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Protein

E3 ubiquitin-protein ligase TRIM17

Gene

TRIM17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as a ubiquitin E3 ligase.1 Publication

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 66RING-typePROSITE-ProRule annotationAdd BLAST51
Zinc fingeri94 – 135B box-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

  • protein binding, bridging Source: UniProtKB
  • ubiquitin-protein transferase activity Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

  • autophagy Source: UniProtKB
  • protein autoubiquitination Source: UniProtKB
  • regulation of protein localization Source: UniProtKB

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-877300 Interferon gamma signaling
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM17 (EC:2.3.2.27)
Alternative name(s):
RING finger protein 16
RING-type E3 ubiquitin transferase TRIM17Curated
Testis RING finger protein
Tripartite motif-containing protein 17
Gene namesi
Name:TRIM17
Synonyms:RBCC, RNF16, TERF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162931.11
HGNCiHGNC:13430 TRIM17
MIMi606123 gene
neXtProtiNX_Q9Y577

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi51127
OpenTargetsiENSG00000162931
PharmGKBiPA37768

Polymorphism and mutation databases

BioMutaiTRIM17
DMDMi38605530

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000562241 – 477E3 ubiquitin-protein ligase TRIM17Add BLAST477

Post-translational modificationi

Auto-ubiquitinated.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ9Y577
PeptideAtlasiQ9Y577
PRIDEiQ9Y577
ProteomicsDBi86309
86310 [Q9Y577-2]

PTM databases

iPTMnetiQ9Y577
PhosphoSitePlusiQ9Y577

Expressioni

Tissue specificityi

Almost exclusively in the testis.1 Publication

Gene expression databases

BgeeiENSG00000162931 Expressed in 84 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_TRIM17
ExpressionAtlasiQ9Y577 baseline and differential
GenevisibleiQ9Y577 HS

Organism-specific databases

HPAiHPA054908

Interactioni

Subunit structurei

Interacts (via coiled coil) with TRIM44 (via coiled coil).1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119314, 22 interactors
IntActiQ9Y577, 23 interactors
STRINGi9606.ENSP00000295033

Structurei

3D structure databases

ProteinModelPortaliQ9Y577
SMRiQ9Y577
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini277 – 475B30.2/SPRYPROSITE-ProRule annotationAdd BLAST199

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili135 – 223Sequence analysisAdd BLAST89

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 66RING-typePROSITE-ProRule annotationAdd BLAST51
Zinc fingeri94 – 135B box-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG2177 Eukaryota
ENOG4111G04 LUCA
GeneTreeiENSGT00760000118893
HOGENOMiHOG000234134
HOVERGENiHBG001357
InParanoidiQ9Y577
KOiK12007
OMAiEPPSHMG
OrthoDBiEOG091G05W2
PhylomeDBiQ9Y577
TreeFamiTF338674

Family and domain databases

CDDicd00021 BBOX, 1 hit
cd15812 SPRY_PRY_TRIM17, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR006574 PRY
IPR003877 SPRY_dom
IPR032918 TRIM17
IPR035687 TRIM17_PRY/SPRY
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PANTHERiPTHR24103:SF397 PTHR24103:SF397, 1 hit
PfamiView protein in Pfam
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00336 BBOX, 1 hit
SM00589 PRY, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y577-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEAVELARKL QEEATCSICL DYFTDPVMTT CGHNFCRACI QLSWEKARGK
60 70 80 90 100
KGRRKRKGSF PCPECREMSP QRNLLPNRLL TKVAEMAQQH PGLQKQDLCQ
110 120 130 140 150
EHHEPLKLFC QKDQSPICVV CRESREHRLH RVLPAEEAVQ GYKLKLEEDM
160 170 180 190 200
EYLREQITRT GNLQAREEQS LAEWQGKVKE RRERIVLEFE KMNLYLVEEE
210 220 230 240 250
QRLLQALETE EEETASRLRE SVACLDRQGH SLELLLLQLE ERSTQGPLQM
260 270 280 290 300
LQDMKEPLSR KNNVSVQCPE VAPPTRPRTV CRVPGQIEVL RGFLEDVVPD
310 320 330 340 350
ATSAYPYLLL YESRQRRYLG SSPEGSGFCS KDRFVAYPCA VGQTAFSSGR
360 370 380 390 400
HYWEVGMNIT GDALWALGVC RDNVSRKDRV PKCPENGFWV VQLSKGTKYL
410 420 430 440 450
STFSALTPVM LMEPPSHMGI FLDFEAGEVS FYSVSDGSHL HTYSQATFPG
460 470
PLQPFFCLGA PKSGQMVIST VTMWVKG
Length:477
Mass (Da):54,418
Last modified:November 1, 1999 - v1
Checksum:iECA4010661ADD28A
GO
Isoform 2 (identifier: Q9Y577-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     295-343: EDVVPDATSA...FVAYPCAVGQ → GKWAPRARTS...DGHWLFTVPS
     344-477: Missing.

