Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q9Y597 (KCTD3_HUMAN)

Entry version 163 (12 Aug 2020)
Sequence version 2 (22 Aug 2006)
Previous versions | rss
Add a publicationFeedback
Protein

BTB/POZ domain-containing protein KCTD3

Gene

KCTD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics.By similarity

Miscellaneous

Reacts with sera from 5-25 per cent of cancer patients but not with sera from normal donors. Seventy per cent of renal cancer patients have antibodies against one or a panel of these antigens.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9Y597

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD3
Alternative name(s):
Renal carcinoma antigen NY-REN-45
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KCTD3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000136636.12

Human Gene Nomenclature Database

More...HGNCi		HGNC:21305, KCTD3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613272, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y597

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		51133

Open Targets

More...OpenTargetsi		ENSG00000136636

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134945859

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y597, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KCTD3

Domain mapping of disease mutations (DMDM)

More...DMDMi		112823993

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002478391 – 815BTB/POZ domain-containing protein KCTD3Add BLAST815

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei604PhosphoserineCombined sources1
Modified residuei664PhosphoserineCombined sources1
Modified residuei711PhosphoserineCombined sources1
Modified residuei793PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9Y597

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9Y597

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9Y597

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y597

PeptideAtlas

More...PeptideAtlasi		Q9Y597

PRoteomics IDEntifications database

More...PRIDEi		Q9Y597

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		86320 [Q9Y597-1]
86321 [Q9Y597-2]
86322 [Q9Y597-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y597

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y597

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Broadly expressed in normal tissues.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000136636, Expressed in left adrenal gland and 231 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9Y597, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Y597, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000136636, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with HCN3.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119320, 140 interactors

Protein interaction database and analysis system

More...IntActi		Q9Y597, 34 interactors

Molecular INTeraction database

More...MINTi		Q9Y597

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000259154

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Y597, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini18 – 87BTBPROSITE-ProRule annotationAdd BLAST70
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati174 – 218WD 1Add BLAST45
Repeati224 – 263WD 2Add BLAST40
Repeati270 – 305WD 3Add BLAST36
Repeati310 – 342WD 4Add BLAST33
Repeati354 – 404WD 5Add BLAST51
Repeati412 – 449WD 6Add BLAST38
Repeati457 – 504WD 7Add BLAST48
Repeati510 – 569WD 8Add BLAST60

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni512 – 815Interaction with HCN3By similarityAdd BLAST304

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the KCTD3 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2714, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153881

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_012214_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y597

KEGG Orthology (KO)

More...KOi		K21915

Identification of Orthologs from Complete Genome Data

More...OMAi		WNVTRFR

Database of Orthologous Groups

More...OrthoDBi		351369at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y597

