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Entry version 132 (26 Feb 2020)
Sequence version 1 (01 Nov 1999)
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Protein

Leucine-rich repeat-containing protein 42

Gene

LRRC42

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 42
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LRRC42
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28792 LRRC42

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y546

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
115353

Open Targets

More...
OpenTargetsi
ENSG00000116212

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671530

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9Y546 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LRRC42

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74762064

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002236221 – 428Leucine-rich repeat-containing protein 42Add BLAST428

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei406PhosphoserineBy similarity1
Modified residuei407PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y546

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Y546

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9Y546

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9Y546

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y546

PeptideAtlas

More...
PeptideAtlasi
Q9Y546

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y546

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
86287

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y546

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y546

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000116212 Expressed in oocyte and 179 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y546 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y546 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA047458
HPA050537
HPA064581

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125429, 12 interactors

Protein interaction database and analysis system

More...
IntActi
Q9Y546, 6 interactors

Molecular INTeraction database

More...
MINTi
Q9Y546

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000360421

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9Y546 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati149 – 170LRR 1Add BLAST22
Repeati174 – 195LRR 2Add BLAST22
Repeati202 – 222LRR 3Add BLAST21
Repeati234 – 255LRR 4Add BLAST22
Repeati259 – 280LRR 5Add BLAST22

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LRRC42 family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHWD Eukaryota
ENOG410YPPD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000002727

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y546

Identification of Orthologs from Complete Genome Data

More...
OMAi
FFGRQKF

Database of Orthologous Groups

More...
OrthoDBi
1204825at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y546

TreeFam database of animal gene trees

More...
TreeFami
TF331102

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR039631 LRRC42

The PANTHER Classification System

More...
PANTHERi
PTHR31994 PTHR31994, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13516 LRR_6, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9Y546-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSYYLSSENH LDPGPIYMRE NGQLHMVNLA LDGVRSSLQK PRPFRLFPKG
60 70 80 90 100
FSVELCMNRE DDTARKEKTD HFIFTYTREG NLRYSAKSLF SLVLGFISDN
110 120 130 140 150
VDHIDSLIGF PEQIAEKLFS AAEARQKFTE PGAGLRALQK FTEAYGSLVL
160 170 180 190 200
CSLCLRNRYL VISEKLEEIK SFRELTCLDL SCCKLGDEHE LLEHLTNEAL
210 220 230 240 250
SSVTQLHLKD NCLSDAGVRK MTAPVRVMKR GLENLTLLDL SCNPEITDAG
260 270 280 290 300
IGYLFSFRKL NCLDISGTGL KDIKTVKHKL QTHIGLVHSK VPLKEFDHSN
310 320 330 340 350
CKTEGWADQI VLQWERVTAE AVKPRETSEP RAAAQRFYGK RSRAEAPLKC
360 370 380 390 400
PLADTHMNSS EKLQFYKEKA PDCHGPVLKH EAISSQESKK SKKRPFEESE
410 420
TEQNNSSQPS KQKYVCLAVE DWDLLNSY
Length:428
Mass (Da):48,571
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEC22D6E407E36B87
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EP35E7EP35_HUMAN
Leucine-rich repeat-containing prot...
LRRC42
239Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A6NL66A6NL66_HUMAN
Leucine-rich repeat-containing prot...
LRRC42
192Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti362K → R in BAC11038 (PubMed:14702039).Curated1
Sequence conflicti395P → S in BAC11038 (PubMed:14702039).Curated1
Sequence conflicti413 – 428KYVCL…LLNSY → IFLLLWCGRGMLWKYVIISN VYFQYIVIFSNKHFCCP (PubMed:14702039).CuratedAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK075201 mRNA Translation: BAC11466.1 Different termination.
AK074521 mRNA Translation: BAC11038.1
CH471059 Genomic DNA Translation: EAX06713.1
CH471059 Genomic DNA Translation: EAX06714.1
CH471059 Genomic DNA Translation: EAX06715.1
BC013101 mRNA Translation: AAH13101.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS585.1

NCBI Reference Sequences

More...
RefSeqi
NP_001243338.1, NM_001256409.1
NP_443172.1, NM_052940.4
XP_006710390.1, XM_006710327.3
XP_006710391.1, XM_006710328.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000319223; ENSP00000318185; ENSG00000116212
ENST00000371370; ENSP00000360421; ENSG00000116212

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
115353

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:115353

UCSC genome browser

More...
UCSCi
uc001cwj.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075201 mRNA Translation: BAC11466.1 Different termination.
AK074521 mRNA Translation: BAC11038.1
CH471059 Genomic DNA Translation: EAX06713.1
CH471059 Genomic DNA Translation: EAX06714.1
CH471059 Genomic DNA Translation: EAX06715.1
BC013101 mRNA Translation: AAH13101.1
CCDSiCCDS585.1
RefSeqiNP_001243338.1, NM_001256409.1
NP_443172.1, NM_052940.4
XP_006710390.1, XM_006710327.3
XP_006710391.1, XM_006710328.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi125429, 12 interactors
IntActiQ9Y546, 6 interactors
MINTiQ9Y546
STRINGi9606.ENSP00000360421

PTM databases

iPTMnetiQ9Y546
PhosphoSitePlusiQ9Y546

Polymorphism and mutation databases

BioMutaiLRRC42
DMDMi74762064

Proteomic databases

EPDiQ9Y546
jPOSTiQ9Y546
MassIVEiQ9Y546
MaxQBiQ9Y546
PaxDbiQ9Y546
PeptideAtlasiQ9Y546
PRIDEiQ9Y546
ProteomicsDBi86287

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
115353

Genome annotation databases

EnsembliENST00000319223; ENSP00000318185; ENSG00000116212
ENST00000371370; ENSP00000360421; ENSG00000116212
GeneIDi115353
KEGGihsa:115353
UCSCiuc001cwj.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
115353
DisGeNETi115353

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LRRC42
HGNCiHGNC:28792 LRRC42
HPAiHPA047458
HPA050537
HPA064581
neXtProtiNX_Q9Y546
OpenTargetsiENSG00000116212
PharmGKBiPA142671530

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IHWD Eukaryota
ENOG410YPPD LUCA
GeneTreeiENSGT00390000002727
InParanoidiQ9Y546
OMAiFFGRQKF
OrthoDBi1204825at2759
PhylomeDBiQ9Y546
TreeFamiTF331102

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
115353
PharosiQ9Y546 Tdark

Protein Ontology

More...
PROi
PR:Q9Y546
RNActiQ9Y546 protein

Gene expression databases

BgeeiENSG00000116212 Expressed in oocyte and 179 other tissues
ExpressionAtlasiQ9Y546 baseline and differential
GenevisibleiQ9Y546 HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR039631 LRRC42
PANTHERiPTHR31994 PTHR31994, 1 hit
PfamiView protein in Pfam
PF13516 LRR_6, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLRC42_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y546
Secondary accession number(s): D3DQ46, Q8N2Q8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: November 1, 1999
Last modified: February 26, 2020
This is version 132 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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