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Protein

RNA polymerase II subunit A C-terminal domain phosphatase

Gene

CTDP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-112382 Formation of RNA Pol II elongation complex
R-HSA-113418 Formation of the Early Elongation Complex
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat
R-HSA-167158 Formation of the HIV-1 Early Elongation Complex
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation
R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript
R-HSA-167287 HIV elongation arrest and recovery
R-HSA-167290 Pausing and recovery of HIV elongation
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-HSA-75955 RNA Polymerase II Transcription Elongation

SIGNOR Signaling Network Open Resource

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SIGNORi
Q9Y5B0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA polymerase II subunit A C-terminal domain phosphatase (EC:3.1.3.16)
Alternative name(s):
TFIIF-associating CTD phosphatase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CTDP1
Synonyms:FCP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000060069.16

Human Gene Nomenclature Database

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HGNCi
HGNC:2498 CTDP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604927 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y5B0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Congenital cataracts, facial dysmorphism, and neuropathy (CCFDN)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive developmental disorder characterized by a complex clinical phenotype with seemingly unrelated features involving multiple organs and systems. Developmental abnormalities include congenital cataracts and microcorneae, hypomyelination of the peripheral nervous system, impaired physical growth, delayed early motor and intellectual development, facial dysmorphism and hypogonadism. Central nervous system involvement, with cerebral and spinal cord atrophy, may be the result of disrupted development with superimposed degenerative changes. Affected individuals are prone to severe rhabdomyolysis after viral infections and to serious complications related to general anesthesia (such as pulmonary edema and epileptic seizures).
See also OMIM:604168

Keywords - Diseasei

Cataract

Organism-specific databases

DisGeNET

More...
DisGeNETi
9150

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
CTDP1

MalaCards human disease database

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MalaCardsi
CTDP1
MIMi604168 phenotype

Open Targets

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OpenTargetsi
ENSG00000060069

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
48431 Congenital cataracts-facial dysmorphism-neuropathy syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA27001

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
CTDP1

Domain mapping of disease mutations (DMDM)

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DMDMi
327478586

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002125641 – 961RNA polymerase II subunit A C-terminal domain phosphataseAdd BLAST961

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei395PhosphoserineCombined sources1
Modified residuei674PhosphoserineCombined sources1
Modified residuei740PhosphoserineCombined sources1
Modified residuei780N6-acetyllysineCombined sources1
Modified residuei839PhosphoserineCombined sources1
Modified residuei869PhosphoserineCombined sources1
Modified residuei872PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated. In the presence of TFIIF, the phosphorylated form has an increased CTD phosphatase activity. The phosphorylation is required for the physical interaction with GTF2F1.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9Y5B0

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9Y5B0

PeptideAtlas

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PeptideAtlasi
Q9Y5B0

PRoteomics IDEntifications database

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PRIDEi
Q9Y5B0

ProteomicsDB human proteome resource

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ProteomicsDBi
86328
86331 [Q9Y5B0-4]

PTM databases

DEPOD human dephosphorylation database

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DEPODi
Q9Y5B0

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9Y5B0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9Y5B0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000060069 Expressed in 185 organ(s), highest expression level in blood

CleanEx database of gene expression profiles

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CleanExi
HS_CTDP1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9Y5B0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9Y5B0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB032641
HPA040394
HPA070389

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Interacts with GTF2F1. Interacts with WDR77, SNRPB and SNRNP70.3 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
114597, 58 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9Y5B0

Database of interacting proteins

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DIPi
DIP-41788N

Protein interaction database and analysis system

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IntActi
Q9Y5B0, 14 interactors

Molecular INTeraction database

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MINTi
Q9Y5B0

STRING: functional protein association networks

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STRINGi
9606.ENSP00000299543

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1961
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Database of protein disorder

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DisProti
DP00177

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9Y5B0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9Y5B0

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q9Y5B0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini178 – 344FCP1 homologyPROSITE-ProRule annotationAdd BLAST167
Domaini629 – 728BRCTPROSITE-ProRule annotationAdd BLAST100

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi455 – 478Ser-richAdd BLAST24
Compositional biasi577 – 582Poly-Glu6

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0323 Eukaryota
COG5190 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000015641