TreeFam database of animal gene trees

More...TreeFami		TF313754

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000210, BTB/POZ_dom
IPR011333, SKP1/BTB/POZ_sf
IPR003131, T1-type_BTB
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR036322, WD40_repeat_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02214, BTB_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00225, BTB, 1 hit
SM00320, WD40, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50978, SSF50978, 1 hit
SSF54695, SSF54695, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50097, BTB, 1 hit
PS00678, WD_REPEATS_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y597-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGGHCGSFP AAAAGSGEIV QLNVGGTRFS TSRQTLMWIP DSFFSSLLSG 
        60         70         80         90        100
RISTLRDETG AIFIDRDPAA FAPILNFLRT KELDLRGVSI NVLRHEAEFY 
       110        120        130        140        150
GITPLVRRLL LCEELERSSC GSVLFHGYLP PPGIPSRKIN NTVRSADSRN 
       160        170        180        190        200
GLNSTEGEAR GNGTQPVLSG TGEETVRLGF PVDPRKVLIV AGHHNWIVAA 
       210        220        230        240        250
YAHFAVCYRI KESSGWQQVF TSPYLDWTIE RVALNAKVVG GPHGDKDKMV 
       260        270        280        290        300
AVASESSIIL WSVQDGGSGS EIGVFSLGVP VDALFFIGNQ LVATSHTGKV 
       310        320        330        340        350
GVWNAVTQHW QVQDVVPITS YDTAGSFLLL GCNNGSIYYI DMQKFPLRMK 
       360        370        380        390        400
DNDLLVTELY HDPSNDAITA LSVYLTPKTS VSGNWIEIAY GTSSGAVRVI 
       410        420        430        440        450
VQHPETVGSG PQLFQTFTVH RSPVTKIMLS EKHLVSVCAD NNHVRTWTVT 
       460        470        480        490        500
RFRGMISTQP GSTPLASFKI LSLEETESHG SYSSGNDIGP FGERDDQQVF 
       510        520        530        540        550
IQKVVPITNK LFVRLSSTGK RICEIQAVDC TTISSFTVRE CEGSSRMGSR 
       560        570        580        590        600
PRRYLFTGHT NGSIQMWDLT TAMDMVNKSE DKDVGGPTEE ELLKLLDQCD 
       610        620        630        640        650
LSTSRCATPN ISPATSVVQH SHLRESNSSL QLQHHDTTHE AATYGSMRPY 
       660        670        680        690        700
RESPLLARAR RTESFHSYRD FQTINLNRNV ERAVPENGNL GPIQAEVKGA 
       710        720        730        740        750
TGECNISERK SPGVEIKSLR ELDSGLEVHK IAEGFSESKK RSSEDENENK 
       760        770        780        790        800
IEFRKKGGFE GGGFLGRKKV PYLASSPSTS DGGTDSPGTA SPSPTKTTPS 
       810 
PRHKKSDSSG QEYSL
Length:815
Mass (Da):88,984
Last modified:August 22, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i65131F449069B5B9
GO
Isoform 2 (identifier: Q9Y597-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     583-584: Missing.

Show »
Length:813
Mass (Da):88,770
Checksum:iC05036A26CBE314C
GO
Isoform 3 (identifier: Q9Y597-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-646: Missing.

Show »
Length:169
Mass (Da):18,514
Checksum:iBD47F0FDC67AFE56
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y566H0Y566_HUMAN
BTB/POZ domain-containing protein K...
KCTD3
213Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y5P8H0Y5P8_HUMAN
BTB/POZ domain-containing protein K...
KCTD3
168Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH13868 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti207C → W in AAD42876 (PubMed:10508479).Curated1
Sequence conflicti503K → I in CAD38743 (PubMed:17974005).Curated1
Sequence conflicti742S → P in CAD38743 (PubMed:17974005).Curated1
Sequence conflicti803H → HK in CAD38743 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0271569F → V1 PublicationCorresponds to variant dbSNP:rs2275768Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0200681 – 646Missing in isoform 3. 1 PublicationAdd BLAST646
Alternative sequenceiVSP_020069583 – 584Missing in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF155110 mRNA Translation: AAD42876.1
AC092799 Genomic DNA No translation available.
AL365315 Genomic DNA No translation available.
CH471100 Genomic DNA Translation: EAW93345.1
BC013868 mRNA Translation: AAH13868.1 Sequence problems.
BC037896 mRNA Translation: AAH37896.1
BC094879 mRNA Translation: AAH94879.1
BC117188 mRNA Translation: AAI17189.1
BC126173 mRNA Translation: AAI26174.1
AL833887 mRNA Translation: CAD38743.2
AL834389 mRNA Translation: CAD39051.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1515.1 [Q9Y597-1]

NCBI Reference Sequences

More...RefSeqi		NP_001306223.1, NM_001319294.1 [Q9Y597-2]
NP_001306224.1, NM_001319295.1
NP_057205.2, NM_016121.4 [Q9Y597-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000259154; ENSP00000259154; ENSG00000136636 [Q9Y597-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51133