Show »
Length:343
Mass (Da):39,153
Checksum:iA57AD2D4185048EF
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RJW6E5RJW6_HUMAN
E3 ubiquitin-protein ligase TRIM17
TRIM17
267Annotation score:
J3KNZ3J3KNZ3_HUMAN
E3 ubiquitin-protein ligase TRIM17
TRIM17
175Annotation score:
E5RI62E5RI62_HUMAN
E3 ubiquitin-protein ligase TRIM17
TRIM17
50Annotation score:
J3KQG0J3KQG0_HUMAN
E3 ubiquitin-protein ligase TRIM17
TRIM17
30Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_040994295 – 343EDVVP…CAVGQ → GKWAPRARTSDPGSLGDAPL YPLASEATNGGGSTSALPGD GHWLFTVPS in isoform 2. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_040995344 – 477Missing in isoform 2. 1 PublicationAdd BLAST134

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156271 mRNA Translation: AAD40286.1
AK301105 mRNA Translation: BAG62704.1
AL670729 Genomic DNA No translation available.
AL139288 Genomic DNA No translation available.
BC033788 mRNA Translation: AAH33788.1
CCDSiCCDS1571.1 [Q9Y577-1]
CCDS44327.1 [Q9Y577-2]
RefSeqiNP_001020111.1, NM_001024940.2 [Q9Y577-1]
NP_001128327.1, NM_001134855.1 [Q9Y577-2]
NP_057186.1, NM_016102.3 [Q9Y577-1]
XP_006711842.1, XM_006711779.2 [Q9Y577-1]
XP_011542511.1, XM_011544209.2 [Q9Y577-1]
XP_011542512.1, XM_011544210.2 [Q9Y577-1]
UniGeneiHs.121748

Genome annotation databases

EnsembliENST00000295033; ENSP00000295033; ENSG00000162931 [Q9Y577-1]
ENST00000366697; ENSP00000355658; ENSG00000162931 [Q9Y577-1]
ENST00000366698; ENSP00000355659; ENSG00000162931 [Q9Y577-1]
ENST00000456946; ENSP00000403312; ENSG00000162931 [Q9Y577-2]
ENST00000645562; ENSP00000496098; ENSG00000285344 [Q9Y577-1]
ENST00000645958; ENSP00000495842; ENSG00000285344 [Q9Y577-1]
ENST00000646778; ENSP00000494586; ENSG00000285344 [Q9Y577-2]
ENST00000647385; ENSP00000493891; ENSG00000285344 [Q9Y577-1]
GeneIDi51127
KEGGihsa:51127
UCSCiuc001hsu.4 human [Q9Y577-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156271 mRNA Translation: AAD40286.1
AK301105 mRNA Translation: BAG62704.1
AL670729 Genomic DNA No translation available.
AL139288 Genomic DNA No translation available.
BC033788 mRNA Translation: AAH33788.1
CCDSiCCDS1571.1 [Q9Y577-1]
CCDS44327.1 [Q9Y577-2]
RefSeqiNP_001020111.1, NM_001024940.2 [Q9Y577-1]
NP_001128327.1, NM_001134855.1 [Q9Y577-2]
NP_057186.1, NM_016102.3 [Q9Y577-1]
XP_006711842.1, XM_006711779.2 [Q9Y577-1]
XP_011542511.1, XM_011544209.2 [Q9Y577-1]
XP_011542512.1, XM_011544210.2 [Q9Y577-1]
UniGeneiHs.121748

3D structure databases

ProteinModelPortaliQ9Y577
SMRiQ9Y577
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119314, 22 interactors
IntActiQ9Y577, 23 interactors
STRINGi9606.ENSP00000295033

PTM databases

iPTMnetiQ9Y577
PhosphoSitePlusiQ9Y577

Polymorphism and mutation databases

BioMutaiTRIM17
DMDMi38605530

Proteomic databases

PaxDbiQ9Y577
PeptideAtlasiQ9Y577
PRIDEiQ9Y577
ProteomicsDBi86309
86310 [Q9Y577-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295033; ENSP00000295033; ENSG00000162931 [Q9Y577-1]
ENST00000366697; ENSP00000355658; ENSG00000162931 [Q9Y577-1]
ENST00000366698; ENSP00000355659; ENSG00000162931 [Q9Y577-1]
ENST00000456946; ENSP00000403312; ENSG00000162931 [Q9Y577-2]
ENST00000645562; ENSP00000496098; ENSG00000285344 [Q9Y577-1]
ENST00000645958; ENSP00000495842; ENSG00000285344 [Q9Y577-1]
ENST00000646778; ENSP00000494586; ENSG00000285344 [Q9Y577-2]
ENST00000647385; ENSP00000493891; ENSG00000285344 [Q9Y577-1]
GeneIDi51127
KEGGihsa:51127
UCSCiuc001hsu.4 human [Q9Y577-1]

Organism-specific databases

CTDi51127
DisGeNETi51127
EuPathDBiHostDB:ENSG00000162931.11
GeneCardsiTRIM17
HGNCiHGNC:13430 TRIM17
HPAiHPA054908
MIMi606123 gene
neXtProtiNX_Q9Y577
OpenTargetsiENSG00000162931
PharmGKBiPA37768
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2177 Eukaryota
ENOG4111G04 LUCA
GeneTreeiENSGT00760000118893
HOGENOMiHOG000234134
HOVERGENiHBG001357
InParanoidiQ9Y577
KOiK12007
OMAiEPPSHMG
OrthoDBiEOG091G05W2
PhylomeDBiQ9Y577
TreeFamiTF338674

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-HSA-877300 Interferon gamma signaling

Miscellaneous databases

GenomeRNAii51127
PROiPR:Q9Y577
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162931 Expressed in 84 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_TRIM17
ExpressionAtlasiQ9Y577 baseline and differential
GenevisibleiQ9Y577 HS

Family and domain databases

CDDicd00021 BBOX, 1 hit
cd15812 SPRY_PRY_TRIM17, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR006574 PRY
IPR003877 SPRY_dom
IPR032918 TRIM17
IPR035687 TRIM17_PRY/SPRY
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PANTHERiPTHR24103:SF397 PTHR24103:SF397, 1 hit
PfamiView protein in Pfam
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00336 BBOX, 1 hit
SM00589 PRY, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRI17_HUMAN
AccessioniPrimary (citable) accession number: Q9Y577
Secondary accession number(s): B4DVJ2, Q5VST8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: November 1, 1999
Last modified: September 12, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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