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000112039

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG051213

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9Y5B0

KEGG Orthology (KO)

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KOi
K15732

Identification of Orthologs from Complete Genome Data

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OMAi
QGIGDIN

Database of Orthologous Groups

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OrthoDBi
EOG091G05JF

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9Y5B0

TreeFam database of animal gene trees

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TreeFami
TF315104

Family and domain databases

Conserved Domains Database

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CDDi
cd00027 BRCT, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.50.1000, 1 hit
3.40.50.10190, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR039189 Fcp1
IPR015388 FCP1_C
IPR004274 FCP1_dom
IPR011947 FCP1_euk
IPR036412 HAD-like_sf
IPR023214 HAD_sf

The PANTHER Classification System

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PANTHERi
PTHR23081 PTHR23081, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF09309 FCP1_C, 1 hit
PF03031 NIF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00292 BRCT, 1 hit
SM00577 CPDc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52113 SSF52113, 1 hit
SSF56784 SSF56784, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR02250 FCP1_euk, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50172 BRCT, 1 hit
PS50969 FCP1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y5B0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEVPAAGRVP AEGAPTAAVA EVRCPGPAPL RLLEWRVAAG AAVRIGSVLA
60 70 80 90 100
VFEAAASAQS SGASQSRVAS GGCVRPARPE RRLRSERAGV VRELCAQPGQ
110 120 130 140 150
VVAPGAVLVR LEGCSHPVVM KGLCAECGQD LTQLQSKNGK QQVPLSTATV
160 170 180 190 200
SMVHSVPELM VSSEQAEQLG REDQQRLHRN RKLVLMVDLD QTLIHTTEQH
210 220 230 240 250
CQQMSNKGIF HFQLGRGEPM LHTRLRPHCK DFLEKIAKLY ELHVFTFGSR
260 270 280 290 300
LYAHTIAGFL DPEKKLFSHR ILSRDECIDP FSKTGNLRNL FPCGDSMVCI
310 320 330 340 350
IDDREDVWKF APNLITVKKY VYFQGTGDMN APPGSRESQT RKKVNHSRGT
360 370 380 390 400
EVSEPSPPVR DPEGVTQAPG VEPSNGLEKP ARELNGSEAA TPRDSPRPGK
410 420 430 440 450
PDERDIWPPA QAPTSSQELA GAPEPQGSCA QGGRVAPGQR PAQGATGTDL
460 470 480 490 500
DFDLSSDSES SSESEGTKSS SSASDGESEG KRGRQKPKAA PEGAGALAQG
510 520 530 540 550
SSLEPGRPAA PSLPGEAEPG AHAPDKEPEL GGQEEGERDG LCGLGNGCAD
560 570 580 590 600
RKEAETESQN SELSGVTAGE SLDQSMEEEE EEDTDEDDHL IYLEEILVRV
610 620 630 640 650
HTDYYAKYDR YLNKEIEEAP DIRKIVPELK SKVLADVAII FSGLHPTNFP
660 670 680 690 700
IEKTREHYHA TALGAKILTR LVLSPDAPDR ATHLIAARAG TEKVLQAQEC
710 720 730 740 750
GHLHVVNPDW LWSCLERWDK VEEQLFPLRD DHTKAQRENS PAAFPDREGV
760 770 780 790 800
PPTALFHPMP VLPKAQPGPE VRIYDSNTGK LIRTGARGPP APSSSLPIRQ
810 820 830 840 850
EPSSFRAVPP PQPQMFGEEL PDAQDGEQPG PSRRKRQPSM SETMPLYTLC
860 870 880 890 900
KEDLESMDKE VDDILGEGSD DSDSEKRRPE EQEEEPQPRK PGTRRERTLG
910 920 930 940 950
APASSERSAA GGRGPRGHKR KLNEEDAASE SSRESSNEDE GSSSEADEMA
960
KALEAELNDL M
Length:961
Mass (Da):104,399
Last modified:April 5, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i62B88FFD9CE4B157
GO
Isoform 4 (identifier: Q9Y5B0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     807-961: AVPPPQPQMF...ALEAELNDLM → WTTSLEKAAT...AGGPEATRGS

