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UniProtKB - Q9Y570 (PPME1_HUMAN)

Entry version 181 (02 Jun 2021)
Sequence version 3 (23 Jan 2007)
Previous versions | rss
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Protein

Protein phosphatase methylesterase 1

Gene

PPME1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1561 Publication1
Active sitei1811 Publication1
Active sitei3491 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Serine esterase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:MONOMER-16514

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.1.1.89, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9Y570

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-69273, Cyclin A/B1/B2 associated events during G2/M transition

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...ESTHERi		human-PPME1, PPase_methylesterase_euk

MEROPS protease database

More...MEROPSi		S33.984

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein phosphatase methylesterase 1 (EC:3.1.1.89)
Short name:
PME-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPME1
Synonyms:PME1
ORF Names:PP2593, PRO0750
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:30178, PPME1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611117, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y570

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000214517.8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		51400

Open Targets

More...OpenTargetsi		ENSG00000214517

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142671152

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y570, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1293320

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2875

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PPME1

Domain mapping of disease mutations (DMDM)

More...DMDMi		47606055

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000903902 – 386Protein phosphatase methylesterase 1Add BLAST385

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei15PhosphoserineCombined sources1
Modified residuei16Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei16Omega-N-methylarginine; alternateCombined sources1
Modified residuei42PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by SIK1 following increases in intracellular sodium, leading to dissociation from the protein phosphatase 2A (PP2A) complex and subsequent dephosphorylation of sodium/potassium-transporting ATPase ATP1A1.By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9Y570

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9Y570

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9Y570

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y570

PeptideAtlas

More...PeptideAtlasi		Q9Y570

PRoteomics IDEntifications database

More...PRIDEi		Q9Y570

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		86296 [Q9Y570-1]
86297 [Q9Y570-2]
86298 [Q9Y570-3]

2D gel databases

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		IPI00007694

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y570

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9Y570

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y570

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9Y570

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000214517, Expressed in frontal cortex and 236 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9Y570, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Y570, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000214517, Tissue enhanced (parathyroid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds PPP2CA and PPP2CB.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119524, 109 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9Y570

Protein interaction database and analysis system

More...IntActi		Q9Y570, 29 interactors

Molecular INTeraction database

More...MINTi		Q9Y570

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000381461

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9Y570

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Y570, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1386
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Y570

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9Y570

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 38DisorderedSequence analysisAdd BLAST38
Regioni254 – 280DisorderedSequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi265 – 280Basic and acidic residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AB hydrolase superfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2564, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000004396

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_024818_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y570

Identification of Orthologs from Complete Genome Data

More...OMAi		WHIRSRT

Database of Orthologous Groups

More...OrthoDBi		911863at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y570

TreeFam database of animal gene trees

More...TreeFami		TF314697

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029058, AB_hydrolase
IPR000073, AB_hydrolase_1
IPR016812, PPase_methylesterase_euk

The PANTHER Classification System

More...PANTHERi		PTHR14189, PTHR14189, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12697, Abhydrolase_6, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF022950, PPase_methylesterase_euk, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53474, SSF53474, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00120, LIPASE_SER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9Y570-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSALEKSMHL GRLPSRPPLP GSGGSQSGAK MRMGPGRKRD FSPVPWSQYF 
        60         70         80         90        100
ESMEDVEVEN ETGKDTFRVY KSGSEGPVLL LLHGGGHSAL SWAVFTAAII 
       110        120        130        140        150
SRVQCRIVAL DLRSHGETKV KNPEDLSAET MAKDVGNVVE AMYGDLPPPI 
       160        170        180        190        200
MLIGHSMGGA IAVHTASSNL VPSLLGLCMI DVVEGTAMDA LNSMQNFLRG 
       210        220        230        240        250
RPKTFKSLEN AIEWSVKSGQ IRNLESARVS MVGQVKQCEG ITSPEGSKSI 
       260        270        280        290        300
VEGIIEEEEE DEEGSESISK RKKEDDMETK KDHPYTWRIE LAKTEKYWDG 
       310        320        330        340        350
WFRGLSNLFL SCPIPKLLLL AGVDRLDKDL TIGQMQGKFQ MQVLPQCGHA 
       360        370        380 
VHEDAPDKVA EAVATFLIRH RFAEPIGGFQ CVFPGC
Length:386
Mass (Da):42,315
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i37B25324583E8578
GO
Isoform 2 (identifier: Q9Y570-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-187: Missing.

Show »
Length:199
Mass (Da):22,462
Checksum:iF39B21A7AD5C5115
GO
Isoform 3 (identifier: Q9Y570-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-276: Missing.
     360-386: AEAVATFLIRHRFAEPIGGFQCVFPGC → SLVLSDCKRT...LCYFIPGPCG

Show »
Length:161
Mass (Da):18,214
Checksum:i53E51B3B7916DBFB
GO
Isoform 4 (identifier: Q9Y570-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     278-278: E → EGLPSETQNLLLFLQ

