UniProtKB - Q9Y566 (SHAN1_HUMAN)

>sp|Q9Y566|SHAN1_HUMAN SH3 and multiple ankyrin repeat domains protein 1 OS=Homo sapiens OX=9606 GN=SHANK1 PE=1 SV=2
MTHSPATSEDEERHSASECPEGGSESDSSPDGPGRGPRGTRGQGSGAPGSLASVRGLQGR
SMSVPDDAHFSMMVFRIGIPDLHQTKCLRFNPDATIWTAKQQVLCALSESLQDVLNYGLF
QPATSGRDANFLEEERLLREYPQSFEKGVPYLEFRYKTRVYKQTNLDEKQLAKLHTKTGL
KKFLEYVQLGTSDKVARLLDKGLDPNYHDSDSGETPLTLAAQTEGSVEVIRTLCLGGAHI
DFRARDGMTALHKAACARHCLALTALLDLGGSPNYKDRRGLTPLFHTAMVGGDPRCCELL
LFNRAQLGIADENGWQEIHQACQRGHSQHLEHLLFYGAEPGAQNASGNTALHICALYNKE
TCARILLYRGADKDVKNNNGQTPFQVAVIAGNFELGELIRNHREQDVVPFQESPKYAARR
RGPPGTGLTVPPALLRANSDTSMALPDWMVFSAPGAASSGAPGPTSGSQGQSQPSAPTTK
LSSGTLRSASSPRGARARSPSRGRHPEDAKRQPRGRPSSSGTPREGPAGGTGGSGGPGGS
LGSRGRRRKLYSAVPGRSFMAVKSYQAQAEGEISLSKGEKIKVLSIGEGGFWEGQVKGRV
GWFPSDCLEEVANRSQESKQESRSDKAKRLFRHYTVGSYDSFDAPSLMDGIGPGSDYIIK
EKTVLLQKKDSEGFGFVLRGAKAQTPIEEFTPTPAFPALQYLESVDEGGVAWRAGLRMGD
FLIEVNGQNVVKVGHRQVVNMIRQGGNTLMVKVVMVTRHPDMDEAVHKKAPQQAKRLPPP
TISLRSKSMTSELEEMEYEQQPAPVPSMEKKRTVYQMALNKLDEILAAAQQTISASESPG
PGGLASLGKHRPKGFFATESSFDPHHRAQPSYERPSFLPPGPGLMLRQKSIGAAEDDRPY
LAPPAMKFSRSLSVPGSEDIPPPPTTSPPEPPYSTPPVPSSSGRLTPSPRGGPFNPGSGG
PLPASSPASFDGPSPPDTRVGSREKSLYHSGPLPPAHHHPPHHHHHHAPPPQPHHHHAHP
PHPPEMETGGSPDDPPPRLALGPQPSLRGWRGGGPSPTPGAPSPSHHGSAGGGGGSSQGP
ALRYFQLPPRAASAAMYVPARSGRGRKGPLVKQTKVEGEPQKGGGLPPAPSPTSPASPQP
PPAVAAPSEKNSIPIPTIIIKAPSTSSSGRSSQGSSTEAEPPTQPEPTGGGGGGGSSPSP
APAMSPVPPSPSPVPTPASPSGPATLDFTSQFGAALVGAARREGGWQNEARRRSTLFLST
DAGDEDGGDGGLGTGAAPGPRLRHSKSIDEGMFSAEPYLRLESAGSGAGYGGYGAGSRAY
GGGGGSSAFTSFLPPRPLVHPLTGKALDPASPLGLALAARERALKESSEGGGAPQPPPRP
PSPRYEAPPPTPHHHSPHAHHEPVLRLWGASPPDPARRELGYRAGLGSQEKSLPASPPAA
RRSLLHRLPPTAPGVGPLLLQLGTEPPAPHPGVSKPWRSAAPEEPERLPLHVRFLENCQP
RAPVTSGRGPPSEDGPGVPPPSPRRSVPPSPTSPRASEENGLPLLVLPPPAPSVDVEDGE
FLFVEPLPPPLEFSNSFEKPESPLTPGPPHPLPDTPAPATPLPPVPPPAVAAAPPTLDST
ASSLTSYDSEVATLTQGASAAPGDPHPPGPPAPAAPAPAAPQPGPDPPPGTDSGIEEVDS
RSSSDHPLETISSASTLSSLSAEGGGSAGGGGGAGAGVASGPELLDTYVAYLDGQAFGGS
STPGPPYPPQLMTPSKLRGRALGASGGLRPGPSGGLRDPVTPTSPTVSVTGAGTDGLLAL
RACSGPPTAGVAGGPVAVEPEVPPVPLPTASSLPRKLLPWEEGPGPPPPPLPGPLAQPQA
SALATVKASIISELSSKLQQFGGSSAAGGALPWARGGSGGGGDSHHGGASYVPERTSSLQ
RQRLSDDSQSSLLSKPVSSLFQNWPKPPLPPLPTGTGVSPTAAAAPGATSPSASSSSTST
RHLQGVEFEMRPPLLRRAPSPSLLPASEHKVSPAPRPSSLPILPSGPLYPGLFDIRGSPT
GGAGGSADPFAPVFVPPHPGISGGLGGALSGASRSLSPTRLLSLPPDKPFGAKPLGFWTK
FDVADWLEWLGLAEHRAQFLDHEIDGSHLPALTKEDYVDLGVTRVGHRMNIDRALKFFLE
R

Entry version 194 (07 Apr 2021)
Sequence version 2 (05 May 2009)
Previous versions | rss

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Protein

SH3 and multiple ankyrin repeat domains protein 1

Gene

SHANK1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction.