Show »
Length:867
Mass (Da):93,485
Checksum:i8B4B87B24644BA6E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MR03A0A0A0MR03_HUMAN
RNA polymerase II subunit A C-termi...
CTDP1
842Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJD2K7EJD2_HUMAN
RNA polymerase II subunit A C-termi...
CTDP1
799Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YWJ4A0A0J9YWJ4_HUMAN
RNA polymerase II subunit A C-termi...
CTDP1
737Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YWB6A0A0J9YWB6_HUMAN
RNA polymerase II subunit A C-termi...
CTDP1
805Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPW4K7EPW4_HUMAN
RNA polymerase II subunit A C-termi...
CTDP1
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC64549 differs from that shown. Cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti61S → A in AAD42088 (PubMed:10385623).Curated1
Sequence conflicti61S → A in AAH63447 (PubMed:15489334).Curated1
Sequence conflicti157P → A in AAC64549 (PubMed:9765293).Curated1
Sequence conflicti281F → I in AAH52576 (PubMed:15489334).Curated1
Sequence conflicti305E → K in AAD42088 (PubMed:10385623).Curated1
Sequence conflicti390A → P in AAC64549 (PubMed:9765293).Curated1
Sequence conflicti478S → T in AAC64549 (PubMed:9765293).Curated1
Sequence conflicti486 – 487KP → NA in AAC64549 (PubMed:9765293).Curated2
Sequence conflicti504 – 505EP → DA in AAC64549 (PubMed:9765293).Curated2
Sequence conflicti513L → V in AAC64549 (PubMed:9765293).Curated1
Sequence conflicti656 – 657EH → DD in AAC64549 (PubMed:9765293).Curated2
Sequence conflicti896 – 900ERTLG → GADAR in AAD42088 (PubMed:10385623).Curated5

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_060440282S → F. Corresponds to variant dbSNP:rs4799078Ensembl.1
Natural variantiVAR_018264340T → M. Corresponds to variant dbSNP:rs2279103EnsemblClinVar.1
Natural variantiVAR_060441519P → H. Corresponds to variant dbSNP:rs557503Ensembl.1
Natural variantiVAR_032763755L → S. Corresponds to variant dbSNP:rs34967023Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_009865807 – 961AVPPP…LNDLM → WTTSLEKAATTATARRGGLR SRRRSPSPGSQGPAGSGRSG HLRPARGARQGAGGPEATRG S in isoform 4. 2 PublicationsAdd BLAST155

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF154115 mRNA Translation: AAD42088.1
AC021594 Genomic DNA No translation available.
AC068473 Genomic DNA No translation available.
CH471117 Genomic DNA Translation: EAW66631.1
BC015010 mRNA Translation: AAH15010.1
BC052576 mRNA Translation: AAH52576.1
BC063447 mRNA Translation: AAH63447.1
AF081287 mRNA Translation: AAC64549.1 Sequence problems.

The Consensus CDS (CCDS) project

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CCDSi
CCDS12017.1 [Q9Y5B0-1]
CCDS12018.1 [Q9Y5B0-4]

NCBI Reference Sequences

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RefSeqi
NP_001189433.1, NM_001202504.1
NP_004706.3, NM_004715.4 [Q9Y5B0-1]
NP_430255.2, NM_048368.3 [Q9Y5B0-4]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.465490
Hs.734021

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000075430; ENSP00000075430; ENSG00000060069 [Q9Y5B0-4]
ENST00000613122; ENSP00000484525; ENSG00000060069 [Q9Y5B0-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9150

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9150

UCSC genome browser

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UCSCi
uc002lnh.3 human [Q9Y5B0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF154115 mRNA Translation: AAD42088.1
AC021594 Genomic DNA No translation available.
AC068473 Genomic DNA No translation available.
CH471117 Genomic DNA Translation: EAW66631.1
BC015010 mRNA Translation: AAH15010.1
BC052576 mRNA Translation: AAH52576.1
BC063447 mRNA Translation: AAH63447.1
AF081287 mRNA Translation: AAC64549.1 Sequence problems.
CCDSiCCDS12017.1 [Q9Y5B0-1]
CCDS12018.1 [Q9Y5B0-4]
RefSeqiNP_001189433.1, NM_001202504.1
NP_004706.3, NM_004715.4 [Q9Y5B0-1]
NP_430255.2, NM_048368.3 [Q9Y5B0-4]
UniGeneiHs.465490
Hs.734021

