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Protein

RNA-binding protein 7

Gene

RBM7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that directs a subset of non-coding short-lived RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (PubMed:27871484). Possible involved in germ cell RNA processing and meiosis (Probable).1 Publication1 Publication

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • single-stranded RNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processMeiosis

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 7
Alternative name(s):
RNA-binding motif protein 7
Gene namesi
Name:RBM7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000076053.10
HGNCiHGNC:9904 RBM7
MIMi612413 gene
neXtProtiNX_Q9Y580

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi25L → E: Impaired interaction with ZCCHC8; when associated with E-29. 1 Publication1
Mutagenesisi29L → E: Impaired interaction with ZCCHC8; when associated with E-25. 1 Publication1
Mutagenesisi65Y → A: Reduced interaction with ZCCHC8, and impaired interaction with SF3B2/SAP145; when associated with E-69. 1 Publication1
Mutagenesisi69L → E: Reduced interaction with ZCCHC8, and impaired interaction with SF3B2/SAP145; when associated with A-65. 1 Publication1

Organism-specific databases

DisGeNETi10179
OpenTargetsiENSG00000076053
PharmGKBiPA34269

Polymorphism and mutation databases

DMDMi9978697

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000817612 – 266RNA-binding protein 7Add BLAST265

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylglycine1 Publication1
Modified residuei137PhosphoserineBy similarity1
Modified residuei152Omega-N-methylarginineCombined sources1
Modified residuei204PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ9Y580
MaxQBiQ9Y580
PaxDbiQ9Y580
PeptideAtlasiQ9Y580
PRIDEiQ9Y580
ProteomicsDBi86311

PTM databases

iPTMnetiQ9Y580
PhosphoSitePlusiQ9Y580

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000076053 Expressed in 215 organ(s), highest expression level in cartilage tissue
CleanExiHS_RBM7
ExpressionAtlasiQ9Y580 baseline and differential
GenevisibleiQ9Y580 HS

Organism-specific databases

HPAiHPA013993
HPA048003

Interactioni

Subunit structurei

Component of the nuclear exosome targeting (NEXT) complex composed of MTREX, ZCCHC8, and RBM7 that directs a subset of non-coding short-lived RNAs for exosomal degradation (PubMed:27905398, PubMed:27871484). Interacts with ZCCHC8 and SF3B2/SAP145 (PubMed:27905398, PubMed:27871484, PubMed:16263084). Binds to MTREX (PubMed:27871484).3 Publications

Protein-protein interaction databases

BioGridi115478, 66 interactors
DIPiDIP-48833N
IntActiQ9Y580, 47 interactors
MINTiQ9Y580
STRINGi9606.ENSP00000439918

Structurei

Secondary structure

1266
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9Y580
SMRiQ9Y580
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 87RRMPROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 35ZCCHC8 bindingCombined sources1 PublicationAdd BLAST11
Regioni59 – 76ZCCHC8 bindingCombined sources1 PublicationAdd BLAST18

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi86 – 196Ser-richPROSITE-ProRule annotationAdd BLAST111

Phylogenomic databases

eggNOGiKOG4454 Eukaryota
ENOG41123B7 LUCA
GeneTreeiENSGT00870000136493
HOGENOMiHOG000059553
HOVERGENiHBG009324
InParanoidiQ9Y580
KOiK13188
PhylomeDBiQ9Y580
TreeFamiTF323596

