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Protein

Transmembrane protein 184B

Gene

TMEM184B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May activate the MAP kinase signaling pathway.1 Publication

Protein family/group databases

TCDBi2.A.82.1.3 the organic solute transporter (ost) family

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 184B
Alternative name(s):
Putative MAPK-activating protein FM08
Gene namesi
Name:TMEM184B
Synonyms:C22orf5
ORF Names:PSEC0108
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000198792.12
HGNCiHGNC:1310 TMEM184B
neXtProtiNX_Q9Y519

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei40 – 60HelicalSequence analysisAdd BLAST21
Transmembranei84 – 104HelicalSequence analysisAdd BLAST21
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Transmembranei178 – 198HelicalSequence analysisAdd BLAST21
Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Transmembranei249 – 269HelicalSequence analysisAdd BLAST21
Transmembranei290 – 310HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi25829
OpenTargetsiENSG00000198792
PharmGKBiPA162406140

Polymorphism and mutation databases

BioMutaiTMEM184B
DMDMi39932737

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002115551 – 407Transmembrane protein 184BAdd BLAST407

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei388PhosphoserineCombined sources1
Modified residuei402PhosphoserineCombined sources1
Modified residuei403PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y519
MaxQBiQ9Y519
PaxDbiQ9Y519
PeptideAtlasiQ9Y519
PRIDEiQ9Y519
ProteomicsDBi86272

PTM databases

iPTMnetiQ9Y519
PhosphoSitePlusiQ9Y519
SwissPalmiQ9Y519

Expressioni

Gene expression databases

BgeeiENSG00000198792 Expressed in 229 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_TMEM184B
ExpressionAtlasiQ9Y519 baseline and differential
GenevisibleiQ9Y519 HS

Organism-specific databases

HPAiHPA024076

Interactioni

Protein-protein interaction databases

BioGridi117357, 22 interactors
IntActiQ9Y519, 1 interactor
STRINGi9606.ENSP00000354441

Structurei

3D structure databases

ProteinModelPortaliQ9Y519
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM184 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2641 Eukaryota
ENOG410XQ3V LUCA
GeneTreeiENSGT00530000063204
HOVERGENiHBG051270
InParanoidiQ9Y519
OMAiKDIMQDA
OrthoDBiEOG091G07BZ
PhylomeDBiQ9Y519
TreeFamiTF314160

Family and domain databases

InterProiView protein in InterPro
IPR005178 Ostalpha/TMEM184C
PANTHERiPTHR23423 PTHR23423, 1 hit
PfamiView protein in Pfam
PF03619 Solute_trans_a, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9Y519-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTVRGDVLAP DPASPTTAAA SPSVSVIPEG SPTAMEQPVF LMTTAAQAIS
60 70 80 90 100
GFFVWTALLI TCHQIYMHLR CYSCPNEQRY IVRILFIVPI YAFDSWLSLL
110 120 130 140 150
FFTNDQYYVY FGTVRDCYEA LVIYNFLSLC YEYLGGESSI MSEIRGKPIE
160 170 180 190 200
SSCMYGTCCL WGKTYSIGFL RFCKQATLQF CVVKPLMAVS TVVLQAFGKY
210 220 230 240 250
RDGDFDVTSG YLYVTIIYNI SVSLALYALF LFYFATRELL SPYSPVLKFF
260 270 280 290 300
MVKSVIFLSF WQGMLLAILE KCGAIPKIHS ARVSVGEGTV AAGYQDFIIC
310 320 330 340 350
VEMFFAALAL RHAFTYKVYA DKRLDAQGRC APMKSISSSL KETMNPHDIV
360 370 380 390 400
QDAIHNFSPA YQQYTQQSTL EPGPTWRGGA HGLSRSHSLS GARDNEKTLL

LSSDDEF
Length:407
Mass (Da):45,562
Last modified:December 15, 2003 - v2
Checksum:i29FEAB1219A42934
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0J9YYJ3A0A0J9YYJ3_HUMAN
Transmembrane protein 184B
TMEM184B
348Annotation score:
F2Z397F2Z397_HUMAN
Transmembrane protein 184B
TMEM184B
72Annotation score:
F8WCD4F8WCD4_HUMAN
Transmembrane protein 184B
TMEM184B
75Annotation score:

