Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Intraflagellar transport protein 25 homolog

Gene

HSPB11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation (By similarity).By similarity

Caution

Was initially classified as a member of the small heat shock family protein. However, it was later shown that it is not the case (PubMed:19921466).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi29Calcium; via carbonyl oxygenBy similarity1
Metal bindingi32CalciumBy similarity1
Metal bindingi37CalciumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDifferentiation, Protein transport, Spermatogenesis, Stress response, Transport
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-5620924 Intraflagellar transport

Names & Taxonomyi

Protein namesi
Recommended name:
Intraflagellar transport protein 25 homolog
Alternative name(s):
Heat shock protein beta-11
Short name:
Hspb11
Placental protein 25
Short name:
PP25
Gene namesi
Name:HSPB11
Synonyms:C1orf41, IFT25
ORF Names:HSPC034
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000081870.11
HGNCiHGNC:25019 HSPB11
neXtProtiNX_Q9Y547

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium

Pathology & Biotechi

Organism-specific databases

DisGeNETi51668
OpenTargetsiENSG00000081870
PharmGKBiPA162391751

Polymorphism and mutation databases

BioMutaiHSPB11
DMDMi67460979

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000585311 – 144Intraflagellar transport protein 25 homologAdd BLAST144

Proteomic databases

EPDiQ9Y547
MaxQBiQ9Y547
PaxDbiQ9Y547
PeptideAtlasiQ9Y547
PRIDEiQ9Y547
ProteomicsDBi86288

PTM databases

iPTMnetiQ9Y547
PhosphoSitePlusiQ9Y547

Expressioni

Tissue specificityi

Detected in placenta.1 Publication

Gene expression databases

BgeeiENSG00000081870 Expressed in 236 organ(s), highest expression level in oocyte
CleanExiHS_HSPB11
ExpressionAtlasiQ9Y547 baseline and differential
GenevisibleiQ9Y547 HS

Organism-specific databases

HPAiHPA030140

Interactioni

Subunit structurei

Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT27. Interacts with IFT88 (By similarity).By similarity

Binary interactionsi

Protein-protein interaction databases

BioGridi119671, 18 interactors
CORUMiQ9Y547
IntActiQ9Y547, 19 interactors
MINTiQ9Y547
STRINGi9606.ENSP00000194214

Structurei

Secondary structure

1144
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9Y547
SMRiQ9Y547
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y547

Family & Domainsi

Sequence similaritiesi

Belongs to the IFT25 family.Curated

Phylogenomic databases

eggNOGiENOG410INPG Eukaryota
ENOG4111WDR LUCA
GeneTreeiENSGT00390000012620
HOGENOMiHOG000232198
HOVERGENiHBG060331
InParanoidiQ9Y547
KOiK19369
OMAiTYLRVII
PhylomeDBiQ9Y547
TreeFamiTF336031

Family and domain databases

Gene3Di2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR000421 FA58C
IPR008979 Galactose-bd-like_sf
IPR033558 IFT25
PANTHERiPTHR33906 PTHR33906, 1 hit
PfamiView protein in Pfam
PF00754 F5_F8_type_C, 1 hit
SUPFAMiSSF49785 SSF49785, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9Y547-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRKIDLCLSS EGSEVILATS SDEKHPPENI IDGNPETFWT TTGMFPQEFI
60 70 80 90 100
ICFHKHVRIE RLVIQSYFVQ TLKIEKSTSK EPVDFEQWIE KDLVHTEGQL
110 120 130 140
QNEEIVAHDG SATYLRFIIV SAFDHFASVH SVSAEGTVVS NLSS
Length:144
Mass (Da):16,297
Last modified:November 1, 1999 - v1
Checksum:i43B7DBDD47A528C9
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6NIR2A6NIR2_HUMAN
Chromosome 1 open reading frame 41,...
HSPB11 C1orf41, hCG_1780523
112Annotation score:
X6R7Y7X6R7Y7_HUMAN
Intraflagellar transport protein 25...
HSPB11
214Annotation score:
A6NG08A6NG08_HUMAN
Intraflagellar transport protein 25...
HSPB11
74Annotation score:

Sequence cautioni

The sequence AAD43011 differs from that shown. Reason: Frameshift at position 77.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF416725 mRNA Translation: AAQ03618.1
AF417114 mRNA Translation: AAQ03994.1
AF100747 mRNA Translation: AAD43011.1 Frameshift.
AL031427 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06717.1
CH471059 Genomic DNA Translation: EAX06719.1
BC005245 mRNA Translation: AAH05245.1
CCDSiCCDS41341.1
RefSeqiNP_001303864.1, NM_001316935.1
NP_057210.2, NM_016126.3
UniGeneiHs.525462
Hs.624686

Genome annotation databases

EnsembliENST00000194214; ENSP00000194214; ENSG00000081870
GeneIDi51668
KEGGihsa:51668
UCSCiuc001cwh.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF416725 mRNA Translation: AAQ03618.1
AF417114 mRNA Translation: AAQ03994.1
AF100747 mRNA Translation: AAD43011.1 Frameshift.
AL031427 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06717.1
CH471059 Genomic DNA Translation: EAX06719.1
BC005245 mRNA Translation: AAH05245.1
CCDSiCCDS41341.1
RefSeqiNP_001303864.1, NM_001316935.1
NP_057210.2, NM_016126.3
UniGeneiHs.525462
Hs.624686

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TVGX-ray1.60A1-143[»]
1XPWNMR-A1-144[»]
ProteinModelPortaliQ9Y547
SMRiQ9Y547
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119671, 18 interactors
CORUMiQ9Y547
IntActiQ9Y547, 19 interactors
MINTiQ9Y547
STRINGi9606.ENSP00000194214

PTM databases

iPTMnetiQ9Y547
PhosphoSitePlusiQ9Y547

Polymorphism and mutation databases

BioMutaiHSPB11
DMDMi67460979

Proteomic databases

EPDiQ9Y547
MaxQBiQ9Y547
PaxDbiQ9Y547
PeptideAtlasiQ9Y547
PRIDEiQ9Y547
ProteomicsDBi86288

Protocols and materials databases

DNASUi51668
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000194214; ENSP00000194214; ENSG00000081870
GeneIDi51668
KEGGihsa:51668
UCSCiuc001cwh.4 human

Organism-specific databases

CTDi51668
DisGeNETi51668
EuPathDBiHostDB:ENSG00000081870.11
GeneCardsiHSPB11
H-InvDBiHIX0029364
HGNCiHGNC:25019 HSPB11
HPAiHPA030140
neXtProtiNX_Q9Y547
OpenTargetsiENSG00000081870
PharmGKBiPA162391751
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INPG Eukaryota
ENOG4111WDR LUCA
GeneTreeiENSGT00390000012620
HOGENOMiHOG000232198
HOVERGENiHBG060331
InParanoidiQ9Y547
KOiK19369
OMAiTYLRVII
PhylomeDBiQ9Y547
TreeFamiTF336031

Enzyme and pathway databases

ReactomeiR-HSA-5620924 Intraflagellar transport

Miscellaneous databases

ChiTaRSiHSPB11 human
EvolutionaryTraceiQ9Y547
GenomeRNAii51668
PROiPR:Q9Y547

Gene expression databases

BgeeiENSG00000081870 Expressed in 236 organ(s), highest expression level in oocyte
CleanExiHS_HSPB11
ExpressionAtlasiQ9Y547 baseline and differential
GenevisibleiQ9Y547 HS

Family and domain databases

Gene3Di2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR000421 FA58C
IPR008979 Galactose-bd-like_sf
IPR033558 IFT25
PANTHERiPTHR33906 PTHR33906, 1 hit
PfamiView protein in Pfam
PF00754 F5_F8_type_C, 1 hit
SUPFAMiSSF49785 SSF49785, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIFT25_HUMAN
AccessioniPrimary (citable) accession number: Q9Y547
Secondary accession number(s): A6NG57, D3DQ45, Q9Y684
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again