UniProtKB - Q9Y534 (CSDC2_HUMAN)
Protein
Cold shock domain-containing protein C2
Gene
CSDC2
Organism
Homo sapiens (Human)
Status
Functioni
RNA-binding factor which binds specifically to the very 3'-UTR ends of both histone H1 and H3.3 mRNAs, encompassing the polyadenylation signal. Might play a central role in the negative regulation of histone variant synthesis in the developing brain (By similarity).By similarity
GO - Molecular functioni
- mRNA 3'-UTR binding Source: GO_Central
- RNA binding Source: UniProtKB
- transcription factor binding Source: Ensembl
GO - Biological processi
- mRNA processing Source: UniProtKB-KW
- regulation of mRNA stability Source: GO_Central
Keywordsi
Molecular function | RNA-binding |
Biological process | mRNA processing |
Enzyme and pathway databases
PathwayCommonsi | Q9Y534 |
Names & Taxonomyi
Protein namesi | Recommended name: Cold shock domain-containing protein C2Alternative name(s): RNA-binding protein PIPPin |
Gene namesi | Name:CSDC2 Synonyms:PIPPIN |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000172346.14 |
HGNCi | HGNC:30359, CSDC2 |
MIMi | 617689, gene |
neXtProti | NX_Q9Y534 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 27254 |
OpenTargetsi | ENSG00000172346 |
PharmGKBi | PA142672071 |
Miscellaneous databases
Pharosi | Q9Y534, Tbio |
Polymorphism and mutation databases
BioMutai | CSDC2 |
DMDMi | 32129852 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000100351 | 1 – 153 | Cold shock domain-containing protein C2Add BLAST | 153 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 19 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9Y534 |
MassIVEi | Q9Y534 |
MaxQBi | Q9Y534 |
PaxDbi | Q9Y534 |
PeptideAtlasi | Q9Y534 |
PRIDEi | Q9Y534 |
ProteomicsDBi | 86281 |
PTM databases
iPTMneti | Q9Y534 |
PhosphoSitePlusi | Q9Y534 |
Expressioni
Gene expression databases
Bgeei | ENSG00000172346, Expressed in heart left ventricle and 176 other tissues |
ExpressionAtlasi | Q9Y534, baseline and differential |
Genevisiblei | Q9Y534, HS |
Organism-specific databases
HPAi | ENSG00000172346, Tissue enhanced (heart muscle, ovary) |
Interactioni
Binary interactionsi
Hide detailsQ9Y534
With | #Exp. | IntAct |
---|---|---|
INCA1 [Q0VD86] | 3 | EBI-1763657,EBI-6509505 |
MEOX2 [P50222] | 3 | EBI-1763657,EBI-748397 |
PPP2R1A [A8K7B7] | 5 | EBI-1763657,EBI-10174513 |
PPP2R1A [P30153] | 6 | EBI-1763657,EBI-302388 |
GO - Molecular functioni
- transcription factor binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 118102, 3 interactors |
IntActi | Q9Y534, 5 interactors |
STRINGi | 9606.ENSP00000302485 |
Miscellaneous databases
RNActi | Q9Y534, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 68 – 135 | CSDAdd BLAST | 68 |
Phylogenomic databases
eggNOGi | KOG3070, Eukaryota |
GeneTreei | ENSGT00390000000022 |
HOGENOMi | CLU_139526_1_0_1 |
InParanoidi | Q9Y534 |
OMAi | FKGICKQ |
OrthoDBi | 1560417at2759 |
PhylomeDBi | Q9Y534 |
TreeFami | TF324381 |
Family and domain databases
CDDi | cd04458, CSP_CDS, 1 hit |
InterProi | View protein in InterPro IPR011129, CSD IPR019844, CSD_1 IPR002059, CSP_DNA-bd IPR012340, NA-bd_OB-fold |
Pfami | View protein in Pfam PF00313, CSD, 1 hit |
SMARTi | View protein in SMART SM00357, CSP, 1 hit |
SUPFAMi | SSF50249, SSF50249, 1 hit |
PROSITEi | View protein in PROSITE PS00352, CSD_1, 1 hit PS51857, CSD_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9Y534-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTSESTSPPV VPPLHSPKSP VWPTFPFHRE GSRVWERGGV PPRDLPSPLP
60 70 80 90 100
TKRTRTYSAT ARASAGPVFK GVCKQFSRSQ GHGFITPENG SEDIFVHVSD