Sequence cautioni

The sequence BAC11607 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB51403 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti218Y → C in BAC11607 (PubMed:16303743).Curated1
Sequence conflicti256I → F in BAC77406 (PubMed:12761501).Curated1
Sequence conflicti366Q → L in BAC11607 (PubMed:16303743).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097053 mRNA Translation: BAC77406.1
CR456413 mRNA Translation: CAG30299.1
BX648345 mRNA Translation: CAH56159.1
AL020993 Genomic DNA No translation available.
AL021977 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60222.1
BC015489 mRNA Translation: AAH15489.2
AL096879 mRNA Translation: CAB51403.1 Different initiation.
AK075417 mRNA Translation: BAC11607.1 Different initiation.
AK292652 mRNA Translation: BAF85341.1
CCDSiCCDS13969.2
RefSeqiNP_001182000.1, NM_001195071.1
NP_001182001.1, NM_001195072.1
NP_036396.2, NM_012264.4
UniGeneiHs.182626

Genome annotation databases

EnsembliENST00000361684; ENSP00000354441; ENSG00000198792
ENST00000361906; ENSP00000355210; ENSG00000198792
GeneIDi25829
KEGGihsa:25829
UCSCiuc003avf.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097053 mRNA Translation: BAC77406.1
CR456413 mRNA Translation: CAG30299.1
BX648345 mRNA Translation: CAH56159.1
AL020993 Genomic DNA No translation available.
AL021977 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60222.1
BC015489 mRNA Translation: AAH15489.2
AL096879 mRNA Translation: CAB51403.1 Different initiation.
AK075417 mRNA Translation: BAC11607.1 Different initiation.
AK292652 mRNA Translation: BAF85341.1
CCDSiCCDS13969.2
RefSeqiNP_001182000.1, NM_001195071.1
NP_001182001.1, NM_001195072.1
NP_036396.2, NM_012264.4
UniGeneiHs.182626

3D structure databases

ProteinModelPortaliQ9Y519
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117357, 22 interactors
IntActiQ9Y519, 1 interactor
STRINGi9606.ENSP00000354441

Protein family/group databases

TCDBi2.A.82.1.3 the organic solute transporter (ost) family

PTM databases

iPTMnetiQ9Y519
PhosphoSitePlusiQ9Y519
SwissPalmiQ9Y519

Polymorphism and mutation databases

BioMutaiTMEM184B
DMDMi39932737

Proteomic databases

EPDiQ9Y519
MaxQBiQ9Y519
PaxDbiQ9Y519
PeptideAtlasiQ9Y519
PRIDEiQ9Y519
ProteomicsDBi86272

Protocols and materials databases

DNASUi25829
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361684; ENSP00000354441; ENSG00000198792
ENST00000361906; ENSP00000355210; ENSG00000198792
GeneIDi25829
KEGGihsa:25829
UCSCiuc003avf.2 human

Organism-specific databases

CTDi25829
DisGeNETi25829
EuPathDBiHostDB:ENSG00000198792.12
GeneCardsiTMEM184B
HGNCiHGNC:1310 TMEM184B
HPAiHPA024076
neXtProtiNX_Q9Y519
OpenTargetsiENSG00000198792
PharmGKBiPA162406140
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2641 Eukaryota
ENOG410XQ3V LUCA
GeneTreeiENSGT00530000063204
HOVERGENiHBG051270
InParanoidiQ9Y519
OMAiKDIMQDA
OrthoDBiEOG091G07BZ
PhylomeDBiQ9Y519
TreeFamiTF314160

Miscellaneous databases

ChiTaRSiTMEM184B human
GeneWikiiTMEM184B
GenomeRNAii25829
PROiPR:Q9Y519

Gene expression databases

BgeeiENSG00000198792 Expressed in 229 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_TMEM184B
ExpressionAtlasiQ9Y519 baseline and differential
GenevisibleiQ9Y519 HS

Family and domain databases

InterProiView protein in InterPro
IPR005178 Ostalpha/TMEM184C
PANTHERiPTHR23423 PTHR23423, 1 hit
PfamiView protein in Pfam
PF03619 Solute_trans_a, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiT184B_HUMAN
AccessioniPrimary (citable) accession number: Q9Y519
Secondary accession number(s): A8K9D7
, Q63HM8, Q7Z421, Q8NBM5, Q9UGT8, Q9UGT9, Q9UGV5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: December 15, 2003
Last modified: November 7, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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