UniProtKB - Q9Y566 (SHAN1_HUMAN)
SH3 and multiple ankyrin repeat domains protein 1
SHANK1
Functioni
Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction.
GO - Molecular functioni
- ankyrin repeat binding Source: BHF-UCL
- identical protein binding Source: BHF-UCL
- ionotropic glutamate receptor binding Source: BHF-UCL
- protein-containing complex binding Source: BHF-UCL
- protein C-terminus binding Source: BHF-UCL
- scaffold protein binding Source: BHF-UCL
- SH3 domain binding Source: BHF-UCL
- somatostatin receptor binding Source: BHF-UCL
- synaptic receptor adaptor activity Source: BHF-UCL
GO - Biological processi
- adult behavior Source: BHF-UCL
- associative learning Source: BHF-UCL
- dendritic spine morphogenesis Source: BHF-UCL
- determination of affect Source: BHF-UCL
- habituation Source: Ensembl
- long-term memory Source: BHF-UCL
- negative regulation of actin filament bundle assembly Source: BHF-UCL
- neuromuscular process controlling balance Source: BHF-UCL
- olfactory behavior Source: Ensembl
- positive regulation of dendritic spine development Source: BHF-UCL
- positive regulation of excitatory postsynaptic potential Source: BHF-UCL
- protein-containing complex assembly Source: BHF-UCL
- protein localization to synapse Source: BHF-UCL
- regulation of AMPA receptor activity Source: BHF-UCL
- righting reflex Source: Ensembl
- social behavior Source: BHF-UCL
- synapse maturation Source: BHF-UCL
- vocalization behavior Source: BHF-UCL
Keywordsi
Biological process | Differentiation, Neurogenesis |
Enzyme and pathway databases
PathwayCommonsi | Q9Y566 |
Reactomei | R-HSA-6794361, Neurexins and neuroligins |
SignaLinki | Q9Y566 |
SIGNORi | Q9Y566 |
Names & Taxonomyi
Protein namesi | Recommended name: SH3 and multiple ankyrin repeat domains protein 1Short name: Shank1 Alternative name(s): Somatostatin receptor-interacting protein Short name: SSTR-interacting protein Short name: SSTRIP |
Gene namesi | Name:SHANK1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15474, SHANK1 |
MIMi | 604999, gene |
neXtProti | NX_Q9Y566 |
VEuPathDBi | HostDB:ENSG00000161681 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- postsynaptic density By similarity
- synapse By similarity
Note: Colocalizes with alpha-latrotoxin receptor 1.By similarity
Cytosol
- cytosol Source: Reactome
Plasma Membrane
- plasma membrane Source: HPA
- postsynaptic membrane Source: BHF-UCL
Other locations
- dendrite Source: UniProtKB
- dendritic spine Source: BHF-UCL
- excitatory synapse Source: BHF-UCL
- glutamatergic synapse Source: Ensembl
- membrane Source: UniProtKB
- neuron projection Source: BHF-UCL
- postsynaptic density Source: BHF-UCL
- Schaffer collateral - CA1 synapse Source: Ensembl
Keywords - Cellular componenti
Cell junction, Cytoplasm, SynapsePathology & Biotechi
Organism-specific databases
DisGeNETi | 50944 |
OpenTargetsi | ENSG00000161681 |
PharmGKBi | PA37965 |
Miscellaneous databases
Pharosi | Q9Y566, Tbio |
Genetic variation databases
BioMutai | SHANK1 |
DMDMi | 229462779 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000174671 | 1 – 2161 | SH3 and multiple ankyrin repeat domains protein 1Add BLAST | 2161 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 186 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 540 | PhosphoserineBy similarity | 1 | |
Modified residuei | 544 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 671 | PhosphoserineBy similarity | 1 | |
Modified residuei | 791 | PhosphoserineBy similarity | 1 | |
Modified residuei | 890 | PhosphoserineBy similarity | 1 | |
Modified residuei | 950 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 1051 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 1090 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 1101 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 1253 | Asymmetric dimethylarginineBy similarity | 1 | |
Modified residuei | 1287 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1423 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 1436 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1895 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 2016 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 2036 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 2074 | Omega-N-methylarginineBy similarity | 1 |
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
MassIVEi | Q9Y566 |
MaxQBi | Q9Y566 |
PaxDbi | Q9Y566 |
PeptideAtlasi | Q9Y566 |
PRIDEi | Q9Y566 |
ProteomicsDBi | 86293 [Q9Y566-1] 86294 [Q9Y566-2] 86295 [Q9Y566-3] |
PTM databases
GlyGeni | Q9Y566, 4 sites, 1 O-linked glycan (4 sites) |
iPTMneti | Q9Y566 |
PhosphoSitePlusi | Q9Y566 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000161681, Expressed in dorsolateral prefrontal cortex and 108 other tissues |
ExpressionAtlasi | Q9Y566, baseline and differential |
Genevisiblei | Q9Y566, HS |
Organism-specific databases
HPAi | ENSG00000161681, Tissue enriched (brain) |
Interactioni
Subunit structurei
May homomultimerize via its SAM domain (By similarity).