GO - Molecular functionⁱ

ankyrin repeat binding Source: BHF-UCL
identical protein binding Source: BHF-UCL
ionotropic glutamate receptor binding Source: BHF-UCL
protein-containing complex binding Source: BHF-UCL
protein C-terminus binding Source: BHF-UCL
scaffold protein binding Source: BHF-UCL
SH3 domain binding Source: BHF-UCL
somatostatin receptor binding Source: BHF-UCL
synaptic receptor adaptor activity Source: BHF-UCL

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Differentiation, Neurogenesis

Biological process

Differentiation, Neurogenesis

Enzyme and pathway databases

PathwayCommonsⁱ	Q9Y566
Reactomeⁱ	R-HSA-6794361, Neurexins and neuroligins
SIGNORⁱ	Q9Y566

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: SH3 and multiple ankyrin repeat domains protein 1 Short name: Shank1 Alternative name(s): Somatostatin receptor-interacting protein Short name: SSTR-interacting protein Short name: SSTRIP
Gene namesⁱ	Name:SHANK1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15474, SHANK1
MIMⁱ	604999, gene
neXtProtⁱ	NX_Q9Y566
VEuPathDBⁱ	HostDB:ENSG00000161681.15

Keywords - Cellular componentⁱ

Cell junction, Cytoplasm, Synapse

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	50944
Open Targets More...OpenTargetsⁱ	ENSG00000161681
PharmGKBⁱ	PA37965

Miscellaneous databases

Pharosⁱ	Q9Y566, Tbio

Pharosⁱ

Q9Y566, Tbio

Genetic variation databases

BioMutaⁱ	SHANK1
DMDMⁱ	229462779

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000174671	1 – 2161	SH3 and multiple ankyrin repeat domains protein 1Add BLAST		2161

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	186	PhosphotyrosineBy similarity	1
Modified residueⁱ	540	PhosphoserineBy similarity	1
Modified residueⁱ	544	Omega-N-methylarginineBy similarity	1
Modified residueⁱ	671	PhosphoserineBy similarity	1
Modified residueⁱ	791	PhosphoserineBy similarity	1
Modified residueⁱ	890	PhosphoserineBy similarity	1
Modified residueⁱ	950	Omega-N-methylarginineBy similarity	1
Modified residueⁱ	1051	Omega-N-methylarginineBy similarity	1
Modified residueⁱ	1090	Omega-N-methylarginineBy similarity	1
Modified residueⁱ	1101	Omega-N-methylarginineBy similarity	1
Modified residueⁱ	1253	Asymmetric dimethylarginineBy similarity	1
Modified residueⁱ	1287	PhosphoserineBy similarity	1
Modified residueⁱ	1423	Omega-N-methylarginineBy similarity	1
Modified residueⁱ	1436	PhosphoserineBy similarity	1
Modified residueⁱ	1895	Omega-N-methylarginineBy similarity	1
Modified residueⁱ	2016	Omega-N-methylarginineBy similarity	1
Modified residueⁱ	2036	Omega-N-methylarginineBy similarity	1
Modified residueⁱ	2074	Omega-N-methylarginineBy similarity	1

Keywords - PTMⁱ

Methylation, Phosphoprotein

Proteomic databases

MassIVEⁱ	Q9Y566
PaxDbⁱ	Q9Y566
PeptideAtlas More...PeptideAtlasⁱ	Q9Y566
PRIDEⁱ	Q9Y566
ProteomicsDBⁱ	86293 [Q9Y566-1] 86294 [Q9Y566-2] 86295 [Q9Y566-3]

PTM databases

iPTMnetⁱ	Q9Y566
PhosphoSitePlusⁱ	Q9Y566

Expressionⁱ

Tissue specificityⁱ

Expressed in brain particularly in the amygdala, hippocampus, substantia nigra and thalamus. Isoform 2 seems to be expressed ubiquitously.

Gene expression databases

Bgeeⁱ	ENSG00000161681, Expressed in dorsolateral prefrontal cortex and 107 other tissues
ExpressionAtlasⁱ	Q9Y566, baseline and differential
Genevisibleⁱ	Q9Y566, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000161681, Tissue enriched (brain)

HPAⁱ

ENSG00000161681, Tissue enriched (brain)

Interactionⁱ

Subunit structureⁱ

May homomultimerize via its SAM domain (By similarity).

Interacts with the C-terminus of SSTR2 via the PDZ domain.

Interacts with IGSF9, SHARPIN, SPTAN1, HOMER1 and DLGAP1/GKAP isoforms 1 and 2 (By similarity).

Part of a complex with DLG4/PSD-95 and DLGAP1/GKAP (By similarity).

Interacts with BAIAP2.

Interacts with HOMER1 and HOMER3 (By similarity).