Show »
Length:400
Mass (Da):43,870
Checksum:i0F9F02DDFABA6C3B
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG22477 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti309F → S in BAA91661 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0103351 – 276Missing in isoform 3. 1 PublicationAdd BLAST276
Alternative sequenceiVSP_0103361 – 187Missing in isoform 2. 1 PublicationAdd BLAST187
Alternative sequenceiVSP_054818278E → EGLPSETQNLLLFLQ in isoform 4. Curated1
Alternative sequenceiVSP_010337360 – 386AEAVA…VFPGC → SLVLSDCKRTTVRITLDVTE DKSLSLSLHCLQQLLWSLCR CSSTSSPTSPWQLLMVLVLC ICAEELLTLCYFIPGPCG in isoform 3. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF157028 mRNA Translation: AAD44976.1
AF111853 mRNA Translation: AAF16692.1
AK001381 mRNA Translation: BAA91661.1
AK022725 mRNA Translation: BAG51108.1
AK123288 mRNA Translation: BAC85574.1
AP000577 Genomic DNA No translation available.
AP002392 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW74932.1
BC003046 mRNA Translation: AAH03046.1
BC050705 mRNA Translation: AAH50705.1
AF193049 mRNA Translation: AAG22477.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS44678.1 [Q9Y570-1]
CCDS60891.1 [Q9Y570-4]

NCBI Reference Sequences

More...RefSeqi		NP_001258522.1, NM_001271593.1 [Q9Y570-4]
NP_057231.1, NM_016147.2 [Q9Y570-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000328257; ENSP00000329867; ENSG00000214517 [Q9Y570-1]
ENST00000398427; ENSP00000381461; ENSG00000214517 [Q9Y570-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51400

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:51400

UCSC genome browser

More...UCSCi		uc001ouw.5, human [Q9Y570-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF157028 mRNA Translation: AAD44976.1
AF111853 mRNA Translation: AAF16692.1
AK001381 mRNA Translation: BAA91661.1
AK022725 mRNA Translation: BAG51108.1
AK123288 mRNA Translation: BAC85574.1
AP000577 Genomic DNA No translation available.
AP002392 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW74932.1
BC003046 mRNA Translation: AAH03046.1
BC050705 mRNA Translation: AAH50705.1
AF193049 mRNA Translation: AAG22477.1 Sequence problems.
CCDSiCCDS44678.1 [Q9Y570-1]
CCDS60891.1 [Q9Y570-4]
RefSeqiNP_001258522.1, NM_001271593.1 [Q9Y570-4]
NP_057231.1, NM_016147.2 [Q9Y570-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3C5VX-ray2.00A39-386[»]
3C5WX-ray2.80P284-386[»]
P39-238[»]
SMRiQ9Y570
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi119524, 109 interactors
CORUMiQ9Y570
IntActiQ9Y570, 29 interactors
MINTiQ9Y570
STRINGi9606.ENSP00000381461

Chemistry databases

BindingDBiQ9Y570
ChEMBLiCHEMBL1293320
GuidetoPHARMACOLOGYi2875

Protein family/group databases

ESTHERihuman-PPME1, PPase_methylesterase_euk
MEROPSiS33.984

PTM databases

iPTMnetiQ9Y570
MetOSiteiQ9Y570
PhosphoSitePlusiQ9Y570
SwissPalmiQ9Y570

Genetic variation databases

BioMutaiPPME1
DMDMi47606055

2D gel databases

REPRODUCTION-2DPAGEiIPI00007694

Proteomic databases

EPDiQ9Y570
jPOSTiQ9Y570
MassIVEiQ9Y570
PaxDbiQ9Y570
PeptideAtlasiQ9Y570
PRIDEiQ9Y570
ProteomicsDBi86296 [Q9Y570-1]
86297 [Q9Y570-2]
86298 [Q9Y570-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3870, 314 antibodies

The DNASU plasmid repository

More...DNASUi		51400

Genome annotation databases

EnsembliENST00000328257; ENSP00000329867; ENSG00000214517 [Q9Y570-1]
ENST00000398427; ENSP00000381461; ENSG00000214517 [Q9Y570-4]
GeneIDi51400
KEGGihsa:51400
UCSCiuc001ouw.5, human [Q9Y570-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51400
DisGeNETi51400

GeneCards: human genes, protein and diseases

More...GeneCardsi		PPME1
HGNCiHGNC:30178, PPME1
HPAiENSG00000214517, Tissue enhanced (parathyroid)
MIMi611117, gene
neXtProtiNX_Q9Y570
OpenTargetsiENSG00000214517
PharmGKBiPA142671152
VEuPathDBiHostDB:ENSG00000214517.8

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2564, Eukaryota
GeneTreeiENSGT00390000004396
HOGENOMiCLU_024818_0_1_1
InParanoidiQ9Y570
OMAiWHIRSRT
OrthoDBi911863at2759
PhylomeDBiQ9Y570
TreeFamiTF314697

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-16514
BRENDAi3.1.1.89, 2681
PathwayCommonsiQ9Y570
ReactomeiR-HSA-69273, Cyclin A/B1/B2 associated events during G2/M transition

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		51400, 169 hits in 995 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PPME1, human
EvolutionaryTraceiQ9Y570

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		51400
PharosiQ9Y570, Tchem

Protein Ontology

More...PROi		PR:Q9Y570
RNActiQ9Y570, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000214517, Expressed in frontal cortex and 236 other tissues
ExpressionAtlasiQ9Y570, baseline and differential
GenevisibleiQ9Y570, HS

Family and domain databases

InterProiView protein in InterPro
IPR029058, AB_hydrolase
IPR000073, AB_hydrolase_1
IPR016812, PPase_methylesterase_euk
PANTHERiPTHR14189, PTHR14189, 1 hit
PfamiView protein in Pfam
PF12697, Abhydrolase_6, 1 hit
PIRSFiPIRSF022950, PPase_methylesterase_euk, 1 hit
SUPFAMiSSF53474, SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00120, LIPASE_SER, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPPME1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y570
Secondary accession number(s): B3KMU6
, B5MEE7, J3QT22, Q8WYG8, Q9NVT5, Q9UI18
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: January 23, 2007
Last modified: June 2, 2021
This is version 181 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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