110 120 130 140 150
IEGEYVPVEG DEVTYKMCPI PPKNQKFQAV EVVLTQLAPH TPHETWSGQV
VGS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH7C4E7 | H7C4E7_HUMAN | Cold shock domain-containing protei... | CSDC2 | 151 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB027011 mRNA Translation: BAA84704.1 CR456457 mRNA Translation: CAG30343.1 AL834417 mRNA Translation: CAD39079.2 AL023553 Genomic DNA No translation available. BC067113 mRNA Translation: AAH67113.1 |
CCDSi | CCDS14019.1 |
RefSeqi | NP_055275.1, NM_014460.3 |
Genome annotation databases
Ensembli | ENST00000306149; ENSP00000302485; ENSG00000172346 |
GeneIDi | 27254 |
KEGGi | hsa:27254 |
UCSCi | uc003bak.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB027011 mRNA Translation: BAA84704.1 CR456457 mRNA Translation: CAG30343.1 AL834417 mRNA Translation: CAD39079.2 AL023553 Genomic DNA No translation available. BC067113 mRNA Translation: AAH67113.1 |
CCDSi | CCDS14019.1 |
RefSeqi | NP_055275.1, NM_014460.3 |
3D structure databases
SMRi | Q9Y534 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 118102, 3 interactors |
IntActi | Q9Y534, 5 interactors |
STRINGi | 9606.ENSP00000302485 |
PTM databases
iPTMneti | Q9Y534 |
PhosphoSitePlusi | Q9Y534 |
Polymorphism and mutation databases
BioMutai | CSDC2 |
DMDMi | 32129852 |
Proteomic databases
EPDi | Q9Y534 |
MassIVEi | Q9Y534 |
MaxQBi | Q9Y534 |
PaxDbi | Q9Y534 |
PeptideAtlasi | Q9Y534 |
PRIDEi | Q9Y534 |
ProteomicsDBi | 86281 |
Protocols and materials databases
Antibodypediai | 310, 143 antibodies |
DNASUi | 27254 |
Genome annotation databases
Ensembli | ENST00000306149; ENSP00000302485; ENSG00000172346 |
GeneIDi | 27254 |
KEGGi | hsa:27254 |
UCSCi | uc003bak.2, human |
Organism-specific databases
CTDi | 27254 |
DisGeNETi | 27254 |
EuPathDBi | HostDB:ENSG00000172346.14 |
GeneCardsi | CSDC2 |
HGNCi | HGNC:30359, CSDC2 |
HPAi | ENSG00000172346, Tissue enhanced (heart muscle, ovary) |
MIMi | 617689, gene |
neXtProti | NX_Q9Y534 |
OpenTargetsi | ENSG00000172346 |
PharmGKBi | PA142672071 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3070, Eukaryota |
GeneTreei | ENSGT00390000000022 |
HOGENOMi | CLU_139526_1_0_1 |
InParanoidi | Q9Y534 |
OMAi | FKGICKQ |
OrthoDBi | 1560417at2759 |
PhylomeDBi | Q9Y534 |
TreeFami | TF324381 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y534 |
Miscellaneous databases
BioGRID-ORCSi | 27254, 11 hits in 861 CRISPR screens |
ChiTaRSi | CSDC2, human |
GeneWikii | CSDC2 |
GenomeRNAii | 27254 |
Pharosi | Q9Y534, Tbio |
PROi | PR:Q9Y534 |
RNActi | Q9Y534, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000172346, Expressed in heart left ventricle and 176 other tissues |
ExpressionAtlasi | Q9Y534, baseline and differential |
Genevisiblei | Q9Y534, HS |
Family and domain databases
CDDi | cd04458, CSP_CDS, 1 hit |
InterProi | View protein in InterPro IPR011129, CSD IPR019844, CSD_1 IPR002059, CSP_DNA-bd IPR012340, NA-bd_OB-fold |
Pfami | View protein in Pfam PF00313, CSD, 1 hit |
SMARTi | View protein in SMART SM00357, CSP, 1 hit |
SUPFAMi | SSF50249, SSF50249, 1 hit |
PROSITEi | View protein in PROSITE PS00352, CSD_1, 1 hit PS51857, CSD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CSDC2_HUMAN | |
Accessioni | Q9Y534Primary (citable) accession number: Q9Y534 Secondary accession number(s): Q8ND37 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 16, 2003 |
Last sequence update: | November 1, 1999 | |
Last modified: | December 2, 2020 | |
This is version 146 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM