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Protein

Ankyrin repeat and SOCS box protein 1

Gene

ASB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in testis development (By similarity). Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 1
Short name:
ASB-1
Gene namesi
Name:ASB1
Synonyms:KIAA1146
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000065802.11
HGNCiHGNC:16011 ASB1
MIMi605758 gene
neXtProtiNX_Q9Y576

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000065802
PharmGKBiPA25027

Polymorphism and mutation databases

BioMutaiASB1
DMDMi20532005

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669231 – 335Ankyrin repeat and SOCS box protein 1Add BLAST335

Proteomic databases

EPDiQ9Y576
MaxQBiQ9Y576
PaxDbiQ9Y576
PeptideAtlasiQ9Y576
PRIDEiQ9Y576
ProteomicsDBi86308

PTM databases

iPTMnetiQ9Y576
PhosphoSitePlusiQ9Y576

Expressioni

Gene expression databases

BgeeiENSG00000065802
CleanExiHS_ASB1
ExpressionAtlasiQ9Y576 baseline and differential
GenevisibleiQ9Y576 HS

Organism-specific databases

HPAiHPA003508

Interactioni

Subunit structurei

Interacts with CUL5 and RNF7.1 Publication

Protein-protein interaction databases

BioGridi119668, 21 interactors
CORUMiQ9Y576
IntActiQ9Y576, 3 interactors
MINTiQ9Y576
STRINGi9606.ENSP00000264607

Structurei

3D structure databases

ProteinModelPortaliQ9Y576
SMRiQ9Y576
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati36 – 68ANK 1Add BLAST33
Repeati77 – 106ANK 2Add BLAST30
Repeati110 – 139ANK 3Add BLAST30
Repeati143 – 172ANK 4Add BLAST30
Repeati191 – 220ANK 5Add BLAST30
Repeati235 – 265ANK 6Add BLAST31
Domaini286 – 335SOCS boxPROSITE-ProRule annotationAdd BLAST50

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00920000148951
HOGENOMiHOG000034084
HOVERGENiHBG107089
InParanoidiQ9Y576
KOiK10323
OMAiPVNTQEF
OrthoDBiEOG091G090M
PhylomeDBiQ9Y576
TreeFamiTF331945

Family and domain databases

CDDicd00204 ANK, 1 hit
cd03720 SOCS_ASB1, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR037331 ASB1_SOCS
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF07525 SOCS_box, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 5 hits
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits
PS50225 SOCS, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y576-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGGSPDGR AGPGSAGRNL KEWLREQFCD HPLEHCEDTR LHDAAYVGDL
60 70 80 90 100
QTLRSLLQEE SYRSRINEKS VWCCGWLPCT PLRIAATAGH GSCVDFLIRK
110 120 130 140 150
GAEVDLVDVK GQTALYVAVV NGHLESTQIL LEAGADPNGS RHHRSTPVYH
160 170 180 190 200
ASRVGRADIL KALIRYGADV DVNHHLTPDV QPRFSRRLTS LVVCPLYISA
210 220 230 240 250
AYHNLQCFRL LLLAGANPDF NCNGPVNTQG FYRGSPGCVM DAVLRHGCEA
260 270 280 290 300
AFVSLLVEFG ANLNLVKWES LGPESRGRRK VDPEALQVFK EARSVPRTLL
310 320 330
CLCRVAVRRA LGKHRLHLIP SLPLPDPIKK FLLHE
Length:335
Mass (Da):37,014
Last modified:November 1, 1999 - v1
Checksum:i0843C96AD1AF60D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156777 mRNA Translation: AAD41894.1
AC016999 Genomic DNA Translation: AAX88934.1
BC014528 mRNA Translation: AAH14528.1
AB032972 mRNA Translation: BAA86460.1
CCDSiCCDS33416.1
RefSeqiNP_001035535.1, NM_001040445.2
UniGeneiHs.516788

Genome annotation databases

EnsembliENST00000264607; ENSP00000264607; ENSG00000065802
GeneIDi51665
KEGGihsa:51665
UCSCiuc002vyg.4 human

Similar proteinsi

Entry informationi

Entry nameiASB1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y576
Secondary accession number(s): A6NL50, Q4ZG29, Q9ULS4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: November 1, 1999
Last modified: June 20, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

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