Interacts with the C-terminus of SSTR2 via the PDZ domain.
Interacts with IGSF9, SHARPIN, SPTAN1, HOMER1 and DLGAP1/GKAP isoforms 1 and 2 (By similarity).
Part of a complex with DLG4/PSD-95 and DLGAP1/GKAP (By similarity).
Interacts with BAIAP2.
Interacts with HOMER1 and HOMER3 (By similarity).
By similarity2 PublicationsBinary interactionsi
Q9Y566
With | #Exp. | IntAct |
---|---|---|
RPS6KA2 [Q15349] | 2 | EBI-3442234,EBI-1384149 |
GO - Molecular functioni
- ankyrin repeat binding Source: BHF-UCL
- identical protein binding Source: BHF-UCL
- ionotropic glutamate receptor binding Source: BHF-UCL
- protein C-terminus binding Source: BHF-UCL
- scaffold protein binding Source: BHF-UCL
- SH3 domain binding Source: BHF-UCL
- somatostatin receptor binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 119171, 25 interactors |
DIPi | DIP-40834N |
ELMi | Q9Y566 |
IntActi | Q9Y566, 22 interactors |
MINTi | Q9Y566 |
STRINGi | 9606.ENSP00000293441 |
Miscellaneous databases
RNActi | Q9Y566, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9Y566 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 212 – 245 | ANK 1Add BLAST | 34 | |
Repeati | 246 – 278 | ANK 2Add BLAST | 33 | |
Repeati | 279 – 312 | ANK 3Add BLAST | 34 | |
Repeati | 313 – 345 | ANK 4Add BLAST | 33 | |
Repeati | 346 – 378 | ANK 5Add BLAST | 33 | |
Repeati | 379 – 395 | ANK 6Add BLAST | 17 | |
Domaini | 554 – 613 | SH3PROSITE-ProRule annotationAdd BLAST | 60 | |
Domaini | 663 – 757 | PDZPROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 2098 – 2161 | SAMPROSITE-ProRule annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 53 | DisorderedSequence analysisAdd BLAST | 53 | |
Regioni | 412 – 433 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 455 – 546 | DisorderedSequence analysisAdd BLAST | 92 | |
Regioni | 832 – 886 | DisorderedSequence analysisAdd BLAST | 55 | |
Regioni | 909 – 1229 | DisorderedSequence analysisAdd BLAST | 321 | |
Regioni | 1241 – 1289 | DisorderedSequence analysisAdd BLAST | 49 | |
Regioni | 1353 – 1720 | DisorderedSequence analysisAdd BLAST | 368 | |
Regioni | 1734 – 1785 | DisorderedSequence analysisAdd BLAST | 52 | |
Regioni | 1827 – 1860 | DisorderedSequence analysisAdd BLAST | 34 | |
Regioni | 1892 – 1983 | DisorderedSequence analysisAdd BLAST | 92 | |
Regioni | 1996 – 2023 | DisorderedSequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 20 | Basic and acidic residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 459 – 495 | Polar residuesSequence analysisAdd BLAST | 37 | |
Compositional biasi | 500 – 514 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 917 – 938 | Pro residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 996 – 1017 | Basic residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 1025 – 1042 | Pro residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 1125 – 1147 | Pro residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 1158 – 1183 | Polar residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 1201 – 1220 | Pro residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 1373 – 1390 | Pro residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 1513 – 1530 | Pro residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 1582 – 1613 | Pro residuesSequence analysisAdd BLAST | 32 | |
