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Entry version 180 (02 Jun 2021)
Sequence version 1 (01 Nov 1999)
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Protein

E3 ubiquitin-protein ligase TRIM17

Gene

TRIM17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as a ubiquitin E3 ligase.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi99ZincPROSITE-ProRule annotation1
Metal bindingi102ZincPROSITE-ProRule annotation1
Metal bindingi121ZincPROSITE-ProRule annotation1
Metal bindingi127ZincPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri16 – 66RING-typePROSITE-ProRule annotationAdd BLAST51
Zinc fingeri94 – 135B box-typePROSITE-ProRule annotationAdd BLAST42

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9Y577

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-877300, Interferon gamma signaling

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM17 (EC:2.3.2.27)
Alternative name(s):
RING finger protein 16
RING-type E3 ubiquitin transferase TRIM17Curated
Testis RING finger protein
Tripartite motif-containing protein 17
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRIM17
Synonyms:RBCC, RNF16, TERF
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13430, TRIM17

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606123, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y577

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000162931.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
51127

Open Targets

More...
OpenTargetsi
ENSG00000162931

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37768

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9Y577, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRIM17

Domain mapping of disease mutations (DMDM)

More...
DMDMi
38605530

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000562241 – 477E3 ubiquitin-protein ligase TRIM17Add BLAST477

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Auto-ubiquitinated.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9Y577

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y577

PeptideAtlas

More...
PeptideAtlasi
Q9Y577

PRoteomics IDEntifications database

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PRIDEi
Q9Y577

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
86309 [Q9Y577-1]
86310 [Q9Y577-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y577

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y577

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Almost exclusively in the testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000162931, Expressed in right hemisphere of cerebellum and 109 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y577, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y577, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000162931, Tissue enhanced (brain, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via coiled coil) with TRIM44 (via coiled coil).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
119314, 29 interactors

Protein interaction database and analysis system

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IntActi
Q9Y577, 25 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000355658

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9Y577, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9Y577

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini277 – 475B30.2/SPRYPROSITE-ProRule annotationAdd BLAST199

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili135 – 223Sequence analysisAdd BLAST89

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 66RING-typePROSITE-ProRule annotationAdd BLAST51
Zinc fingeri94 – 135B box-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2177, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162155

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_013137_0_3_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y577

Identification of Orthologs from Complete Genome Data

More...
OMAi
TEPPSHM

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y577

TreeFam database of animal gene trees

More...
TreeFami
TF338674

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15812, SPRY_PRY_TRIM17, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.920, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR003879, Butyrophylin_SPRY
IPR013320, ConA-like_dom_sf
IPR006574, PRY
IPR003877, SPRY_dom
IPR032918, TRIM17
IPR035687, TRIM17_PRY/SPRY
IPR027370, Znf-RING_LisH
IPR000315, Znf_B-box
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS

The PANTHER Classification System

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PANTHERi
PTHR24103:SF397, PTHR24103:SF397, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00622, SPRY, 1 hit
PF00643, zf-B_box, 1 hit
PF13445, zf-RING_UBOX, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01407, BUTYPHLNCDUF

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00336, BBOX, 1 hit
SM00589, PRY, 1 hit
SM00184, RING, 1 hit
SM00449, SPRY, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899, SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50188, B302_SPRY, 1 hit
PS50119, ZF_BBOX, 1 hit
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y577-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEAVELARKL QEEATCSICL DYFTDPVMTT CGHNFCRACI QLSWEKARGK
60 70 80 90 100
KGRRKRKGSF PCPECREMSP QRNLLPNRLL TKVAEMAQQH PGLQKQDLCQ
110 120 130 140 150
EHHEPLKLFC QKDQSPICVV CRESREHRLH RVLPAEEAVQ GYKLKLEEDM
160 170 180 190 200
EYLREQITRT GNLQAREEQS LAEWQGKVKE RRERIVLEFE KMNLYLVEEE
210 220 230 240 250
QRLLQALETE EEETASRLRE SVACLDRQGH SLELLLLQLE ERSTQGPLQM
260 270 280 290 300
LQDMKEPLSR KNNVSVQCPE VAPPTRPRTV CRVPGQIEVL RGFLEDVVPD
310 320 330 340 350
ATSAYPYLLL YESRQRRYLG SSPEGSGFCS KDRFVAYPCA VGQTAFSSGR
360 370 380 390 400
HYWEVGMNIT GDALWALGVC RDNVSRKDRV PKCPENGFWV VQLSKGTKYL
410 420 430 440 450
STFSALTPVM LMEPPSHMGI FLDFEAGEVS FYSVSDGSHL HTYSQATFPG
460 470
PLQPFFCLGA PKSGQMVIST VTMWVKG
Length:477
Mass (Da):54,418
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iECA4010661ADD28A
GO
Isoform 2 (identifier: Q9Y577-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     295-343: EDVVPDATSA...FVAYPCAVGQ → GKWAPRARTS...DGHWLFTVPS
     344-477: Missing.

