UniProtKB - Q9Y597 (KCTD3_HUMAN)
Protein
BTB/POZ domain-containing protein KCTD3
Gene
KCTD3
Organism
Homo sapiens (Human)
Status
Functioni
Accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics.By similarity
Miscellaneous
Reacts with sera from 5-25 per cent of cancer patients but not with sera from normal donors. Seventy per cent of renal cancer patients have antibodies against one or a panel of these antigens.
GO - Biological processi
- protein homooligomerization Source: InterPro
Enzyme and pathway databases
PathwayCommonsi | Q9Y597 |
Names & Taxonomyi
Protein namesi | Recommended name: BTB/POZ domain-containing protein KCTD3Alternative name(s): Renal carcinoma antigen NY-REN-45 |
Gene namesi | Name:KCTD3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21305, KCTD3 |
MIMi | 613272, gene |
neXtProti | NX_Q9Y597 |
VEuPathDBi | HostDB:ENSG00000136636.12 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity
Plasma Membrane
- plasma membrane Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 51133 |
OpenTargetsi | ENSG00000136636 |
PharmGKBi | PA134945859 |
Miscellaneous databases
Pharosi | Q9Y597, Tdark |
Genetic variation databases
BioMutai | KCTD3 |
DMDMi | 112823993 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000247839 | 1 – 815 | BTB/POZ domain-containing protein KCTD3Add BLAST | 815 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 604 | PhosphoserineCombined sources | 1 | |
Modified residuei | 664 | PhosphoserineCombined sources | 1 | |
Modified residuei | 711 | PhosphoserineCombined sources | 1 | |
Modified residuei | 793 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9Y597 |
jPOSTi | Q9Y597 |
MassIVEi | Q9Y597 |
PaxDbi | Q9Y597 |
PeptideAtlasi | Q9Y597 |
PRIDEi | Q9Y597 |
ProteomicsDBi | 86320 [Q9Y597-1] 86321 [Q9Y597-2] 86322 [Q9Y597-3] |
PTM databases
iPTMneti | Q9Y597 |
PhosphoSitePlusi | Q9Y597 |
Expressioni
Tissue specificityi
Broadly expressed in normal tissues.1 Publication
Gene expression databases
Bgeei | ENSG00000136636, Expressed in left adrenal gland and 231 other tissues |
ExpressionAtlasi | Q9Y597, baseline and differential |
Genevisiblei | Q9Y597, HS |
Organism-specific databases
HPAi | ENSG00000136636, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with HCN3.
By similarityProtein-protein interaction databases
BioGRIDi | 119320, 144 interactors |
IntActi | Q9Y597, 34 interactors |
MINTi | Q9Y597 |
STRINGi | 9606.ENSP00000259154 |
Miscellaneous databases
RNActi | Q9Y597, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 18 – 87 | BTBPROSITE-ProRule annotationAdd BLAST | 70 | |
Repeati | 174 – 218 | WD 1Add BLAST | 45 | |
Repeati | 224 – 263 | WD 2Add BLAST | 40 | |
Repeati | 270 – 305 | WD 3Add BLAST | 36 | |
Repeati | 310 – 342 | WD 4Add BLAST | 33 | |
Repeati | 354 – 404 | WD 5Add BLAST | 51 | |
Repeati | 412 – 449 | WD 6Add BLAST | 38 | |
Repeati | 457 – 504 | WD 7Add BLAST | 48 | |
Repeati | 510 – 569 | WD 8Add BLAST | 60 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 512 – 815 | Interaction with HCN3By similarityAdd BLAST | 304 |
Sequence similaritiesi
Belongs to the KCTD3 family.Curated
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG2714, Eukaryota |
GeneTreei | ENSGT00940000153881 |
HOGENOMi | CLU_012214_1_0_1 |
InParanoidi | Q9Y597 |
OMAi | WNVTRFR |
OrthoDBi | 351369at2759 |
PhylomeDBi | Q9Y597 |
