CSDC2

Functionⁱ

RNA-binding factor which binds specifically to the very 3'-UTR ends of both histone H1 and H3.3 mRNAs, encompassing the polyadenylation signal. Might play a central role in the negative regulation of histone variant synthesis in the developing brain (By similarity).By similarity

GO - Molecular functionⁱ

DNA binding Source: InterPro
mRNA 3'-UTR binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA binding
Source: UniProtKB
Non-traceable author statementⁱ
- 12801884
transcription factor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mRNA processing Source: UniProtKB-KW
regulation of mRNA stability
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of transcription, DNA-templated Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	RNA-binding
Biological process	mRNA processing

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cold shock domain-containing protein C2 Alternative name(s): RNA-binding protein PIPPin
Gene namesⁱ	Name:CSDC2 Synonyms:PIPPIN
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 22

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000172346.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30359 CSDC2
MIMⁱ	617689 gene
neXtProtⁱ	NX_Q9Y534

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000172346
PharmGKBⁱ	PA142672071

Polymorphism and mutation databases

BioMutaⁱ	CSDC2
DMDMⁱ	32129852

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000100351	1 – 153	Cold shock domain-containing protein C2Add BLAST		153

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	19	PhosphoserineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9Y534
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9Y534
PaxDbⁱ	Q9Y534
PeptideAtlas More...PeptideAtlasⁱ	Q9Y534
PRIDEⁱ	Q9Y534
ProteomicsDBⁱ	86281

PTM databases

iPTMnetⁱ	Q9Y534
PhosphoSitePlusⁱ	Q9Y534

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000172346 Expressed in 161 organ(s), highest expression level in heart left ventricle
CleanExⁱ	HS_CSDC2
ExpressionAtlasⁱ	Q9Y534 baseline and differential
Genevisibleⁱ	Q9Y534 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA003073 HPA076549

HPAⁱ

HPA003073
HPA076549

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
MEOX2	P50222	3	EBI-1763657,EBI-748397
PPP2R1A	A8K7B7	5	EBI-1763657,EBI-10174513
PPP2R1A	P30153	4	EBI-1763657,EBI-302388

GO - Molecular functionⁱ

transcription factor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	118102, 2 interactors
IntActⁱ	Q9Y534, 5 interactors
STRINGⁱ	9606.ENSP00000302485

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9Y534
SMRⁱ	Q9Y534
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	68 – 135	CSDAdd BLAST		68

Phylogenomic databases

eggNOGⁱ	KOG3070 Eukaryota COG1278 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000000022
HOGENOMⁱ	HOG000059524
HOVERGENⁱ	HBG050947
InParanoidⁱ	Q9Y534
OMAⁱ	WPTFPFQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0TYX
PhylomeDBⁱ	Q9Y534
TreeFamⁱ	TF324381

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd04458 CSP_CDS, 1 hit
InterProⁱ	View protein in InterPro IPR019844 Cold-shock_CS IPR011129 CSD IPR002059 CSP_DNA-bd IPR012340 NA-bd_OB-fold
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00313 CSD, 1 hit
SMARTⁱ	View protein in SMART SM00357 CSP, 1 hit
SUPFAMⁱ	SSF50249 SSF50249, 1 hit
PROSITEⁱ	View protein in PROSITE PS00352 CSD_1, 1 hit PS51857 CSD_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q9Y534-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTSESTSPPV VPPLHSPKSP VWPTFPFHRE GSRVWERGGV PPRDLPSPLP 
        60         70         80         90        100
TKRTRTYSAT ARASAGPVFK GVCKQFSRSQ GHGFITPENG SEDIFVHVSD 
       110        120        130        140        150
IEGEYVPVEG DEVTYKMCPI PPKNQKFQAV EVVLTQLAPH TPHETWSGQV 

VGS

Length:153

Mass (Da):16,786

Last modified:November 1, 1999 - v1

Checksum:ⁱF0CB947289356E93

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	H7C4E7	H7C4E7_HUMAN		Cold shock domain-containing protei... Cold shock domain-containing protein C2	CSDC2	151	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB027011 mRNA Translation: BAA84704.1 CR456457 mRNA Translation: CAG30343.1 AL834417 mRNA Translation: CAD39079.2 AL023553 Genomic DNA No translation available. BC067113 mRNA Translation: AAH67113.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14019.1
NCBI Reference Sequences More...RefSeqⁱ	NP_055275.1, NM_014460.3
UniGeneⁱ	Hs.310893