Show »
Length:343
Mass (Da):39,153
Checksum:iA57AD2D4185048EF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RJW6E5RJW6_HUMAN
E3 ubiquitin-protein ligase TRIM17
TRIM17
267Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RI62E5RI62_HUMAN
E3 ubiquitin-protein ligase TRIM17
TRIM17
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KNZ3J3KNZ3_HUMAN
E3 ubiquitin-protein ligase TRIM17
TRIM17
175Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KQG0J3KQG0_HUMAN
E3 ubiquitin-protein ligase TRIM17
TRIM17
30Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_040994295 – 343EDVVP…CAVGQ → GKWAPRARTSDPGSLGDAPL YPLASEATNGGGSTSALPGD GHWLFTVPS in isoform 2. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_040995344 – 477Missing in isoform 2. 1 PublicationAdd BLAST134

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF156271 mRNA Translation: AAD40286.1
AK301105 mRNA Translation: BAG62704.1
AL670729 Genomic DNA No translation available.
AL139288 Genomic DNA No translation available.
BC033788 mRNA Translation: AAH33788.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1571.1 [Q9Y577-1]
CCDS44327.1 [Q9Y577-2]

NCBI Reference Sequences

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RefSeqi
NP_001020111.1, NM_001024940.2 [Q9Y577-1]
NP_001128327.1, NM_001134855.1 [Q9Y577-2]
NP_057186.1, NM_016102.3 [Q9Y577-1]
XP_006711842.1, XM_006711779.2 [Q9Y577-1]
XP_011542511.1, XM_011544209.2 [Q9Y577-1]
XP_011542512.1, XM_011544210.2 [Q9Y577-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000295033; ENSP00000295033; ENSG00000162931 [Q9Y577-1]
ENST00000366697; ENSP00000355658; ENSG00000162931 [Q9Y577-1]
ENST00000366698; ENSP00000355659; ENSG00000162931 [Q9Y577-1]
ENST00000456946; ENSP00000403312; ENSG00000162931 [Q9Y577-2]
ENST00000645562; ENSP00000496098; ENSG00000285344 [Q9Y577-1]
ENST00000645958; ENSP00000495842; ENSG00000285344 [Q9Y577-1]
ENST00000646778; ENSP00000494586; ENSG00000285344 [Q9Y577-2]
ENST00000647385; ENSP00000493891; ENSG00000285344 [Q9Y577-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
51127

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:51127

UCSC genome browser

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UCSCi
uc001hsu.4, human [Q9Y577-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156271 mRNA Translation: AAD40286.1
AK301105 mRNA Translation: BAG62704.1
AL670729 Genomic DNA No translation available.
AL139288 Genomic DNA No translation available.
BC033788 mRNA Translation: AAH33788.1
CCDSiCCDS1571.1 [Q9Y577-1]
CCDS44327.1 [Q9Y577-2]
RefSeqiNP_001020111.1, NM_001024940.2 [Q9Y577-1]
NP_001128327.1, NM_001134855.1 [Q9Y577-2]
NP_057186.1, NM_016102.3 [Q9Y577-1]
XP_006711842.1, XM_006711779.2 [Q9Y577-1]
XP_011542511.1, XM_011544209.2 [Q9Y577-1]
XP_011542512.1, XM_011544210.2 [Q9Y577-1]