By similarity2 Publications

Binary interactionsⁱ

Q9Y566

With	#Exp.	IntAct
RPS6KA2 [Q15349]	2	EBI-3442234,EBI-1384149

GO - Molecular functionⁱ

ankyrin repeat binding Source: BHF-UCL
identical protein binding Source: BHF-UCL
ionotropic glutamate receptor binding Source: BHF-UCL
protein C-terminus binding Source: BHF-UCL
scaffold protein binding Source: BHF-UCL
SH3 domain binding Source: BHF-UCL
somatostatin receptor binding Source: BHF-UCL

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	119171, 23 interactors
Database of interacting proteins More...DIPⁱ	DIP-40834N
ELMⁱ	Q9Y566
IntActⁱ	Q9Y566, 21 interactors
Molecular INTeraction database More...MINTⁱ	Q9Y566
STRINGⁱ	9606.ENSP00000293441

Miscellaneous databases

RNActⁱ	Q9Y566, protein

RNActⁱ

Q9Y566, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	559 – 563	Combined sources	5
Beta strandⁱ	569 – 572	Combined sources	4
Beta strandⁱ	580 – 586	Combined sources	7
Beta strandⁱ	591 – 596	Combined sources	6
Beta strandⁱ	599 – 604	Combined sources	6
Helixⁱ	605 – 607	Combined sources	3

Show more details

3D structure databases

SMRⁱ	Q9Y566
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	212 – 245	ANK 1Add BLAST	34
Repeatⁱ	246 – 278	ANK 2Add BLAST	33
Repeatⁱ	279 – 312	ANK 3Add BLAST	34
Repeatⁱ	313 – 345	ANK 4Add BLAST	33
Repeatⁱ	346 – 378	ANK 5Add BLAST	33
Repeatⁱ	379 – 395	ANK 6Add BLAST	17
Domainⁱ	554 – 613	SH3PROSITE-ProRule annotationAdd BLAST	60
Domainⁱ	663 – 757	PDZPROSITE-ProRule annotationAdd BLAST	95
Domainⁱ	2098 – 2161	SAMPROSITE-ProRule annotationAdd BLAST	64

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	1002 – 1007	Poly-His	6
Compositional biasⁱ	1014 – 1019	Poly-His	6
Compositional biasⁱ	1189 – 1195	Poly-Gly	7
Compositional biasⁱ	1709 – 1717	Poly-Gly	9
Compositional biasⁱ	1844 – 1854	Poly-ProAdd BLAST	11
Compositional biasⁱ	1896 – 1902	Poly-Gly	7
Compositional biasⁱ	1970 – 1979	Poly-Ser	10

Sequence similaritiesⁱ

Belongs to the SHANK family.Curated

Keywords - Domainⁱ

ANK repeat, Repeat, SH3 domain

Phylogenomic databases

eggNOGⁱ	KOG0504, Eukaryota KOG4375, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000153561
HOGENOMⁱ	CLU_001824_1_0_1
InParanoidⁱ	Q9Y566
PhylomeDBⁱ	Q9Y566
TreeFamⁱ	TF324593

Family and domain databases

Gene3Dⁱ	1.10.150.50, 1 hit 1.25.40.20, 1 hit 2.30.42.10, 1 hit
InterProⁱ	View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR001478, PDZ IPR041489, PDZ_6 IPR036034, PDZ_sf IPR001660, SAM IPR013761, SAM/pointed_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12796, Ank_2, 2 hits PF17820, PDZ_6, 1 hit PF00536, SAM_1, 1 hit PF07653, SH3_2, 1 hit
SMARTⁱ	View protein in SMART SM00248, ANK, 6 hits SM00228, PDZ, 1 hit SM00454, SAM, 1 hit SM00326, SH3, 1 hit
SUPFAMⁱ	SSF47769, SSF47769, 1 hit SSF48403, SSF48403, 1 hit SSF50044, SSF50044, 1 hit SSF50156, SSF50156, 1 hit
PROSITEⁱ	View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 3 hits PS50106, PDZ, 1 hit PS50105, SAM_DOMAIN, 1 hit PS50002, SH3, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9Y566-1) [UniParc]FASTA Add to basket

