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Protein

Zinc finger and SCAN domain-containing protein 21

Gene

ZSCAN21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Strong transcriptional activator.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri277 – 299C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri305 – 327C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri333 – 354C2H2-type 3PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri360 – 382C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri388 – 410C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri416 – 438C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri444 – 466C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • positive regulation of transcription by RNA polymerase II Source: NTNU_SB
  • regulation of transcription, DNA-templated Source: UniProtKB

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 21
Alternative name(s):
Renal carcinoma antigen NY-REN-21
Zinc finger protein 38 homolog
Short name:
Zfp-38
Gene namesi
Name:ZSCAN21
Synonyms:ZFP38, ZNF38
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000166529.14
HGNCiHGNC:13104 ZSCAN21
neXtProtiNX_Q9Y5A6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000166529
PharmGKBiPA162410981

Polymorphism and mutation databases

BioMutaiZSCAN21
DMDMi20141976

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000472971 – 473Zinc finger and SCAN domain-containing protein 21Add BLAST473

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki27Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki221Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki232Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki349Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ9Y5A6
MaxQBiQ9Y5A6
PaxDbiQ9Y5A6
PeptideAtlasiQ9Y5A6
PRIDEiQ9Y5A6
ProteomicsDBi86323

PTM databases

iPTMnetiQ9Y5A6
PhosphoSitePlusiQ9Y5A6

Expressioni

Gene expression databases

BgeeiENSG00000166529 Expressed in 180 organ(s), highest expression level in oocyte
CleanExiHS_ZSCAN21
ExpressionAtlasiQ9Y5A6 baseline and differential
GenevisibleiQ9Y5A6 HS

Organism-specific databases

HPAiHPA016948
HPA023591

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi113416, 42 interactors
IntActiQ9Y5A6, 27 interactors
STRINGi9606.ENSP00000292450

Structurei

3D structure databases

ProteinModelPortaliQ9Y5A6
SMRiQ9Y5A6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 127SCAN boxPROSITE-ProRule annotationAdd BLAST83

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri277 – 299C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri305 – 327C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri333 – 354C2H2-type 3PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri360 – 382C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri388 – 410C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri416 – 438C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri444 – 466C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118881
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiQ9Y5A6
KOiK09230
OMAiRLERQWV
OrthoDBiEOG091G02KC
PhylomeDBiQ9Y5A6
TreeFamiTF338304

Family and domain databases

CDDicd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 7 hits
SMARTiView protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 7 hits
SUPFAMiSSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9Y5A6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMTKVLGMAP VLGPRPPQEQ VGPLMVKVEE KEEKGKYLPS LEMFRQRFRQ
60 70 80 90 100
FGYHDTPGPR EALSQLRVLC CEWLRPEIHT KEQILELLVL EQFLTILPQE
110 120 130 140 150
LQAWVQEHCP ESAEEAVTLL EDLERELDEP GHQVSTPPNE QKPVWEKISS
160 170 180 190 200
SGTAKESPSS MQPQPLETSH KYESWGPLYI QESGEEQEFA QDPRKVRDCR
210 220 230 240 250
LSTQHEESAD EQKGSEAEGL KGDIISVIIA NKPEASLERQ CVNLENEKGT
260 270 280 290 300
KPPLQEAGSK KGRESVPTKP TPGERRYICA ECGKAFSNSS NLTKHRRTHT
310 320 330 340 350
GEKPYVCTKC GKAFSHSSNL TLHYRTHLVD RPYDCKCGKA FGQSSDLLKH
360 370 380 390 400
QRMHTEEAPY QCKDCGKAFS GKGSLIRHYR IHTGEKPYQC NECGKSFSQH
410 420 430 440 450
AGLSSHQRLH TGEKPYKCKE CGKAFNHSSN FNKHHRIHTG EKPYWCHHCG
460 470
KTFCSKSNLS KHQRVHTGEG EAP
Length:473
Mass (Da):53,658
Last modified:December 19, 2001 - v2
Checksum:iD9A26694B114B96F
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V1M0G3V1M0_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN21 DKFZp686H10254
436Annotation score:
G3V0F4G3V0F4_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN21 ZNF38, hCG_1641359
450Annotation score:
C9JHD9C9JHD9_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN21
181Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136865 mRNA Translation: CAB66799.1
CH236956 Genomic DNA Translation: EAL23860.1
CH471091 Genomic DNA Translation: EAW76609.1
CH471091 Genomic DNA Translation: EAW76610.1
BC047309 mRNA Translation: AAH47309.1
AF155100 mRNA Translation: AAD42866.1
CCDSiCCDS5681.1
RefSeqiNP_666019.1, NM_145914.2
XP_005250625.1, XM_005250568.4
XP_006716176.1, XM_006716113.3
XP_016868073.1, XM_017012584.1
UniGeneiHs.632294

Genome annotation databases

EnsembliENST00000292450; ENSP00000292450; ENSG00000166529
GeneIDi7589
KEGGihsa:7589
UCSCiuc003uso.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136865 mRNA Translation: CAB66799.1
CH236956 Genomic DNA Translation: EAL23860.1
CH471091 Genomic DNA Translation: EAW76609.1
CH471091 Genomic DNA Translation: EAW76610.1
BC047309 mRNA Translation: AAH47309.1
AF155100 mRNA Translation: AAD42866.1
CCDSiCCDS5681.1
RefSeqiNP_666019.1, NM_145914.2
XP_005250625.1, XM_005250568.4
XP_006716176.1, XM_006716113.3
XP_016868073.1, XM_017012584.1
UniGeneiHs.632294

3D structure databases

ProteinModelPortaliQ9Y5A6
SMRiQ9Y5A6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113416, 42 interactors
IntActiQ9Y5A6, 27 interactors
STRINGi9606.ENSP00000292450

PTM databases

iPTMnetiQ9Y5A6
PhosphoSitePlusiQ9Y5A6

Polymorphism and mutation databases

BioMutaiZSCAN21
DMDMi20141976

Proteomic databases

EPDiQ9Y5A6
MaxQBiQ9Y5A6
PaxDbiQ9Y5A6
PeptideAtlasiQ9Y5A6
PRIDEiQ9Y5A6
ProteomicsDBi86323

Protocols and materials databases

DNASUi7589
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292450; ENSP00000292450; ENSG00000166529
GeneIDi7589
KEGGihsa:7589
UCSCiuc003uso.5 human

Organism-specific databases

CTDi7589
EuPathDBiHostDB:ENSG00000166529.14
GeneCardsiZSCAN21
HGNCiHGNC:13104 ZSCAN21
HPAiHPA016948
HPA023591
neXtProtiNX_Q9Y5A6
OpenTargetsiENSG00000166529
PharmGKBiPA162410981
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118881
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiQ9Y5A6
KOiK09230
OMAiRLERQWV
OrthoDBiEOG091G02KC
PhylomeDBiQ9Y5A6
TreeFamiTF338304

Miscellaneous databases

GeneWikiiZSCAN21
GenomeRNAii7589
PROiPR:Q9Y5A6

Gene expression databases

BgeeiENSG00000166529 Expressed in 180 organ(s), highest expression level in oocyte
CleanExiHS_ZSCAN21
ExpressionAtlasiQ9Y5A6 baseline and differential
GenevisibleiQ9Y5A6 HS

Family and domain databases

CDDicd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 7 hits
SMARTiView protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 7 hits
SUPFAMiSSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZSC21_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5A6
Secondary accession number(s): A4D2A6, D6W5T9, Q9H0B5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 19, 2001
Last modified: November 7, 2018
This is version 174 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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