NEUROG3

Functionⁱ

Acts as a transcriptional regulator. Together with NKX2-2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types (By similarity).By similarity

GO - Molecular functionⁱ

chromatin DNA binding Source: UniProtKB
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
protein dimerization activity Source: InterPro
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from direct assayⁱ
- 14576336
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 14576336
transcription coactivator activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

central nervous system development
Source: ProtInc
Traceable author statementⁱ
- 9000438
endocrine pancreas development Source: InterPro
epithelial cell differentiation Source: Ensembl
forebrain development Source: Ensembl
hindbrain development Source: Ensembl
negative regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 14576336
nervous system development
Source: ProtInc
Traceable author statementⁱ
- 9000438
peripheral nervous system development
Source: ProtInc
Traceable author statementⁱ
- 9000438
positive regulation of DNA-binding transcription factor activity Source: UniProtKB
positive regulation of neuron differentiation Source: Ensembl
positive regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 16511571
regulation of dendrite morphogenesis Source: Ensembl
spinal cord development Source: Ensembl
transdifferentiation Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Developmental protein, DNA-binding
Biological process	Differentiation, Neurogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210746 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
SIGNORⁱ	Q9Y4Z2

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Neurogenin-3 Short name: NGN-3 Alternative name(s): Class A basic helix-loop-helix protein 7 Short name: bHLHa7 Protein atonal homolog 5
Gene namesⁱ	Name:NEUROG3 Synonyms:ATOH5, BHLHA7, NGN3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000122859.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13806 NEUROG3
MIMⁱ	604882 gene
neXtProtⁱ	NX_Q9Y4Z2

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Diarrhea 4, malabsorptive, congenital (DIAR4)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disease characterized by severe, life-threatening watery diarrhea associated with generalized malabsorption and a paucity of enteroendocrine cells.

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	50674
MalaCards human disease database More...MalaCardsⁱ	NEUROG3
MIMⁱ	610370 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000122859
Orphanetⁱ	83620 Enteric anendocrinosis
PharmGKBⁱ	PA31571

Polymorphism and mutation databases

BioMutaⁱ	NEUROG3
DMDMⁱ	229462908

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000127402	1 – 214	Neurogenin-3Add BLAST		214

Proteomic databases

PaxDbⁱ	Q9Y4Z2
PRIDEⁱ	Q9Y4Z2
ProteomicsDBⁱ	86268

PTM databases

iPTMnetⁱ	Q9Y4Z2
PhosphoSitePlusⁱ	Q9Y4Z2

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000122859 Expressed in 18 organ(s), highest expression level in Ammon's horn
CleanExⁱ	HS_NEUROG3
Genevisibleⁱ	Q9Y4Z2 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA039785

HPAⁱ

HPA039785

Interactionⁱ

Subunit structureⁱ

Efficient DNA binding requires dimerization with another bHLH protein. Interacts with ATOH8.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
REL	Q04864	3	EBI-10328570,EBI-307352
TCF12	Q99081	3	EBI-10328570,EBI-722877
TCF12	Q99081-3	5	EBI-10328570,EBI-11952764

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	119118, 48 interactors
IntActⁱ	Q9Y4Z2, 4 interactors
STRINGⁱ	9606.ENSP00000242462

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9Y4Z2
SMRⁱ	Q9Y4Z2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	83 – 135	bHLHPROSITE-ProRule annotationAdd BLAST		53

Phylogenomic databases

eggNOGⁱ	KOG3898 Eukaryota ENOG4111U26 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00680000099860
HOGENOMⁱ	HOG000063655
HOVERGENⁱ	HBG031743
InParanoidⁱ	Q9Y4Z2
KEGG Orthology (KO) More...KOⁱ	K08028
OMAⁱ	ADHSFYG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0PNH
PhylomeDBⁱ	Q9Y4Z2
TreeFamⁱ	TF315153

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR032656 Ngn3
PANTHERⁱ	PTHR19290:SF94 PTHR19290:SF94, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9Y4Z2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTPQPSGAPT VQVTRETERS FPRASEDEVT CPTSAPPSPT RTRGNCAEAE 
        60         70         80         90        100
EGGCRGAPRK LRARRGGRSR PKSELALSKQ RRSRRKKAND RERNRMHNLN 
       110        120        130        140        150
SALDALRGVL PTFPDDAKLT KIETLRFAHN YIWALTQTLR IADHSLYALE 
       160        170        180        190        200
PPAPHCGELG SPGGSPGDWG SLYSPVSQAG SLSPAASLEE RPGLLGATFS 
       210 
ACLSPGSLAF SDFL

Length:214

Mass (Da):23,077

Last modified:May 5, 2009 - v2

Checksum:ⁱ2E80623E46F88B83

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	43	R → P in CAB45384 (Ref. 1) Curated	1
Sequence conflictⁱ	98	N → D in CAB45384 (Ref. 1) Curated	1
Sequence conflictⁱ	165	S → P in CAB45384 (Ref. 1) Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_029003	93	R → L in DIAR4; attenuated NEUROG3 function in vivo. 1 PublicationCorresponds to variant dbSNP:rs121917838EnsemblClinVar.	1
Natural variantⁱVAR_029004	107	R → S in DIAR4; attenuated NEUROG3 function in vivo. 1 PublicationCorresponds to variant dbSNP:rs121917837EnsemblClinVar.	1
Natural variantⁱVAR_055316	199	F → S3 PublicationsCorresponds to variant dbSNP:rs4536103EnsemblClinVar.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ133776 Genomic DNA Translation: CAB45384.1 AF234829 Genomic DNA Translation: AAK15022.1 AK313952 mRNA Translation: BAG36669.1 AL450311 Genomic DNA No translation available. CH471083 Genomic DNA Translation: EAW54328.1 BC074938 mRNA Translation: AAH74938.1 BC074939 mRNA Translation: AAH74939.1 BC117488 mRNA Translation: AAI17489.1 BC126468 mRNA Translation: AAI26469.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31212.1
NCBI Reference Sequences More...RefSeqⁱ	NP_066279.2, NM_020999.3 XP_016871769.1, XM_017016280.1
UniGeneⁱ	Hs.532682