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:51133

UCSC genome browser

More...UCSCi		uc001hks.5, human [Q9Y597-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155110 mRNA Translation: AAD42876.1
AC092799 Genomic DNA No translation available.
AL365315 Genomic DNA No translation available.
CH471100 Genomic DNA Translation: EAW93345.1
BC013868 mRNA Translation: AAH13868.1 Sequence problems.
BC037896 mRNA Translation: AAH37896.1
BC094879 mRNA Translation: AAH94879.1
BC117188 mRNA Translation: AAI17189.1
BC126173 mRNA Translation: AAI26174.1
AL833887 mRNA Translation: CAD38743.2
AL834389 mRNA Translation: CAD39051.1
CCDSiCCDS1515.1 [Q9Y597-1]
RefSeqiNP_001306223.1, NM_001319294.1 [Q9Y597-2]
NP_001306224.1, NM_001319295.1
NP_057205.2, NM_016121.4 [Q9Y597-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi119320, 140 interactors
IntActiQ9Y597, 34 interactors
MINTiQ9Y597
STRINGi9606.ENSP00000259154

PTM databases

iPTMnetiQ9Y597
PhosphoSitePlusiQ9Y597

Polymorphism and mutation databases

BioMutaiKCTD3
DMDMi112823993

Proteomic databases

EPDiQ9Y597
jPOSTiQ9Y597
MassIVEiQ9Y597
PaxDbiQ9Y597
PeptideAtlasiQ9Y597
PRIDEiQ9Y597
ProteomicsDBi86320 [Q9Y597-1]
86321 [Q9Y597-2]
86322 [Q9Y597-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2795, 118 antibodies

The DNASU plasmid repository

More...DNASUi		51133

Genome annotation databases

EnsembliENST00000259154; ENSP00000259154; ENSG00000136636 [Q9Y597-1]
GeneIDi51133
KEGGihsa:51133
UCSCiuc001hks.5, human [Q9Y597-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51133
DisGeNETi51133
EuPathDBiHostDB:ENSG00000136636.12

GeneCards: human genes, protein and diseases

More...GeneCardsi		KCTD3
HGNCiHGNC:21305, KCTD3
HPAiENSG00000136636, Low tissue specificity
MIMi613272, gene
neXtProtiNX_Q9Y597
OpenTargetsiENSG00000136636
PharmGKBiPA134945859

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2714, Eukaryota
GeneTreeiENSGT00940000153881
HOGENOMiCLU_012214_1_0_1
InParanoidiQ9Y597
KOiK21915
OMAiWNVTRFR
OrthoDBi351369at2759
PhylomeDBiQ9Y597
TreeFamiTF313754

Enzyme and pathway databases

PathwayCommonsiQ9Y597

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		51133, 7 hits in 872 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		KCTD3, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		51133
PharosiQ9Y597, Tdark

Protein Ontology

More...PROi		PR:Q9Y597
RNActiQ9Y597, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000136636, Expressed in left adrenal gland and 231 other tissues
ExpressionAtlasiQ9Y597, baseline and differential
GenevisibleiQ9Y597, HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR000210, BTB/POZ_dom
IPR011333, SKP1/BTB/POZ_sf
IPR003131, T1-type_BTB
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR036322, WD40_repeat_dom_sf
PfamiView protein in Pfam
PF02214, BTB_2, 1 hit
SMARTiView protein in SMART
SM00225, BTB, 1 hit
SM00320, WD40, 3 hits
SUPFAMiSSF50978, SSF50978, 1 hit
SSF54695, SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097, BTB, 1 hit
PS00678, WD_REPEATS_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCTD3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y597
Secondary accession number(s): A0AV15
, D3DTA6, Q49AG7, Q504Q9, Q6PJN6, Q8ND58, Q8NDJ0, Q8WX16
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 22, 2006
Last sequence update: August 22, 2006
Last modified: August 12, 2020
This is version 163 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again