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Protein

C-C motif chemokine 27

Gene

CCL27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. Binds to CCR10.

GO - Molecular functioni

  • CCR3 chemokine receptor binding Source: UniProtKB
  • chemokine activity Source: ProtInc

GO - Biological processi

  • antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
  • cell-cell signaling Source: ProtInc
  • chemotaxis Source: ProtInc
  • G-protein coupled receptor signaling pathway Source: Reactome
  • immune response Source: ProtInc
  • killing of cells of other organism Source: UniProtKB

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 27
Alternative name(s):
CC chemokine ILC
Cutaneous T-cell-attracting chemokine
Short name:
CTACK
ESkine
IL-11 R-alpha-locus chemokine
Skinkine
Small-inducible cytokine A27
Gene namesi
Name:CCL27
Synonyms:ILC, SCYA27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000213927.3
HGNCiHGNC:10626 CCL27
MIMi604833 gene
neXtProtiNX_Q9Y4X3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi10850
OpenTargetsiENSG00000213927
PharmGKBiPA35558

Polymorphism and mutation databases

BioMutaiCCL27
DMDMi7674366

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
ChainiPRO_000000523925 – 112C-C motif chemokine 27Add BLAST88

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 621 Publication
Disulfide bondi34 ↔ 771 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9Y4X3
PeptideAtlasiQ9Y4X3
PRIDEiQ9Y4X3
ProteomicsDBi86261

Expressioni

Tissue specificityi

Testis, thymus, placenta, ovary and skin.

Gene expression databases

BgeeiENSG00000213927
CleanExiHS_CCL27
ExpressionAtlasiQ9Y4X3 baseline and differential
GenevisibleiQ9Y4X3 HS

Organism-specific databases

HPAiHPA073848

Interactioni

Subunit structurei

Monomer, dimer, and tetramer. Heparin avidly promotes oligomerization.1 Publication

GO - Molecular functioni

  • CCR3 chemokine receptor binding Source: UniProtKB
  • chemokine activity Source: ProtInc

Protein-protein interaction databases

DIPiDIP-5872N
IntActiQ9Y4X3, 1 interactor
STRINGi9606.ENSP00000259631

Structurei

Secondary structure

1112
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi44 – 47Combined sources4
Beta strandi52 – 56Combined sources5
Turni58 – 61Combined sources4
Beta strandi62 – 64Combined sources3
Beta strandi66 – 71Combined sources6
Beta strandi74 – 78Combined sources5
Helixi83 – 94Combined sources12
Helixi96 – 98Combined sources3
Turni106 – 110Combined sources5

3D structure databases

ProteinModelPortaliQ9Y4X3
SMRiQ9Y4X3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y4X3

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4BK Eukaryota
ENOG41118KC LUCA
GeneTreeiENSGT00530000063923
HOGENOMiHOG000231671
HOVERGENiHBG050833
InParanoidiQ9Y4X3
KOiK16598
OMAiRRSVCIH
OrthoDBiEOG091G0OWP
PhylomeDBiQ9Y4X3
TreeFamiTF337014

Family and domain databases

InterProiView protein in InterPro
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y4X3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGPPTFCSL LLLSLLLSPD PTAAFLLPPS TACCTQLYRK PLSDKLLRKV
60 70 80 90 100
IQVELQEADG DCHLQAFVLH LAQRSICIHP QNPSLSQWFE HQERKLHGTL
110
PKLNFGMLRK MG
Length:112
Mass (Da):12,618
Last modified:November 1, 1999 - v1
Checksum:i7B5940E147ABF820
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02210378I → V. Corresponds to variant dbSNP:rs11575594Ensembl.1
Natural variantiVAR_02210496L → F. Corresponds to variant dbSNP:rs11575584Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010445 mRNA Translation: BAA87046.1
AF082393 mRNA Translation: AAD41238.1
AJ243542 mRNA Translation: CAB46983.1
CCDSiCCDS6569.1
RefSeqiNP_006655.1, NM_006664.3
UniGeneiHs.648124

Genome annotation databases

EnsembliENST00000259631; ENSP00000259631; ENSG00000213927
GeneIDi10850
KEGGihsa:10850
UCSCiuc003zvm.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCCL27_HUMAN
AccessioniPrimary (citable) accession number: Q9Y4X3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: June 20, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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