Genome annotation databases

Ensemblⁱ	ENST00000242462; ENSP00000242462; ENSG00000122859
GeneIDⁱ	50674
KEGGⁱ	hsa:50674
UCSC genome browser More...UCSCⁱ	uc001jpp.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Y4Z2	Neurogenin 3 (Fragment)		HUMAN		77	UniRef100_Q9Y4Z2

Protein	Similar proteins		Species	Score	Length	Source
Q9Y4Z2	Neurogenin 3 (Fragment)		HUMAN		77	UniRef90_Q9Y4Z2
Uncharacterized protein		MACMU		215
Uncharacterized protein		CHLSB		215
NEUROG3 isoform 1		PANTR		214
Uncharacterized protein		PANPA		214
+12

Protein	Similar proteins		Species	Score	Length	Source
Q9Y4Z2	Neurogenin-3		MOUSE		214	UniRef50_P70661
Neurogenin 3		RAT		214
Uncharacterized protein		OTOGA		215
Uncharacterized protein		SARHA		222
Neurogenin-3		HETGA		215
+105

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ133776 Genomic DNA Translation: CAB45384.1 AF234829 Genomic DNA Translation: AAK15022.1 AK313952 mRNA Translation: BAG36669.1 AL450311 Genomic DNA No translation available. CH471083 Genomic DNA Translation: EAW54328.1 BC074938 mRNA Translation: AAH74938.1 BC074939 mRNA Translation: AAH74939.1 BC117488 mRNA Translation: AAI17489.1 BC126468 mRNA Translation: AAI26469.1
CCDSⁱ	CCDS31212.1
RefSeqⁱ	NP_066279.2, NM_020999.3 XP_016871769.1, XM_017016280.1
UniGeneⁱ	Hs.532682

3D structure databases

ProteinModelPortalⁱ	Q9Y4Z2
SMRⁱ	Q9Y4Z2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119118, 48 interactors
IntActⁱ	Q9Y4Z2, 4 interactors
STRINGⁱ	9606.ENSP00000242462

PTM databases

iPTMnetⁱ	Q9Y4Z2
PhosphoSitePlusⁱ	Q9Y4Z2

Polymorphism and mutation databases

BioMutaⁱ	NEUROG3
DMDMⁱ	229462908

Proteomic databases

PaxDbⁱ	Q9Y4Z2
PRIDEⁱ	Q9Y4Z2
ProteomicsDBⁱ	86268

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	50674
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000242462; ENSP00000242462; ENSG00000122859
GeneIDⁱ	50674
KEGGⁱ	hsa:50674
UCSCⁱ	uc001jpp.4 human

Organism-specific databases

CTDⁱ	50674
DisGeNETⁱ	50674
EuPathDBⁱ	HostDB:ENSG00000122859.4
GeneCardsⁱ	NEUROG3
H-InvDBⁱ	HIX0035408
HGNCⁱ	HGNC:13806 NEUROG3
HPAⁱ	HPA039785
MalaCardsⁱ	NEUROG3
MIMⁱ	604882 gene 610370 phenotype
neXtProtⁱ	NX_Q9Y4Z2
OpenTargetsⁱ	ENSG00000122859
Orphanetⁱ	83620 Enteric anendocrinosis
PharmGKBⁱ	PA31571
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3898 Eukaryota ENOG4111U26 LUCA
GeneTreeⁱ	ENSGT00680000099860
HOGENOMⁱ	HOG000063655
HOVERGENⁱ	HBG031743
InParanoidⁱ	Q9Y4Z2
KOⁱ	K08028
OMAⁱ	ADHSFYG
OrthoDBⁱ	EOG091G0PNH
PhylomeDBⁱ	Q9Y4Z2
TreeFamⁱ	TF315153

Enzyme and pathway databases

Reactomeⁱ	R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210746 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
SIGNORⁱ	Q9Y4Z2

Miscellaneous databases

GeneWikiⁱ	NEUROG3
GenomeRNAiⁱ	50674
Protein Ontology More...PROⁱ	PR:Q9Y4Z2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000122859 Expressed in 18 organ(s), highest expression level in Ammon's horn
CleanExⁱ	HS_NEUROG3
Genevisibleⁱ	Q9Y4Z2 HS

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR032656 Ngn3
PANTHERⁱ	PTHR19290:SF94 PTHR19290:SF94, 1 hit
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NGN3_HUMAN
Accessionⁱ	Q9Y4Z2Primary (citable) accession number: Q9Y4Z2 Secondary accession number(s): Q5VVI0, Q6DJX6, Q9BY24
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 27, 2002
	Last sequence update:	May 5, 2009
	Last modified:	November 7, 2018
	This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9Y4Z2 (NGN3_HUMAN)

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Neurogenin-3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