Also known as: A

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MTHSPATSED EERHSASECP EGGSESDSSP DGPGRGPRGT RGQGSGAPGS 
        60         70         80         90        100
LASVRGLQGR SMSVPDDAHF SMMVFRIGIP DLHQTKCLRF NPDATIWTAK 
       110        120        130        140        150
QQVLCALSES LQDVLNYGLF QPATSGRDAN FLEEERLLRE YPQSFEKGVP 
       160        170        180        190        200
YLEFRYKTRV YKQTNLDEKQ LAKLHTKTGL KKFLEYVQLG TSDKVARLLD 
       210        220        230        240        250
KGLDPNYHDS DSGETPLTLA AQTEGSVEVI RTLCLGGAHI DFRARDGMTA 
       260        270        280        290        300
LHKAACARHC LALTALLDLG GSPNYKDRRG LTPLFHTAMV GGDPRCCELL 
       310        320        330        340        350
LFNRAQLGIA DENGWQEIHQ ACQRGHSQHL EHLLFYGAEP GAQNASGNTA 
       360        370        380        390        400
LHICALYNKE TCARILLYRG ADKDVKNNNG QTPFQVAVIA GNFELGELIR 
       410        420        430        440        450
NHREQDVVPF QESPKYAARR RGPPGTGLTV PPALLRANSD TSMALPDWMV 
       460        470        480        490        500
FSAPGAASSG APGPTSGSQG QSQPSAPTTK LSSGTLRSAS SPRGARARSP 
       510        520        530        540        550
SRGRHPEDAK RQPRGRPSSS GTPREGPAGG TGGSGGPGGS LGSRGRRRKL 
       560        570        580        590        600
YSAVPGRSFM AVKSYQAQAE GEISLSKGEK IKVLSIGEGG FWEGQVKGRV 
       610        620        630        640        650
GWFPSDCLEE VANRSQESKQ ESRSDKAKRL FRHYTVGSYD SFDAPSLMDG 
       660        670        680        690        700
IGPGSDYIIK EKTVLLQKKD SEGFGFVLRG AKAQTPIEEF TPTPAFPALQ 
       710        720        730        740        750
YLESVDEGGV AWRAGLRMGD FLIEVNGQNV VKVGHRQVVN MIRQGGNTLM 
       760        770        780        790        800
VKVVMVTRHP DMDEAVHKKA PQQAKRLPPP TISLRSKSMT SELEEMEYEQ 
       810        820        830        840        850
QPAPVPSMEK KRTVYQMALN KLDEILAAAQ QTISASESPG PGGLASLGKH 
       860        870        880        890        900
RPKGFFATES SFDPHHRAQP SYERPSFLPP GPGLMLRQKS IGAAEDDRPY 
       910        920        930        940        950
LAPPAMKFSR SLSVPGSEDI PPPPTTSPPE PPYSTPPVPS SSGRLTPSPR 
       960        970        980        990       1000
GGPFNPGSGG PLPASSPASF DGPSPPDTRV GSREKSLYHS GPLPPAHHHP 
      1010       1020       1030       1040       1050
PHHHHHHAPP PQPHHHHAHP PHPPEMETGG SPDDPPPRLA LGPQPSLRGW 
      1060       1070       1080       1090       1100
RGGGPSPTPG APSPSHHGSA GGGGGSSQGP ALRYFQLPPR AASAAMYVPA 
      1110       1120       1130       1140       1150
RSGRGRKGPL VKQTKVEGEP QKGGGLPPAP SPTSPASPQP PPAVAAPSEK 
      1160       1170       1180       1190       1200
NSIPIPTIII KAPSTSSSGR SSQGSSTEAE PPTQPEPTGG GGGGGSSPSP 
      1210       1220       1230       1240       1250
APAMSPVPPS PSPVPTPASP SGPATLDFTS QFGAALVGAA RREGGWQNEA 
      1260       1270       1280       1290       1300
RRRSTLFLST DAGDEDGGDG GLGTGAAPGP RLRHSKSIDE GMFSAEPYLR 
      1310       1320       1330       1340       1350
LESAGSGAGY GGYGAGSRAY GGGGGSSAFT SFLPPRPLVH PLTGKALDPA 
      1360       1370       1380       1390       1400
SPLGLALAAR ERALKESSEG GGAPQPPPRP PSPRYEAPPP TPHHHSPHAH 
      1410       1420       1430       1440       1450
HEPVLRLWGA SPPDPARREL GYRAGLGSQE KSLPASPPAA RRSLLHRLPP 
      1460       1470       1480       1490       1500
TAPGVGPLLL QLGTEPPAPH PGVSKPWRSA APEEPERLPL HVRFLENCQP 
      1510       1520       1530       1540       1550
RAPVTSGRGP PSEDGPGVPP PSPRRSVPPS PTSPRASEEN GLPLLVLPPP 
      1560       1570       1580       1590       1600
APSVDVEDGE FLFVEPLPPP LEFSNSFEKP ESPLTPGPPH PLPDTPAPAT 
      1610       1620       1630       1640       1650
PLPPVPPPAV AAAPPTLDST ASSLTSYDSE VATLTQGASA APGDPHPPGP 
      1660       1670       1680       1690       1700
PAPAAPAPAA PQPGPDPPPG TDSGIEEVDS RSSSDHPLET ISSASTLSSL 
      1710       1720       1730       1740       1750
SAEGGGSAGG GGGAGAGVAS GPELLDTYVA YLDGQAFGGS STPGPPYPPQ 
      1760       1770       1780       1790       1800
LMTPSKLRGR ALGASGGLRP GPSGGLRDPV TPTSPTVSVT GAGTDGLLAL 
      1810       1820       1830       1840       1850
RACSGPPTAG VAGGPVAVEP EVPPVPLPTA SSLPRKLLPW EEGPGPPPPP 
      1860       1870       1880       1890       1900
LPGPLAQPQA SALATVKASI ISELSSKLQQ FGGSSAAGGA LPWARGGSGG 
      1910       1920       1930       1940       1950
GGDSHHGGAS YVPERTSSLQ RQRLSDDSQS SLLSKPVSSL FQNWPKPPLP 
      1960       1970       1980       1990       2000
PLPTGTGVSP TAAAAPGATS PSASSSSTST RHLQGVEFEM RPPLLRRAPS 
      2010       2020       2030       2040       2050
PSLLPASEHK VSPAPRPSSL PILPSGPLYP GLFDIRGSPT GGAGGSADPF 
      2060       2070       2080       2090       2100
APVFVPPHPG ISGGLGGALS GASRSLSPTR LLSLPPDKPF GAKPLGFWTK 
      2110       2120       2130       2140       2150
FDVADWLEWL GLAEHRAQFL DHEIDGSHLP ALTKEDYVDL GVTRVGHRMN 
      2160 
IDRALKFFLE R

Length:2,161

Mass (Da):224,959

Last modified:May 5, 2009 - v2

Checksum:ⁱ94BDE56D3D5F319D

Isoform 2 (identifier: Q9Y566-2) [UniParc]FASTA Add to basket

Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
1-613: Missing.
614-654: RSQESKQESR...PSLMDGIGPG → MQLMALEQRF...PPPHFSCLPA