Family and domain databases

CDDicd12592 RRM_RBM7, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034500 RBM7_RRM
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q9Y580-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAAAAEADR TLFVGNLETK VTEELLFELF HQAGPVIKVK IPKDKDGKPK
60 70 80 90 100
QFAFVNFKHE VSVPYAMNLL NGIKLYGRPI KIQFRSGSSH APQDVSLSYP
110 120 130 140 150
QHHVGNSSPT STSPSRYERT MDNMTSSAQI IQRSFSSPEN FQRQAVMNSA
160 170 180 190 200
LRQMSYGGKF GSSPLDQSGF SPSVQSHSHS FNQSSSSQWR QGTPSSQRKV
210 220 230 240 250
RMNSYPYLAD RHYSREQRYT DHGSDHHYRG KRDDFFYEDR NHDDWSHDYD
260
NRRDSSRDGK WRSSRH
Length:266
Mass (Da):30,504
Last modified:November 1, 1999 - v1
Checksum:i31D344EBFC54B22F
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KPD3J3KPD3_HUMAN
RNA binding motif protein 7, isofor...
RBM7 hCG_2032547
267Annotation score:
G3V1T9G3V1T9_HUMAN
RNA binding motif protein 7, isofor...
RBM7 hCG_2032547
146Annotation score:
F5GXV8F5GXV8_HUMAN
RNA-binding protein 7
RBM7
149Annotation score:
F5H606F5H606_HUMAN
RNA-binding protein 7
RBM7
123Annotation score:
F5GY08F5GY08_HUMAN
RNA-binding protein 7
RBM7
220Annotation score:
F5H674F5H674_HUMAN
RNA-binding protein 7
RBM7
70Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti102H → Y in BAA92036 (PubMed:14702039).Curated1
Sequence conflicti114P → PS in BAA92036 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156098 mRNA Translation: AAD39257.1
AK002015 mRNA Translation: BAA92036.1
AK312619 mRNA Translation: BAG35505.1
CH471065 Genomic DNA Translation: EAW67247.1
BC034381 mRNA Translation: AAH34381.1
CCDSiCCDS8370.1
RefSeqiNP_001272974.1, NM_001286045.1
NP_001272975.1, NM_001286046.1
NP_001272976.1, NM_001286047.1
NP_001272977.1, NM_001286048.1
NP_057174.1, NM_016090.3
UniGeneiHs.7527

Genome annotation databases

EnsembliENST00000540163; ENSP00000439918; ENSG00000076053
GeneIDi10179
KEGGihsa:10179
UCSCiuc001pov.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156098 mRNA Translation: AAD39257.1
AK002015 mRNA Translation: BAA92036.1
AK312619 mRNA Translation: BAG35505.1
CH471065 Genomic DNA Translation: EAW67247.1
BC034381 mRNA Translation: AAH34381.1
CCDSiCCDS8370.1
RefSeqiNP_001272974.1, NM_001286045.1
NP_001272975.1, NM_001286046.1
NP_001272976.1, NM_001286047.1
NP_001272977.1, NM_001286048.1
NP_057174.1, NM_016090.3
UniGeneiHs.7527

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2M8HNMR-A4-94[»]
5IQQX-ray2.52A/B/C/D/E1-91[»]
5LXRX-ray2.00A1-86[»]
5LXYX-ray2.85A/B/E/G/I/K/M1-86[»]
ProteinModelPortaliQ9Y580
SMRiQ9Y580
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115478, 66 interactors
DIPiDIP-48833N
IntActiQ9Y580, 47 interactors
MINTiQ9Y580
STRINGi9606.ENSP00000439918

PTM databases

iPTMnetiQ9Y580
PhosphoSitePlusiQ9Y580

Polymorphism and mutation databases

DMDMi9978697

Proteomic databases

EPDiQ9Y580
MaxQBiQ9Y580
PaxDbiQ9Y580
PeptideAtlasiQ9Y580
PRIDEiQ9Y580
ProteomicsDBi86311

Protocols and materials databases

DNASUi10179
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000540163; ENSP00000439918; ENSG00000076053
GeneIDi10179
KEGGihsa:10179
UCSCiuc001pov.5 human

Organism-specific databases

CTDi10179
DisGeNETi10179
EuPathDBiHostDB:ENSG00000076053.10
GeneCardsiRBM7
HGNCiHGNC:9904 RBM7
HPAiHPA013993
HPA048003
MIMi612413 gene
neXtProtiNX_Q9Y580
OpenTargetsiENSG00000076053
PharmGKBiPA34269
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4454 Eukaryota
ENOG41123B7 LUCA
GeneTreeiENSGT00870000136493
HOGENOMiHOG000059553
HOVERGENiHBG009324
InParanoidiQ9Y580
KOiK13188
PhylomeDBiQ9Y580
TreeFamiTF323596

Miscellaneous databases

ChiTaRSiRBM7 human
GeneWikiiRBM7
GenomeRNAii10179
PROiPR:Q9Y580
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000076053 Expressed in 215 organ(s), highest expression level in cartilage tissue
CleanExiHS_RBM7
ExpressionAtlasiQ9Y580 baseline and differential
GenevisibleiQ9Y580 HS

Family and domain databases

CDDicd12592 RRM_RBM7, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034500 RBM7_RRM
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRBM7_HUMAN
AccessioniPrimary (citable) accession number: Q9Y580
Secondary accession number(s): B2R6K8, Q9NUT4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: September 12, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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