Compositional biasi | 1616 – 1636 | Polar residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 1643 – 1670 | Pro residuesSequence analysisAdd BLAST | 28 | |
Compositional biasi | 1685 – 1703 | Polar residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 1840 – 1856 | Pro residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 1911 – 1941 | Polar residuesSequence analysisAdd BLAST | 31 | |
Compositional biasi | 1963 – 1983 | Polar residuesSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Keywords - Domaini
ANK repeat, Repeat, SH3 domainPhylogenomic databases
eggNOGi | KOG0504, Eukaryota KOG4375, Eukaryota |
GeneTreei | ENSGT00940000153561 |
HOGENOMi | CLU_001824_1_0_1 |
InParanoidi | Q9Y566 |
OMAi | KPLPFWT |
PhylomeDBi | Q9Y566 |
TreeFami | TF324593 |
Family and domain databases
Gene3Di | 1.10.150.50, 1 hit 1.25.40.20, 1 hit 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR001478, PDZ IPR041489, PDZ_6 IPR036034, PDZ_sf IPR001660, SAM IPR013761, SAM/pointed_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
Pfami | View protein in Pfam PF12796, Ank_2, 2 hits PF17820, PDZ_6, 1 hit PF00536, SAM_1, 1 hit PF07653, SH3_2, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 6 hits SM00228, PDZ, 1 hit SM00454, SAM, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit SSF48403, SSF48403, 1 hit SSF50044, SSF50044, 1 hit SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 3 hits PS50106, PDZ, 1 hit PS50105, SAM_DOMAIN, 1 hit PS50002, SH3, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTHSPATSED EERHSASECP EGGSESDSSP DGPGRGPRGT RGQGSGAPGS
60 70 80 90 100
LASVRGLQGR SMSVPDDAHF SMMVFRIGIP DLHQTKCLRF NPDATIWTAK
110 120 130 140 150
QQVLCALSES LQDVLNYGLF QPATSGRDAN FLEEERLLRE YPQSFEKGVP
160 170 180 190 200
YLEFRYKTRV YKQTNLDEKQ LAKLHTKTGL KKFLEYVQLG TSDKVARLLD
210 220 230 240 250
KGLDPNYHDS DSGETPLTLA AQTEGSVEVI RTLCLGGAHI DFRARDGMTA
260 270 280 290 300
LHKAACARHC LALTALLDLG GSPNYKDRRG LTPLFHTAMV GGDPRCCELL
310 320 330 340 350
LFNRAQLGIA DENGWQEIHQ ACQRGHSQHL EHLLFYGAEP GAQNASGNTA
360 370 380 390 400
LHICALYNKE TCARILLYRG ADKDVKNNNG QTPFQVAVIA GNFELGELIR
410 420 430 440 450
NHREQDVVPF QESPKYAARR RGPPGTGLTV PPALLRANSD TSMALPDWMV
460 470 480 490 500
FSAPGAASSG APGPTSGSQG QSQPSAPTTK LSSGTLRSAS SPRGARARSP
510 520 530 540 550
SRGRHPEDAK RQPRGRPSSS GTPREGPAGG TGGSGGPGGS LGSRGRRRKL
560 570 580 590 600
YSAVPGRSFM AVKSYQAQAE GEISLSKGEK IKVLSIGEGG FWEGQVKGRV
610 620 630 640 650
GWFPSDCLEE VANRSQESKQ ESRSDKAKRL FRHYTVGSYD SFDAPSLMDG
660 670 680 690 700
IGPGSDYIIK EKTVLLQKKD SEGFGFVLRG AKAQTPIEEF TPTPAFPALQ
710 720 730 740 750
YLESVDEGGV AWRAGLRMGD FLIEVNGQNV VKVGHRQVVN MIRQGGNTLM