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        10         20         30         40         50
MQLMALEQRF GSGLPGGGQP LCLMMSSPLP PPPPHFSCLP ASDYIIKEKT 
        60         70         80         90        100
VLLQKKDSEG FGFVLRGAKA QTPIEEFTPT PAFPALQYLE SVDEGGVAWR 
       110        120        130        140        150
AGLRMGDFLI EVNGQNVVKV GHRQVVNMIR QGGNTLMVKV VMVTRHPDMD 
       160        170        180        190        200
EAVHKKAPQQ AKRLPPPTIS LRSKSMTSEL EEMEYEQQPA PVPSMEKKRT 
       210        220        230        240        250
VYQMALNKLD EILAAAQQTI SASESPGPGG LASLGKHRPK GFFATESSFD 
       260        270        280        290        300
PHHRAQPSYE RPSFLPPGPG LMLRQKSIGA AEDDRPYLAP PAMKFSRSLS 
       310        320        330        340        350
VPGSEDIPPP PTTSPPEPPY STPPVPSSSG RLTPSPRGGP FNPGSGGPLP 
       360        370        380        390        400
ASSPASFDGP SPPDTRVGSR EKSLYHSGPL PPAHHHPPHH HHHHAPPPQP 
       410        420        430        440        450
HHHHAHPPHP PEMETGGSPD DPPPRLALGP QPSLRGWRGG GPSPTPGAPS 
       460        470        480        490        500
PSHHGSAGGG GGSSQGPALR YFQLPPRAAS AAMYVPARSG RGRKGPLVKQ 
       510        520        530        540        550
TKVEGEPQKG GGLPPAPSPT SPASPQPPPA VAAPSEKNSI PIPTIIIKAP 
       560        570        580        590        600
STSSSGRSSQ GSSTEAEPPT QPEPTGGGGG GGSSPSPAPA MSPVPPSPSP 
       610        620        630        640        650
VPTPASPSGP ATLDFTSQFG AALVGAARRE GGWQNEARRR STLFLSTDAG 
       660        670        680        690        700
DEDGGDGGLG TGAAPGPRLR HSKSIDEGMF SAEPYLRLES AGSGAGYGGY 
       710        720        730        740        750
GAGSRAYGGG GGSSAFTSFL PPRPLVHPLT GKALDPASPL GLALAARERA 
       760        770        780        790        800
LKESSEGGGA PQPPPRPPSP RYEAPPPTPH HHSPHAHHEP VLRLWGASPP 
       810        820        830        840        850
DPARRELGYR AGLGSQEKSL PASPPAARRS LLHRLPPTAP GVGPLLLQLG 
       860        870        880        890        900
TEPPAPHPGV SKPWRSAAPE EPERLPLHVR FLENCQPRAP VTSGRGPPSE 
       910        920        930        940        950
DGPGVPPPSP RRSVPPSPTS PRASEENGLP LLVLPPPAPS VDVEDGEFLF 
       960        970        980        990       1000
VEPLPPPLEF SNSFEKPESP LTPGPPHPLP DTPAPATPLP PVPPPAVAAA 
      1010       1020       1030       1040       1050
PPTLDSTASS LTSYDSEVAT LTQGASAAPG DPHPPGPPAP AAPAPAAPQP 
      1060       1070       1080       1090       1100
GPDPPPGTDS GIEEVDSRSS SDHPLETISS ASTLSSLSAE GGGSAGGGGG 
      1110       1120       1130       1140       1150
AGAGVASGPE LLDTYVAYLD GQAFGGSSTP GPPYPPQLMT PSKLRGRALG 
      1160       1170       1180       1190       1200
ASGGLRPGPS GGLRDPVTPT SPTVSVTGAG TDGLLALRAC SGPPTAGVAG 
      1210       1220       1230       1240       1250
GPVAVEPEVP PVPLPTASSL PRKLLPWEEG PGPPPPPLPG PLAQPQASAL 
      1260       1270       1280       1290       1300
ATVKASIISE LSSKLQQFGG SSAAGGALPW ARGGSGGGGD SHHGGASYVP 
      1310       1320       1330       1340       1350
ERTSSLQRQR LSDDSQSSLL SKPVSSLFQN WPKPPLPPLP TGTGVSPTAA 
      1360       1370       1380       1390       1400
AAPGATSPSA SSSSTSTRHL QGVEFEMRPP LLRRAPSPSL LPASEHKVSP 
      1410       1420       1430       1440       1450
APRPSSLPIL PSGPLYPGLF DIRGSPTGGA GGSADPFAPV FVPPHPGISG 
      1460       1470       1480       1490       1500
GLGGALSGAS RSLSPTRLLS LPPDKPFGAK PLGFWTKFDV ADWLEWLGLA 
      1510       1520       1530       1540 
EHRAQFLDHE IDGSHLPALT KEDYVDLGVT RVGHRMNIDR ALKFFLER

Show »

Length:1,548

Mass (Da):158,792

Checksum:ⁱ450025F37316FBEF

Isoform 3 (identifier: Q9Y566-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
646-654: Missing.

