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Protein

Cold shock domain-containing protein C2

Gene

CSDC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA-binding factor which binds specifically to the very 3'-UTR ends of both histone H1 and H3.3 mRNAs, encompassing the polyadenylation signal. Might play a central role in the negative regulation of histone variant synthesis in the developing brain (By similarity).By similarity

GO - Molecular functioni

  • DNA binding Source: InterPro
  • mRNA 3'-UTR binding Source: GO_Central
  • RNA binding Source: UniProtKB
  • transcription factor binding Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Cold shock domain-containing protein C2
Alternative name(s):
RNA-binding protein PIPPin
Gene namesi
Name:CSDC2
Synonyms:PIPPIN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000172346.14
HGNCiHGNC:30359 CSDC2
MIMi617689 gene
neXtProtiNX_Q9Y534

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000172346
PharmGKBiPA142672071

Polymorphism and mutation databases

BioMutaiCSDC2
DMDMi32129852

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001003511 – 153Cold shock domain-containing protein C2Add BLAST153

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y534
MaxQBiQ9Y534
PaxDbiQ9Y534
PeptideAtlasiQ9Y534
PRIDEiQ9Y534
ProteomicsDBi86281

PTM databases

iPTMnetiQ9Y534
PhosphoSitePlusiQ9Y534

Expressioni

Gene expression databases

BgeeiENSG00000172346 Expressed in 161 organ(s), highest expression level in heart left ventricle
CleanExiHS_CSDC2
ExpressionAtlasiQ9Y534 baseline and differential
GenevisibleiQ9Y534 HS

Organism-specific databases

HPAiHPA003073
HPA076549

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi118102, 2 interactors
IntActiQ9Y534, 5 interactors
STRINGi9606.ENSP00000302485

Structurei

3D structure databases

ProteinModelPortaliQ9Y534
SMRiQ9Y534
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 135CSDAdd BLAST68

Phylogenomic databases

eggNOGiKOG3070 Eukaryota
COG1278 LUCA
GeneTreeiENSGT00390000000022
HOGENOMiHOG000059524
HOVERGENiHBG050947
InParanoidiQ9Y534
OMAiWPTFPFQ
OrthoDBiEOG091G0TYX
PhylomeDBiQ9Y534
TreeFamiTF324381

Family and domain databases

CDDicd04458 CSP_CDS, 1 hit
InterProiView protein in InterPro
IPR019844 Cold-shock_CS
IPR011129 CSD
IPR002059 CSP_DNA-bd
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF00313 CSD, 1 hit
SMARTiView protein in SMART
SM00357 CSP, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
PROSITEiView protein in PROSITE
PS00352 CSD_1, 1 hit
PS51857 CSD_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9Y534-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSESTSPPV VPPLHSPKSP VWPTFPFHRE GSRVWERGGV PPRDLPSPLP
60 70 80 90 100
TKRTRTYSAT ARASAGPVFK GVCKQFSRSQ GHGFITPENG SEDIFVHVSD
110 120 130 140 150
IEGEYVPVEG DEVTYKMCPI PPKNQKFQAV EVVLTQLAPH TPHETWSGQV

VGS
Length:153
Mass (Da):16,786
Last modified:November 1, 1999 - v1
Checksum:iF0CB947289356E93
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C4E7H7C4E7_HUMAN
Cold shock domain-containing protei...
CSDC2
151Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB027011 mRNA Translation: BAA84704.1
CR456457 mRNA Translation: CAG30343.1
AL834417 mRNA Translation: CAD39079.2
AL023553 Genomic DNA No translation available.
BC067113 mRNA Translation: AAH67113.1
CCDSiCCDS14019.1
RefSeqiNP_055275.1, NM_014460.3
UniGeneiHs.310893

Genome annotation databases

EnsembliENST00000306149; ENSP00000302485; ENSG00000172346
GeneIDi27254
KEGGihsa:27254
UCSCiuc003bak.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB027011 mRNA Translation: BAA84704.1
CR456457 mRNA Translation: CAG30343.1
AL834417 mRNA Translation: CAD39079.2
AL023553 Genomic DNA No translation available.
BC067113 mRNA Translation: AAH67113.1
CCDSiCCDS14019.1
RefSeqiNP_055275.1, NM_014460.3
UniGeneiHs.310893

3D structure databases

ProteinModelPortaliQ9Y534
SMRiQ9Y534
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118102, 2 interactors
IntActiQ9Y534, 5 interactors
STRINGi9606.ENSP00000302485

PTM databases

iPTMnetiQ9Y534
PhosphoSitePlusiQ9Y534

Polymorphism and mutation databases

BioMutaiCSDC2
DMDMi32129852

Proteomic databases

EPDiQ9Y534
MaxQBiQ9Y534
PaxDbiQ9Y534
PeptideAtlasiQ9Y534
PRIDEiQ9Y534
ProteomicsDBi86281

Protocols and materials databases

DNASUi27254
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306149; ENSP00000302485; ENSG00000172346
GeneIDi27254
KEGGihsa:27254
UCSCiuc003bak.2 human

Organism-specific databases

CTDi27254
EuPathDBiHostDB:ENSG00000172346.14
GeneCardsiCSDC2
HGNCiHGNC:30359 CSDC2
HPAiHPA003073
HPA076549
MIMi617689 gene
neXtProtiNX_Q9Y534
OpenTargetsiENSG00000172346
PharmGKBiPA142672071
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3070 Eukaryota
COG1278 LUCA
GeneTreeiENSGT00390000000022
HOGENOMiHOG000059524
HOVERGENiHBG050947
InParanoidiQ9Y534
OMAiWPTFPFQ
OrthoDBiEOG091G0TYX
PhylomeDBiQ9Y534
TreeFamiTF324381

Miscellaneous databases

GeneWikiiCSDC2
GenomeRNAii27254
PROiPR:Q9Y534
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172346 Expressed in 161 organ(s), highest expression level in heart left ventricle
CleanExiHS_CSDC2
ExpressionAtlasiQ9Y534 baseline and differential
GenevisibleiQ9Y534 HS

Family and domain databases

CDDicd04458 CSP_CDS, 1 hit
InterProiView protein in InterPro
IPR019844 Cold-shock_CS
IPR011129 CSD
IPR002059 CSP_DNA-bd
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF00313 CSD, 1 hit
SMARTiView protein in SMART
SM00357 CSP, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
PROSITEiView protein in PROSITE
PS00352 CSD_1, 1 hit
PS51857 CSD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCSDC2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y534
Secondary accession number(s): Q8ND37
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: November 1, 1999
Last modified: September 12, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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