760 770 780 790 800
VKVVMVTRHP DMDEAVHKKA PQQAKRLPPP TISLRSKSMT SELEEMEYEQ
810 820 830 840 850
QPAPVPSMEK KRTVYQMALN KLDEILAAAQ QTISASESPG PGGLASLGKH
860 870 880 890 900
RPKGFFATES SFDPHHRAQP SYERPSFLPP GPGLMLRQKS IGAAEDDRPY
910 920 930 940 950
LAPPAMKFSR SLSVPGSEDI PPPPTTSPPE PPYSTPPVPS SSGRLTPSPR
960 970 980 990 1000
GGPFNPGSGG PLPASSPASF DGPSPPDTRV GSREKSLYHS GPLPPAHHHP
1010 1020 1030 1040 1050
PHHHHHHAPP PQPHHHHAHP PHPPEMETGG SPDDPPPRLA LGPQPSLRGW
1060 1070 1080 1090 1100
RGGGPSPTPG APSPSHHGSA GGGGGSSQGP ALRYFQLPPR AASAAMYVPA
1110 1120 1130 1140 1150
RSGRGRKGPL VKQTKVEGEP QKGGGLPPAP SPTSPASPQP PPAVAAPSEK
1160 1170 1180 1190 1200
NSIPIPTIII KAPSTSSSGR SSQGSSTEAE PPTQPEPTGG GGGGGSSPSP
1210 1220 1230 1240 1250
APAMSPVPPS PSPVPTPASP SGPATLDFTS QFGAALVGAA RREGGWQNEA
1260 1270 1280 1290 1300
RRRSTLFLST DAGDEDGGDG GLGTGAAPGP RLRHSKSIDE GMFSAEPYLR
1310 1320 1330 1340 1350
LESAGSGAGY GGYGAGSRAY GGGGGSSAFT SFLPPRPLVH PLTGKALDPA
1360 1370 1380 1390 1400
SPLGLALAAR ERALKESSEG GGAPQPPPRP PSPRYEAPPP TPHHHSPHAH
1410 1420 1430 1440 1450
HEPVLRLWGA SPPDPARREL GYRAGLGSQE KSLPASPPAA RRSLLHRLPP
1460 1470 1480 1490 1500
TAPGVGPLLL QLGTEPPAPH PGVSKPWRSA APEEPERLPL HVRFLENCQP
1510 1520 1530 1540 1550
RAPVTSGRGP PSEDGPGVPP PSPRRSVPPS PTSPRASEEN GLPLLVLPPP
1560 1570 1580 1590 1600
APSVDVEDGE FLFVEPLPPP LEFSNSFEKP ESPLTPGPPH PLPDTPAPAT
1610 1620 1630 1640 1650
PLPPVPPPAV AAAPPTLDST ASSLTSYDSE VATLTQGASA APGDPHPPGP
1660 1670 1680 1690 1700
PAPAAPAPAA PQPGPDPPPG TDSGIEEVDS RSSSDHPLET ISSASTLSSL
1710 1720 1730 1740 1750
SAEGGGSAGG GGGAGAGVAS GPELLDTYVA YLDGQAFGGS STPGPPYPPQ
1760 1770 1780 1790 1800
LMTPSKLRGR ALGASGGLRP GPSGGLRDPV TPTSPTVSVT GAGTDGLLAL
1810 1820 1830 1840 1850
RACSGPPTAG VAGGPVAVEP EVPPVPLPTA SSLPRKLLPW EEGPGPPPPP
1860 1870 1880 1890 1900
LPGPLAQPQA SALATVKASI ISELSSKLQQ FGGSSAAGGA LPWARGGSGG
1910 1920 1930 1940 1950
GGDSHHGGAS YVPERTSSLQ RQRLSDDSQS SLLSKPVSSL FQNWPKPPLP
1960 1970 1980 1990 2000
PLPTGTGVSP TAAAAPGATS PSASSSSTST RHLQGVEFEM RPPLLRRAPS
2010 2020 2030 2040 2050
PSLLPASEHK VSPAPRPSSL PILPSGPLYP GLFDIRGSPT GGAGGSADPF
2060 2070 2080 2090 2100
APVFVPPHPG ISGGLGGALS GASRSLSPTR LLSLPPDKPF GAKPLGFWTK
2110 2120 2130 2140 2150
FDVADWLEWL GLAEHRAQFL DHEIDGSHLP ALTKEDYVDL GVTRVGHRMN
2160
IDRALKFFLE R
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH9KV90 | H9KV90_HUMAN | SH3 and multiple ankyrin repeat dom... | SHANK1 | 2,169 | Annotation score: | ||
M0QYB5 | M0QYB5_HUMAN | SH3 and multiple ankyrin repeat dom... | SHANK1 | 183 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 927 | S → Y in AAD45121 (PubMed:10551867).Curated | 1 | |
Sequence conflicti | 927 | S → Y in AAF35887 (PubMed:10551867).Curated | 1 | |
Sequence conflicti | 937 | P → T in AAD45121 (PubMed:10551867).Curated | 1 | |
Sequence conflicti | 937 | P → T in AAF35887 (PubMed:10551867).Curated | 1 | |
Sequence conflicti | 969 | S → T in AAD45121 (PubMed:10551867).Curated | 1 | |
Sequence conflicti | 969 | S → T in AAF35887 (PubMed:10551867).Curated | 1 | |