« Hide

        10         20         30         40         50
MTHSPATSED EERHSASECP EGGSESDSSP DGPGRGPRGT RGQGSGAPGS 
        60         70         80         90        100
LASVRGLQGR SMSVPDDAHF SMMVFRIGIP DLHQTKCLRF NPDATIWTAK 
       110        120        130        140        150
QQVLCALSES LQDVLNYGLF QPATSGRDAN FLEEERLLRE YPQSFEKGVP 
       160        170        180        190        200
YLEFRYKTRV YKQTNLDEKQ LAKLHTKTGL KKFLEYVQLG TSDKVARLLD 
       210        220        230        240        250
KGLDPNYHDS DSGETPLTLA AQTEGSVEVI RTLCLGGAHI DFRARDGMTA 
       260        270        280        290        300
LHKAACARHC LALTALLDLG GSPNYKDRRG LTPLFHTAMV GGDPRCCELL 
       310        320        330        340        350
LFNRAQLGIA DENGWQEIHQ ACQRGHSQHL EHLLFYGAEP GAQNASGNTA 
       360        370        380        390        400
LHICALYNKE TCARILLYRG ADKDVKNNNG QTPFQVAVIA GNFELGELIR 
       410        420        430        440        450
NHREQDVVPF QESPKYAARR RGPPGTGLTV PPALLRANSD TSMALPDWMV 
       460        470        480        490        500
FSAPGAASSG APGPTSGSQG QSQPSAPTTK LSSGTLRSAS SPRGARARSP 
       510        520        530        540        550
SRGRHPEDAK RQPRGRPSSS GTPREGPAGG TGGSGGPGGS LGSRGRRRKL 
       560        570        580        590        600
YSAVPGRSFM AVKSYQAQAE GEISLSKGEK IKVLSIGEGG FWEGQVKGRV 
       610        620        630        640        650
GWFPSDCLEE VANRSQESKQ ESRSDKAKRL FRHYTVGSYD SFDAPSDYII 
       660        670        680        690        700
KEKTVLLQKK DSEGFGFVLR GAKAQTPIEE FTPTPAFPAL QYLESVDEGG 
       710        720        730        740        750
VAWRAGLRMG DFLIEVNGQN VVKVGHRQVV NMIRQGGNTL MVKVVMVTRH 
       760        770        780        790        800
PDMDEAVHKK APQQAKRLPP PTISLRSKSM TSELEEMEYE QQPAPVPSME 
       810        820        830        840        850
KKRTVYQMAL NKLDEILAAA QQTISASESP GPGGLASLGK HRPKGFFATE 
       860        870        880        890        900
SSFDPHHRAQ PSYERPSFLP PGPGLMLRQK SIGAAEDDRP YLAPPAMKFS 
       910        920        930        940        950
RSLSVPGSED IPPPPTTSPP EPPYSTPPVP SSSGRLTPSP RGGPFNPGSG 
       960        970        980        990       1000
GPLPASSPAS FDGPSPPDTR VGSREKSLYH SGPLPPAHHH PPHHHHHHAP 
      1010       1020       1030       1040       1050
PPQPHHHHAH PPHPPEMETG GSPDDPPPRL ALGPQPSLRG WRGGGPSPTP 
      1060       1070       1080       1090       1100
GAPSPSHHGS AGGGGGSSQG PALRYFQLPP RAASAAMYVP ARSGRGRKGP 
      1110       1120       1130       1140       1150
LVKQTKVEGE PQKGGGLPPA PSPTSPASPQ PPPAVAAPSE KNSIPIPTII 
      1160       1170       1180       1190       1200
IKAPSTSSSG RSSQGSSTEA EPPTQPEPTG GGGGGGSSPS PAPAMSPVPP 
      1210       1220       1230       1240       1250
SPSPVPTPAS PSGPATLDFT SQFGAALVGA ARREGGWQNE ARRRSTLFLS 
      1260       1270       1280       1290       1300
TDAGDEDGGD GGLGTGAAPG PRLRHSKSID EGMFSAEPYL RLESAGSGAG 
      1310       1320       1330       1340       1350
YGGYGAGSRA YGGGGGSSAF TSFLPPRPLV HPLTGKALDP ASPLGLALAA 
      1360       1370       1380       1390       1400
RERALKESSE GGGAPQPPPR PPSPRYEAPP PTPHHHSPHA HHEPVLRLWG 
      1410       1420       1430       1440       1450
ASPPDPARRE LGYRAGLGSQ EKSLPASPPA ARRSLLHRLP PTAPGVGPLL 
      1460       1470       1480       1490       1500
LQLGTEPPAP HPGVSKPWRS AAPEEPERLP LHVRFLENCQ PRAPVTSGRG 
      1510       1520       1530       1540       1550
PPSEDGPGVP PPSPRRSVPP SPTSPRASEE NGLPLLVLPP PAPSVDVEDG 
      1560       1570       1580       1590       1600
EFLFVEPLPP PLEFSNSFEK PESPLTPGPP HPLPDTPAPA TPLPPVPPPA 
      1610       1620       1630       1640       1650
VAAAPPTLDS TASSLTSYDS EVATLTQGAS AAPGDPHPPG PPAPAAPAPA 
      1660       1670       1680       1690       1700
APQPGPDPPP GTDSGIEEVD SRSSSDHPLE TISSASTLSS LSAEGGGSAG 
      1710       1720       1730       1740       1750
GGGGAGAGVA SGPELLDTYV AYLDGQAFGG SSTPGPPYPP QLMTPSKLRG 
      1760       1770       1780       1790       1800
RALGASGGLR PGPSGGLRDP VTPTSPTVSV TGAGTDGLLA LRACSGPPTA 
      1810       1820       1830       1840       1850
GVAGGPVAVE PEVPPVPLPT ASSLPRKLLP WEEGPGPPPP PLPGPLAQPQ 
      1860       1870       1880       1890       1900
ASALATVKAS IISELSSKLQ QFGGSSAAGG ALPWARGGSG GGGDSHHGGA 
      1910       1920       1930       1940       1950
SYVPERTSSL QRQRLSDDSQ SSLLSKPVSS LFQNWPKPPL PPLPTGTGVS 
      1960       1970       1980       1990       2000
PTAAAAPGAT SPSASSSSTS TRHLQGVEFE MRPPLLRRAP SPSLLPASEH 
      2010       2020       2030       2040       2050
KVSPAPRPSS LPILPSGPLY PGLFDIRGSP TGGAGGSADP FAPVFVPPHP 
      2060       2070       2080       2090       2100
GISGGLGGAL SGASRSLSPT RLLSLPPDKP FGAKPLGFWT KFDVADWLEW 
      2110       2120       2130       2140       2150
LGLAEHRAQF LDHEIDGSHL PALTKEDYVD LGVTRVGHRM NIDRALKFFL 