3D structure databases

SMRiQ9Y577
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi119314, 29 interactors
IntActiQ9Y577, 25 interactors
STRINGi9606.ENSP00000355658

PTM databases

iPTMnetiQ9Y577
PhosphoSitePlusiQ9Y577

Genetic variation databases

BioMutaiTRIM17
DMDMi38605530

Proteomic databases

MassIVEiQ9Y577
PaxDbiQ9Y577
PeptideAtlasiQ9Y577
PRIDEiQ9Y577
ProteomicsDBi86309 [Q9Y577-1]
86310 [Q9Y577-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
20781, 161 antibodies

The DNASU plasmid repository

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DNASUi
51127

Genome annotation databases

EnsembliENST00000295033; ENSP00000295033; ENSG00000162931 [Q9Y577-1]
ENST00000366697; ENSP00000355658; ENSG00000162931 [Q9Y577-1]
ENST00000366698; ENSP00000355659; ENSG00000162931 [Q9Y577-1]
ENST00000456946; ENSP00000403312; ENSG00000162931 [Q9Y577-2]
ENST00000645562; ENSP00000496098; ENSG00000285344 [Q9Y577-1]
ENST00000645958; ENSP00000495842; ENSG00000285344 [Q9Y577-1]
ENST00000646778; ENSP00000494586; ENSG00000285344 [Q9Y577-2]
ENST00000647385; ENSP00000493891; ENSG00000285344 [Q9Y577-1]
GeneIDi51127
KEGGihsa:51127
UCSCiuc001hsu.4, human [Q9Y577-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
51127
DisGeNETi51127

GeneCards: human genes, protein and diseases

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GeneCardsi
TRIM17
HGNCiHGNC:13430, TRIM17
HPAiENSG00000162931, Tissue enhanced (brain, testis)
MIMi606123, gene
neXtProtiNX_Q9Y577
OpenTargetsiENSG00000162931
PharmGKBiPA37768
VEuPathDBiHostDB:ENSG00000162931.11

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2177, Eukaryota
GeneTreeiENSGT00940000162155
HOGENOMiCLU_013137_0_3_1
InParanoidiQ9Y577
OMAiTEPPSHM
PhylomeDBiQ9Y577
TreeFamiTF338674

Enzyme and pathway databases

UniPathwayiUPA00143
PathwayCommonsiQ9Y577
ReactomeiR-HSA-877300, Interferon gamma signaling

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
51127, 9 hits in 983 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
51127
PharosiQ9Y577, Tbio

Protein Ontology

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PROi
PR:Q9Y577
RNActiQ9Y577, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000162931, Expressed in right hemisphere of cerebellum and 109 other tissues
ExpressionAtlasiQ9Y577, baseline and differential
GenevisibleiQ9Y577, HS

Family and domain databases

CDDicd15812, SPRY_PRY_TRIM17, 1 hit
Gene3Di2.60.120.920, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR003879, Butyrophylin_SPRY
IPR013320, ConA-like_dom_sf
IPR006574, PRY
IPR003877, SPRY_dom
IPR032918, TRIM17
IPR035687, TRIM17_PRY/SPRY
IPR027370, Znf-RING_LisH
IPR000315, Znf_B-box
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS
PANTHERiPTHR24103:SF397, PTHR24103:SF397, 1 hit
PfamiView protein in Pfam
PF00622, SPRY, 1 hit
PF00643, zf-B_box, 1 hit
PF13445, zf-RING_UBOX, 1 hit
PRINTSiPR01407, BUTYPHLNCDUF
SMARTiView protein in SMART
SM00336, BBOX, 1 hit
SM00589, PRY, 1 hit
SM00184, RING, 1 hit
SM00449, SPRY, 1 hit
SUPFAMiSSF49899, SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188, B302_SPRY, 1 hit
PS50119, ZF_BBOX, 1 hit
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRI17_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y577
Secondary accession number(s): B4DVJ2, Q5VST8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: November 1, 1999
Last modified: June 2, 2021
This is version 180 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families
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