Sequence conflicti | 1085 | F → I in AAD45121 (PubMed:10551867).Curated | 1 | |
Sequence conflicti | 1085 | F → I in AAF35887 (PubMed:10551867).Curated | 1 | |
Sequence conflicti | 1133 | T → S in AAD45121 (PubMed:10551867).Curated | 1 | |
Sequence conflicti | 1133 | T → S in AAF35887 (PubMed:10551867).Curated | 1 | |
Sequence conflicti | 1832 | S → C in AAD45121 (PubMed:10551867).Curated | 1 | |
Sequence conflicti | 1832 | S → C in AAF35887 (PubMed:10551867).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_055318 | 6 | A → V. Corresponds to variant dbSNP:rs10423744Ensembl. | 1 | |
Natural variantiVAR_036541 | 569 | A → D in a colorectal cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_022123 | 1504 | V → A. Corresponds to variant dbSNP:rs3745521Ensembl. | 1 | |
Natural variantiVAR_036542 | 2026 | G → R in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs200040610Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_006069 | 1 – 613 | Missing in isoform 2. 1 PublicationAdd BLAST | 613 | |
Alternative sequenceiVSP_006070 | 614 – 654 | RSQES…GIGPG → MQLMALEQRFGSGLPGGGQP LCLMMSSPLPPPPPHFSCLP A in isoform 2. 1 PublicationAdd BLAST | 41 | |
Alternative sequenceiVSP_006071 | 646 – 654 | Missing in isoform 3. 1 Publication | 9 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF163302 mRNA Translation: AAD45121.1 AF226728 mRNA Translation: AAF35887.1 AC008743 Genomic DNA No translation available. AC010325 Genomic DNA No translation available. |
CCDSi | CCDS12799.1 [Q9Y566-1] |
RefSeqi | NP_057232.2, NM_016148.3 [Q9Y566-1] XP_006723296.1, XM_006723233.3 XP_011525316.1, XM_011527014.2 [Q9Y566-3] |
Genome annotation databases
Ensembli | ENST00000293441; ENSP00000293441; ENSG00000161681 ENST00000359082; ENSP00000351984; ENSG00000161681 [Q9Y566-3] |
GeneIDi | 50944 |
KEGGi | hsa:50944 |
MANE-Selecti | ENST00000293441.6; ENSP00000293441.1; NM_016148.5; NP_057232.2 |
UCSCi | uc002psw.2, human [Q9Y566-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF163302 mRNA Translation: AAD45121.1 AF226728 mRNA Translation: AAF35887.1 AC008743 Genomic DNA No translation available. AC010325 Genomic DNA No translation available. |
CCDSi | CCDS12799.1 [Q9Y566-1] |
RefSeqi | NP_057232.2, NM_016148.3 [Q9Y566-1] XP_006723296.1, XM_006723233.3 XP_011525316.1, XM_011527014.2 [Q9Y566-3] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6CPI | NMR | - | A | 554-613 | [»] | |
6YWZ | X-ray | 2.12 | A/B | 654-762 | [»] | |
6YX0 | X-ray | 1.57 | A/B | 654-762 | [»] | |
6YX1 | X-ray | 1.80 | A/B | 654-762 | [»] | |
6YX2 | X-ray | 1.62 | A/B | 654-762 | [»] | |
7A00 | X-ray | 1.78 | A/B | 654-762 | [»] | |
SMRi | Q9Y566 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119171, 25 interactors |
DIPi | DIP-40834N |
ELMi | Q9Y566 |
IntActi | Q9Y566, 22 interactors |
MINTi | Q9Y566 |
STRINGi | 9606.ENSP00000293441 |
PTM databases
GlyGeni | Q9Y566, 4 sites, 1 O-linked glycan (4 sites) |
iPTMneti | Q9Y566 |