ER

Show »

Length:2,152

Mass (Da):224,131

Checksum:ⁱ2BC1557113CF4DDF

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H9KV90	H9KV90_HUMAN	SH3 and multiple ankyrin repeat dom... SH3 and multiple ankyrin repeat domains protein 1	SHANK1	2,169	Annotation score:
M0QYB5	M0QYB5_HUMAN	SH3 and multiple ankyrin repeat dom... SH3 and multiple ankyrin repeat domains protein 1	SHANK1	183	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	927	S → Y in AAD45121 (PubMed:10551867).Curated	1
Sequence conflictⁱ	927	S → Y in AAF35887 (PubMed:10551867).Curated	1
Sequence conflictⁱ	937	P → T in AAD45121 (PubMed:10551867).Curated	1
Sequence conflictⁱ	937	P → T in AAF35887 (PubMed:10551867).Curated	1
Sequence conflictⁱ	969	S → T in AAD45121 (PubMed:10551867).Curated	1
Sequence conflictⁱ	969	S → T in AAF35887 (PubMed:10551867).Curated	1
Sequence conflictⁱ	1085	F → I in AAD45121 (PubMed:10551867).Curated	1
Sequence conflictⁱ	1085	F → I in AAF35887 (PubMed:10551867).Curated	1
Sequence conflictⁱ	1133	T → S in AAD45121 (PubMed:10551867).Curated	1
Sequence conflictⁱ	1133	T → S in AAF35887 (PubMed:10551867).Curated	1
Sequence conflictⁱ	1832	S → C in AAD45121 (PubMed:10551867).Curated	1
Sequence conflictⁱ	1832	S → C in AAF35887 (PubMed:10551867).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_055318	6	A → V. Corresponds to variant dbSNP:rs10423744Ensembl.	1
Natural variantⁱVAR_036541	569	A → D in a colorectal cancer sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_022123	1504	V → A. Corresponds to variant dbSNP:rs3745521Ensembl.	1
Natural variantⁱVAR_036542	2026	G → R in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs200040610Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_006069	1 – 613	Missing in isoform 2. 1 PublicationAdd BLAST	613
Alternative sequenceⁱVSP_006070	614 – 654	RSQES…GIGPG → MQLMALEQRFGSGLPGGGQP LCLMMSSPLPPPPPHFSCLP A in isoform 2. 1 PublicationAdd BLAST	41
Alternative sequenceⁱVSP_006071	646 – 654	Missing in isoform 3. 1 Publication	9

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF163302 mRNA Translation: AAD45121.1 AF226728 mRNA Translation: AAF35887.1 AC008743 Genomic DNA No translation available. AC010325 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12799.1 [Q9Y566-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_057232.2, NM_016148.3 [Q9Y566-1] XP_006723296.1, XM_006723233.3 XP_011525316.1, XM_011527014.2 [Q9Y566-3]

Genome annotation databases

Ensemblⁱ	ENST00000293441; ENSP00000293441; ENSG00000161681 [Q9Y566-1] ENST00000359082; ENSP00000351984; ENSG00000161681 [Q9Y566-3]
GeneIDⁱ	50944
KEGGⁱ	hsa:50944
UCSC genome browser More...UCSCⁱ	uc002psw.2, human [Q9Y566-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Y566	SH3 and multiple ankyrin repeat domains protein 1		HUMAN		2169	UniRef90_Q9Y566
Isoform 3 of SH3 and multiple ankyrin repeat domains protein 1		HUMAN		2152
Q9Y566-2	SHANK1 isoform 1		PANTR		1548	UniRef90_Q9Y566-2
SH3 and multiple ankyrin repeat domains 1		MACNE		1302
+1

Protein	Similar proteins		Species	Score	Length	Source
Q9Y566	SH3 and multiple ankyrin repeat domains protein 1	)	RAT		2167	UniRef50_Q9WV48
SH3 and multiple ankyrin repeat domains protein 1		MOUSE		2167
SH3 and multiple ankyrin repeat domains protein 1 isoform X1		MUSCR		2167
SH3 and multiple ankyrin repeat domains 1		ROUAE		2166
SH3 and multiple ankyrin repeat domains protein 1		PHYMC		2156
+302
Q9Y566-2	SHANK1 isoform 1		PANTR		1548	UniRef50_Q9Y566-2
SH3 and multiple ankyrin repeat domains 1		MACNE		1302
Uncharacterized protein		SARHA		1546
SH3 and multiple ankyrin repeat domains 1		PSETE		1296
SH3 and multiple ankyrin repeat domains protein 1		CRIGR		1330
+10