Genome annotation databases

Ensemblⁱ	ENST00000306149; ENSP00000302485; ENSG00000172346
GeneIDⁱ	27254
KEGGⁱ	hsa:27254
UCSC genome browser More...UCSCⁱ	uc003bak.2 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Y534	CSDC2 isoform 2		PANTR		153	UniRef100_Q9Y534
CSDC2 isoform 2		PONAB		153
Uncharacterized protein		CERAT		153
Uncharacterized protein		RHIRO		153
Uncharacterized protein		PAPAN		153
+4

Protein	Similar proteins		Species	Score	Length	Source
Q9Y534	Cold shock domain-containing protein C2		RAT		154	UniRef90_Q63430
Cold shock domain-containing protein C2		MOUSE		154
Cold shock domain containing C2		CANLF		159
Cold shock domain-containing protein C2		TUPCH		154
CSDC2 isoform 2		PANTR		153
+58

Protein	Similar proteins		Species	Score	Length	Source
Q9Y534	Cold shock domain-containing protein C2		RAT		154	UniRef50_Q63430
Cold shock domain-containing protein C2		MOUSE		154
Cold shock domain containing C2		CANLF		159
Cold shock domain-containing protein C2		TUPCH		154
cold shock domain-containing protein C2		LEPWE		153
+175

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB027011 mRNA Translation: BAA84704.1 CR456457 mRNA Translation: CAG30343.1 AL834417 mRNA Translation: CAD39079.2 AL023553 Genomic DNA No translation available. BC067113 mRNA Translation: AAH67113.1
CCDSⁱ	CCDS14019.1
RefSeqⁱ	NP_055275.1, NM_014460.3
UniGeneⁱ	Hs.310893

3D structure databases

ProteinModelPortalⁱ	Q9Y534
SMRⁱ	Q9Y534
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	118102, 2 interactors
IntActⁱ	Q9Y534, 5 interactors
STRINGⁱ	9606.ENSP00000302485

PTM databases

iPTMnetⁱ	Q9Y534
PhosphoSitePlusⁱ	Q9Y534

Polymorphism and mutation databases

BioMutaⁱ	CSDC2
DMDMⁱ	32129852

Proteomic databases

EPDⁱ	Q9Y534
MaxQBⁱ	Q9Y534
PaxDbⁱ	Q9Y534
PeptideAtlasⁱ	Q9Y534
PRIDEⁱ	Q9Y534
ProteomicsDBⁱ	86281

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	27254
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000306149; ENSP00000302485; ENSG00000172346
GeneIDⁱ	27254
KEGGⁱ	hsa:27254
UCSCⁱ	uc003bak.2 human

Organism-specific databases

CTDⁱ	27254
EuPathDBⁱ	HostDB:ENSG00000172346.14
GeneCardsⁱ	CSDC2
HGNCⁱ	HGNC:30359 CSDC2
HPAⁱ	HPA003073 HPA076549
MIMⁱ	617689 gene
neXtProtⁱ	NX_Q9Y534
OpenTargetsⁱ	ENSG00000172346
PharmGKBⁱ	PA142672071
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3070 Eukaryota COG1278 LUCA
GeneTreeⁱ	ENSGT00390000000022
HOGENOMⁱ	HOG000059524
HOVERGENⁱ	HBG050947
InParanoidⁱ	Q9Y534
OMAⁱ	WPTFPFQ
OrthoDBⁱ	EOG091G0TYX
PhylomeDBⁱ	Q9Y534
TreeFamⁱ	TF324381

Miscellaneous databases

GeneWikiⁱ	CSDC2
GenomeRNAiⁱ	27254
Protein Ontology More...PROⁱ	PR:Q9Y534
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000172346 Expressed in 161 organ(s), highest expression level in heart left ventricle
CleanExⁱ	HS_CSDC2
ExpressionAtlasⁱ	Q9Y534 baseline and differential
Genevisibleⁱ	Q9Y534 HS

Family and domain databases

CDDⁱ	cd04458 CSP_CDS, 1 hit
InterProⁱ	View protein in InterPro IPR019844 Cold-shock_CS IPR011129 CSD IPR002059 CSP_DNA-bd IPR012340 NA-bd_OB-fold
Pfamⁱ	View protein in Pfam PF00313 CSD, 1 hit
SMARTⁱ	View protein in SMART SM00357 CSP, 1 hit
SUPFAMⁱ	SSF50249 SSF50249, 1 hit
PROSITEⁱ	View protein in PROSITE PS00352 CSD_1, 1 hit PS51857 CSD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CSDC2_HUMAN
Accessionⁱ	Q9Y534Primary (citable) accession number: Q9Y534 Secondary accession number(s): Q8ND37
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 16, 2003
	Last sequence update:	November 1, 1999
	Last modified:	September 12, 2018
	This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM

UniProtKB

UniParc

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UniProtKB - Q9Y534 (CSDC2_HUMAN)

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Cold shock domain-containing protein C2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