PhosphoSitePlusi | Q9Y566 |
Genetic variation databases
BioMutai | SHANK1 |
DMDMi | 229462779 |
Proteomic databases
MassIVEi | Q9Y566 |
MaxQBi | Q9Y566 |
PaxDbi | Q9Y566 |
PeptideAtlasi | Q9Y566 |
PRIDEi | Q9Y566 |
ProteomicsDBi | 86293 [Q9Y566-1] 86294 [Q9Y566-2] 86295 [Q9Y566-3] |
Protocols and materials databases
ABCDi | Q9Y566, 1 sequenced antibody |
Antibodypediai | 18886, 231 antibodies from 27 providers |
DNASUi | 50944 |
Genome annotation databases
Ensembli | ENST00000293441; ENSP00000293441; ENSG00000161681 ENST00000359082; ENSP00000351984; ENSG00000161681 [Q9Y566-3] |
GeneIDi | 50944 |
KEGGi | hsa:50944 |
MANE-Selecti | ENST00000293441.6; ENSP00000293441.1; NM_016148.5; NP_057232.2 |
UCSCi | uc002psw.2, human [Q9Y566-1] |
Organism-specific databases
CTDi | 50944 |
DisGeNETi | 50944 |
GeneCardsi | SHANK1 |
HGNCi | HGNC:15474, SHANK1 |
HPAi | ENSG00000161681, Tissue enriched (brain) |
MIMi | 604999, gene |
neXtProti | NX_Q9Y566 |
OpenTargetsi | ENSG00000161681 |
PharmGKBi | PA37965 |
VEuPathDBi | HostDB:ENSG00000161681 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0504, Eukaryota KOG4375, Eukaryota |
GeneTreei | ENSGT00940000153561 |
HOGENOMi | CLU_001824_1_0_1 |
InParanoidi | Q9Y566 |
OMAi | KPLPFWT |
PhylomeDBi | Q9Y566 |
TreeFami | TF324593 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y566 |
Reactomei | R-HSA-6794361, Neurexins and neuroligins |
SignaLinki | Q9Y566 |
SIGNORi | Q9Y566 |
Miscellaneous databases
BioGRID-ORCSi | 50944, 2 hits in 1039 CRISPR screens |
ChiTaRSi | SHANK1, human |
GeneWikii | SHANK1 |
GenomeRNAii | 50944 |
Pharosi | Q9Y566, Tbio |
PROi | PR:Q9Y566 |
RNActi | Q9Y566, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000161681, Expressed in dorsolateral prefrontal cortex and 108 other tissues |
ExpressionAtlasi | Q9Y566, baseline and differential |
Genevisiblei | Q9Y566, HS |
Family and domain databases
Gene3Di | 1.10.150.50, 1 hit 1.25.40.20, 1 hit 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR001478, PDZ IPR041489, PDZ_6 IPR036034, PDZ_sf IPR001660, SAM IPR013761, SAM/pointed_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
Pfami | View protein in Pfam PF12796, Ank_2, 2 hits PF17820, PDZ_6, 1 hit PF00536, SAM_1, 1 hit PF07653, SH3_2, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 6 hits SM00228, PDZ, 1 hit SM00454, SAM, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit SSF48403, SSF48403, 1 hit SSF50044, SSF50044, 1 hit SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 3 hits PS50106, PDZ, 1 hit PS50105, SAM_DOMAIN, 1 hit PS50002, SH3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SHAN1_HUMAN | |
Accessioni | Q9Y566Primary (citable) accession number: Q9Y566 Secondary accession number(s): A8MXP5, B7WNY6, Q9NYW9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 26, 2002 |
Last sequence update: | May 5, 2009 | |
Last modified: | February 23, 2022 | |
This is version 197 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families