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF163302 mRNA Translation: AAD45121.1 AF226728 mRNA Translation: AAF35887.1 AC008743 Genomic DNA No translation available. AC010325 Genomic DNA No translation available.
CCDSⁱ	CCDS12799.1 [Q9Y566-1]
RefSeqⁱ	NP_057232.2, NM_016148.3 [Q9Y566-1] XP_006723296.1, XM_006723233.3 XP_011525316.1, XM_011527014.2 [Q9Y566-3]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	6CPI	NMR	-	A	554-613	[»]
SMRⁱ	Q9Y566
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	119171, 23 interactors
DIPⁱ	DIP-40834N
ELMⁱ	Q9Y566
IntActⁱ	Q9Y566, 21 interactors
MINTⁱ	Q9Y566
STRINGⁱ	9606.ENSP00000293441

PTM databases

iPTMnetⁱ	Q9Y566
PhosphoSitePlusⁱ	Q9Y566

Genetic variation databases

BioMutaⁱ	SHANK1
DMDMⁱ	229462779

Proteomic databases

MassIVEⁱ	Q9Y566
PaxDbⁱ	Q9Y566
PeptideAtlasⁱ	Q9Y566
PRIDEⁱ	Q9Y566
ProteomicsDBⁱ	86293 [Q9Y566-1] 86294 [Q9Y566-2] 86295 [Q9Y566-3]

Protocols and materials databases

ABCDⁱ	Q9Y566, 1 sequenced antibody
Antibodypediaⁱ	18886, 225 antibodies

Genome annotation databases

Ensemblⁱ	ENST00000293441; ENSP00000293441; ENSG00000161681 [Q9Y566-1] ENST00000359082; ENSP00000351984; ENSG00000161681 [Q9Y566-3]
GeneIDⁱ	50944
KEGGⁱ	hsa:50944
UCSCⁱ	uc002psw.2, human [Q9Y566-1]

Organism-specific databases

CTDⁱ	50944
DisGeNETⁱ	50944
GeneCardsⁱ	SHANK1
HGNCⁱ	HGNC:15474, SHANK1
HPAⁱ	ENSG00000161681, Tissue enriched (brain)
MIMⁱ	604999, gene
neXtProtⁱ	NX_Q9Y566
OpenTargetsⁱ	ENSG00000161681
PharmGKBⁱ	PA37965
VEuPathDBⁱ	HostDB:ENSG00000161681.15
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0504, Eukaryota KOG4375, Eukaryota
GeneTreeⁱ	ENSGT00940000153561
HOGENOMⁱ	CLU_001824_1_0_1
InParanoidⁱ	Q9Y566
PhylomeDBⁱ	Q9Y566
TreeFamⁱ	TF324593

Enzyme and pathway databases

PathwayCommonsⁱ	Q9Y566
Reactomeⁱ	R-HSA-6794361, Neurexins and neuroligins
SIGNORⁱ	Q9Y566

Miscellaneous databases

BioGRID-ORCSⁱ	50944, 1 hit in 988 CRISPR screens
ChiTaRSⁱ	SHANK1, human
GeneWikiⁱ	SHANK1
GenomeRNAiⁱ	50944
Pharosⁱ	Q9Y566, Tbio
Protein Ontology More...PROⁱ	PR:Q9Y566
RNActⁱ	Q9Y566, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000161681, Expressed in dorsolateral prefrontal cortex and 107 other tissues
ExpressionAtlasⁱ	Q9Y566, baseline and differential
Genevisibleⁱ	Q9Y566, HS

Family and domain databases

Gene3Dⁱ	1.10.150.50, 1 hit 1.25.40.20, 1 hit 2.30.42.10, 1 hit
InterProⁱ	View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR001478, PDZ IPR041489, PDZ_6 IPR036034, PDZ_sf IPR001660, SAM IPR013761, SAM/pointed_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain
Pfamⁱ	View protein in Pfam PF12796, Ank_2, 2 hits PF17820, PDZ_6, 1 hit PF00536, SAM_1, 1 hit PF07653, SH3_2, 1 hit
SMARTⁱ	View protein in SMART SM00248, ANK, 6 hits SM00228, PDZ, 1 hit SM00454, SAM, 1 hit SM00326, SH3, 1 hit
SUPFAMⁱ	SSF47769, SSF47769, 1 hit SSF48403, SSF48403, 1 hit SSF50044, SSF50044, 1 hit SSF50156, SSF50156, 1 hit
PROSITEⁱ	View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 3 hits PS50106, PDZ, 1 hit PS50105, SAM_DOMAIN, 1 hit PS50002, SH3, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SHAN1_HUMAN
Accessionⁱ	Q9Y566Primary (citable) accession number: Q9Y566 Secondary accession number(s): A8MXP5, B7WNY6, Q9NYW9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 26, 2002
	Last sequence update:	May 5, 2009
	Last modified:	April 7, 2021
	This is version 194 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

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UniProtKB - Q9Y566 (SHAN1_HUMAN)

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SH3 and multiple ankyrin repeat domains protein 1

SHANK1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoplasm and Cytosol

Other locations

Cytosol

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Miscellaneous databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Q9Y566

GO - Molecular functioni

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