TreeFami | TF313754 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR003131, T1-type_BTB IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF02214, BTB_2, 1 hit |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00320, WD40, 3 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit SSF54695, SSF54695, 1 hit |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00678, WD_REPEATS_1, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9Y597-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAGGHCGSFP AAAAGSGEIV QLNVGGTRFS TSRQTLMWIP DSFFSSLLSG
60 70 80 90 100
RISTLRDETG AIFIDRDPAA FAPILNFLRT KELDLRGVSI NVLRHEAEFY
110 120 130 140 150
GITPLVRRLL LCEELERSSC GSVLFHGYLP PPGIPSRKIN NTVRSADSRN
160 170 180 190 200
GLNSTEGEAR GNGTQPVLSG TGEETVRLGF PVDPRKVLIV AGHHNWIVAA
210 220 230 240 250
YAHFAVCYRI KESSGWQQVF TSPYLDWTIE RVALNAKVVG GPHGDKDKMV
260 270 280 290 300
AVASESSIIL WSVQDGGSGS EIGVFSLGVP VDALFFIGNQ LVATSHTGKV
310 320 330 340 350
GVWNAVTQHW QVQDVVPITS YDTAGSFLLL GCNNGSIYYI DMQKFPLRMK
360 370 380 390 400
DNDLLVTELY HDPSNDAITA LSVYLTPKTS VSGNWIEIAY GTSSGAVRVI
410 420 430 440 450
VQHPETVGSG PQLFQTFTVH RSPVTKIMLS EKHLVSVCAD NNHVRTWTVT
460 470 480 490 500
RFRGMISTQP GSTPLASFKI LSLEETESHG SYSSGNDIGP FGERDDQQVF
510 520 530 540 550
IQKVVPITNK LFVRLSSTGK RICEIQAVDC TTISSFTVRE CEGSSRMGSR
560 570 580 590 600
PRRYLFTGHT NGSIQMWDLT TAMDMVNKSE DKDVGGPTEE ELLKLLDQCD
610 620 630 640 650
LSTSRCATPN ISPATSVVQH SHLRESNSSL QLQHHDTTHE AATYGSMRPY
660 670 680 690 700
RESPLLARAR RTESFHSYRD FQTINLNRNV ERAVPENGNL GPIQAEVKGA
710 720 730 740 750
TGECNISERK SPGVEIKSLR ELDSGLEVHK IAEGFSESKK RSSEDENENK
760 770 780 790 800
IEFRKKGGFE GGGFLGRKKV PYLASSPSTS DGGTDSPGTA SPSPTKTTPS
810
PRHKKSDSSG QEYSL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0Y566 | H0Y566_HUMAN | BTB/POZ domain-containing protein K... | KCTD3 | 213 | Annotation score: | ||
H0Y5P8 | H0Y5P8_HUMAN | BTB/POZ domain-containing protein K... | KCTD3 | 168 | Annotation score: |
Sequence cautioni
The sequence AAH13868 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 207 | C → W in AAD42876 (PubMed:10508479).Curated | 1 | |
Sequence conflicti | 503 | K → I in CAD38743 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 742 | S → P in CAD38743 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 803 | H → HK in CAD38743 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_027156 | 9 | F → V1 PublicationCorresponds to variant dbSNP:rs2275768Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_020068 | 1 – 646 | Missing in isoform 3. 1 PublicationAdd BLAST | 646 | |
Alternative sequenceiVSP_020069 | 583 – 584 | Missing in isoform 2. 1 Publication | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF155110 mRNA Translation: AAD42876.1 AC092799 Genomic DNA No translation available. AL365315 Genomic DNA No translation available. CH471100 Genomic DNA Translation: EAW93345.1 BC013868 mRNA Translation: AAH13868.1 Sequence problems. BC037896 mRNA Translation: AAH37896.1 BC094879 mRNA Translation: AAH94879.1 BC117188 mRNA Translation: AAI17189.1 BC126173 mRNA Translation: AAI26174.1 AL833887 mRNA Translation: CAD38743.2 AL834389 mRNA Translation: CAD39051.1 |
CCDSi | CCDS1515.1 [Q9Y597-1] |
RefSeqi | NP_001306223.1, NM_001319294.1 [Q9Y597-2] NP_001306224.1, NM_001319295.1 NP_057205.2, NM_016121.4 [Q9Y597-1] |
Genome annotation databases
