, DM10, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9Y5B8-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNHSERFVFI AEWYDPNASL LRRYELLFYP GDGSVEMHDV KNHRTFLKRT
60 70 80 90 100
KYDNLHLEDL FIGNKVNVFS RQLVLIDYGD QYTARQLGSR KEKTLALIKP
110 120 130 140 150
DAISKAGEII EIINKAGFTI TKLKMMMLSR KEALDFHVDH QSRPFFNELI
160 170 180 190 200
QFITTGPIIA MEILRDDAIC EWKRLLGPAN SGVARTDASE SIRALFGTDG
210 220 230 240 250
IRNAAHGPDS FASAAREMEL FFPSSGGCGP ANTAKFTNCT CCIVKPHAVS
260 270 280 290 300
EGLLGKILMA IRDAGFEISA MQMFNMDRVN VEEFYEVYKG VVTEYHDMVT
310 320 330 340 350
EMYSGPCVAM EIQQNNATKT FREFCGPADP EIARHLRPGT LRAIFGKTKI
360 370
QNAVHCTDLP EDGLLEVQYF FKILDN
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB4DXC8 | B4DXC8_HUMAN | Nucleoside diphosphate kinase 7 | NME7 | 339 | Annotation score: | ||
E9PNU1 | E9PNU1_HUMAN | Nucleoside diphosphate kinase 7 | NME7 | 256 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_040996 | 1 – 36 | Missing in isoform 2. 1 PublicationAdd BLAST | 36 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF153191 mRNA Translation: AAD34622.1 AK094513 mRNA Translation: BAG52881.1 AK290701 mRNA Translation: BAF83390.1 AL031726 Genomic DNA No translation available. Z99758 Genomic DNA No translation available. AL356852 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW90834.1 CH471067 Genomic DNA Translation: EAW90835.1 BC006983 mRNA Translation: AAH06983.1 |
CCDSi | CCDS1277.1 [Q9Y5B8-1] CCDS44274.1 [Q9Y5B8-2] |
RefSeqi | NP_037462.1, NM_013330.4 [Q9Y5B8-1] NP_932076.1, NM_197972.2 [Q9Y5B8-2] |
Genome annotation databases
Ensembli | ENST00000367811; ENSP00000356785; ENSG00000143156 [Q9Y5B8-1] ENST00000472647; ENSP00000433341; ENSG00000143156 [Q9Y5B8-2] |
GeneIDi | 29922 |
KEGGi | hsa:29922 |
UCSCi | uc001gft.5, human [Q9Y5B8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF153191 mRNA Translation: AAD34622.1 AK094513 mRNA Translation: BAG52881.1 AK290701 mRNA Translation: BAF83390.1 AL031726 Genomic DNA No translation available. Z99758 Genomic DNA No translation available. AL356852 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW90834.1 CH471067 Genomic DNA Translation: EAW90835.1 BC006983 mRNA Translation: AAH06983.1 |
CCDSi | CCDS1277.1 [Q9Y5B8-1] CCDS44274.1 [Q9Y5B8-2] |
RefSeqi | NP_037462.1, NM_013330.4 [Q9Y5B8-1] NP_932076.1, NM_197972.2 [Q9Y5B8-2] |
3D structure databases
SMRi | Q9Y5B8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 118963, 128 interactors |
IntActi | Q9Y5B8, 118 interactors |
MINTi | Q9Y5B8 |
STRINGi | 9606.ENSP00000356785 |
PTM databases
iPTMneti | Q9Y5B8 |
PhosphoSitePlusi | Q9Y5B8 |
Genetic variation databases
BioMutai | NME7 |
DMDMi | 12230353 |
Proteomic databases
EPDi | Q9Y5B8 |
jPOSTi | Q9Y5B8 |
MassIVEi | Q9Y5B8 |
PaxDbi | Q9Y5B8 |
PeptideAtlasi | Q9Y5B8 |
PRIDEi | Q9Y5B8 |
ProteomicsDBi | 86336 [Q9Y5B8-1] 86337 [Q9Y5B8-2] |
Protocols and materials databases
Antibodypediai | 34356, 151 antibodies |
DNASUi | 29922 |
Genome annotation databases
Ensembli | ENST00000367811; ENSP00000356785; ENSG00000143156 [Q9Y5B8-1] ENST00000472647; ENSP00000433341; ENSG00000143156 [Q9Y5B8-2] |
GeneIDi | 29922 |
KEGGi | hsa:29922 |
UCSCi | uc001gft.5, human [Q9Y5B8-1] |
Organism-specific databases
CTDi | 29922 |
DisGeNETi | 29922 |
GeneCardsi | NME7 |
HGNCi | HGNC:20461, NME7 |
HPAi | ENSG00000143156, Low tissue specificity |
MalaCardsi | NME7 |
MIMi | 613465, gene |
neXtProti | NX_Q9Y5B8 |
OpenTargetsi | ENSG00000143156 |
Orphaneti | 101063, Situs inversus totalis |
PharmGKBi | PA134962167 |
VEuPathDBi | HostDB:ENSG00000143156.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0888, Eukaryota |
GeneTreei | ENSGT00940000158946 |
HOGENOMi | CLU_060216_3_1_1 |
InParanoidi | Q9Y5B8 |
OMAi | NLELQYM |
OrthoDBi | 1230088at2759 |
PhylomeDBi | Q9Y5B8 |
TreeFami | TF106374 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y5B8 |
Reactomei | R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes R-HSA-380320, Recruitment of NuMA to mitotic centrosomes |
Miscellaneous databases
BioGRID-ORCSi | 29922, 3 hits in 870 CRISPR screens |
ChiTaRSi | NME7, human |
GenomeRNAii | 29922 |
Pharosi | Q9Y5B8, Tbio |
PROi | PR:Q9Y5B8 |
RNActi | Q9Y5B8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000143156, Expressed in cerebellar vermis and 241 other tissues |
ExpressionAtlasi | Q9Y5B8, baseline and differential |
Genevisiblei | Q9Y5B8, HS |
Family and domain databases
CDDi | cd04415, NDPk7A, 1 hit cd04412, NDPk7B, 1 hit |
Gene3Di | 3.30.70.141, 2 hits |
InterProi | View protein in InterPro IPR034907, NDK-like_dom IPR036850, NDK-like_dom_sf IPR011410, NDPK7 IPR035525, NDPk7A IPR037993, NDPk7B IPR001564, Nucleoside_diP_kinase IPR006602, Uncharacterised_DM10 |
PANTHERi | PTHR43109, PTHR43109, 1 hit |
Pfami | View protein in Pfam PF00334, NDK, 2 hits |
PIRSFi | PIRSF036503, NDK7, 1 hit |
PRINTSi | PR01243, NUCDPKINASE |
SMARTi | View protein in SMART SM00676, DM10, 1 hit SM00562, NDK, 2 hits |
SUPFAMi | SSF54919, SSF54919, 2 hits |
PROSITEi | View protein in PROSITE PS51336, DM10, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NDK7_HUMAN | |
Accessioni | Q9Y5B8Primary (citable) accession number: Q9Y5B8 Secondary accession number(s): A8K3T6 Q5TGZ4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2001 |
Last sequence update: | November 1, 1999 | |
Last modified: | February 10, 2021 | |
This is version 178 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families