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J2XX-ray2.00B944-961[»]
1ONVNMR-B879-961[»]
2K7LNMR-B582-600[»]
DisProtiDP00177
ProteinModelPortaliQ9Y5B0
SMRiQ9Y5B0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114597, 58 interactors
CORUMiQ9Y5B0
DIPiDIP-41788N
IntActiQ9Y5B0, 14 interactors
MINTiQ9Y5B0
STRINGi9606.ENSP00000299543

PTM databases

DEPODiQ9Y5B0
iPTMnetiQ9Y5B0
PhosphoSitePlusiQ9Y5B0

Polymorphism and mutation databases

BioMutaiCTDP1
DMDMi327478586

Proteomic databases

EPDiQ9Y5B0
PaxDbiQ9Y5B0
PeptideAtlasiQ9Y5B0
PRIDEiQ9Y5B0
ProteomicsDBi86328
86331 [Q9Y5B0-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
9150
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000075430; ENSP00000075430; ENSG00000060069 [Q9Y5B0-4]
ENST00000613122; ENSP00000484525; ENSG00000060069 [Q9Y5B0-1]
GeneIDi9150
KEGGihsa:9150
UCSCiuc002lnh.3 human [Q9Y5B0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9150
DisGeNETi9150
EuPathDBiHostDB:ENSG00000060069.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CTDP1
GeneReviewsiCTDP1
HGNCiHGNC:2498 CTDP1
HPAiCAB032641
HPA040394
HPA070389
MalaCardsiCTDP1
MIMi604168 phenotype
604927 gene
neXtProtiNX_Q9Y5B0
OpenTargetsiENSG00000060069
Orphaneti48431 Congenital cataracts-facial dysmorphism-neuropathy syndrome
PharmGKBiPA27001

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0323 Eukaryota
COG5190 LUCA
GeneTreeiENSGT00390000015641
HOGENOMiHOG000112039
HOVERGENiHBG051213
InParanoidiQ9Y5B0
KOiK15732
OMAiQGIGDIN
OrthoDBiEOG091G05JF
PhylomeDBiQ9Y5B0
TreeFamiTF315104

Enzyme and pathway databases

ReactomeiR-HSA-112382 Formation of RNA Pol II elongation complex
R-HSA-113418 Formation of the Early Elongation Complex
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat
R-HSA-167158 Formation of the HIV-1 Early Elongation Complex
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation
R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript
R-HSA-167287 HIV elongation arrest and recovery
R-HSA-167290 Pausing and recovery of HIV elongation
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-HSA-75955 RNA Polymerase II Transcription Elongation
SIGNORiQ9Y5B0

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CTDP1 human
EvolutionaryTraceiQ9Y5B0

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CTDP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9150

Protein Ontology

More...
PROi
PR:Q9Y5B0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000060069 Expressed in 185 organ(s), highest expression level in blood
CleanExiHS_CTDP1
ExpressionAtlasiQ9Y5B0 baseline and differential
GenevisibleiQ9Y5B0 HS

Family and domain databases

CDDicd00027 BRCT, 1 hit
Gene3Di3.40.50.1000, 1 hit
3.40.50.10190, 1 hit
InterProiView protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR039189 Fcp1
IPR015388 FCP1_C
IPR004274 FCP1_dom
IPR011947 FCP1_euk
IPR036412 HAD-like_sf
IPR023214 HAD_sf
PANTHERiPTHR23081 PTHR23081, 1 hit
PfamiView protein in Pfam
PF09309 FCP1_C, 1 hit
PF03031 NIF, 1 hit
SMARTiView protein in SMART
SM00292 BRCT, 1 hit
SM00577 CPDc, 1 hit
SUPFAMiSSF52113 SSF52113, 1 hit
SSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR02250 FCP1_euk, 1 hit
PROSITEiView protein in PROSITE
PS50172 BRCT, 1 hit
PS50969 FCP1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCTDP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y5B0
Secondary accession number(s): A8MY97
, Q7Z644, Q96BZ1, Q9Y6F5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 5, 2011
Last modified: December 5, 2018
This is version 179 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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