Ensembli | ENST00000259154; ENSP00000259154; ENSG00000136636 [Q9Y597-1] |
GeneIDi | 51133 |
KEGGi | hsa:51133 |
UCSCi | uc001hks.5, human [Q9Y597-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF155110 mRNA Translation: AAD42876.1 AC092799 Genomic DNA No translation available. AL365315 Genomic DNA No translation available. CH471100 Genomic DNA Translation: EAW93345.1 BC013868 mRNA Translation: AAH13868.1 Sequence problems. BC037896 mRNA Translation: AAH37896.1 BC094879 mRNA Translation: AAH94879.1 BC117188 mRNA Translation: AAI17189.1 BC126173 mRNA Translation: AAI26174.1 AL833887 mRNA Translation: CAD38743.2 AL834389 mRNA Translation: CAD39051.1 |
CCDSi | CCDS1515.1 [Q9Y597-1] |
RefSeqi | NP_001306223.1, NM_001319294.1 [Q9Y597-2] NP_001306224.1, NM_001319295.1 NP_057205.2, NM_016121.4 [Q9Y597-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 119320, 144 interactors |
IntActi | Q9Y597, 34 interactors |
MINTi | Q9Y597 |
STRINGi | 9606.ENSP00000259154 |
PTM databases
iPTMneti | Q9Y597 |
PhosphoSitePlusi | Q9Y597 |
Genetic variation databases
BioMutai | KCTD3 |
DMDMi | 112823993 |
Proteomic databases
EPDi | Q9Y597 |
jPOSTi | Q9Y597 |
MassIVEi | Q9Y597 |
PaxDbi | Q9Y597 |
PeptideAtlasi | Q9Y597 |
PRIDEi | Q9Y597 |
ProteomicsDBi | 86320 [Q9Y597-1] 86321 [Q9Y597-2] 86322 [Q9Y597-3] |
Protocols and materials databases
Antibodypediai | 2795, 119 antibodies |
DNASUi | 51133 |
Genome annotation databases
Ensembli | ENST00000259154; ENSP00000259154; ENSG00000136636 [Q9Y597-1] |
GeneIDi | 51133 |
KEGGi | hsa:51133 |
UCSCi | uc001hks.5, human [Q9Y597-1] |
Organism-specific databases
CTDi | 51133 |
DisGeNETi | 51133 |
GeneCardsi | KCTD3 |
HGNCi | HGNC:21305, KCTD3 |
HPAi | ENSG00000136636, Low tissue specificity |
MIMi | 613272, gene |
neXtProti | NX_Q9Y597 |
OpenTargetsi | ENSG00000136636 |
PharmGKBi | PA134945859 |
VEuPathDBi | HostDB:ENSG00000136636.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2714, Eukaryota |
GeneTreei | ENSGT00940000153881 |
HOGENOMi | CLU_012214_1_0_1 |
InParanoidi | Q9Y597 |
OMAi | WNVTRFR |
OrthoDBi | 351369at2759 |
PhylomeDBi | Q9Y597 |
TreeFami | TF313754 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y597 |
Miscellaneous databases
BioGRID-ORCSi | 51133, 10 hits in 995 CRISPR screens |
ChiTaRSi | KCTD3, human |
GenomeRNAii | 51133 |
Pharosi | Q9Y597, Tdark |
PROi | PR:Q9Y597 |
RNActi | Q9Y597, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000136636, Expressed in left adrenal gland and 231 other tissues |
ExpressionAtlasi | Q9Y597, baseline and differential |
Genevisiblei | Q9Y597, HS |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR003131, T1-type_BTB IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF02214, BTB_2, 1 hit |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00320, WD40, 3 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit SSF54695, SSF54695, 1 hit |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00678, WD_REPEATS_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KCTD3_HUMAN | |
Accessioni | Q9Y597Primary (citable) accession number: Q9Y597 Secondary accession number(s): A0AV15 Q8WX16 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 22, 2006 |
Last sequence update: | August 22, 2006 | |
Last modified: | April 7, 2021 | |
This is version 166 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families